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MX9306666A - Nuevas azetidinonas substituidas como agentes antiinflamatorios y antidegenerativos. - Google Patents

Nuevas azetidinonas substituidas como agentes antiinflamatorios y antidegenerativos.

Info

Publication number
MX9306666A
MX9306666A MX9306666A MX9306666A MX9306666A MX 9306666 A MX9306666 A MX 9306666A MX 9306666 A MX9306666 A MX 9306666A MX 9306666 A MX9306666 A MX 9306666A MX 9306666 A MX9306666 A MX 9306666A
Authority
MX
Mexico
Prior art keywords
inflammatory
new
degenerative agents
azetidinones
degenerative
Prior art date
Application number
MX9306666A
Other languages
English (en)
Inventor
Paul E Finke
Malcolm Maccoss
Sander G Mills
Shrenik K Shan
Soumya P Sahoo
Jeffrey J Hale
Thomas J Lanza
William K Hagman
James B Doherty
Conrad P Dorn
Phillippe L Durette
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9306666A publication Critical patent/MX9306666A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen nuevas azetidinonas substituidas de la fórmula general (I), las cuales se ha descubierto que son potentes inhibidores de elastasa y por lo mismo, útiles agentes antiinflamatorios y antidegenerativos. (Ver Fórmula).
MX9306666A 1992-10-27 1993-10-26 Nuevas azetidinonas substituidas como agentes antiinflamatorios y antidegenerativos. MX9306666A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96680092A 1992-10-27 1992-10-27
US99183892A 1992-12-17 1992-12-17

Publications (1)

Publication Number Publication Date
MX9306666A true MX9306666A (es) 1994-04-29

Family

ID=27130493

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306666A MX9306666A (es) 1992-10-27 1993-10-26 Nuevas azetidinonas substituidas como agentes antiinflamatorios y antidegenerativos.

Country Status (29)

Country Link
EP (1) EP0595557B1 (es)
JP (1) JPH082868B2 (es)
KR (1) KR950704250A (es)
CN (1) CN1043884C (es)
AT (1) ATE270273T1 (es)
AU (1) AU663806B2 (es)
CA (1) CA2108584C (es)
CY (1) CY2529B1 (es)
CZ (1) CZ106895A3 (es)
DE (1) DE69333563T2 (es)
DK (1) DK0595557T3 (es)
DZ (1) DZ1724A1 (es)
ES (1) ES2224095T3 (es)
FI (1) FI951992A7 (es)
HR (1) HRP931309A2 (es)
HU (2) HUT72084A (es)
IL (1) IL107321A (es)
LV (1) LV13338B (es)
MX (1) MX9306666A (es)
MY (1) MY128261A (es)
NO (1) NO305697B1 (es)
NZ (1) NZ257755A (es)
PL (1) PL308545A1 (es)
PT (1) PT595557E (es)
RU (1) RU2148056C1 (es)
SI (1) SI9300566A (es)
SK (1) SK53795A3 (es)
TW (1) TW275621B (es)
WO (1) WO1994010142A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420010A (en) * 1993-07-30 1995-05-30 Merck & Co., Inc. Assay for evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones
AU5014496A (en) * 1995-03-23 1996-10-08 Japan Tobacco Inc. Diphenylmethyl-azetidinone compounds and elastase inhibitor
US5523233A (en) * 1995-05-03 1996-06-04 Merck & Co., Inc. Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters
CA2234640A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Process for preparing substituted azetidinones
US5808056A (en) * 1995-10-31 1998-09-15 Merck & Co., Inc. Process for preparing substituted azetidinones
JP2000502079A (ja) * 1995-12-08 2000-02-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー アテローム性動脈硬化症の治療のための単環β―ラクタム誘導体
AU2698697A (en) * 1996-04-26 1997-11-19 Smithkline Beecham Plc Azetidinone derivatives for the treatment of atherosclerosis
HUP0104308A3 (en) * 1998-06-25 2002-06-28 Bristol Myers Squibb Co Amidino and guanidino azetidinone derivatives as tryptase inhibitors, process for their preparation, pharmaceutical compositions thereof and intermediates
WO2000005204A1 (en) * 1998-07-23 2000-02-03 Shionogi & Co., Ltd. MONOCYCLIC β-LACTAM COMPOUNDS AND CHYMASE INHIBITORS CONTAINING THE SAME
RU2191570C1 (ru) * 2001-04-25 2002-10-27 Закрытое акционерное общество "ВЕРОФАРМ" Твердая лекарственная форма антимикробного средства
RU2207115C1 (ru) * 2001-12-27 2003-06-27 Закрытое акционерное общество "Брынцалов-А" Противомикробное средство тариферид
RU2217196C2 (ru) * 2002-02-28 2003-11-27 Небольсин Владимир Евгеньевич Способ индукции дифференцировки клеток
FR2861991B1 (fr) * 2003-11-07 2008-01-18 Centre Nat Rech Scient Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
FR2937972B1 (fr) * 2008-11-04 2013-03-29 Galderma Res & Dev Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique
EP2407466B1 (en) * 2009-03-09 2016-01-13 Taiho Pharmaceutical Co., Ltd. Piperazine compound capable of inhibiting prostaglandin d synthase
FR2981933B1 (fr) * 2011-11-02 2013-11-15 Galderma Res & Dev Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89835A0 (en) * 1988-04-11 1989-12-15 Merck & Co Inc Substituted azetidinones,their preparation and pharmaceutical compositions containing them
IL99658A0 (en) * 1990-10-15 1992-08-18 Merck & Co Inc Substituted azetidinones and pharmaceutical compositions containing them
WO1993000332A1 (en) * 1991-06-25 1993-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents

Also Published As

Publication number Publication date
PT595557E (pt) 2004-10-29
SK53795A3 (en) 1995-09-13
KR950704250A (ko) 1995-11-17
NO951593L (no) 1995-06-23
DE69333563T2 (de) 2005-08-18
AU5028393A (en) 1994-05-12
PL308545A1 (en) 1995-08-21
HRP931309A2 (en) 1997-02-28
CN1090272A (zh) 1994-08-03
HU211619A9 (en) 1995-12-28
HU9501184D0 (en) 1995-06-28
IL107321A (en) 1998-08-16
SI9300566A (en) 1994-09-30
EP0595557A1 (en) 1994-05-04
NO305697B1 (no) 1999-07-12
IL107321A0 (en) 1994-01-25
RU2148056C1 (ru) 2000-04-27
LV13338B (en) 2006-01-20
DE69333563D1 (de) 2004-08-05
JPH082868B2 (ja) 1996-01-17
NO951593D0 (no) 1995-04-26
HUT72084A (en) 1996-03-28
RU95109936A (ru) 1997-01-10
CA2108584C (en) 1998-11-24
CY2529B1 (en) 2006-04-12
WO1994010142A1 (en) 1994-05-11
TW275621B (es) 1996-05-11
JPH06263723A (ja) 1994-09-20
FI951992A0 (fi) 1995-04-26
CN1043884C (zh) 1999-06-30
FI951992A7 (fi) 1995-04-26
EP0595557B1 (en) 2004-06-30
NZ257755A (en) 1998-03-25
DK0595557T3 (da) 2004-10-25
AU663806B2 (en) 1995-10-19
CA2108584A1 (en) 1994-04-28
MY128261A (en) 2007-01-31
CZ106895A3 (en) 1996-03-13
DZ1724A1 (fr) 2002-02-17
ATE270273T1 (de) 2004-07-15
ES2224095T3 (es) 2005-03-01

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Legal Events

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MM Annulment or lapse due to non-payment of fees