NO127425B

NO127425B -

Info

Publication number: NO127425B
Application number: NO00168765A
Authority: NO
Inventors: Andrew Oakley Dubois
Original assignee: Libbey Owens Ford Glass Co
Priority date: 1966-07-13
Filing date: 1967-06-27
Publication date: 1973-06-18
Also published as: NL6709464A; BE701306A; US3360600A; CH463232A; DE1621203A1; ES342858A1; AT294511B; DE1621203B2; SE335269B; LU53955A1; GB1151126A

Description

Fremgangsmåte for fremstilling av injiserbare oppløsninger av bidronningforsaft. Process for the production of injectable solutions of queen bee sap.

Det er tidligere kjent at bidronningforsaft administret oralt eller perkutant It is previously known that queen bee juice is administered orally or percutaneously

har en utmerket roborerende virkning på has an excellent roboring effect on

almentilstanden, henholdsvis på den be-handlede hud, særlig hos aldrende men-nesker. Det var hittil ikke mulig klinisk å the general condition, respectively on the treated skin, especially in aging people. It was not possible until now clinically to

fastlegge virkningen av bidronningforsaften på den menneskelige organisme enty-dig, og likeså litt kunne man forhindre determine the effect of the queen bee juice on the human organism unequivocally, and just as little could be prevented

opptreden av ikke ønskede bivirkninger ved appearance of unwanted side effects by

behandlingen. the treatment.

Nærværende oppfinnelse angår nå en The present invention now relates to a

fremgangsmåte for fremstilling av injiserbare oppløsninger av bidronningforsaft, method for producing injectable solutions of queen bee juice,

ved hvilken det er blitt mulig å fastlegge by which it has become possible to determine

virkningen vesentlig mere eksakt og ut-preget, og samtidig unngå at ikke ønskede the effect significantly more exact and distinct, and at the same time avoid that you did not want

bivirkninger opptrer. side effects occur.

Oppfinnelsen består i at bidronningforsaft behandles så lenge med vann, inntil størstedelen av det virksomme stoff er The invention consists in treating bee sap for a long time with water, until the majority of the active substance is

gått i oppløsning, og felles ut fra oppløs-ningen og skilles fra de eggehviteholdige dissolved, and precipitated from the solution and separated from those containing egg whites

stoffer ved opphetning eller ved tilsetning substances by heating or by addition

av organiske oppløsningsmidler. Etter fore-liggende oppfinnelse kan man ryste bidronningforsaften med destillert vann i of organic solvents. According to the present invention, the queen bee juice can be shaken with distilled water in it

flere timer, derpå oppvarmes langsomt under stadig omrøring til 90°, ved hvilken several hours, then slowly heated with constant stirring to 90°, at which

temperatur væsken holdes 2—30 minutter temperature the liquid is kept for 2-30 minutes

under omrøring. De virksomme stoffer har while stirring. The active substances have

ved denne behandling spaltet seg fra egge-hvitemolekylene og foreligger nå i vandig by this treatment split from the egg-white molecules and is now present in water

oppløsning, som kan filtreres fra og fylles solution, which can be filtered from and filled

i ampuller. in ampoules.

Etter en ytterligere utformning av After a further design of

fremgangsmåten kan man også koke opp the method can also be boiled

Claims

the queen bee sap in isotonic saline solution and then digest for 24 hours with constant stirring. The solution is filtered and filled into ampoules. Finally, you can also prepare an aqueous slurry of queen bee sap, make this homogeneous and slowly add an organic solvent to it, such as acetone or a lower alcohol. After the precipitate has settled, additional solvent is added to the above clear solution until no further clouding occurs. The solution is then filtered from the undissolved and the solvent is distilled off in a vacuum. The solution is then brought to the desired concentration and filled into ampoules.

1. Process for the production of injectable solutions of queen bee juice, characterized in that the queen bee juice is treated with water until most of the active substance has dissolved, and that the substances containing egg white are precipitated and separated from the solution by heating or by adding organic solvents.

2. Method according to claim 1, characterized in that the queen bee sap is shaken for several hours with distilled water, then heated with constant stirring to 90°, kept at this temperature with stirring for 2-30 minutes and then filtered.

3. Method according to claim 1, characterized in that queen bee juice is boiled in isotonic saline solution and digested for 24 hours with constant stirring, after which the solution is filtered. Method according to claim 1, characterized in that queen bee sap is slurried in distilled water, an organic solvent such as a lower alcohol or acetone is added while stirring, the precipitate is allowed to settle, after which the above clear solution is added to the more solvent until further clouding no longer occurs, after which the solvent, after filtering off the precipitate, is distilled off in a vacuum and the solution is brought to the desired concentration.