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ES2131313T3 - Derivados de acido nipecotico como compuestos antitromboticos. - Google Patents

Derivados de acido nipecotico como compuestos antitromboticos.

Info

Publication number
ES2131313T3
ES2131313T3 ES95914023T ES95914023T ES2131313T3 ES 2131313 T3 ES2131313 T3 ES 2131313T3 ES 95914023 T ES95914023 T ES 95914023T ES 95914023 T ES95914023 T ES 95914023T ES 2131313 T3 ES2131313 T3 ES 2131313T3
Authority
ES
Spain
Prior art keywords
acid derivatives
nipecotic acid
antithrombotic compounds
compounds
antithrombotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95914023T
Other languages
English (en)
Inventor
Mary Pat Beavers
Patricia Andrade-Gordon
William J Hoekstra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of ES2131313T3 publication Critical patent/ES2131313T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REVELAN COMPUESTOS DERIVADOS DE ACIDO NIPECOTICO DE FORMULA (I) SON EXPUESTOS COMO UTILES EN EL TRATAMIENTO DE TRASTORNOS TROMBOTICOS TRANSMITIDOS POR LAS PLAQUETAS.
ES95914023T 1994-03-16 1995-03-14 Derivados de acido nipecotico como compuestos antitromboticos. Expired - Lifetime ES2131313T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21377294A 1994-03-16 1994-03-16
US36489694A 1994-12-27 1994-12-27

Publications (1)

Publication Number Publication Date
ES2131313T3 true ES2131313T3 (es) 1999-07-16

Family

ID=26908383

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95914023T Expired - Lifetime ES2131313T3 (es) 1994-03-16 1995-03-14 Derivados de acido nipecotico como compuestos antitromboticos.

Country Status (20)

Country Link
US (1) US5770575A (es)
EP (1) EP0746545B1 (es)
JP (1) JPH09510453A (es)
KR (1) KR100328287B1 (es)
CN (1) CN1083834C (es)
AT (1) ATE180470T1 (es)
AU (1) AU703397B2 (es)
CA (1) CA2163027A1 (es)
DE (1) DE69509875T2 (es)
DK (1) DK0746545T3 (es)
ES (1) ES2131313T3 (es)
FI (1) FI113763B (es)
GR (1) GR3030566T3 (es)
HU (1) HUT74871A (es)
MX (1) MX9504800A (es)
NO (1) NO304885B1 (es)
NZ (1) NZ283209A (es)
RU (1) RU2135470C1 (es)
TW (1) TW318179B (es)
WO (1) WO1995025091A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT73174A (en) * 1993-09-22 1996-06-28 Fujisawa Pharmaceutical Co N-(3-piperidinylcarbonyl)-beta-alanine derivatives as paf antagonists, pharmaceutical compositions containing them and process for producing them
WO1996029309A1 (en) * 1995-03-17 1996-09-26 Fujisawa Pharmaceutical Co., Ltd. N-ACYLPIPERIDINYLCARBONYLAMINOCARBOXYLIC ACIDS AND THEIR USE AS GLYCOPROTEIN IIB/IIa ANTAGONISTS AND FIBRINOGEN-BLOOD PLATELETS BINDING INHIBITORS
KR19990087694A (ko) * 1996-03-13 1999-12-27 후지야마 아키라 피브리노겐 수용체 길항제로서의 N-[(R)-１-{３-(４-피페리딜)프로피오닐-３-피페리딜카보닐]-２(S)-아세틸아미노-β-알라닌
EP1184374B1 (en) * 1996-05-01 2009-01-28 Ortho-McNeil Pharmaceutical, Inc. Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
NZ332585A (en) * 1996-05-01 2000-04-28 Ortho Mcneil Pharm Inc Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
WO1999025685A1 (en) * 1997-11-18 1999-05-27 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
PT1165543E (pt) * 1999-03-22 2003-10-31 Ortho Mcneil Pharm Inc Processo para a preparacao de acido ¬s-(r*,s*)|-beta-¬¬¬1-¬1-oxo-3-(4-piperidinil)propil|-3-piperidinil|-carbonil|amino|-3-piridinopropanoico e derivados
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
JP4910695B2 (ja) 2004-02-25 2012-04-04 アステラス製薬株式会社 血栓造影剤
RU2349304C1 (ru) * 2007-08-10 2009-03-20 Закрытое Акционерное Общество "Канонфарма Продакшн" Таблетированная лекарственная форма клопидогрела или его фармацевтически приемлемой соли, способ ее получения и применение
EP3184149A1 (en) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Soluble glycoprotein v for treating thrombotic diseases
CN109734655B (zh) * 2019-03-11 2020-06-02 都创(上海)医药科技有限公司 一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
TW201303B (es) * 1990-07-05 1993-03-01 Hoffmann La Roche
MX9100517A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
CA2117282A1 (en) * 1991-11-22 1993-05-27 Ofer Lider Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprosing them
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
US5358934A (en) * 1992-12-11 1994-10-25 The United States Of America As Represented By The Secretary Of Agriculture Materials and methods for control of pests
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins

Also Published As

Publication number Publication date
WO1995025091A2 (en) 1995-09-21
NO304885B1 (no) 1999-03-01
AU703397B2 (en) 1999-03-25
CN1128022A (zh) 1996-07-31
CA2163027A1 (en) 1995-09-21
GR3030566T3 (en) 1999-10-29
NZ283209A (en) 1998-04-27
EP0746545B1 (en) 1999-05-26
HU9503270D0 (en) 1996-05-28
JPH09510453A (ja) 1997-10-21
FI113763B (fi) 2004-06-15
MX9504800A (es) 1997-05-31
DE69509875D1 (de) 1999-07-01
DK0746545T3 (da) 1999-11-08
HUT74871A (en) 1997-02-28
TW318179B (en) 1997-10-21
DE69509875T2 (de) 1999-12-09
FI955498A0 (fi) 1995-11-15
FI955498L (fi) 1996-01-15
US5770575A (en) 1998-06-23
WO1995025091A3 (en) 1995-10-12
RU2135470C1 (ru) 1999-08-27
NO954609L (no) 1996-01-05
AU2119195A (en) 1995-10-03
NO954609D0 (no) 1995-11-15
EP0746545A1 (en) 1996-12-11
ATE180470T1 (de) 1999-06-15
KR100328287B1 (ko) 2002-10-11
CN1083834C (zh) 2002-05-01

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