MXPA03005334A - Derivados de aminotriazolopiridina como ligandos del receptor de adenosina. - Google Patents
Derivados de aminotriazolopiridina como ligandos del receptor de adenosina.Info
- Publication number
- MXPA03005334A MXPA03005334A MXPA03005334A MXPA03005334A MXPA03005334A MX PA03005334 A MXPA03005334 A MX PA03005334A MX PA03005334 A MXPA03005334 A MX PA03005334A MX PA03005334 A MXPA03005334 A MX PA03005334A MX PA03005334 A MXPA03005334 A MX PA03005334A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- substituted
- unsubstituted
- dihydro
- halogen
- Prior art date
Links
- 102000009346 Adenosine receptors Human genes 0.000 title 1
- 108050000203 Adenosine receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- -1 3,4-dihydro-1H-isoquinolin-2-yl Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invencion se refiere a compuestos de formula general i (Ver formula) en donde R1 es alcoxi inferior, cicloalquilo o arilo, sustituido o no sustituido por halogeno o alcoxi inferior, o es -NR'R", en donde R' y R" son independientemente uno del otro hidrogeno, alquilo inferior, alquenilo inferior, no alquinilo inferior, - (CR2)n-arilo, sustituidos o sustituidos por uno a tres sustituyentes, seleccionados del grupo, consistente en halogeno o alcoxi inferior, o son - ( CH2 ) n+1NR2, - (CH2)n-piridinilo, - (CH2)n-indanilo, - (CH2) n- cicloalquilo, - (CH2)n -O-alquilo inferior, - (CH2) n-C(O) -NR2, - (CH2) n-CF3, o R' y R" son junto al atomo de N al cual estan unidos pirrolidin-1-ilo, piperidin-1-ilo, 3,4-dihidro-1H- isoquinolin-2-ilo, morfolinilo, azatidin-1-ilo, 3,6-dihidro- 2H-piridin-1-ilo, tiomorfolinilo, 2,5-dihidro-pirrol-1-ilo tiazolidin-3-ilo, piperazinilo, azocan-1-ilo, azepan-1-ilo, octahidroquinolin-1-ilo, octahidroquinolin-2-ilo, 1,3,4,9- tetrahidro-b-carbolin-2-ilo, cuyos anillos pueden estar sustituidos o no sustituidos por uno a tres sustituyentes, seleccionados del grupo, consistente en alquilo inferior, fenilo, bencilo, piridilo, -C (O) -NR2, - (CH2)n-O-alquilo inferior o -NR- (C (O) -alquilo inferior; R2 es arilo o un grupo heteroarilo de 5 O 6 miembros, cuyos anillos estan sustituidos o no sustituidos por alquilo inferior, halogeno, hidroxi o alcoxi inferior; X es un enlace o -N(R)CH2-; R es hidrogeno o alquilo inferior; n es 0, 1, 2, 3, 4, 5 o 6; y sus sales farmaceuticamente aceptables. Los compuestos tienen una buena afinidad con el receptor de adenosina y se pueden usar en el tratamiento de enfermedades relacionadas a este receptor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00127567 | 2000-12-15 | ||
| PCT/EP2001/014399 WO2002048145A1 (en) | 2000-12-15 | 2001-12-07 | Aminotriazolopyridiine derivatives as adenosine receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03005334A true MXPA03005334A (es) | 2004-04-02 |
Family
ID=8170683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03005334A MXPA03005334A (es) | 2000-12-15 | 2001-12-07 | Derivados de aminotriazolopiridina como ligandos del receptor de adenosina. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6506772B1 (es) |
| EP (1) | EP1347974B1 (es) |
| JP (1) | JP4049672B2 (es) |
| KR (1) | KR100540628B1 (es) |
| CN (1) | CN1221551C (es) |
| AR (1) | AR031799A1 (es) |
| AT (1) | ATE281456T1 (es) |
| AU (2) | AU3167402A (es) |
| BR (1) | BR0116193A (es) |
| CA (1) | CA2437006C (es) |
| DE (1) | DE60106974T2 (es) |
| DK (1) | DK1347974T3 (es) |
| ES (1) | ES2230387T3 (es) |
| GT (1) | GT200100253A (es) |
| MX (1) | MXPA03005334A (es) |
| PA (1) | PA8534701A1 (es) |
| PE (1) | PE20020666A1 (es) |
| PT (1) | PT1347974E (es) |
| UY (1) | UY27074A1 (es) |
| WO (1) | WO2002048145A1 (es) |
| ZA (1) | ZA200304481B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL370067A1 (en) * | 2001-10-08 | 2005-05-16 | F.Hoffmann-La Roche Ag | 8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide |
| CA2502429A1 (en) * | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
| KR101389246B1 (ko) | 2004-07-15 | 2014-04-24 | 브리스톨-마이어스스퀴브컴파니 | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| EP2046788A1 (en) * | 2006-07-12 | 2009-04-15 | Syngeta Participations AG | Triazolopyridine derivatives as herbicides |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| CN102638982B (zh) * | 2009-05-12 | 2015-07-08 | 百时美施贵宝公司 | (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途 |
| CN102458123A (zh) * | 2009-05-12 | 2012-05-16 | 阿尔巴尼分子研究公司 | 芳基、杂芳基和杂环取代的四氢异喹啉及其用途 |
| CN102595902B (zh) * | 2009-05-12 | 2015-04-29 | 阿尔巴尼分子研究公司 | 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途 |
| US20140235667A1 (en) | 2011-09-22 | 2014-08-21 | Merck Sharp & Dohme Corp. | Imidazopyridyl compounds as aldosterone synthase inhibitors |
| WO2013043520A1 (en) | 2011-09-22 | 2013-03-28 | Merck Sharp & Dohme Corp. | Triazolopyridyl compounds as aldosterone synthase inhibitors |
| JP7399589B2 (ja) * | 2018-09-12 | 2023-12-18 | 日本化薬株式会社 | 有害生物防除剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226735D0 (en) | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
| US5356894A (en) | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
| AU2639299A (en) | 1998-02-24 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies/preventives for parkinson's disease |
| US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
-
2001
- 2001-11-30 US US09/998,323 patent/US6506772B1/en not_active Expired - Fee Related
- 2001-12-07 ES ES01991804T patent/ES2230387T3/es not_active Expired - Lifetime
- 2001-12-07 BR BR0116193-8A patent/BR0116193A/pt not_active Application Discontinuation
- 2001-12-07 KR KR1020037008004A patent/KR100540628B1/ko not_active Expired - Fee Related
- 2001-12-07 DK DK01991804T patent/DK1347974T3/da active
- 2001-12-07 MX MXPA03005334A patent/MXPA03005334A/es active IP Right Grant
- 2001-12-07 AT AT01991804T patent/ATE281456T1/de active
- 2001-12-07 JP JP2002549676A patent/JP4049672B2/ja not_active Expired - Fee Related
- 2001-12-07 PT PT01991804T patent/PT1347974E/pt unknown
- 2001-12-07 WO PCT/EP2001/014399 patent/WO2002048145A1/en not_active Ceased
- 2001-12-07 CN CNB018220304A patent/CN1221551C/zh not_active Expired - Fee Related
- 2001-12-07 AU AU3167402A patent/AU3167402A/xx active Pending
- 2001-12-07 AU AU2002231674A patent/AU2002231674B2/en not_active Ceased
- 2001-12-07 CA CA002437006A patent/CA2437006C/en not_active Expired - Fee Related
- 2001-12-07 EP EP01991804A patent/EP1347974B1/en not_active Expired - Lifetime
- 2001-12-07 DE DE60106974T patent/DE60106974T2/de not_active Expired - Lifetime
- 2001-12-12 PA PA20018534701A patent/PA8534701A1/es unknown
- 2001-12-12 AR ARP010105765A patent/AR031799A1/es unknown
- 2001-12-12 PE PE2001001245A patent/PE20020666A1/es not_active Application Discontinuation
- 2001-12-14 GT GT200100253A patent/GT200100253A/es unknown
- 2001-12-14 UY UY27074A patent/UY27074A1/es not_active Application Discontinuation
-
2003
- 2003-06-09 ZA ZA200304481A patent/ZA200304481B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100540628B1 (ko) | 2006-01-11 |
| JP4049672B2 (ja) | 2008-02-20 |
| PT1347974E (pt) | 2005-02-28 |
| KR20030061446A (ko) | 2003-07-18 |
| AR031799A1 (es) | 2003-10-01 |
| DK1347974T3 (da) | 2005-03-14 |
| BR0116193A (pt) | 2003-09-23 |
| ATE281456T1 (de) | 2004-11-15 |
| CN1221551C (zh) | 2005-10-05 |
| PA8534701A1 (es) | 2002-08-26 |
| ES2230387T3 (es) | 2005-05-01 |
| EP1347974A1 (en) | 2003-10-01 |
| UY27074A1 (es) | 2002-07-31 |
| AU3167402A (en) | 2002-06-24 |
| GT200100253A (es) | 2002-07-31 |
| ZA200304481B (en) | 2004-09-09 |
| CA2437006C (en) | 2009-10-27 |
| AU2002231674B2 (en) | 2006-07-06 |
| EP1347974B1 (en) | 2004-11-03 |
| CA2437006A1 (en) | 2002-06-20 |
| CN1486314A (zh) | 2004-03-31 |
| PE20020666A1 (es) | 2002-07-27 |
| DE60106974D1 (de) | 2004-12-09 |
| WO2002048145A1 (en) | 2002-06-20 |
| US6506772B1 (en) | 2003-01-14 |
| DE60106974T2 (de) | 2005-11-03 |
| JP2004521096A (ja) | 2004-07-15 |
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