GR3036867T3 - Hydroxymethylimidazodiazepines and their esters - Google Patents
Hydroxymethylimidazodiazepines and their estersInfo
- Publication number
- GR3036867T3 GR3036867T3 GR20010401730T GR20010401730T GR3036867T3 GR 3036867 T3 GR3036867 T3 GR 3036867T3 GR 20010401730 T GR20010401730 T GR 20010401730T GR 20010401730 T GR20010401730 T GR 20010401730T GR 3036867 T3 GR3036867 T3 GR 3036867T3
- Authority
- GR
- Greece
- Prior art keywords
- esters
- hydroxymethylimidazodiazepines
- imidazodiazepines
- anxiolytic
- anticonvulsant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2895 | 1995-01-06 | ||
| PCT/CH1996/000001 WO1996020941A1 (de) | 1995-01-06 | 1996-01-03 | Hydroxymethyl-imidazodiazepine und deren ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3036867T3 true GR3036867T3 (en) | 2002-01-31 |
Family
ID=4177731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010401730T GR3036867T3 (en) | 1995-01-06 | 2001-10-11 | Hydroxymethylimidazodiazepines and their esters |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6174881B1 (el) |
| EP (1) | EP0801651B1 (el) |
| JP (1) | JP3001979B2 (el) |
| CN (1) | CN1168140A (el) |
| AT (1) | ATE203026T1 (el) |
| AU (1) | AU4296196A (el) |
| BR (1) | BR9606823A (el) |
| CA (1) | CA2209424A1 (el) |
| DE (1) | DE59607274D1 (el) |
| DK (1) | DK0801651T3 (el) |
| ES (1) | ES2159714T3 (el) |
| FI (1) | FI972865L (el) |
| GR (1) | GR3036867T3 (el) |
| PT (1) | PT801651E (el) |
| TR (1) | TR199700587T1 (el) |
| WO (1) | WO1996020941A1 (el) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0875247B1 (en) * | 1997-04-18 | 2003-05-28 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Method for controlling the plasma level of lipoproteins |
| US6444664B1 (en) | 1997-04-18 | 2002-09-03 | Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) | Method for controlling the plasma level of lipoproteins to treat alzheimeris disease |
| CN1164590C (zh) * | 1999-05-12 | 2004-09-01 | 弗·哈夫曼-拉罗切有限公司 | 咪唑二氮杂�衍生物 |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| TWI232863B (en) * | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
| CN101029051B (zh) * | 2001-06-14 | 2010-06-09 | 欧加农股份有限公司 | 作为AMPA受体正性调节剂的（噻吩并）-[f]-氧杂吖庚因-5-酮衍生物 |
| PT2081921E (pt) | 2006-07-10 | 2010-12-10 | Paion Uk Ltd | Sais de benzodiazepina de acção curta e suas formas polimórficas |
| GB0613693D0 (en) | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| US20100234359A1 (en) * | 2007-08-20 | 2010-09-16 | Evotec Neurosciences Gmbh | Treatment of sleep disorders |
| US20090054412A1 (en) * | 2007-08-20 | 2009-02-26 | John Alan Kemp | Treatment of Sleep Disorders |
| JP6022442B2 (ja) * | 2010-05-14 | 2016-11-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 男性用避妊組成物および使用方法 |
| MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
| DK2571503T3 (en) | 2010-05-14 | 2015-04-20 | Dana Farber Cancer Inst Inc | COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| SI2852389T1 (en) | 2012-05-22 | 2018-02-28 | Paion Uk Limited | Compositions comprising short-acting benzodiazepines |
| CN103012408B (zh) * | 2012-11-28 | 2015-02-04 | 中国科学院广州生物医药与健康研究院 | 依匹斯汀的合成方法 |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| BR112016001457A2 (pt) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | Inibidores de fatores de transcrição e usos dos mesmos |
| CA2929652A1 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| JP2017504651A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体の使用 |
| CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| KR20160130778A (ko) | 2014-02-28 | 2016-11-14 | 텐샤 세러퓨틱스 인코포레이티드 | 고인슐린혈증과 관련된 질환의 치료 |
| EP3160969B1 (en) * | 2014-06-26 | 2023-09-13 | The Johns Hopkins University | Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system |
| JP2017526741A (ja) | 2014-08-08 | 2017-09-14 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体およびその使用 |
| KR20170032474A (ko) | 2014-08-08 | 2017-03-22 | 다나-파버 캔서 인스티튜트 인크. | 디히드로프테리디논 유도체 및 그의 용도 |
| AU2015339511B2 (en) | 2014-10-27 | 2020-05-14 | Tensha Therapeutics, Inc. | Bromodomain inhibitors |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| CA2996974A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
| HK1256419A1 (zh) | 2015-09-11 | 2019-09-20 | 达纳-法伯癌症研究所股份有限公司 | 乙酰胺噻吩並三唑並二氮雜環庚三烯及其用途 |
| CN108472295B (zh) | 2015-11-25 | 2022-04-15 | 达纳-法伯癌症研究所股份有限公司 | 二价溴结构域抑制剂及其用途 |
| US20190175613A1 (en) | 2016-04-14 | 2019-06-13 | Paion Uk Limited | Orally inhaled and nasal benzodiazepines |
| CN107325101B (zh) * | 2017-06-29 | 2019-03-26 | 上海合全药物研发有限公司 | 6-羟甲基-6,7-二氢-5h,9h-咪唑并二氮杂卓-8-羧酸叔丁酯的合成方法 |
| CN113087713B (zh) * | 2021-03-29 | 2022-10-04 | 中国人民解放军军事科学院军事医学研究院 | 一类苯并二氮䓬衍生物及其制备方法和用途 |
| USD1023445S1 (en) * | 2022-03-03 | 2024-04-16 | Elc Management Llc | Cosmetic applicator |
| USD1017893S1 (en) * | 2022-03-03 | 2024-03-12 | Elc Management Llc | Cosmetic applicator |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902794A (en) | 1971-04-28 | 1990-02-20 | The Upjohn Company | Triazolo-benzodiazepines |
| US3763179A (en) * | 1972-05-05 | 1973-10-02 | Upjohn Co | 2-imidazol-1-yl benzophenones |
| US4280957A (en) | 1974-09-11 | 1981-07-28 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| DE2547652A1 (de) * | 1974-11-15 | 1976-05-20 | Upjohn Co | Pharmazeutische zubereitung |
| DE3432974A1 (de) | 1983-09-12 | 1985-04-04 | The Upjohn Co., Kalamazoo, Mich. | Arzneimittel zur prophylaxe oder therapie der negativen shizophreniesymtome bei menschen |
| DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| US5439906A (en) | 1993-11-22 | 1995-08-08 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
| CA2176020A1 (en) | 1993-11-22 | 1995-06-01 | John J. Baldwin | Benzodiazepines |
-
1996
- 1996-01-03 PT PT96900024T patent/PT801651E/pt unknown
- 1996-01-03 AT AT96900024T patent/ATE203026T1/de not_active IP Right Cessation
- 1996-01-03 JP JP8520662A patent/JP3001979B2/ja not_active Expired - Lifetime
- 1996-01-03 AU AU42961/96A patent/AU4296196A/en not_active Abandoned
- 1996-01-03 FI FI972865A patent/FI972865L/fi unknown
- 1996-01-03 CA CA002209424A patent/CA2209424A1/en not_active Abandoned
- 1996-01-03 ES ES96900024T patent/ES2159714T3/es not_active Expired - Lifetime
- 1996-01-03 EP EP96900024A patent/EP0801651B1/de not_active Expired - Lifetime
- 1996-01-03 DK DK96900024T patent/DK0801651T3/da not_active Application Discontinuation
- 1996-01-03 DE DE59607274T patent/DE59607274D1/de not_active Expired - Fee Related
- 1996-01-03 BR BR9606823A patent/BR9606823A/pt not_active Application Discontinuation
- 1996-01-03 WO PCT/CH1996/000001 patent/WO1996020941A1/de not_active Ceased
- 1996-01-03 US US08/860,785 patent/US6174881B1/en not_active Expired - Fee Related
- 1996-01-03 CN CN96191369A patent/CN1168140A/zh active Pending
- 1996-01-03 TR TR97/00587T patent/TR199700587T1/xx unknown
-
2001
- 2001-10-11 GR GR20010401730T patent/GR3036867T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0801651T3 (da) | 2001-10-22 |
| US6174881B1 (en) | 2001-01-16 |
| FI972865A0 (fi) | 1997-07-04 |
| WO1996020941A1 (de) | 1996-07-11 |
| FI972865A7 (fi) | 1997-09-03 |
| DE59607274D1 (de) | 2001-08-16 |
| ES2159714T3 (es) | 2001-10-16 |
| TR199700587T1 (xx) | 1998-02-21 |
| MX9705061A (es) | 1997-10-31 |
| ATE203026T1 (de) | 2001-07-15 |
| PT801651E (pt) | 2001-12-28 |
| FI972865L (fi) | 1997-09-03 |
| EP0801651B1 (de) | 2001-07-11 |
| JPH10500998A (ja) | 1998-01-27 |
| BR9606823A (pt) | 1997-12-30 |
| CA2209424A1 (en) | 1996-07-11 |
| AU4296196A (en) | 1996-07-24 |
| CN1168140A (zh) | 1997-12-17 |
| EP0801651A1 (de) | 1997-10-22 |
| JP3001979B2 (ja) | 2000-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |