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MXPA05011270A - Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3. - Google Patents

Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3.

Info

Publication number
MXPA05011270A
MXPA05011270A MXPA05011270A MXPA05011270A MXPA05011270A MX PA05011270 A MXPA05011270 A MX PA05011270A MX PA05011270 A MXPA05011270 A MX PA05011270A MX PA05011270 A MXPA05011270 A MX PA05011270A MX PA05011270 A MXPA05011270 A MX PA05011270A
Authority
MX
Mexico
Prior art keywords
compounds
treatment
imadazopyridine
receptor
dyspepsia
Prior art date
Application number
MXPA05011270A
Other languages
English (en)
Inventor
Hirohide Noguchi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MXPA05011270A publication Critical patent/MXPA05011270A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invencion proporciona un compuesto de formula (I): (Ver formula (I)) en la que R1 representa un atomo de hidrogeno o un atomo de halogeno; R2 representa un grupo metilo o un grupo etilo; o sales farmaceuticamente aceptables del mismo, estos compuestos tienen actividad agonista del receptor 5-HT4 y actividad antagonista del receptor 5-HT3, y de esta forma son utiles para el tratamiento de la enfermedad de reflujo gastroesofagico, dispepsia no ulcerosa, dispepsia funcional, sindrome del intestino irritable, diabetes o similares en mamiferos, especialmente en seres humanos; la presente invencion tambien se refiere a una composicion farmaceutica, a un procedimiento de tratamiento y uso, que comprenden los compuestos anteriores.
MXPA05011270A 2003-04-21 2004-04-13 Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3. MXPA05011270A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46426303P 2003-04-21 2003-04-21
PCT/IB2004/001269 WO2004094418A1 (en) 2003-04-21 2004-04-13 Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity

Publications (1)

Publication Number Publication Date
MXPA05011270A true MXPA05011270A (es) 2006-01-24

Family

ID=33310862

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011270A MXPA05011270A (es) 2003-04-21 2004-04-13 Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3.

Country Status (6)

Country Link
US (1) US20040266814A1 (es)
EP (1) EP1620435A1 (es)
BR (1) BRPI0409592A (es)
CA (1) CA2523077A1 (es)
MX (1) MXPA05011270A (es)
WO (1) WO2004094418A1 (es)

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TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
WO2006029520A1 (en) * 2004-09-14 2006-03-23 Mcgill University Stimulators of 5-ht4 receptors and uses thereof
ES2332808T3 (es) * 2004-11-05 2010-02-12 Theravance, Inc. Compuestos agonistas del receptor 5-ht4.
US7396933B2 (en) * 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
MX2007007818A (es) * 2004-12-22 2007-09-11 Theravance Inc Compuestos de indazol-carboxamida.
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
US8642772B2 (en) 2008-10-14 2014-02-04 Sk Biopharmaceuticals Co., Ltd. Piperidine compounds, pharmaceutical composition comprising the same and its use
US8232315B2 (en) 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
AU2010316106B2 (en) 2009-11-06 2015-10-22 Sk Biopharmaceuticals Co., Ltd. Methods for treating attention-deficit/hyperactivity disorder
EP2496227B1 (en) 2009-11-06 2019-05-22 SK Biopharmaceuticals Co., Ltd. Methods for treating fibromyalgia syndrome
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
SG11201604849YA (en) 2013-12-16 2016-07-28 Suven Life Sciences Ltd INDAZOLE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS
SMT202400187T1 (it) 2014-11-06 2024-07-09 Bial R&D Investments S A Pirazolo(1,5-a)pirimidine sostituite e loro utilizzo nel trattamento di disturbi medici
ES2958391T3 (es) 2014-11-06 2024-02-08 Bial R&D Invest S A Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
EP3215509B1 (en) 2014-11-06 2020-02-26 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
WO2017176962A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics, Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
AU2017246455B2 (en) 2016-04-06 2021-09-30 Bial - R&D Investments, S.A. Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US10787454B2 (en) 2016-04-06 2020-09-29 BIAL—BioTech Investments, Inc. Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US11345698B2 (en) 2016-05-05 2022-05-31 Bial—R&D Investments, S.A. Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders
BR112018072552A8 (pt) 2016-05-05 2023-03-14 Lysosomal Therapeutics Inc Compostos de imidazo [1,2-b]piridazinas e imidazo [1,5-b] piridazinas substituídas, composição farmacêutica que os compreende e seu uso no tratamento de distúrbios médicos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9221468D0 (en) * 1992-10-13 1992-11-25 Smithkline Beecham Plc Pharmaceuticals
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
IT1303123B1 (it) * 1998-10-13 2000-10-30 Rotta Research Lab Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed
CA2461159A1 (en) * 2001-10-22 2003-05-01 Pfizer Inc. Imidazopyridine compounds as 5-ht4 receptor modulators
US6624162B2 (en) * 2001-10-22 2003-09-23 Pfizer Inc. Imidazopyridine compounds as 5-HT4 receptor modulators
DOP2003000703A (es) * 2002-09-20 2004-03-31 Pfizer Compuestos de imidazopiradina como agonistas del receptor 5-ht4
CA2499494A1 (en) * 2002-09-20 2004-04-01 Pfizer Inc. N-substituted piperidinyl-imidazopyridine compounds as 5-ht4 receptor modulators

Also Published As

Publication number Publication date
WO2004094418A8 (en) 2005-09-29
EP1620435A1 (en) 2006-02-01
US20040266814A1 (en) 2004-12-30
WO2004094418A1 (en) 2004-11-04
CA2523077A1 (en) 2004-11-04
BRPI0409592A (pt) 2006-05-02

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