DK0801651T3 - Hydroxymethyl-imidazodiazepiner og deres estere - Google Patents

Hydroxymethyl-imidazodiazepiner og deres estere

Info

Publication number: DK0801651T3
Authority: DK; Denmark
Prior art keywords: imidazodiazepines; hydroxymethyl; esters; anxiolytic; anticonvulsant
Prior art date: 1995-01-06

Application number

DK96900024T

Other languages

English (en)

Inventor

Rene Borer

Bernd Buettelmann

Max Gerecke

Andre Szente

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-06

Filing date

1996-01-03

Publication date

2001-10-22

1996-01-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2001-10-22 Application granted granted Critical

2001-10-22 Publication of DK0801651T3 publication Critical patent/DK0801651T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK96900024T 1995-01-06 1996-01-03 Hydroxymethyl-imidazodiazepiner og deres estere DK0801651T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH2895		1995-01-06
PCT/CH1996/000001 WO1996020941A1 (de)	1995-01-06	1996-01-03	Hydroxymethyl-imidazodiazepine und deren ester

Publications (1)

Publication Number	Publication Date
DK0801651T3 true DK0801651T3 (da)	2001-10-22

Family

ID=4177731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96900024T DK0801651T3 (da)	1995-01-06	1996-01-03	Hydroxymethyl-imidazodiazepiner og deres estere

Country Status (16)

Country	Link
US (1)	US6174881B1 (da)
EP (1)	EP0801651B1 (da)
JP (1)	JP3001979B2 (da)
CN (1)	CN1168140A (da)
AT (1)	ATE203026T1 (da)
AU (1)	AU4296196A (da)
BR (1)	BR9606823A (da)
CA (1)	CA2209424A1 (da)
DE (1)	DE59607274D1 (da)
DK (1)	DK0801651T3 (da)
ES (1)	ES2159714T3 (da)
FI (1)	FI972865L (da)
GR (1)	GR3036867T3 (da)
PT (1)	PT801651E (da)
TR (1)	TR199700587T1 (da)
WO (1)	WO1996020941A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0875247B1 (en) *	1997-04-18	2003-05-28	Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno	Method for controlling the plasma level of lipoproteins
US6444664B1 (en)	1997-04-18	2002-09-03	Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno)	Method for controlling the plasma level of lipoproteins to treat alzheimeris disease
CN1164590C (zh) *	1999-05-12	2004-09-01	弗·哈夫曼-拉罗切有限公司	咪唑二氮杂�衍生物
US7160880B1 (en)	1999-05-14	2007-01-09	Cenes Limited	Short-acting benzodiazepines
TWI232863B (en)	2001-06-11	2005-05-21	Akzo Nobel Nv	Benzoxazepine derivatives
CN1255413C (zh) *	2001-06-14	2006-05-10	阿克佐诺贝尔公司	作为ampa受体正性调节剂的(吡啶并/噻吩并)－[f]－氧杂吖庚因－5－酮衍生物
GB0613693D0 (en)	2006-07-10	2006-08-16	Cenes Ltd	Benzodiazepine salts (3)
SI2081921T1 (sl)	2006-07-10	2011-01-31	Paion Uk Ltd	Soli benzodiazepina s kratkotrajnim učinkom ter njihove polimorfne oblike
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
CA2696703C (en)	2007-08-20	2016-07-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
HUE031073T2 (en)	2010-05-14	2017-06-28	Dana Farber Cancer Inst Inc	Thieno triazolo-diazepine compounds for the treatment of neoplasia
WO2011143657A1 (en)	2010-05-14	2011-11-17	Dana-Farber Cancer Institute, Inc.	Male contraceptive compositions and methods of use
CA2799403C (en)	2010-05-14	2020-01-21	Dana-Farber Cancer Institute, Inc.	Compositions and methods for treating leukemia
EP2450039A1 (en)	2010-11-08	2012-05-09	PAION UK Ltd.	Dosing regimen for sedation with CNS 7056 (Remimazolam)
PE20150683A1 (es)	2012-05-22	2015-06-03	Paion Uk Ltd	Composiciones que comprenden benzodiazepinas de accion corta
CN103012408B (zh) *	2012-11-28	2015-02-04	中国科学院广州生物医药与健康研究院	依匹斯汀的合成方法
AR094963A1 (es)	2013-03-04	2015-09-09	Ono Pharmaceutical Co	Reacción de oxidación excelente en el índice de conversión
KR20160034379A (ko)	2013-07-25	2016-03-29	다나-파버 캔서 인스티튜트 인크.	전사 인자의 억제제 및 그의 용도
RU2016122654A (ru)	2013-11-08	2017-12-14	Дана-Фарбер Кэнсер Инститьют, Инк.	Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка
US10793571B2 (en)	2014-01-31	2020-10-06	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
US10150756B2 (en)	2014-01-31	2018-12-11	Dana-Farber Cancer Institute, Inc.	Diaminopyrimidine benzenesulfone derivatives and uses thereof
CA2940472A1 (en)	2014-02-28	2015-09-03	Tensha Therapeutics, Inc.	Treatment of conditions associated with hyperinsulinaemia
EP3160969B1 (en)	2014-06-26	2023-09-13	The Johns Hopkins University	Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
RU2017104897A (ru)	2014-08-08	2018-09-10	Дана-Фарбер Кэнсер Инститьют, Инк.	Производные диазепана и их применения
EP3177147A4 (en)	2014-08-08	2018-01-24	Dana-Farber Cancer Institute, Inc.	Dihydropteridinone derivatives and uses thereof
EA033325B1 (ru)	2014-10-27	2019-09-30	Тэнша Терапеутикс, Инк.	Ингибиторы бромодомена
CA2986441A1 (en)	2015-06-12	2016-12-15	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
KR20180051576A (ko)	2015-09-11	2018-05-16	다나-파버 캔서 인스티튜트 인크.	아세트아미드 티에노트리아졸로디아제핀 및 그의 용도
CN108472300A (zh)	2015-09-11	2018-08-31	达纳-法伯癌症研究所股份有限公司	氰基噻吩并三唑并二氮杂环庚三烯及其用途
PE20181298A1 (es)	2015-11-25	2018-08-07	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos
KR20180131617A (ko)	2016-04-14	2018-12-10	파이온 유케이 리미티드	경구 흡입 및 비 벤조디아제핀
CN107325101B (zh) *	2017-06-29	2019-03-26	上海合全药物研发有限公司	6-羟甲基-6,7-二氢-5h,9h-咪唑并二氮杂卓-8-羧酸叔丁酯的合成方法
CN113087713B (zh) *	2021-03-29	2022-10-04	中国人民解放军军事科学院军事医学研究院	一类苯并二氮䓬衍生物及其制备方法和用途
USD1017893S1 (en) *	2022-03-03	2024-03-12	Elc Management Llc	Cosmetic applicator
USD1023445S1 (en) *	2022-03-03	2024-04-16	Elc Management Llc	Cosmetic applicator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4902794A (en) *	1971-04-28	1990-02-20	The Upjohn Company	Triazolo-benzodiazepines
US3763179A (en) *	1972-05-05	1973-10-02	Upjohn Co	2-imidazol-1-yl benzophenones
US4280957A (en) *	1974-09-11	1981-07-28	Hoffmann-La Roche Inc.	Imidazodiazepines and processes therefor
DE2547652A1 (de) *	1974-11-15	1976-05-20	Upjohn Co	Pharmazeutische zubereitung
DE3432974A1 (de) *	1983-09-12	1985-04-04	The Upjohn Co., Kalamazoo, Mich.	Arzneimittel zur prophylaxe oder therapie der negativen shizophreniesymtome bei menschen
DE3435973A1 (de) *	1984-10-01	1986-04-10	Boehringer Ingelheim KG, 6507 Ingelheim	Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
US5439906A (en)	1993-11-22	1995-08-08	Merck & Co., Inc.	Antiarrhythmic benzodiazepines
JP2840454B2 (ja)	1993-11-22	1998-12-24	メルクエンドカンパニーインコーポレーテッド	ベンゾジアゼピン類

1996
- 1996-01-03 FI FI972865A patent/FI972865L/fi unknown
- 1996-01-03 AU AU42961/96A patent/AU4296196A/en not_active Abandoned
- 1996-01-03 AT AT96900024T patent/ATE203026T1/de not_active IP Right Cessation
- 1996-01-03 DE DE59607274T patent/DE59607274D1/de not_active Expired - Fee Related
- 1996-01-03 TR TR97/00587T patent/TR199700587T1/xx unknown
- 1996-01-03 US US08/860,785 patent/US6174881B1/en not_active Expired - Fee Related
- 1996-01-03 CN CN96191369A patent/CN1168140A/zh active Pending
- 1996-01-03 PT PT96900024T patent/PT801651E/pt unknown
- 1996-01-03 EP EP96900024A patent/EP0801651B1/de not_active Expired - Lifetime
- 1996-01-03 WO PCT/CH1996/000001 patent/WO1996020941A1/de not_active Ceased
- 1996-01-03 JP JP8520662A patent/JP3001979B2/ja not_active Expired - Lifetime
- 1996-01-03 CA CA002209424A patent/CA2209424A1/en not_active Abandoned
- 1996-01-03 ES ES96900024T patent/ES2159714T3/es not_active Expired - Lifetime
- 1996-01-03 DK DK96900024T patent/DK0801651T3/da not_active Application Discontinuation
- 1996-01-03 BR BR9606823A patent/BR9606823A/pt not_active Application Discontinuation
2001
- 2001-10-11 GR GR20010401730T patent/GR3036867T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6174881B1 (en)	2001-01-16
ATE203026T1 (de)	2001-07-15
DE59607274D1 (de)	2001-08-16
FI972865A0 (fi)	1997-07-04
CN1168140A (zh)	1997-12-17
WO1996020941A1 (de)	1996-07-11
ES2159714T3 (es)	2001-10-16
PT801651E (pt)	2001-12-28
GR3036867T3 (en)	2002-01-31
EP0801651A1 (de)	1997-10-22
BR9606823A (pt)	1997-12-30
EP0801651B1 (de)	2001-07-11
CA2209424A1 (en)	1996-07-11
FI972865A7 (fi)	1997-09-03
FI972865L (fi)	1997-09-03
JPH10500998A (ja)	1998-01-27
JP3001979B2 (ja)	2000-01-24
AU4296196A (en)	1996-07-24
MX9705061A (es)	1997-10-31
TR199700587T1 (xx)	1998-02-21

Publication	Publication Date	Title
DK0801651T3 (da)	2001-10-22	Hydroxymethyl-imidazodiazepiner og deres estere
ZA981936B (en)	1999-09-06	Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
EA199700061A1 (ru)	1997-12-30	Способ получения силденафила
MX9700557A (es)	1997-12-31	Dihidrobenzofuranos.
ATE214928T1 (de)	2002-04-15	Thrombininhibitoren
NO302573B1 (no)	1998-03-23	Nye merkaptodiazepinderivater som er anvendbare som inhibitorer av enkefalinase og ACE
DE59310137D1 (de)	2001-02-15	Verwendung von substituierten Benzimidazolen zur Bekämpfung parasitärer Protozoen
ATE225772T1 (de)	2002-10-15	Thrombin-inhibitoren
GR960100438A (el)	1997-08-29	Νεα παρασιτοκτονα.
DE69615682D1 (de)	2001-11-08	N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h-benzo[b][1,5]-diazepin-3-yl)-acetamide
TR199900856T2 (xx)	1999-07-21	Bron�la ilgili terapi maddeleri olarak benzonaftiridinler
DK0705100T3 (da)	2003-11-17	Terapeutiske substituerede guanidiner
DE69317764D1 (de)	1998-05-07	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
BR9606799A (pt)	1997-12-30	Formulações inibidoras de corrosão aperfeiçoadas com nitrito de cálcio
ATE267180T1 (de)	2004-06-15	Phosphorderivate zur behandlung von aids
NO992337L (no)	1999-05-14	Bicykliske arylkarboksamider og deres terapeutiske anvendelse
ES2157992T3 (es)	2001-09-01	Alcoxi-alquil-carbamatos de imidazo(1,2-a)piridinas.
DE69610628D1 (de)	2000-11-16	N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide
DE69627344D1 (de)	2003-05-15	N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide
FI962481A0 (fi)	1996-06-14	4-bentsoyyli-isokatsolit ja niiden käyttö herbisideinä
FI940999L (fi)	1994-09-04	Piperidin-2-alkyylikarboksylaattien entsymaattinen toisiintuminen ja saatujen yhdisteiden käyttö synteesin välituotteina
ES2187656T3 (es)	2003-06-16	Derivados de acido fosfinico con actividad inhibidora de metalopeptidasa.
DE69802828D1 (de)	2002-01-17	Verwendung von 6,7-substituierter 2-aminotetraline zur behandlung von zytokin-vermittleten entzündungszuständen
DE69626010D1 (de)	2003-03-06	Verwendung von tropolon derivate zur hemmung des inositmono phosphatase
NO953272L (no)	1995-08-21	Kombinasjoner av retrovirale inhibitorer

Legal Events

Date	Code	Title	Description
1998-03-16	AHS	Application shelved for other reasons than non-payment