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NO20014728L - Derivater av pyrimido[6,1-a]isokinolin-4-on - Google Patents

Derivater av pyrimido[6,1-a]isokinolin-4-on

Info

Publication number
NO20014728L
NO20014728L NO20014728A NO20014728A NO20014728L NO 20014728 L NO20014728 L NO 20014728L NO 20014728 A NO20014728 A NO 20014728A NO 20014728 A NO20014728 A NO 20014728A NO 20014728 L NO20014728 L NO 20014728L
Authority
NO
Norway
Prior art keywords
pyrimido
isoquinolin
derivatives
relates
isoenzymes
Prior art date
Application number
NO20014728A
Other languages
English (en)
Other versions
NO20014728D0 (no
Inventor
Alexander William Oxford
David Jack
Original Assignee
Vernalis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9907454.4A external-priority patent/GB9907454D0/en
Priority claimed from GBGB9909802.2A external-priority patent/GB9909802D0/en
Application filed by Vernalis Ltd filed Critical Vernalis Ltd
Publication of NO20014728D0 publication Critical patent/NO20014728D0/no
Publication of NO20014728L publication Critical patent/NO20014728L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
NO20014728A 1999-03-31 2001-09-28 Derivater av pyrimido[6,1-a]isokinolin-4-on NO20014728L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9907454.4A GB9907454D0 (en) 1999-03-31 1999-03-31 Compounds
GBGB9909802.2A GB9909802D0 (en) 1999-04-28 1999-04-28 Compounds
PCT/GB2000/001193 WO2000058308A1 (en) 1999-03-31 2000-03-29 DERIVATIVES OF PYRIMIDO[6,1-a]ISOQUINOLIN-4-ONE

Publications (2)

Publication Number Publication Date
NO20014728D0 NO20014728D0 (no) 2001-09-28
NO20014728L true NO20014728L (no) 2001-11-23

Family

ID=26315369

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014728A NO20014728L (no) 1999-03-31 2001-09-28 Derivater av pyrimido[6,1-a]isokinolin-4-on

Country Status (16)

Country Link
US (5) US6794391B2 (no)
EP (1) EP1165558B1 (no)
JP (1) JP4685243B2 (no)
CN (1) CN100415743C (no)
AT (1) ATE250602T1 (no)
AU (1) AU773504B2 (no)
BR (1) BRPI0009446B8 (no)
CA (1) CA2368413C (no)
DE (1) DE60005493T2 (no)
DK (1) DK1165558T3 (no)
ES (1) ES2208310T3 (no)
MX (1) MXPA01009846A (no)
NO (1) NO20014728L (no)
NZ (1) NZ514158A (no)
PT (1) PT1165558E (no)
WO (1) WO2000058308A1 (no)

Families Citing this family (42)

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EP1165558B1 (en) * 1999-03-31 2003-09-24 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one
EP1898894A1 (en) * 2005-06-17 2008-03-19 Boehringer Ingelheim International GmbH Mrp iv inhibitors for the treatment of respiratory diseases
EP2138495A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
PH12013500261A1 (en) * 2010-08-09 2013-03-04 Verona Pharma Plc Crystalline form of pyrimidio[6,1-a]isoquinolin-4-one compound
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
PT2968313T (pt) 2013-03-15 2018-02-21 Verona Pharma Plc Combinação de fármacos
SI3231444T1 (sl) 2014-05-12 2020-04-30 Verona Pharma Plc Novo zdravljenje
DK3494962T3 (da) 2014-09-15 2021-06-21 Verona Pharma Plc Flydende inhalationsformulering omfattende RPL554
GB201502260D0 (en) 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
PL3822272T4 (pl) * 2018-07-13 2025-07-28 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Skondensowane związki tri-cykliczne jako podwójny inhibitor pde3/pde4
GB2578093B (en) 2018-10-09 2020-11-18 Verona Pharma Plc Liquid pharmaceutical composition comprising RPL554 and HFA-134A
GB201911517D0 (en) 2019-08-12 2019-09-25 Verona Pharma Plc Pharmaceutical composition
DK4092022T3 (da) * 2020-01-15 2025-12-01 Chia Tai Tianqing Pharmaceutical Group Co Ltd Kristal af pde3/pde4-dualhæmmer og anvendelse deraf
ES2995084T3 (en) 2020-01-15 2025-02-05 Chia Tai Tianqing Pharmaceutical Group Co Ltd Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound
GB202002786D0 (en) 2020-02-27 2020-04-15 Verona Pharma Plc Liquid pharmaceutical composition
GB2594480A (en) * 2020-04-28 2021-11-03 Verona Pharma Plc New treatment
JP2024517583A (ja) 2021-04-29 2024-04-23 ▲蘇▼州盛迪▲亞▼生物医▲薬▼有限公司 イソキノリノン系化合物及びその用途
EP4423085A1 (en) 2021-10-29 2024-09-04 Teva Pharmaceuticals International GmbH Solid state forms of ensifentrine and process for preparation thereof
WO2023109802A1 (zh) * 2021-12-14 2023-06-22 海思科医药集团股份有限公司 三环稠杂环类pde3/4双重抑制及其用途
WO2023138676A1 (zh) 2022-01-21 2023-07-27 四川海思科制药有限公司 三环稠杂环类pde3/4双重抑制及其用途
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
KR20250048092A (ko) 2022-08-08 2025-04-07 베로나 파마 피엘씨 만성 폐쇄성 폐질환 악화 빈도 및/또는 중증도 감소를 위한 엔시펜트린(rpl-554)
WO2024033627A1 (en) 2022-08-08 2024-02-15 Verona Pharma Plc Liquid pharmaceutical composition
JP2025535129A (ja) 2022-10-20 2025-10-22 ヴェローナ ファーマ ピーエルシー エンシフェントリンでの特発性肺線維症の治療
JP2025534762A (ja) * 2022-10-28 2025-10-17 江蘇恒瑞医薬股▲ふん▼有限公司 イソキノリノン系化合物を含む医薬組成物及びその調製方法
CN120077043A (zh) * 2022-10-28 2025-05-30 江苏恒瑞医药股份有限公司 一种异喹啉酮类化合物的晶型及其制备方法
EP4378942A1 (en) 2022-12-02 2024-06-05 Sandoz AG Crystal form of a pde3/4 inhibitor
WO2024127413A1 (en) * 2022-12-14 2024-06-20 Cipla Limited Solid state forms of ensifentrine
GB202306663D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Combination therapy
TW202506117A (zh) 2023-06-26 2025-02-16 英商維羅納製藥Ｐｌｃ公司 顆粒組成物
WO2025003643A1 (en) 2023-06-26 2025-01-02 Verona Pharma Plc Particulate composition comprising ensifetrine
CN118955496A (zh) * 2023-06-28 2024-11-15 郑州德迈药业有限公司 一种化合物及其应用
US20250073240A1 (en) 2023-09-06 2025-03-06 Verona Pharma Plc New treatment
WO2025093848A1 (en) 2023-11-01 2025-05-08 Verona Pharma Plc Ensifentrine for treating bronchiectasis
WO2025124462A1 (zh) * 2023-12-13 2025-06-19 石家庄以岭药业股份有限公司 三环稠杂环类pde3/4双重抑制剂及其制备方法与应用
CN120136868A (zh) * 2023-12-13 2025-06-13 石家庄以岭药业股份有限公司 三环稠杂环类pde3/4双重抑制剂及其制备方法与应用
CN120136869A (zh) * 2023-12-13 2025-06-13 石家庄以岭药业股份有限公司 三环稠杂环类pde3/4双重抑制剂及其制备方法与应用
WO2025168546A1 (en) 2024-02-05 2025-08-14 Verona Pharma Plc Ensifentrine for the treatment of copd
WO2025168706A1 (en) 2024-02-07 2025-08-14 Verona Pharma Plc Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease
US20250249008A1 (en) 2024-02-07 2025-08-07 Verona Pharma Plc Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease
WO2025176871A1 (en) 2024-02-23 2025-08-28 Inke, S.A. Process for preparing pyrimido[6,1-a]isoquinoline-4-ones

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ185900A (en) * 1976-12-10 1981-04-24 Hoechst Ag Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US4254121A (en) * 1979-08-13 1981-03-03 Ayerst, Mckenna & Harrison Inc. 3-Oxo-5H-pyrimido[2,1-c][1,4 ]benzoxazines
US4307092A (en) * 1979-08-13 1981-12-22 Ayerst Mckenna & Harrison, Inc. 1-Oxo-5H-pyrimido[2,1-C]benzoxazine-2-carboxylic acid esters
US4254118A (en) * 1979-08-13 1981-03-03 Ayerst, Mckenna & Harrison Inc. 1-Oxo-5H-pyrimido[2,1-c][1,4]benzthiazine-2-carboxylic acid esters
CA1237429A (en) * 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
DE3816995A1 (de) * 1988-05-19 1989-11-23 Hoechst Ag Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen
US5728705A (en) * 1993-10-04 1998-03-17 The Trustees Of Columbia University In The City Of New York Method of inducing vasorelaxation to treat pulmonary hypertension
DE4430128A1 (de) * 1994-08-25 1996-02-29 Hoechst Ag Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen
US5665737B1 (en) * 1994-10-12 1999-02-16 Euro Celtique Sa Substituted benzoxazoles
JPH10287655A (ja) * 1997-04-10 1998-10-27 Kaken Pharmaceut Co Ltd ピラゾール誘導体
EP1165558B1 (en) * 1999-03-31 2003-09-24 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one

Also Published As

Publication number Publication date
CN100415743C (zh) 2008-09-03
NZ514158A (en) 2000-03-29
US20120302533A1 (en) 2012-11-29
US8242127B2 (en) 2012-08-14
MXPA01009846A (es) 2003-06-24
BRPI0009446B8 (pt) 2021-05-25
US7105663B2 (en) 2006-09-12
US20040171828A1 (en) 2004-09-02
EP1165558A1 (en) 2002-01-02
JP2002540207A (ja) 2002-11-26
JP4685243B2 (ja) 2011-05-18
DE60005493D1 (de) 2003-10-30
BRPI0009446B1 (pt) 2016-11-01
AU773504B2 (en) 2004-05-27
WO2000058308A1 (en) 2000-10-05
EP1165558B1 (en) 2003-09-24
DE60005493T2 (de) 2004-07-01
BR0009446A (pt) 2002-01-15
CA2368413C (en) 2008-07-29
CN1348453A (zh) 2002-05-08
DK1165558T3 (da) 2004-02-09
US6794391B2 (en) 2004-09-21
NO20014728D0 (no) 2001-09-28
CA2368413A1 (en) 2000-10-05
AU4127400A (en) 2000-10-16
US7378424B2 (en) 2008-05-27
US20080206163A1 (en) 2008-08-28
US20040176353A1 (en) 2004-09-09
PT1165558E (pt) 2004-02-27
ES2208310T3 (es) 2004-06-16
US20030036542A1 (en) 2003-02-20
ATE250602T1 (de) 2003-10-15

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application