[go: up one dir, main page]

MX383757B - Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos - Google Patents

Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos

Info

Publication number
MX383757B
MX383757B MX2018006790A MX2018006790A MX383757B MX 383757 B MX383757 B MX 383757B MX 2018006790 A MX2018006790 A MX 2018006790A MX 2018006790 A MX2018006790 A MX 2018006790A MX 383757 B MX383757 B MX 383757B
Authority
MX
Mexico
Prior art keywords
tetrahydrouridine
azacitidine
compositions containing
decitabine
containing decitabine
Prior art date
Application number
MX2018006790A
Other languages
English (en)
Other versions
MX2018006790A (es
Inventor
Henry Lau
Joseph Desimone
Santhosh Vadivelu
Yogen Saunthararajah
Original Assignee
Epidestiny Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epidestiny Inc filed Critical Epidestiny Inc
Publication of MX2018006790A publication Critical patent/MX2018006790A/es
Publication of MX383757B publication Critical patent/MX383757B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen composiciones que comprenden decitabina y tetrahidrouridina o 5-azacitidina y tetrahidrouridina para el tratamiento del cancer. Las composiciones en forma de pildora se administran a un sujeto humano en secuencia o de manera alternada en funcion de la medicion de biomarcadores predictivos.
MX2018006790A 2015-12-03 2016-12-05 Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos MX383757B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562262839P 2015-12-03 2015-12-03
US201662429292P 2016-12-02 2016-12-02
PCT/US2016/064935 WO2017096357A1 (en) 2015-12-03 2016-12-05 Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof

Publications (2)

Publication Number Publication Date
MX2018006790A MX2018006790A (es) 2019-05-02
MX383757B true MX383757B (es) 2025-03-04

Family

ID=58798100

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021007569A MX393043B (es) 2015-12-03 2016-12-05 Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos
MX2018006790A MX383757B (es) 2015-12-03 2016-12-05 Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2021007569A MX393043B (es) 2015-12-03 2016-12-05 Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos

Country Status (9)

Country Link
US (3) US11376270B2 (es)
EP (2) EP3960182B1 (es)
JP (2) JP7194021B2 (es)
CN (1) CN109789155B (es)
BR (1) BR112018011324A2 (es)
CA (1) CA3007357C (es)
DK (2) DK3383406T3 (es)
MX (2) MX393043B (es)
WO (1) WO2017096357A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220226355A1 (en) * 2019-05-24 2022-07-21 The Cleveland Clinic Foundation Timed alternate administration of decitabine and 5-azacytidine for cancer treatment
US20210077492A1 (en) * 2019-09-17 2021-03-18 The Trustees Of Indiana University Methods and compositions of treating pancreatic cancer
US20230055298A1 (en) * 2020-04-16 2023-02-23 Akirabio, Inc. Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers
WO2023069529A1 (en) 2021-10-19 2023-04-27 Akirabio, Inc. Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760208A (en) 1996-08-14 1998-06-02 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Process to prepare pyrimidine nucleosides
AU3354500A (en) 1999-03-01 2000-09-21 Halogenetics, Inc. Dramatic simplification of a method to treat neoplastic disease by radiation
US6861513B2 (en) 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US20050056280A1 (en) 2002-12-31 2005-03-17 Nektar Therapeutics Receptacle for an aerosolizable pharmaceutical formulation
WO2005115410A2 (en) 2004-05-06 2005-12-08 University Of Rochester Context dependent inhibitors of cytidine deaminases and uses thereof
US20060063735A1 (en) 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
US20060069060A1 (en) * 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
US20060128653A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of decitabine
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7601699B2 (en) 2005-08-01 2009-10-13 Nupotential, Inc. Production of reprogrammed cells with restored potential
AU2008304380A1 (en) 2007-09-26 2009-04-02 Mount Sinai School Of Medicine Azacytidine analogues and uses thereof
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
LT3692983T (lt) 2008-05-15 2021-11-10 Celgene Corporation Citidino analogų peroralinės kompozicijos ir jų naudojimo būdai
US9265785B2 (en) * 2008-12-22 2016-02-23 The Board Of Trustees Of The University Of Illinois Compositions comprising decitabine and tetrahydrouridine and uses thereof
CA2750891C (en) * 2008-12-22 2018-08-28 Board Of Trustees Of The University Of Illinois Compositions comprising decitabine and tetrahydrouridine and uses thereof
CA2789365A1 (en) 2009-02-10 2010-08-19 Celgene International Sarl Methods for treating non-small cell lung cancer using 5-azacytidine
JP5730854B2 (ja) 2009-04-06 2015-06-10 大塚製薬株式会社 デシタビンとシチジンデアミナーゼ阻害剤との組合せ、およびがんの治療におけるその使用
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
US8329665B2 (en) 2009-04-06 2012-12-11 Eisai Inc. Compositions and methods for treating cancer
CN102485232A (zh) * 2010-12-06 2012-06-06 苏州科耐尔医药科技有限公司 一种含地西他滨的药物组合物
EP2670396A1 (en) * 2011-01-31 2013-12-11 Celgene Corporation Pharmaceutical compositions of cytidine analogs and methods of use thereof
US8426143B2 (en) * 2011-05-24 2013-04-23 Saladax Biomedical Inc. Gemcitabine immunoassay
US9476099B2 (en) 2012-08-10 2016-10-25 Trustees Of Dartmouth College Method for determining sensitivity to decitabine treatment
US20140100182A1 (en) 2012-10-05 2014-04-10 The Cleveland Clinic Foundation Nanogel-Mediated Drug Delivery
KR20150141968A (ko) 2013-03-15 2015-12-21 에피제네틱스 파마 엘엘씨 플루오르화된 피리미딘 유사체 및 그의 사용 방법
WO2017158396A1 (en) 2016-03-16 2017-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Cytidine deaminase inhibitors for the treatment of pancreatic cancer

Also Published As

Publication number Publication date
EP3383406A1 (en) 2018-10-10
WO2017096357A1 (en) 2017-06-08
MX393043B (es) 2025-03-24
US11376270B2 (en) 2022-07-05
DK3383406T3 (da) 2022-01-10
CN109789155A (zh) 2019-05-21
JP2022184941A (ja) 2022-12-13
US20220152075A1 (en) 2022-05-19
CN109789155B (zh) 2025-02-07
EP3383406A4 (en) 2019-08-21
US20200246368A1 (en) 2020-08-06
JP2018538370A (ja) 2018-12-27
EP3960182A1 (en) 2022-03-02
US20240165142A1 (en) 2024-05-23
EP3960182B1 (en) 2025-03-19
CA3007357C (en) 2023-12-05
JP7194021B2 (ja) 2022-12-21
EP3383406B1 (en) 2021-10-20
BR112018011324A2 (pt) 2018-12-04
US11779591B2 (en) 2023-10-10
CA3007357A1 (en) 2017-06-08
DK3960182T3 (da) 2025-04-07
MX2021007569A (es) 2022-06-09
MX2018006790A (es) 2019-05-02

Similar Documents

Publication Publication Date Title
IL258358A (en) Quantitative heart testing
CL2018001384A1 (es) Polipéptidos biparatópicos que antagonizan la señalización wnt en células tumorales
CO2019005909A2 (es) Anticuerpos y polipéptidos dirigidos contra cd127
DK3475295T3 (da) Hidtil ukendt nukleosidtriphosphat-transportør og anvendelser deraf
MX2016011538A (es) Acidos nucleicos antisentido.
MX2017000569A (es) Emulsiones de silicona.
EP3351188A4 (en) ENDOSCOPE TREATMENT INSTRUMENT
MX2020009154A (es) Nuc-1031 (gemcitabina-[fenil-benzoxi-l-alaninil])-fosfato) para usarse en el tratamiento neoadyuvante y adyuvante en pacientes con cáncer.
ECSP15026557A (es) Compuestos y sus métodos de empleo
EP3351186A4 (en) ENDOSCOPE TREATMENT INSTRUMENT
EP3351187A4 (en) ENDOSCOPE TREATMENT INSTRUMENT
ECSP17003946A (es) Anticuerpos antagonistas del interferón alfa y omega
CL2018001569A1 (es) Compuestos heteroaromáticos como inhibidores de btk
MX2018002955A (es) Acido nucleico antisentido.
CR20150648A (es) Derivados de nucleósido 4´-azido, 3´-desoxi-3´-fluoro sustituido
DK3795072T3 (da) Intermitterende måling af partialtrykket af en analyt i hudvævet
PL3186244T3 (pl) Analogi dioksolanowe urydyny w leczeniu raka
CL2016003260A1 (es) Profármacos de gemcitabina
EP3329400A4 (en) DISAMBING OF SEARCH QUESTIONS
SV2018005730A (es) Biomarcadores para copanlisib
DK3114215T3 (da) Grupperede nk-celler fra navlestrengsblod og anvendelse deraf til behandling af cancer og kronisk infektionssygdom
MX2018015410A (es) Esteres de oxaborol y sus usos.
EA201691887A1 (ru) Лечение внутрипеченочных холестатических заболеваний
EP3458836C0 (en) NON-INVASIVE BLOOD ANALYSIS
MX383757B (es) Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos