MXPA03011562A - Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa. - Google Patents
Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa.Info
- Publication number
- MXPA03011562A MXPA03011562A MXPA03011562A MXPA03011562A MXPA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A MX PA03011562 A MXPA03011562 A MX PA03011562A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- derivatives
- thieno
- pyrido
- alkyloxy
- Prior art date
Links
- 102000003678 AMPA Receptors Human genes 0.000 title abstract 2
- 108090000078 AMPA Receptors Proteins 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- -1 (C1-4)-alkyloxy Chemical group 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000009782 synaptic response Effects 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se refiere a derivados de (pirido/tieno)-[f]-oxazepin-5-ona que tienen la formula general (I) en donde R1, R2 y R3 son independientemente H o alquilo de 1 a 4 atomos de carbono; Ar representa un anillo de tiofeno o piridina fusionado substituido opcionalmente con uno o mas substituyentes seleccionados de alquilo de 1 a 4 atomos de carbono, alquiloxi de 1 a 4 atomos de carbono, alquiloxi de 1 a 4 atomos de carbono-alquilo de 1 a 4 atomos de carbono, CF3, halogeno, nitro, ciano, NR4R5, NR4COR6, y CONR4R5; R4 y R5 son independientemente H o alquilo de 1 a 4 atomos de carbono; o R4 y R5 forman juntos con el atomo de nitrogeno al cual estan unidos un anillo heterociclico saturado de 5 o 6 miembros, conteniendo opcionalmente un heteroatomo adicional seleccionado de O, S o NR6; R6 es alquilo de 1 a 4 atomos de carbono; A representa el residuo de un anillo heterociclico saturado de 4 a 7 miembros, conteniendo opcionalmente un atomo de oxigeno, estando el anillo substituido opcionalmente con 1 a 3 substituyentes seleccionados de alquilo de 1 a 4 atomos de carbono, alquiloxi de 1 a 4 atomos de carbono, hidroxi, halogeno y oxo; o una sal del mismo farmaceuticamente aceptable. La invencion se refiere tambien a composiciones farmaceuticas que comprenden dichos derivados y al uso de estos derivados de (pirido/tieno)-[f]-oxazepin-5-ona en el tratamiento de enfermedades neurologicas y desordenes psiquiatricos que respondan al aumento de respuestas sinapticas mediadas por receptores AMPA en el sistema nervioso central.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202284 | 2001-06-14 | ||
| PCT/EP2002/006364 WO2002102808A2 (en) | 2001-06-14 | 2002-06-10 | (PYRIDO/THIENO)-[f]-OXAZEPIN-5-ONE DERIVATIVES AS POSITIVE MODULATORS OF THE AMPA RECEPTOR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03011562A true MXPA03011562A (es) | 2004-03-18 |
Family
ID=8180476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03011562A MXPA03011562A (es) | 2001-06-14 | 2002-06-10 | Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa. |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7345036B2 (es) |
| EP (1) | EP1446407A2 (es) |
| JP (1) | JP4435562B2 (es) |
| KR (1) | KR100864267B1 (es) |
| CN (2) | CN1255413C (es) |
| AR (1) | AR034482A1 (es) |
| AU (1) | AU2002320841B2 (es) |
| BR (1) | BR0210307A (es) |
| CA (1) | CA2449215C (es) |
| CO (1) | CO5550448A2 (es) |
| CZ (1) | CZ296217B6 (es) |
| EC (1) | ECSP034890A (es) |
| HR (1) | HRP20031013A2 (es) |
| HU (1) | HUP0400196A3 (es) |
| IL (2) | IL158928A0 (es) |
| IS (1) | IS7042A (es) |
| MX (1) | MXPA03011562A (es) |
| NO (1) | NO328710B1 (es) |
| NZ (1) | NZ529671A (es) |
| PE (1) | PE20030271A1 (es) |
| PL (1) | PL367185A1 (es) |
| RU (1) | RU2286347C2 (es) |
| SK (1) | SK287583B6 (es) |
| WO (1) | WO2002102808A2 (es) |
| ZA (1) | ZA200309096B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200817385A (en) * | 2006-07-04 | 2008-04-16 | Organon Nv | Heterocyclic derivatives |
| GB0624879D0 (en) * | 2006-12-14 | 2007-01-24 | Shs Int Ltd | Treatment of pervasive development disorders |
| FR2964969B1 (fr) * | 2010-09-16 | 2012-08-24 | Servier Lab | Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1238719A (es) * | 1968-11-01 | 1971-07-07 | ||
| PT651746E (pt) | 1992-07-24 | 2002-09-30 | Univ California | Drogas que intensificam as respostas sinapticas mediadas por receptores de ampa |
| JP3887785B2 (ja) * | 1994-11-02 | 2007-02-28 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ５−ｈｔ２レセプター親和性を有する置換四環状オキサゼピン及びチアゼピン誘導体 |
| DK0801651T3 (da) | 1995-01-06 | 2001-10-22 | Hoffmann La Roche | Hydroxymethyl-imidazodiazepiner og deres estere |
| US5650409A (en) | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| ATE303997T1 (de) * | 1997-06-09 | 2005-09-15 | Pfizer Prod Inc | Chinazolin-4-on ampa antagonisten |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| ZA991301B (en) | 1998-02-18 | 1999-09-13 | Neurosearch As | Glutamate receptor modulators. |
| US6124278A (en) | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
| CA2372791A1 (en) | 1999-05-12 | 2000-11-16 | Nouri Neamati | Thiazepine and oxazepine inhibitors of hiv-1 integrase |
| TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
-
2002
- 2002-06-10 PL PL02367185A patent/PL367185A1/xx unknown
- 2002-06-10 EP EP02754652A patent/EP1446407A2/en not_active Withdrawn
- 2002-06-10 NZ NZ529671A patent/NZ529671A/en unknown
- 2002-06-10 JP JP2003506280A patent/JP4435562B2/ja not_active Expired - Fee Related
- 2002-06-10 RU RU2004100702/04A patent/RU2286347C2/ru not_active IP Right Cessation
- 2002-06-10 SK SK1526-2003A patent/SK287583B6/sk not_active IP Right Cessation
- 2002-06-10 KR KR1020037016248A patent/KR100864267B1/ko not_active Expired - Fee Related
- 2002-06-10 CN CNB028118154A patent/CN1255413C/zh not_active Expired - Fee Related
- 2002-06-10 MX MXPA03011562A patent/MXPA03011562A/es active IP Right Grant
- 2002-06-10 CA CA2449215A patent/CA2449215C/en not_active Expired - Fee Related
- 2002-06-10 CZ CZ20033392A patent/CZ296217B6/cs not_active IP Right Cessation
- 2002-06-10 HU HU0400196A patent/HUP0400196A3/hu unknown
- 2002-06-10 US US10/480,569 patent/US7345036B2/en not_active Expired - Fee Related
- 2002-06-10 HR HR20031013A patent/HRP20031013A2/hr not_active Application Discontinuation
- 2002-06-10 CN CN2006100598858A patent/CN101029051B/zh not_active Expired - Fee Related
- 2002-06-10 AU AU2002320841A patent/AU2002320841B2/en not_active Ceased
- 2002-06-10 BR BR0210307-9A patent/BR0210307A/pt not_active Application Discontinuation
- 2002-06-10 IL IL15892802A patent/IL158928A0/xx active IP Right Grant
- 2002-06-10 WO PCT/EP2002/006364 patent/WO2002102808A2/en not_active Ceased
- 2002-06-13 AR ARP020102223A patent/AR034482A1/es unknown
- 2002-06-13 PE PE2002000511A patent/PE20030271A1/es not_active Application Discontinuation
-
2003
- 2003-11-17 IS IS7042A patent/IS7042A/is unknown
- 2003-11-18 IL IL158928A patent/IL158928A/en not_active IP Right Cessation
- 2003-11-21 ZA ZA200309096A patent/ZA200309096B/en unknown
- 2003-12-11 NO NO20035523A patent/NO328710B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004890A patent/ECSP034890A/es unknown
- 2003-12-16 CO CO03109961A patent/CO5550448A2/es not_active Application Discontinuation
-
2008
- 2008-02-01 US US12/024,597 patent/US7566778B2/en not_active Expired - Fee Related
-
2009
- 2009-02-20 US US12/389,968 patent/US8034804B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights | ||
| FG | Grant or registration |