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MX336966B - Novedosos derivados y su uso en el tratamiento de transtornos neurologicos. - Google Patents

Novedosos derivados y su uso en el tratamiento de transtornos neurologicos.

Info

Publication number
MX336966B
MX336966B MX2013008108A MX2013008108A MX336966B MX 336966 B MX336966 B MX 336966B MX 2013008108 A MX2013008108 A MX 2013008108A MX 2013008108 A MX2013008108 A MX 2013008108A MX 336966 B MX336966 B MX 336966B
Authority
MX
Mexico
Prior art keywords
treatment
novel heterocyclic
neurological disorders
heterocyclic derivatives
bace
Prior art date
Application number
MX2013008108A
Other languages
English (en)
Other versions
MX2013008108A (es
Inventor
Marina Tintelnot-Blomley
Siem Jacob Veenstra
Rainer Machauer
Heinrich Rueeger
Rainer Martin Lueoend
Sangamesh Badiger
Murali Chebrolu
Markus Voegtle
Konztanze Hurth
Sébastien Jacquier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46491227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX336966(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2013008108A publication Critical patent/MX2013008108A/es
Publication of MX336966B publication Critical patent/MX336966B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a novedosos compuestos heterocíclicos de la fórmula (I): (Ver Formula) en donde todas las variables son como se definen en la memoria descriptiva, a composiciones farmacéuticas de los mismos, a combinaciones de los mismos, y a su uso como medicamentos, en particular para el tratamiento de la enfermedad de Alzheimer o de diabetes, por medio de la inhibición de BACE-1 o BACE-2.
MX2013008108A 2011-01-13 2012-01-11 Novedosos derivados y su uso en el tratamiento de transtornos neurologicos. MX336966B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN77DE2011 2011-01-13
US201161534591P 2011-09-14 2011-09-14
PCT/EP2012/050395 WO2012095469A1 (en) 2011-01-13 2012-01-11 Novel heterocyclic derivatives and their use in the treatment of neurological disorders

Publications (2)

Publication Number Publication Date
MX2013008108A MX2013008108A (es) 2013-10-30
MX336966B true MX336966B (es) 2016-02-08

Family

ID=46491227

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008108A MX336966B (es) 2011-01-13 2012-01-11 Novedosos derivados y su uso en el tratamiento de transtornos neurologicos.

Country Status (40)

Country Link
US (6) US8637508B2 (es)
EP (1) EP2663561B1 (es)
JP (1) JP5715710B2 (es)
KR (1) KR101569260B1 (es)
CN (2) CN103403001B (es)
AP (1) AP3807A (es)
AR (1) AR084849A1 (es)
AU (1) AU2012206561B2 (es)
CA (1) CA2824220C (es)
CL (2) CL2013001964A1 (es)
CO (1) CO6751293A2 (es)
CR (1) CR20130339A (es)
CU (1) CU20130101A7 (es)
CY (1) CY1117580T1 (es)
DK (1) DK2663561T3 (es)
EA (1) EA024059B1 (es)
ES (1) ES2576182T3 (es)
GT (1) GT201300179A (es)
HR (1) HRP20160647T1 (es)
HU (1) HUE029226T2 (es)
IL (1) IL227294A (es)
JO (1) JO3146B1 (es)
MA (1) MA34898B1 (es)
ME (1) ME02409B (es)
MX (1) MX336966B (es)
MY (1) MY162413A (es)
PE (1) PE20141110A1 (es)
PH (1) PH12013501480A1 (es)
PL (1) PL2663561T3 (es)
PT (1) PT2663561E (es)
RS (1) RS54782B1 (es)
SG (1) SG191812A1 (es)
SI (1) SI2663561T1 (es)
SM (1) SMT201600144B (es)
TN (1) TN2013000285A1 (es)
TW (1) TWI531570B (es)
UA (1) UA113051C2 (es)
UY (1) UY33865A (es)
WO (1) WO2012095469A1 (es)
ZA (1) ZA201304921B (es)

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