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MX384637B - Compuestos oxadiazoespíricos para el tratamiento del abuso y la adicción a las drogas. - Google Patents

Compuestos oxadiazoespíricos para el tratamiento del abuso y la adicción a las drogas.

Info

Publication number
MX384637B
MX384637B MX2018005439A MX2018005439A MX384637B MX 384637 B MX384637 B MX 384637B MX 2018005439 A MX2018005439 A MX 2018005439A MX 2018005439 A MX2018005439 A MX 2018005439A MX 384637 B MX384637 B MX 384637B
Authority
MX
Mexico
Prior art keywords
compounds
addiction
drug abuse
oxadiazoespiric
treatment
Prior art date
Application number
MX2018005439A
Other languages
English (en)
Other versions
MX2018005439A (es
Inventor
Carlos Alegret-Molina
Rosales Carmen Almansa
Marina Virgili-Bernado
Original Assignee
Esteve Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals Sa filed Critical Esteve Pharmaceuticals Sa
Publication of MX2018005439A publication Critical patent/MX2018005439A/es
Publication of MX384637B publication Critical patent/MX384637B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a compuestos con actividad farmacológica contra el receptor sigma (s), y más en particular a compuestos oxadiazaespíricos con dicha actividad farmacológica, a procesos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular contra el abuso y la adicción a las drogas.
MX2018005439A 2015-11-16 2016-11-15 Compuestos oxadiazoespíricos para el tratamiento del abuso y la adicción a las drogas. MX384637B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15382566 2015-11-16
PCT/EP2016/001907 WO2017084752A1 (en) 2015-11-16 2016-11-15 Oxadiazaspiro compounds for the treatment of drug abuse and addiction

Publications (2)

Publication Number Publication Date
MX2018005439A MX2018005439A (es) 2018-11-09
MX384637B true MX384637B (es) 2025-03-14

Family

ID=54707728

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005439A MX384637B (es) 2015-11-16 2016-11-15 Compuestos oxadiazoespíricos para el tratamiento del abuso y la adicción a las drogas.

Country Status (30)

Country Link
US (2) US10927128B2 (es)
EP (1) EP3377500B1 (es)
JP (1) JP6884974B2 (es)
KR (2) KR20180080327A (es)
CN (1) CN108349999A (es)
AR (1) AR106697A1 (es)
AU (1) AU2016356488B2 (es)
CA (1) CA3002286A1 (es)
CO (1) CO2018004665A2 (es)
DK (1) DK3377500T3 (es)
ES (1) ES2932000T3 (es)
HR (1) HRP20221343T1 (es)
HU (1) HUE060275T2 (es)
IL (1) IL259035B (es)
LT (1) LT3377500T (es)
MA (1) MA43250B1 (es)
MX (1) MX384637B (es)
MY (1) MY193423A (es)
PH (1) PH12018500814A1 (es)
PL (1) PL3377500T3 (es)
PT (1) PT3377500T (es)
RS (1) RS63734B1 (es)
SG (1) SG11201803153RA (es)
SI (1) SI3377500T1 (es)
SM (1) SMT202200460T1 (es)
TN (1) TN2018000122A1 (es)
TW (1) TWI756196B (es)
UA (1) UA123775C2 (es)
WO (1) WO2017084752A1 (es)
ZA (1) ZA201802845B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108349999A (zh) 2015-11-16 2018-07-31 埃斯蒂文博士实验室股份有限公司 用于治疗药物滥用和成瘾的氧杂二氮杂螺环化合物
WO2020157026A1 (en) * 2019-01-28 2020-08-06 Esteve Pharmaceuticals, S.A. Hydroxylated derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
CA3230908A1 (en) 2021-09-20 2023-03-23 Jose-Miguel Vela-Hernandez Oxadiazaspiro compounds for use in the treatment of motoneuron degeneration or in neuroprotection
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244961A (en) * 1978-10-26 1981-01-13 Syntex (U.S.A.) Inc. 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
US4332804A (en) 1981-03-23 1982-06-01 Syntex (U.S.A.) Inc. 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
US4353900A (en) 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
US4353901A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
JP2007522160A (ja) * 2004-02-10 2007-08-09 エフ．ホフマン−ラ　ロシュ　アーゲー ケモカインｃｃｒ５受容体モジュレーター
EP1720551B9 (en) 2004-03-03 2011-09-21 Vital Health Sciences Pty Ltd. Alkaloid formulations
US7951816B2 (en) * 2004-08-27 2011-05-31 Ono Pharmaceutical Co., Ltd. Compound containing basic group and use thereof
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
CN101228127B (zh) 2005-05-30 2012-05-16 Msdk.K.公司 哌啶衍生物
CN101203567A (zh) * 2005-06-07 2008-06-18 西巴特殊化学品控股有限公司 抗刮擦聚烯烃
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DK1940821T3 (da) 2005-10-19 2013-06-10 Gruenenthal Gmbh Nye vanilloid-receptorligander og deres anvendelse til fremstilling af lægemidler.
PT1961744E (pt) 2005-11-18 2013-05-15 Ono Pharmaceutical Co Composto que contém um grupo básico e sua utilização
EP1829869A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
CN101622241B (zh) 2007-03-01 2013-05-22 田边三菱制药株式会社 苯并咪唑化合物及其医药用途
EP1982714A1 (en) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) * 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
US20110190280A1 (en) 2007-08-29 2011-08-04 George Adjabeng Thiazole And Oxazole Kinase Inhibitors
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
EA018711B1 (ru) 2008-02-06 2013-10-30 Астразенека Аб Производные диазаспиро[5.5]ундекана в качестве антагонистов мускариновых рецепторов и агонистов бета-адренорецепторов для применения в лечении легочных расстройств
EP2108643A1 (en) * 2008-04-10 2009-10-14 Laboratorios Del. Dr. Esteve, S.A. 4-methyl-4, 5-dihydro-1H-pyrazole-3-carboxamide useful as a cannabinoid CB1 neutral antagonist
GB201016912D0 (en) * 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
EP2686325B1 (en) 2011-03-14 2016-12-14 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
GB201107985D0 (en) 2011-05-13 2011-06-29 Astrazeneca Ab Process
WO2013052716A1 (en) * 2011-10-07 2013-04-11 Glaxosmithkline Llc Fatty acid synthase inhibitors
JPWO2013115294A1 (ja) 2012-01-31 2015-05-11 東レ株式会社 ジアザスピロウレア誘導体及びその医薬用途
EP3027625B1 (en) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
TWI685497B (zh) * 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
EP3250204B1 (en) 2015-01-29 2019-10-30 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CN108349999A (zh) 2015-11-16 2018-07-31 埃斯蒂文博士实验室股份有限公司 用于治疗药物滥用和成瘾的氧杂二氮杂螺环化合物

Also Published As

Publication number Publication date
BR112018009279A2 (pt) 2018-11-06
US20210115062A1 (en) 2021-04-22
UA123775C2 (uk) 2021-06-02
IL259035B (en) 2021-06-30
EP3377500A1 (en) 2018-09-26
JP6884974B2 (ja) 2021-06-09
RU2018120748A3 (es) 2020-02-07
BR112018009279A8 (pt) 2019-02-26
KR20180080327A (ko) 2018-07-11
PL3377500T3 (pl) 2023-01-23
SI3377500T1 (sl) 2023-02-28
CO2018004665A2 (es) 2018-07-19
ES2932000T3 (es) 2023-01-09
HRP20221343T1 (hr) 2022-12-23
US10927128B2 (en) 2021-02-23
CN108349999A (zh) 2018-07-31
DK3377500T3 (da) 2022-11-21
PT3377500T (pt) 2022-11-25
IL259035A (en) 2018-06-28
SG11201803153RA (en) 2018-06-28
HUE060275T2 (hu) 2023-02-28
PH12018500814A1 (en) 2018-10-29
TWI756196B (zh) 2022-03-01
AR106697A1 (es) 2018-02-07
US20180327422A1 (en) 2018-11-15
RS63734B1 (sr) 2022-12-30
US11649248B2 (en) 2023-05-16
WO2017084752A1 (en) 2017-05-26
JP2018533598A (ja) 2018-11-15
AU2016356488A1 (en) 2018-05-10
MA43250B1 (fr) 2022-12-30
ZA201802845B (en) 2021-10-27
TN2018000122A1 (en) 2019-10-04
MY193423A (en) 2022-10-12
TW201731854A (zh) 2017-09-16
CA3002286A1 (en) 2017-05-26
SMT202200460T1 (it) 2023-01-13
AU2016356488B2 (en) 2020-10-22
MX2018005439A (es) 2018-11-09
MA43250A (fr) 2021-04-14
EP3377500B1 (en) 2022-10-19
RU2018120748A (ru) 2019-12-05
KR20250069710A (ko) 2025-05-19
LT3377500T (lt) 2022-12-12

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