[go: up one dir, main page]

NO20021974L - Fargemerkede imidazokinolinforbindelser - Google Patents

Fargemerkede imidazokinolinforbindelser

Info

Publication number
NO20021974L
NO20021974L NO20021974A NO20021974A NO20021974L NO 20021974 L NO20021974 L NO 20021974L NO 20021974 A NO20021974 A NO 20021974A NO 20021974 A NO20021974 A NO 20021974A NO 20021974 L NO20021974 L NO 20021974L
Authority
NO
Norway
Prior art keywords
labeled
color
imidazoquinoline compounds
compounds
imidazoquinoline
Prior art date
Application number
NO20021974A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021974D0 (no
Inventor
Ai-Ping Wei
Mark Tomai
Michael J Rice
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of NO20021974D0 publication Critical patent/NO20021974D0/no
Publication of NO20021974L publication Critical patent/NO20021974L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/10—Metal complexes of organic compounds not being dyes in uncomplexed form
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
NO20021974A 1999-11-05 2002-04-25 Fargemerkede imidazokinolinforbindelser NO20021974L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16372499P 1999-11-05 1999-11-05
US09/705,072 US6376669B1 (en) 1999-11-05 2000-11-02 Dye labeled imidazoquinoline compounds
PCT/US2000/030366 WO2001034709A1 (fr) 1999-11-05 2000-11-03 Compose d'imidazoquinoline marques par colorant

Publications (2)

Publication Number Publication Date
NO20021974D0 NO20021974D0 (no) 2002-04-25
NO20021974L true NO20021974L (no) 2002-06-28

Family

ID=22591299

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021974A NO20021974L (no) 1999-11-05 2002-04-25 Fargemerkede imidazokinolinforbindelser

Country Status (12)

Country Link
US (2) US6376669B1 (fr)
EP (1) EP1228147B1 (fr)
JP (1) JP2004500347A (fr)
AT (1) ATE258963T1 (fr)
AU (1) AU1756601A (fr)
CA (1) CA2390163A1 (fr)
DE (1) DE60008133T2 (fr)
DK (1) DK1228147T3 (fr)
ES (1) ES2211650T3 (fr)
NO (1) NO20021974L (fr)
PT (1) PT1228147E (fr)
WO (1) WO2001034709A1 (fr)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576419B1 (en) 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
US5741908A (en) * 1996-06-21 1998-04-21 Minnesota Mining And Manufacturing Company Process for reparing imidazoquinolinamines
UA67760C2 (uk) 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
US6558951B1 (en) * 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
US6573273B1 (en) 1999-06-10 2003-06-03 3M Innovative Properties Company Urea substituted imidazoquinolines
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6756382B2 (en) 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6916925B1 (en) 1999-11-05 2005-07-12 3M Innovative Properties Co. Dye labeled imidazoquinoline compounds
JP3436512B2 (ja) * 1999-12-28 2003-08-11 株式会社デンソー アクセル装置
US6677348B2 (en) 2000-12-08 2004-01-13 3M Innovative Properties Company Aryl ether substituted imidazoquinolines
US6677347B2 (en) * 2000-12-08 2004-01-13 3M Innovative Properties Company Sulfonamido ether substituted imidazoquinolines
US6664265B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US20060142202A1 (en) * 2000-12-08 2006-06-29 3M Innovative Properties Company Compositions and methods for targeted delivery of immune response modifiers
US6545016B1 (en) 2000-12-08 2003-04-08 3M Innovative Properties Company Amide substituted imidazopyridines
US20020107262A1 (en) * 2000-12-08 2002-08-08 3M Innovative Properties Company Substituted imidazopyridines
US6667312B2 (en) * 2000-12-08 2003-12-23 3M Innovative Properties Company Thioether substituted imidazoquinolines
US6660747B2 (en) * 2000-12-08 2003-12-09 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US6660735B2 (en) * 2000-12-08 2003-12-09 3M Innovative Properties Company Urea substituted imidazoquinoline ethers
US6545017B1 (en) 2000-12-08 2003-04-08 3M Innovative Properties Company Urea substituted imidazopyridines
US6525064B1 (en) 2000-12-08 2003-02-25 3M Innovative Properties Company Sulfonamido substituted imidazopyridines
UA74852C2 (en) * 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
US7226928B2 (en) * 2001-06-15 2007-06-05 3M Innovative Properties Company Methods for the treatment of periodontal disease
JP2005501550A (ja) * 2001-08-30 2005-01-20 スリーエム イノベイティブ プロパティズ カンパニー 免疫反応調整剤分子を用いた形質細胞様樹状細胞を成熟させる方法
AU2002343728A1 (en) * 2001-11-16 2003-06-10 3M Innovative Properties Company Methods and compositions related to irm compounds and toll-like receptor pathways
CA2467828C (fr) * 2001-11-29 2011-10-04 3M Innovative Properties Company Formulations pharmaceutiques comprenant un modificateur de reponse immunitaire
CA2365732A1 (fr) * 2001-12-20 2003-06-20 Ibm Canada Limited-Ibm Canada Limitee Etalonnages
US6677349B1 (en) * 2001-12-21 2004-01-13 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US7030129B2 (en) * 2002-02-22 2006-04-18 3M Innovative Properties Company Method of reducing and treating UVB-induced immunosuppression
WO2003103584A2 (fr) * 2002-06-07 2003-12-18 3M Innovative Properties Company Imidazopyridines a substitution ether
KR101088615B1 (ko) 2002-08-15 2011-11-30 쓰리엠 이노베이티브 프로퍼티즈 컴파니 면역자극 조성물 및 면역 반응을 자극하는 방법
WO2004028539A2 (fr) * 2002-09-26 2004-04-08 3M Innovative Properties Company Dimeres 1h-imidazo
WO2004053057A2 (fr) * 2002-12-11 2004-06-24 3M Innovative Properties Company Systemes d'expression genetique et lignees cellulaires de recombinaison
WO2004053452A2 (fr) * 2002-12-11 2004-06-24 3M Innovative Properties Company Analyses relatives a l'activite du recepteur de type toll
MXPA05006740A (es) 2002-12-20 2005-10-05 3M Innovative Properties Co Imidazoquinolinas arilo-sustituidas.
EP2572715A1 (fr) * 2002-12-30 2013-03-27 3M Innovative Properties Company Combinaisons immunostimulantes
US7375180B2 (en) * 2003-02-13 2008-05-20 3M Innovative Properties Company Methods and compositions related to IRM compounds and Toll-like receptor 8
US7485432B2 (en) * 2003-02-27 2009-02-03 3M Innovative Properties Company Selective modulation of TLR-mediated biological activity
EP1601365A4 (fr) 2003-03-04 2009-11-11 3M Innovative Properties Co Traitement prophylactique de la neoplasie epidermique induite par les uv
US7163947B2 (en) * 2003-03-07 2007-01-16 3M Innovative Properties Company 1-Amino 1H-imidazoquinolines
BRPI0408125A (pt) * 2003-03-07 2006-03-01 3M Innovative Properties Co 1-amino 1h-imidazoquinolinas
US7179253B2 (en) 2003-03-13 2007-02-20 3M Innovative Properties Company Method of tattoo removal
CA2518282C (fr) * 2003-03-13 2012-11-06 3M Innovative Properties Company Procedes pour ameliorer la qualite de la peau
US7699057B2 (en) * 2003-03-13 2010-04-20 3M Innovative Properties Company Methods for treating skin lesions
US20040192585A1 (en) * 2003-03-25 2004-09-30 3M Innovative Properties Company Treatment for basal cell carcinoma
US20040265351A1 (en) * 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
JP2006522823A (ja) * 2003-04-10 2006-10-05 スリーエム イノベイティブ プロパティズ カンパニー 免疫反応調節物質化合物の送達
US20040214851A1 (en) * 2003-04-28 2004-10-28 3M Innovative Properties Company Compositions and methods for induction of opioid receptors
AR044466A1 (es) * 2003-06-06 2005-09-14 3M Innovative Properties Co Proceso para la preparacion de imidazo [4,5-c] piridin-4-aminas
WO2004110991A2 (fr) * 2003-06-06 2004-12-23 3M Innovative Properties Company PROCESSUS DE PREPARATION D'IMIDAZO[4,5-c]PYRIDINE-4-AMINES
BRPI0413143A (pt) * 2003-07-31 2006-10-03 3M Innovative Properties Co composições para encapsulação e liberação controlada
AU2004264336B2 (en) * 2003-08-05 2010-12-23 3M Innovative Properties Company Formulations containing an immune response modifier
JP2007502288A (ja) * 2003-08-12 2007-02-08 スリーエム イノベイティブ プロパティズ カンパニー オキシム置換イミダゾ含有化合物
CA2535338C (fr) 2003-08-14 2013-05-28 3M Innovative Properties Company 1h-imidazo(4,5-c)pyridine-4-amines, 1h-imidazo(4,5-c)quinolein n-4-amines et 1h-imidazo(4,5-c)naphthyridine-4-amines substitues comme modificateurs de la reponse immunitaire
US8961477B2 (en) * 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
WO2005018574A2 (fr) * 2003-08-25 2005-03-03 3M Innovative Properties Company Combinaisons et traitements immunostimulatoires
AU2004268625B2 (en) * 2003-08-27 2011-03-31 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
CN1845736A (zh) * 2003-09-02 2006-10-11 3M创新有限公司 治疗粘膜相关病症的方法
CA2537763A1 (fr) * 2003-09-05 2005-03-17 3M Innovative Properties Company Traitement pour le lymphome a cellules b cd5<sp>+</sp>
CA2536530A1 (fr) * 2003-10-01 2005-04-14 Taro Pharmaceuticals U.S.A., Inc. Procede de preparation de 4-amino-1h-imidazo(4,5-c)quinolines et sels d'ajout acides de celles-ci
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
US20090075980A1 (en) * 2003-10-03 2009-03-19 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and Analogs Thereof
ES2584863T3 (es) 2003-10-03 2016-09-29 3M Innovative Properties Company Pirazolopiridinas y análogos de las mismas
WO2005032484A2 (fr) 2003-10-03 2005-04-14 3M Innovative Properties Company Imidazoquinolines a substitution alcoxy
JP2007509987A (ja) * 2003-10-31 2007-04-19 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調節剤化合物による好中球活性化
JP2007511527A (ja) * 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー オキシム置換イミダゾ環化合物
CA2545825A1 (fr) 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitue par hydroxylamine
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
JP2007512349A (ja) * 2003-11-25 2007-05-17 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミンおよびオキシム置換した、イミダゾキノリン、イミダゾピリジン、およびイミダゾナフチリジン
US20050226878A1 (en) * 2003-12-02 2005-10-13 3M Innovative Properties Company Therapeutic combinations and methods including IRM compounds
JP2007513165A (ja) * 2003-12-02 2007-05-24 スリーエム イノベイティブ プロパティズ カンパニー Ｉｒｍ化合物を含む併用薬および治療方法
CA2549216A1 (fr) * 2003-12-04 2005-08-25 3M Innovative Properties Company Ethers cycliques imidazo substitues au sulfone
US7888349B2 (en) * 2003-12-29 2011-02-15 3M Innovative Properties Company Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds
WO2005066170A1 (fr) * 2003-12-29 2005-07-21 3M Innovative Properties Company Imidazoquinolines a substitution arylalcenyle et arylalkynyle
EP1699398A4 (fr) * 2003-12-30 2007-10-17 3M Innovative Properties Co Amelioration de la reponse immunitaire
JP2007517044A (ja) * 2003-12-30 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー イミダゾキノリニル、イミダゾピリジニル、およびイミダゾナフチリジニルスルホンアミド
ES2665342T3 (es) 2004-03-15 2018-04-25 Meda Ab Formulaciones y métodos para modificadores de la respuesta inmune
US8697873B2 (en) * 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US20070166384A1 (en) * 2004-04-09 2007-07-19 Zarraga Isidro Angelo E Methods , composition and preparations for delivery of immune response modifiers
CN101426524A (zh) * 2004-04-28 2009-05-06 3M创新有限公司 用于粘膜接种疫苗的组合物和方法
US20050267145A1 (en) * 2004-05-28 2005-12-01 Merrill Bryon A Treatment for lung cancer
WO2005123079A2 (fr) * 2004-06-14 2005-12-29 3M Innovative Properties Company Imidazopyridines, imidazoquinolines et imidazonaphthyridines a substitution uree
WO2005123080A2 (fr) * 2004-06-15 2005-12-29 3M Innovative Properties Company Imidazoquinolines et imidazonaphthyridines substituees par un heterocyclyle contenant un azote
EP1765348B1 (fr) * 2004-06-18 2016-08-03 3M Innovative Properties Company Imidazoquinolines, imidazopyridines, et imidazonaphthyridines substituees
US7897609B2 (en) * 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) * 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US8541438B2 (en) 2004-06-18 2013-09-24 3M Innovative Properties Company Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
US7915281B2 (en) * 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US20060045886A1 (en) * 2004-08-27 2006-03-02 Kedl Ross M HIV immunostimulatory compositions
CA2578741C (fr) * 2004-09-02 2014-01-14 3M Innovative Properties Company Systemes cycliques 1-alcoxy 1h-imidazo et procedes associes
US20090270443A1 (en) * 2004-09-02 2009-10-29 Doris Stoermer 1-amino imidazo-containing compounds and methods
US8143270B2 (en) 2004-09-02 2012-03-27 3M Innovative Properties Company 2-amino 1H-in-imidazo ring systems and methods
WO2006029223A2 (fr) * 2004-09-08 2006-03-16 Children's Medical Center Corporation Methode de stimulation de la reponse immunitaire chez des nouveau-nes
JP2008515928A (ja) * 2004-10-08 2008-05-15 スリーエム イノベイティブ プロパティズ カンパニー Ｄｎａワクチンのためのアジュバント
US20110070575A1 (en) * 2004-12-08 2011-03-24 Coley Pharmaceutical Group, Inc. Immunomodulatory Compositions, Combinations and Methods
US8080560B2 (en) * 2004-12-17 2011-12-20 3M Innovative Properties Company Immune response modifier formulations containing oleic acid and methods
WO2006073939A2 (fr) * 2004-12-30 2006-07-13 Takeda Pharmaceutical Company Limited 1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphtyridin-4-amine ethanesulfonate et 1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphtyridin-4-amine methanesulfonate
US8436176B2 (en) * 2004-12-30 2013-05-07 Medicis Pharmaceutical Corporation Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine
CA2594674C (fr) 2004-12-30 2016-05-17 3M Innovative Properties Company Composes chiraux [1,2]imidazo[4,5-c] substitues a noyau fusionne
PT1830876E (pt) * 2004-12-30 2015-07-13 Meda Ab Utilização de imiquimod para o tratamento de metástases cutâneas derivadas de um tumor cancerígeno da mama
US7943609B2 (en) * 2004-12-30 2011-05-17 3M Innovative Proprerties Company Chiral fused [1,2]imidazo[4,5-C] ring compounds
EP1844201B1 (fr) * 2005-02-04 2016-08-24 3M Innovative Properties Company Formulations des gel aqueux contenant des modificateurs de reponse immunitaire
ES2475728T3 (es) * 2005-02-09 2014-07-11 3M Innovative Properties Company Tiazoloquinolinas y tiazolonaftiridinas sustituidas con alcoxi
EP1877056A2 (fr) 2005-02-09 2008-01-16 Coley Pharmaceutical Group, Inc. Composes cycliques thiazoloý4,5-c¨a substitution oxime et hydroxylamine et procedes associés
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
CA2597446A1 (fr) * 2005-02-11 2006-08-31 Coley Pharmaceutical Group, Inc. Imidazoquinolines et imidazonaphthyridines substituees
US8846710B2 (en) * 2005-02-23 2014-09-30 3M Innovative Properties Company Method of preferentially inducing the biosynthesis of interferon
US8158794B2 (en) * 2005-02-23 2012-04-17 3M Innovative Properties Company Hydroxyalkyl substituted imidazoquinoline compounds and methods
EP1851224A2 (fr) * 2005-02-23 2007-11-07 3M Innovative Properties Company Imidazoquinolines a substitution hydroxyalkyle
CA2598639A1 (fr) 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Imidazonaphthyridines a substitution hydroxyalkyle
MX2007011112A (es) 2005-03-14 2007-11-07 Graceway Pharmaceuticals Llc Metodo para tratar queratosis actinica.
AU2006232377A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
AU2006232375A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
EP1874345B1 (fr) * 2005-04-25 2012-08-15 3M Innovative Properties Company Compositions immunostimulantes
ZA200803029B (en) * 2005-09-09 2009-02-25 Coley Pharm Group Inc Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
EP1922317A4 (fr) * 2005-09-09 2009-04-15 Coley Pharm Group Inc Derives amide et carbamate de n-{2-ý4-amino-2-(ethoxymethyl)-1h-imidazoý4,5-c¨quinolin-1-yl¨-1,1-dimethylethyl}methanesulfonamide et procedes associes
US8889154B2 (en) 2005-09-15 2014-11-18 Medicis Pharmaceutical Corporation Packaging for 1-(2-methylpropyl)-1H-imidazo[4,5-c] quinolin-4-amine-containing formulation
CA2628131C (fr) * 2005-11-04 2012-03-20 Coley Pharmaceutical Group, Inc. 1h-imidazoquinolines substituees par hydroxy et alcoxy et procedes correspondants
EP1988896A4 (fr) 2006-02-22 2011-07-27 3M Innovative Properties Co Conjugués du modificateur de réponse immune
WO2007106854A2 (fr) * 2006-03-15 2007-09-20 Coley Pharmaceutical Group, Inc. 1h-imidazonaphthyridines hydroxy et alcoxy substituées, et procédés associés
WO2008008432A2 (fr) * 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants
US8178539B2 (en) * 2006-09-06 2012-05-15 3M Innovative Properties Company Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods
US20080149123A1 (en) 2006-12-22 2008-06-26 Mckay William D Particulate material dispensing hairbrush with combination bristles
CA2719544C (fr) 2008-03-24 2018-01-09 4Sc Ag Imidazoquinolines substituees
US20110033515A1 (en) * 2009-08-04 2011-02-10 Rst Implanted Cell Technology Tissue contacting material
PT2606047T (pt) 2010-08-17 2017-04-07 3M Innovative Properties Co Composições, formulações e métodos de um composto lipidado modificador da resposta imunitária
US8728486B2 (en) 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
CN103582496B (zh) 2011-06-03 2016-05-11 3M创新有限公司 具有聚乙二醇链段的异双官能连接基以及由其制成的免疫应答调节剂缀合物
EP2718292B1 (fr) 2011-06-03 2018-03-14 3M Innovative Properties Company Hydrazino 1h-imidazoquinoléine-4-amines et conjugués obtenus à partir de celles-ci
US20130023736A1 (en) 2011-07-21 2013-01-24 Stanley Dale Harpstead Systems for drug delivery and monitoring
PL2844282T3 (pl) 2012-05-04 2019-11-29 Pfizer Antygeny związane z gruczołem krokowym i schematy immunoterapii oparte na szczepionce
SMT202000597T1 (it) 2013-01-07 2021-01-05 Univ Pennsylvania Composizioni e metodi per la cura del linfoma cutaneo cellule t
CR20160214A (es) 2013-11-05 2016-10-11 3M Innovative Properties Co Formulaciones de inyección con base en aceite de sésamo
EP3092256B1 (fr) 2014-01-10 2022-05-18 Birdie Biopharmaceuticals Inc. Composés et compositions pour l'immunothérapie
DK3166976T3 (da) 2014-07-09 2022-04-11 Birdie Biopharmaceuticals Inc Anti-pd-l1-kombinationer til behandling af tumorer
CN105017329B (zh) * 2015-07-23 2017-11-03 北京大学 一类基于三齿阴离子配体的铕配合物发光材料
WO2017059280A1 (fr) 2015-10-02 2017-04-06 The University Of North Carolina At Chapel Hill Nouveaux inhibiteurs de pan-tam et doubles inhibiteurs de mer/axl
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
CN106943597A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-egfr组合
CN106943598A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-her2组合
CN115554406A (zh) 2016-01-07 2023-01-03 博笛生物科技有限公司 用于治疗肿瘤的抗-cd20组合
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
WO2018232725A1 (fr) 2017-06-23 2018-12-27 Birdie Biopharmaceuticals, Inc. Compositions pharmaceutiques
WO2019123178A1 (fr) 2017-12-20 2019-06-27 3M Innovative Properties Company Composés imidazo [4,5-c]quinoléine à substitution amide ayant un groupe de liaison à chaîne ramifiée destinés à être utilisés en tant que modificateur de la réponse immunitaire
MX387358B (es) 2018-02-28 2025-03-18 Pfizer Variantes de il-15 y usos de las mismas
JP7057843B2 (ja) 2018-05-23 2022-04-20 ファイザー・インク ＧＵＣＹ２ｃに特異的な抗体及びその使用
MX2020012539A (es) 2018-05-23 2021-02-16 Pfizer Anticuerpos especificos para cd3 y sus usos.
US20220370606A1 (en) 2018-12-21 2022-11-24 Pfizer Inc. Combination Treatments Of Cancer Comprising A TLR Agonist
AU2020410410A1 (en) 2019-12-17 2022-06-09 Pfizer Inc. Antibodies specific for CD47, PD-L1, and uses thereof
TW202216779A (zh) 2020-07-17 2022-05-01 美商輝瑞股份有限公司 治療性抗體類和彼等之用途
WO2025104289A1 (fr) 2023-11-17 2025-05-22 Medincell S.A. Combinaisons antinéoplasiques

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314941A (en) 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
US3917624A (en) 1972-09-27 1975-11-04 Pfizer Process for producing 2-amino-nicotinonitrile intermediates
ZA848968B (en) 1983-11-18 1986-06-25 Riker Laboratories Inc 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines
IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5238944A (en) 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US5756747A (en) 1989-02-27 1998-05-26 Riker Laboratories, Inc. 1H-imidazo 4,5-c!quinolin-4-amines
US4929624A (en) 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5037986A (en) 1989-03-23 1991-08-06 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo[4,5-c]quinolin-4-amines
US4988815A (en) 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
ES2071340T3 (es) 1990-10-05 1995-06-16 Minnesota Mining & Mfg Procedimiento para la preparacion de imidazo(4,5-c)quinolin-4-aminas.
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5175296A (en) 1991-03-01 1992-12-29 Minnesota Mining And Manufacturing Company Imidazo[4,5-c]quinolin-4-amines and processes for their preparation
US5389640A (en) 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5268376A (en) 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5266575A (en) 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
DE4222254A1 (de) * 1992-07-07 1994-01-13 Bayer Ag Fotochemische Markierung von Nukleinsäuren mit Digoxigenin-Reagenzien und ihre Verwendung in Gensondentestsystemen
DE4239430A1 (de) * 1992-11-24 1994-05-26 Merck Patent Gmbh Mittel und Verfahren zur immunoloigschen Bestimmung von Amiodaron und dessen Metaboliten
US5395937A (en) 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
DK0708772T3 (da) 1993-07-15 2000-09-18 Minnesota Mining & Mfg Imidazo[4,5,-c]pyridin-4-aminer
US5352784A (en) 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
US5648516A (en) 1994-07-20 1997-07-15 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
US5644063A (en) 1994-09-08 1997-07-01 Minnesota Mining And Manufacturing Company Imidazo[4,5-c]pyridin-4-amine intermediates
US5482936A (en) 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
US5585612A (en) 1995-03-20 1996-12-17 Harp Enterprises, Inc. Method and apparatus for voting
JPH09208584A (ja) 1996-01-29 1997-08-12 Terumo Corp アミド誘導体、およびそれを含有する医薬製剤、および合成中間体
US5693811A (en) 1996-06-21 1997-12-02 Minnesota Mining And Manufacturing Company Process for preparing tetrahdroimidazoquinolinamines
US5741908A (en) 1996-06-21 1998-04-21 Minnesota Mining And Manufacturing Company Process for reparing imidazoquinolinamines
WO1998015564A1 (fr) * 1996-10-08 1998-04-16 Kreatech Biotechnology B.V. Procedes de marquage de nucleotides, nucleotides marques et intermediaires utiles
KR100518903B1 (ko) 1996-10-25 2005-10-06 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 Ｔｈ2 매개 질병 및 관련 질병의 치료용 면역 반응 조절 화합물
US5939090A (en) 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
US6069149A (en) 1997-01-09 2000-05-30 Terumo Kabushiki Kaisha Amide derivatives and intermediates for the synthesis thereof
WO1999024452A2 (fr) * 1997-11-07 1999-05-20 Isis Pharmaceuticals, Inc. Derives de pyrimidine pour partenaires de liaison marques
UA67760C2 (uk) 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
JPH11255926A (ja) 1998-03-13 1999-09-21 Toray Ind Inc シリコーン成型品およびその製造方法
US6110929A (en) 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
JP2000119271A (ja) 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6451810B1 (en) 1999-06-10 2002-09-17 3M Innovative Properties Company Amide substituted imidazoquinolines

Also Published As

Publication number Publication date
ES2211650T3 (es) 2004-07-16
WO2001034709A1 (fr) 2001-05-17
ATE258963T1 (de) 2004-02-15
EP1228147B1 (fr) 2004-02-04
CA2390163A1 (fr) 2001-05-17
JP2004500347A (ja) 2004-01-08
NO20021974D0 (no) 2002-04-25
AU1756601A (en) 2001-06-06
US6376669B1 (en) 2002-04-23
DE60008133T2 (de) 2004-09-16
PT1228147E (pt) 2004-05-31
DK1228147T3 (da) 2004-05-10
EP1228147A1 (fr) 2002-08-07
DE60008133D1 (de) 2004-03-11
US6630588B2 (en) 2003-10-07
US20020120141A1 (en) 2002-08-29

Similar Documents

Publication Publication Date Title
DK1228147T3 (da) Farvemærkede imidazoquinolinforbindelser
TR200102029T2 (tr) 1-Heterosiklil ikameli diarilaminler.
DE69809758D1 (de) Indol verbindungen als cox-2 inhibitoren
NO20015272L (no) Glukokortikoid reseptor modulatorer
EE9900359A (et) Diasendatud bitsüklilised heterotsüklid, nende valmistamine ja kasutamine ravimitena
PL331091A1 (en) Therapeutic multispecific compounds encompassing antibodies against the fcalpha receptor
ATE264863T1 (de) 28-epirapaloge
ATE359275T1 (de) Substituierte bizyclische derivate verwendbar als antitumor mittel
DE69943352D1 (de) Azabicycloalkane als ccr5-modulatoren
DZ3191A1 (fr) Composés d&#39;indazole et compositions pharmaceutiques inhibant les protéines kinases, et procédés d&#39;utilisation de ceux-ci.
ATE216999T1 (de) Pyrimidin-4-on derivate als pestizidesmittel
TR199801255T2 (xx) Vitronektin resept�r antagonistleri.
DK0918774T3 (da) Androgenreceptormodulatorforbindelser og fremgangsmåder
ATE349440T1 (de) Als antikrebsmittel verwendbare heterocyklische derivate
TR200100922T2 (tr) Aktif maddelerin akciğerler yolu ile tatbik edilmesi.
ATE273956T1 (de) Arylsubstituierte olefinische amine und ihre verwendung als cholinergische rezeptoragonisten
NO20013456D0 (no) Funksjonaliserte heterocykler som chemokin-reseptor- modulatorer
DE60009888T2 (de) Substituierte 3-cyano-[1.7], [1.5] und [1.8]naphthyridininhibitoren von tyrosin kinasen
DE69814894D1 (de) Isochinolin derivate als urokinase inhibitoren
ATE203519T1 (de) Chinolinderivate als antimalariamittel
ATE267012T1 (de) Tetrahydro-beta carbolinverbindungen
FI991268L (fi) Lähetin-vastaanottimen testaus
DE60026350D1 (de) Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel
TR199800152T1 (xx) Endotelin Resept�r Antagonistleri
ATE395935T1 (de) An der oberfläche von karzinomzellen lokalisiertes colligin/hsp47

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application