FR2861991B1 - Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose - Google Patents
Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidoseInfo
- Publication number
- FR2861991B1 FR2861991B1 FR0313134A FR0313134A FR2861991B1 FR 2861991 B1 FR2861991 B1 FR 2861991B1 FR 0313134 A FR0313134 A FR 0313134A FR 0313134 A FR0313134 A FR 0313134A FR 2861991 B1 FR2861991 B1 FR 2861991B1
- Authority
- FR
- France
- Prior art keywords
- glucosidase inhibitors
- mucoviscidose
- therapy
- gen
- delf508
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0313134A FR2861991B1 (fr) | 2003-11-07 | 2003-11-07 | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| HR20090159T HRP20090159T1 (en) | 2003-11-07 | 2004-11-05 | Use of glucosidase inhibitors for therapy of mucovisidosis |
| BRPI0416228-5A BRPI0416228A (pt) | 2003-11-07 | 2004-11-05 | uso de inibidores glucosidade para terapia de mucovisidose |
| DE602004019674T DE602004019674D1 (de) | 2003-11-07 | 2004-11-05 | Verwendung von glucosidase-hemmern zur behandlung von mukoviszidose |
| DK04805405T DK1680105T3 (da) | 2003-11-07 | 2004-11-05 | Anvendelse af en glukosidaseinhibitorer til behandling af mucoviscidose |
| AU2004289083A AU2004289083B2 (en) | 2003-11-07 | 2004-11-05 | Use of glucosidase inhibitors for therapy of mucovisidosis |
| AT04805405T ATE423561T1 (de) | 2003-11-07 | 2004-11-05 | Verwendung von glucosidase-hemmern zur behandlung von mukoviszidose |
| RU2006119914/14A RU2358725C2 (ru) | 2003-11-07 | 2004-11-05 | Применение ингибиторов глюкозидазы для терапии муковисцидоза |
| NZ547261A NZ547261A (en) | 2003-11-07 | 2004-11-05 | Use of glucosidase inhibitors for therapy of mucovisidosis |
| JP2006538890A JP4740868B2 (ja) | 2003-11-07 | 2004-11-05 | 膵線維症の治療のためのグルコシダーゼ阻害剤の使用 |
| US10/578,328 US7973054B2 (en) | 2003-11-07 | 2004-11-05 | Use of glucosidase inhibitors for therapy of mucovisidosis |
| ZA200603726A ZA200603726B (en) | 2003-11-07 | 2004-11-05 | Use of glucosidase inhibitors for therapy of mucovisidosis |
| KR1020107004147A KR20100038452A (ko) | 2003-11-07 | 2004-11-05 | 글루코시다제 억제제를 포함하는 낭성 섬유증 치료용 약제학적 조성물 |
| KR1020067010948A KR100979276B1 (ko) | 2003-11-07 | 2004-11-05 | 글루코시다제 억제제를 포함하는 낭성 섬유증 치료용 약제학적 조성물 |
| SI200431106T SI1680105T1 (sl) | 2003-11-07 | 2004-11-05 | Uporaba inhibitorjev glukozidaze za zdravljenje mukoviscidoze |
| PCT/FR2004/002858 WO2005046672A2 (fr) | 2003-11-07 | 2004-11-05 | Utilisation d’inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| CNB2004800382212A CN100534432C (zh) | 2003-11-07 | 2004-11-05 | 葡糖苷酶抑制剂在粘液粘稠病治疗中的应用 |
| ES04805405T ES2321725T3 (es) | 2003-11-07 | 2004-11-05 | Utilizacion de inhibidores de glucosidasa para un tratamiento de la mucoviscidosis. |
| PL04805405T PL1680105T3 (pl) | 2003-11-07 | 2004-11-05 | Zastosowanie inhibitorów glukozydazy do leczenia mukowiscydozy |
| EP04805405A EP1680105B1 (fr) | 2003-11-07 | 2004-11-05 | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| CA2545133A CA2545133C (fr) | 2003-11-07 | 2004-11-05 | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| PT04805405T PT1680105E (pt) | 2003-11-07 | 2004-11-05 | Utilização de inibidores de glucosidase para o tratamento de mucoviscidose |
| IL175453A IL175453A (en) | 2003-11-07 | 2006-05-04 | Use of glucosidase inhibitor, 1-butyl,2-hydroxymethyl-piperidine-3alpha,4beta,5-triol, for the preparation of a medicament for therapy of mucoviscidosis |
| NO20062617A NO336904B1 (no) | 2003-11-07 | 2006-06-07 | Anvendelse av glukosidaseinhibitorer for fremstilling av medikamenter for behandling av mukovisidose |
| CY20091100518T CY1110468T1 (el) | 2003-11-07 | 2009-05-14 | Χρηση αναστολεων γλυκοσιδασης για μια θεραπεια της κυστικης ινωσεως |
| US13/116,482 US8242136B2 (en) | 2003-11-07 | 2011-05-26 | Use of glucosidase inhibitors for therapy of mucovisidosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0313134A FR2861991B1 (fr) | 2003-11-07 | 2003-11-07 | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2861991A1 FR2861991A1 (fr) | 2005-05-13 |
| FR2861991B1 true FR2861991B1 (fr) | 2008-01-18 |
Family
ID=34508347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0313134A Expired - Fee Related FR2861991B1 (fr) | 2003-11-07 | 2003-11-07 | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7973054B2 (fr) |
| EP (1) | EP1680105B1 (fr) |
| JP (1) | JP4740868B2 (fr) |
| KR (2) | KR100979276B1 (fr) |
| CN (1) | CN100534432C (fr) |
| AT (1) | ATE423561T1 (fr) |
| AU (1) | AU2004289083B2 (fr) |
| BR (1) | BRPI0416228A (fr) |
| CA (1) | CA2545133C (fr) |
| CY (1) | CY1110468T1 (fr) |
| DE (1) | DE602004019674D1 (fr) |
| DK (1) | DK1680105T3 (fr) |
| ES (1) | ES2321725T3 (fr) |
| FR (1) | FR2861991B1 (fr) |
| HR (1) | HRP20090159T1 (fr) |
| IL (1) | IL175453A (fr) |
| NO (1) | NO336904B1 (fr) |
| NZ (1) | NZ547261A (fr) |
| PL (1) | PL1680105T3 (fr) |
| PT (1) | PT1680105E (fr) |
| RU (1) | RU2358725C2 (fr) |
| SI (1) | SI1680105T1 (fr) |
| WO (1) | WO2005046672A2 (fr) |
| ZA (1) | ZA200603726B (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2572148T3 (es) | 2005-05-17 | 2016-05-30 | Amicus Therapeutics Inc | Un método para el tratamiento de la enfermedad de Pompe usando 1-desoxinojirimicina y derivados |
| US8410081B2 (en) * | 2006-04-24 | 2013-04-02 | Academisch Medisch Centrum | Treatment of cystic fibrosis |
| HUE027569T2 (en) | 2006-05-16 | 2016-10-28 | Amicus Therapeutics Inc | Preparation for the treatment of Fabry disease |
| EP2352828B1 (fr) * | 2008-09-11 | 2015-02-25 | Galapagos N.V. | Procédé d'identification de composés pour augmenter l'activité de mutant de cystic fibrosis transmembrane conductance regulator (cftr) associé à cf |
| ITFE20080032A1 (it) * | 2008-10-23 | 2010-04-24 | Azienda Ospedaliera Istituti Ospit Alieri Di Vero | Effetto anti infiammatorio del miglustat cellule dell'epitelio bronchiale |
| GB201000499D0 (en) | 2010-01-13 | 2010-03-03 | Fleet George W J | Treatment of cystic fibrosis |
| WO2011095772A2 (fr) | 2010-02-04 | 2011-08-11 | Summit Corporation Plc | Nouveaux agents thérapeutiques iminosucres |
| GB201006434D0 (en) * | 2010-04-19 | 2010-06-02 | Summit Corp Plc | Novel iminosugar combinations |
| KR20230066482A (ko) | 2012-03-07 | 2023-05-15 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물 |
| HK1222129A1 (zh) * | 2013-09-16 | 2017-06-23 | Emergent Virology Llc | 脱氧野尻霉素衍生物及其使用方法 |
| FR3017536B1 (fr) | 2014-02-18 | 2017-05-26 | Univ La Rochelle | Compositions pour la prevention et/ou le traitement de pathologies liees a l'alpha-glucosidase |
| EA038986B1 (ru) | 2014-09-30 | 2021-11-18 | Амикус Терапьютикс, Инк. | Высокоактивная кислая альфа-глюкозидаза с повышенным содержанием углеводов |
| KR20250007693A (ko) | 2015-12-30 | 2025-01-14 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병 치료용의 강화된 산 알파-글루코시다제 |
| KR102444612B1 (ko) | 2016-03-30 | 2022-09-21 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 재조합 산 알파-글루코시다제를 포함하는 제형 |
| KR102790256B1 (ko) | 2016-03-30 | 2025-04-04 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 고 m6p 재조합 단백질의 선택 방법 |
| EP3448410A1 (fr) * | 2016-04-29 | 2019-03-06 | Institut Pasteur | Procédés et compositions destinés à modifier l'activité régulatrice de la conductance transmembranaire d'une fibrose kystique |
| US10478427B2 (en) * | 2016-07-07 | 2019-11-19 | National University Corporation Chiba University | Therapeutic agent for fibrosis and inhibitor of nuclear translocation of phosphorylated smad |
| JP7193476B2 (ja) | 2017-05-15 | 2022-12-20 | アミカス セラピューティックス インコーポレイテッド | 組換えヒト酸性アルファグリコシダーゼ |
| AU2018278247B2 (en) * | 2017-06-01 | 2022-07-28 | Idorsia Pharmaceuticals Ltd | Crystalline form of N-butyldeoxygalactonojirimycin |
| CN108187051A (zh) * | 2018-01-30 | 2018-06-22 | 中国药科大学 | α-L-岩藻糖苷酶及抑制剂用于制备防治心肌缺血损伤的药物的用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| CA2108584C (fr) * | 1992-10-27 | 1998-11-24 | James B. Doherty | Utilisation d'azetidinones substituees comme anti-inflammatoires et agents anti-degeneratifs |
| WO1998020123A2 (fr) | 1996-11-04 | 1998-05-14 | Institut Curie | Lignes cellulaires stables exprimant la proteine cftr ou un mutant de cette proteine, outil pour selectionner des molecules ayant un effet sur le transport intracellulaire desdites proteines |
| TW589174B (en) | 1997-12-10 | 2004-06-01 | Takeda Chemical Industries Ltd | Agent for treating high-risk impaired glucose tolerance |
| US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| WO2001002586A1 (fr) * | 1999-06-29 | 2001-01-11 | Mcgill University | Alpha 1,2-mannosidase humaine |
| US6476194B1 (en) * | 1999-06-29 | 2002-11-05 | National Research Council Of Canada | Method for folding unfolded proteins |
| AU7398900A (en) * | 1999-09-23 | 2001-04-24 | Hospital For Sick Children, The | Three-dimensional structure and crystal of a class i alpha1,2-mannosidase, and methods of use thereof |
| US20050053625A1 (en) * | 2001-10-30 | 2005-03-10 | Block Timothy M | Method of treating viral infections |
| US7081260B2 (en) | 2002-10-29 | 2006-07-25 | Council Of Scientific And Industrial Research | α-Glucosidase inhibitors from a natural source |
| MX344587B (es) | 2003-01-31 | 2016-12-20 | Mount Sinai School Of Medicine Of New York Univ | Metodo para incrementar la estabilidad in vitro e in vivo de enzimas asociadas al transtorno lisosomal. |
| US7071341B2 (en) | 2003-02-28 | 2006-07-04 | Council Of Scientific And Industrial Research | α-Glucosidase inhibitors and their synthesis from a natural source |
-
2003
- 2003-11-07 FR FR0313134A patent/FR2861991B1/fr not_active Expired - Fee Related
-
2004
- 2004-11-05 DE DE602004019674T patent/DE602004019674D1/de not_active Expired - Lifetime
- 2004-11-05 CN CNB2004800382212A patent/CN100534432C/zh not_active Expired - Fee Related
- 2004-11-05 EP EP04805405A patent/EP1680105B1/fr not_active Expired - Lifetime
- 2004-11-05 PT PT04805405T patent/PT1680105E/pt unknown
- 2004-11-05 ES ES04805405T patent/ES2321725T3/es not_active Expired - Lifetime
- 2004-11-05 ZA ZA200603726A patent/ZA200603726B/en unknown
- 2004-11-05 RU RU2006119914/14A patent/RU2358725C2/ru not_active IP Right Cessation
- 2004-11-05 AU AU2004289083A patent/AU2004289083B2/en not_active Ceased
- 2004-11-05 JP JP2006538890A patent/JP4740868B2/ja not_active Expired - Fee Related
- 2004-11-05 KR KR1020067010948A patent/KR100979276B1/ko not_active Expired - Fee Related
- 2004-11-05 CA CA2545133A patent/CA2545133C/fr not_active Expired - Fee Related
- 2004-11-05 KR KR1020107004147A patent/KR20100038452A/ko not_active Withdrawn
- 2004-11-05 DK DK04805405T patent/DK1680105T3/da active
- 2004-11-05 SI SI200431106T patent/SI1680105T1/sl unknown
- 2004-11-05 US US10/578,328 patent/US7973054B2/en not_active Expired - Fee Related
- 2004-11-05 BR BRPI0416228-5A patent/BRPI0416228A/pt not_active Application Discontinuation
- 2004-11-05 HR HR20090159T patent/HRP20090159T1/xx unknown
- 2004-11-05 NZ NZ547261A patent/NZ547261A/en not_active IP Right Cessation
- 2004-11-05 PL PL04805405T patent/PL1680105T3/pl unknown
- 2004-11-05 AT AT04805405T patent/ATE423561T1/de active
- 2004-11-05 WO PCT/FR2004/002858 patent/WO2005046672A2/fr not_active Ceased
-
2006
- 2006-05-04 IL IL175453A patent/IL175453A/en active IP Right Grant
- 2006-06-07 NO NO20062617A patent/NO336904B1/no not_active IP Right Cessation
-
2009
- 2009-05-14 CY CY20091100518T patent/CY1110468T1/el unknown
-
2011
- 2011-05-26 US US13/116,482 patent/US8242136B2/en not_active Expired - Fee Related
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