NL2004200C2 - Use of sialyl oligosaccharides in weight management. - Google Patents

Use of sialyl oligosaccharides in weight management. Download PDF

Info

Publication number: NL2004200C2
Authority: NL; Netherlands
Prior art keywords: sialyl; bacteroides; composition; disialyllacto; sialyllacto
Prior art date: 2010-02-05

Application number

NL2004200A

Other languages

English (en)

Dutch (nl)

Inventor

Arjen Nauta

Ruprecht Jules Joost Neerven

Hermiena Christina Schoterman

Original Assignee

Friesland Brands Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-02-05

Filing date

2010-02-05

Publication date

2011-08-08

2010-02-05 Application filed by Friesland Brands Bv filed Critical Friesland Brands Bv

2010-02-05 Priority to NL2004200A priority Critical patent/NL2004200C2/en

2011-02-04 Priority to PCT/NL2011/050078 priority patent/WO2011096808A1/fr

2011-08-08 Application granted granted Critical

2011-08-08 Publication of NL2004200C2 publication Critical patent/NL2004200C2/en

Links

229920001542 oligosaccharide Polymers 0.000 title claims description 46
-1 sialyl oligosaccharides Chemical class 0.000 title claims description 27
230000037221 weight management Effects 0.000 title description 4
239000000203 mixture Substances 0.000 claims description 69
235000013350 formula milk Nutrition 0.000 claims description 48
241000606125 Bacteroides Species 0.000 claims description 47
235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 32
150000003271 galactooligosaccharides Chemical class 0.000 claims description 32
235000013406 prebiotics Nutrition 0.000 claims description 25
210000001035 gastrointestinal tract Anatomy 0.000 claims description 22
150000002482 oligosaccharides Chemical class 0.000 claims description 21
235000016709 nutrition Nutrition 0.000 claims description 20
208000008589 Obesity Diseases 0.000 claims description 13
235000013336 milk Nutrition 0.000 claims description 13
239000008267 milk Substances 0.000 claims description 13
210000004080 milk Anatomy 0.000 claims description 13
235000020824 obesity Nutrition 0.000 claims description 13
108010046377 Whey Proteins Proteins 0.000 claims description 12
TYALNJQZQRNQNQ-UHFFFAOYSA-N #alpha;2,6-sialyllactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OCC1C(O)C(O)C(O)C(OC2C(C(O)C(O)OC2CO)O)O1 TYALNJQZQRNQNQ-UHFFFAOYSA-N 0.000 claims description 11
206010033307 Overweight Diseases 0.000 claims description 11
TYALNJQZQRNQNQ-JLYOMPFMSA-N alpha-Neup5Ac-(2->6)-beta-D-Galp-(1->4)-beta-D-Glcp Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O1 TYALNJQZQRNQNQ-JLYOMPFMSA-N 0.000 claims description 11
CILYIEBUXJIHCO-UHFFFAOYSA-N 102778-91-6 Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC2C(C(O)C(O)OC2CO)O)OC(CO)C1O CILYIEBUXJIHCO-UHFFFAOYSA-N 0.000 claims description 10
DVGKRPYUFRZAQW-UHFFFAOYSA-N 3 prime Natural products CC(=O)NC1OC(CC(O)C1C(O)C(O)CO)(OC2C(O)C(CO)OC(OC3C(O)C(O)C(O)OC3CO)C2O)C(=O)O DVGKRPYUFRZAQW-UHFFFAOYSA-N 0.000 claims description 10
CILYIEBUXJIHCO-UITFWXMXSA-N N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O[C@H](CO)[C@@H]1O CILYIEBUXJIHCO-UITFWXMXSA-N 0.000 claims description 10
OIZGSVFYNBZVIK-UHFFFAOYSA-N N-acetylneuraminosyl-D-lactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1O OIZGSVFYNBZVIK-UHFFFAOYSA-N 0.000 claims description 10
239000005862 Whey Substances 0.000 claims description 10
102000007544 Whey Proteins Human genes 0.000 claims description 10
150000001720 carbohydrates Chemical class 0.000 claims description 9
235000005911 diet Nutrition 0.000 claims description 9
239000008194 pharmaceutical composition Substances 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 9
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 7
241000606124 Bacteroides fragilis Species 0.000 claims description 6
241000606123 Bacteroides thetaiotaomicron Species 0.000 claims description 6
241000606215 Bacteroides vulgatus Species 0.000 claims description 6
102000011632 Caseins Human genes 0.000 claims description 6
108010076119 Caseins Proteins 0.000 claims description 6
241001465754 Metazoa Species 0.000 claims description 6
SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 6
230000000378 dietary effect Effects 0.000 claims description 6
SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims description 6
241001135228 Bacteroides ovatus Species 0.000 claims description 5
239000005018 casein Substances 0.000 claims description 5
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 5
235000021240 caseins Nutrition 0.000 claims description 5
239000002773 nucleotide Substances 0.000 claims description 5
125000003729 nucleotide group Chemical group 0.000 claims description 5
239000002417 nutraceutical Substances 0.000 claims description 4
235000021436 nutraceutical agent Nutrition 0.000 claims description 4
235000020209 toddler milk formula Nutrition 0.000 claims description 4
MKNNYTWMAUAKMA-FHHHURIISA-N (2s,4s,5r,6r)-5-acetamido-2-[(2s,3r,4s,5s,6r)-2-[(2r,3s,4r,5r)-5-amino-1,2,4-trihydroxy-6-oxohexan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1r,2r)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](N)C=O)O[C@H](CO)[C@@H]1O MKNNYTWMAUAKMA-FHHHURIISA-N 0.000 claims description 3
LAQPKDLYOBZWBT-NYLDSJSYSA-N (2s,4s,5r,6r)-5-acetamido-2-{[(2s,3r,4s,5s,6r)-2-{[(2r,3r,4r,5r)-5-acetamido-1,2-dihydroxy-6-oxo-4-{[(2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1r,2r)-1,2,3-trihydrox Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@@H](NC(C)=O)C=O)[C@@H]([C@H](O)CO)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 LAQPKDLYOBZWBT-NYLDSJSYSA-N 0.000 claims description 3
MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 3
FNCPZGGSTQEGGK-DRSOAOOLSA-N 3'-Sialyl-3-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@@H](O)C=O)[C@@H]([C@H](O)CO)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 FNCPZGGSTQEGGK-DRSOAOOLSA-N 0.000 claims description 3
INZOTETZQBPBCE-NYLDSJSYSA-N 3-sialyl lewis Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@H](O)CO)[C@@H]([C@@H](NC(C)=O)C=O)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 INZOTETZQBPBCE-NYLDSJSYSA-N 0.000 claims description 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
102000003886 Glycoproteins Human genes 0.000 claims description 3
108090000288 Glycoproteins Proteins 0.000 claims description 3
102000010445 Lactoferrin Human genes 0.000 claims description 3
108010063045 Lactoferrin Proteins 0.000 claims description 3
241000606210 Parabacteroides distasonis Species 0.000 claims description 3
SXMGGNXBTZBGLU-IBUUTZGMSA-N Sialyllacto-N-neotetraose c Chemical compound O([C@H]([C@@H]([C@@H](O)[C@H]1O)O)O[C@H]2[C@H](O)[C@H]([C@@H](O[C@@H]2CO)O[C@@H]2[C@H]([C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@@H]2O)O)NC(=O)C)C1CO[C@]1(C(O)=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1 SXMGGNXBTZBGLU-IBUUTZGMSA-N 0.000 claims description 3
RPSBVJXBTXEJJG-LURNZOHQSA-N alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine Chemical compound O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)O1 RPSBVJXBTXEJJG-LURNZOHQSA-N 0.000 claims description 3
IESOVNOGVZBLMG-BUZVEHKISA-N alpha-Neup5Ac-(2->8)-alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@H](CO)[C@@H](O)[C@H]1[C@H](NC(C)=O)[C@@H](O)C[C@@](C(O)=O)(O[C@@H]2[C@H]([C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)O[C@@H]3CO)O)O[C@H](CO)[C@@H]2O)O)O1 IESOVNOGVZBLMG-BUZVEHKISA-N 0.000 claims description 3
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 3
239000011575 calcium Substances 0.000 claims description 3
229910052791 calcium Inorganic materials 0.000 claims description 3
150000001875 compounds Chemical class 0.000 claims description 3
230000037213 diet Effects 0.000 claims description 3
KNWXPODBRXAWBX-PFNBIPCHSA-N disialyllacto-n-fucopentaose ii Chemical compound OC1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)[C@H](OC2[C@H]([C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@@H]2O)O)O[C@@H]1CO[C@@]1(C(O)=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C1 KNWXPODBRXAWBX-PFNBIPCHSA-N 0.000 claims description 3
UUZWLWYXBNTJDG-UHFFFAOYSA-N disialyllacto-n-hexaose i Chemical compound C1C(C(O)C(O)CO)C(NC(=O)C)C(O)OC1(C(O)=O)OC1C(O)C(OC2C(C(OC3C(C(OC(C(O)CO)C(O)C(O)C=O)OC(COC4C(C(O)C(OC5C(C(O)C(O)C(COC6(OC(C(NC(C)=O)C(O)C6)C(O)C(O)CO)C(O)=O)O5)O)C(CO)O4)NC(C)=O)C3O)O)OC(CO)C2O)NC(C)=O)OC(CO)C1O UUZWLWYXBNTJDG-UHFFFAOYSA-N 0.000 claims description 3
DUVKOIQTTLSEBM-UHFFFAOYSA-N disialyllacto-n-hexaose ii Chemical compound OCC1OC(OCC2C(C(OC3C(C(OC4C(C(OC5(OC(C(NC(C)=O)C(O)C5)C(O)C(O)CO)C(O)=O)C(O)C(CO)O4)O)C(O)C(COC4(OC(C(NC(C)=O)C(O)C4)C(O)C(O)CO)C(O)=O)O3)NC(C)=O)C(O)C(OC(C(O)CO)C(O)C(O)C=O)O2)O)C(NC(=O)C)C(O)C1OC1OC(CO)C(O)C(O)C1O DUVKOIQTTLSEBM-UHFFFAOYSA-N 0.000 claims description 3
229960002442 glucosamine Drugs 0.000 claims description 3
CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 3
235000021242 lactoferrin Nutrition 0.000 claims description 3
229940078795 lactoferrin Drugs 0.000 claims description 3
230000002265 prevention Effects 0.000 claims description 3
ARDCDNROJUBBMX-NJMSAGAYSA-N sialyl lea tetra Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)OC1O[C@H]1C(O[C@H]2[C@@H](C(O[C@]3(OC([C@H](NC(C)=O)[C@@H](O)C3)C(O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)[C@H](O[C@H]([C@@H](O)C=O)[C@@H](O)[C@H](O)CO)O[C@@H]1CO ARDCDNROJUBBMX-NJMSAGAYSA-N 0.000 claims description 3
240000008886 Ceratonia siliqua Species 0.000 claims description 2
235000013912 Ceratonia siliqua Nutrition 0.000 claims description 2
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 2
PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims description 2
108060003951 Immunoglobulin Proteins 0.000 claims description 2
229920001202 Inulin Polymers 0.000 claims description 2
SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 2
210000003022 colostrum Anatomy 0.000 claims description 2
235000021277 colostrum Nutrition 0.000 claims description 2
235000013312 flour Nutrition 0.000 claims description 2
150000002270 gangliosides Chemical class 0.000 claims description 2
102000018358 immunoglobulin Human genes 0.000 claims description 2
229940072221 immunoglobulins Drugs 0.000 claims description 2
JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 2
229940029339 inulin Drugs 0.000 claims description 2
239000001814 pectin Substances 0.000 claims description 2
229920001277 pectin Polymers 0.000 claims description 2
235000010987 pectin Nutrition 0.000 claims description 2
150000003904 phospholipids Chemical class 0.000 claims description 2
235000008452 baby food Nutrition 0.000 claims 6
241001148536 Bacteroides sp. Species 0.000 claims 1
102000004407 Lactalbumin Human genes 0.000 claims 1
108090000942 Lactalbumin Proteins 0.000 claims 1
208000007683 Pediatric Obesity Diseases 0.000 claims 1
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238000012360 testing method Methods 0.000 description 1
235000019157 thiamine Nutrition 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
239000011721 thiamine Substances 0.000 description 1
KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
239000004474 valine Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019163 vitamin B12 Nutrition 0.000 description 1
239000011715 vitamin B12 Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
150000003721 vitamin K derivatives Chemical class 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940011671 vitamin b6 Drugs 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
229940046010 vitamin k Drugs 0.000 description 1
230000036642 wellbeing Effects 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
235000008924 yoghurt drink Nutrition 0.000 description 1
235000013618 yogurt Nutrition 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Nutrition Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Child & Adolescent Psychology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Pediatric Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NL2004200A 2010-02-05 2010-02-05 Use of sialyl oligosaccharides in weight management. NL2004200C2 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
NL2004200A NL2004200C2 (en)	2010-02-05	2010-02-05	Use of sialyl oligosaccharides in weight management.
PCT/NL2011/050078 WO2011096808A1 (fr)	2010-02-05	2011-02-04	Utilisation de sialyl-oligosaccharides pour gestion du poids

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL2004200A NL2004200C2 (en)	2010-02-05	2010-02-05	Use of sialyl oligosaccharides in weight management.
NL2004200		2010-02-05

Publications (1)

Publication Number	Publication Date
NL2004200C2 true NL2004200C2 (en)	2011-08-08

Family

ID=42340788

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL2004200A NL2004200C2 (en)	2010-02-05	2010-02-05	Use of sialyl oligosaccharides in weight management.

Country Status (2)

Country	Link
NL (1)	NL2004200C2 (fr)
WO (1)	WO2011096808A1 (fr)

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GB201520638D0 (en)	2015-11-23	2016-01-06	4D Pharma Res Ltd	Compositions comprising bacterial strains
GB201520631D0 (en)	2015-11-23	2016-01-06	4D Pharma Res Ltd	Compositions comprising bacterial strains
CN106852938A (zh) *	2015-12-09	2017-06-16	深圳华大基因研究院	拟杆菌(Bacteroides)在治疗和预防肥胖相关疾病中的应用
US20210205341A1 (en) *	2016-01-26	2021-07-08	Nestec S.A.	Compositions comprising human milk oligosaccharides for use in infants or young children to prevent or treat a health disorder by increasing glp-1 secretion
EP3407892A1 (fr) *	2016-01-26	2018-12-05	Nestec S.A.	Compositions comprenant des oligosaccharides sialylés pour utilisation chez les nourrissons ou les enfants en bas âge à des fins de prévention de l'obésité ou des comorbidités associées survenant plus tard dans la vie et pour favoriser une bonne croissance
GB201612191D0 (en)	2016-07-13	2016-08-24	4D Pharma Plc	Compositions comprising bacterial strains
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GB201621123D0 (en)	2016-12-12	2017-01-25	4D Pharma Plc	Compositions comprising bacterial strains
TWI787272B (zh)	2017-05-22	2022-12-21	英商4D製藥研究有限公司	包含細菌菌株之組合物
JP6978514B2 (ja)	2017-05-24	2021-12-08	フォーディーファーマリサーチリミテッド4D Pharma Research Limited	細菌株を含む組成物
WO2018229236A2 (fr)	2017-06-14	2018-12-20	4D Pharma Research Limited	Compositions comprenant des souches bactériennes
ES2841902T3 (es)	2017-06-14	2021-07-12	4D Pharma Res Ltd	Composiciones que comprenden cepas bacterianas
SG11201912105PA (en)	2017-06-14	2020-01-30	4D Pharma Res Ltd	Compositions comprising bacterial strains
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WO2019002607A1 (fr)	2017-06-30	2019-01-03	N.V. Nutricia	Composition symbiotique pour la prévention de troubles
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2010
- 2010-02-05 NL NL2004200A patent/NL2004200C2/en not_active IP Right Cessation
2011
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Also Published As

Publication number	Publication date
WO2011096808A1 (fr)	2011-08-11

Publication	Publication Date	Title
NL2004200C2 (en)	2011-08-08	Use of sialyl oligosaccharides in weight management.
NL2004201C2 (en)	2011-08-08	Use of sialyl oligosaccharides to modulate the immune system.
Russell et al.	2011	Metabolic activities and probiotic potential of bifidobacteria
US8591919B2 (en)	2013-11-26	Synergistic mixture of beta-galacto-oligosaccharides with beta-1,3 and beta -1,4/1,6 linkages
ES2702631T3 (es)	2019-03-04	Composición nutricional con prebióticos y probióticos
AU2016102461A4 (en)	2021-05-27	Nutritional compositions and infant formulas comprising Bifidobacterium animalis ssp. lactis and optionally a mix of oligosaccharides for inducing a gut microbiota close to the one of breast fed infants
US20210330687A1 (en)	2021-10-28	Bifidogenic hypoallergenic gos compositions and methods for providing the same involving beta-galactosidase from a strain of lactobacillus delbrueckii ssp bulgaricus
TW201242518A (en)	2012-11-01	Oligosaccharide mixture and food product comprising this mixture, especially infant formula
CN103797021A (zh)	2014-05-14	寡糖混合物以及包含该混合物的食品，特别是婴儿配方产品
TW201100537A (en)	2011-01-01	Short-time high temperature treatment generates microbial preparations with anti-inflammatory profiles
JP2011504365A (ja)	2011-02-10	乳児のための年齢に合わせた栄養システム
HUE031289T2 (hu)	2017-07-28	Fermentált bébitápszer emészthetetlen oligoszacharidokkal
Ogueke et al.	2010	Probiotics and prebiotics: Unfolding prospects for better human health
US20230270798A1 (en)	2023-08-31	Synbiotic composition
AU2014368585A1 (en)	2016-05-19	Nutritional composition for use in reducing metabolic stress in infants, decreasing gut permeability and approximating growth rate of breast-fed infants
US20210244777A1 (en)	2021-08-12	Novel bifidobacterium bacteria and composition including novel bifidobacterium bacteria
CN113015440B (zh)	2024-04-05	包含尿素和不可消化寡糖的营养组合物
WO2024227719A1 (fr)	2024-11-07	Composition nutritionnelle
WO2024227720A1 (fr)	2024-11-07	Composition nutritionnelle
RU2804305C2 (ru)	2023-09-27	Пищевая композиция, содержащая мочевину и неперевариваемые олигосахариды
WO2021255229A1 (fr)	2021-12-23	Composition nutritionnelle comprenant de l'acide 3-hydroxybutyrique pour améliorer la barrière gastro-intestinale

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Date	Code	Title	Description
2013-09-11	V1	Lapsed because of non-payment of the annual fee	Effective date: 20130901