[go: up one dir, main page]

MX2022004627A - Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico. - Google Patents

Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.

Info

Publication number
MX2022004627A
MX2022004627A MX2022004627A MX2022004627A MX2022004627A MX 2022004627 A MX2022004627 A MX 2022004627A MX 2022004627 A MX2022004627 A MX 2022004627A MX 2022004627 A MX2022004627 A MX 2022004627A MX 2022004627 A MX2022004627 A MX 2022004627A
Authority
MX
Mexico
Prior art keywords
pyrazole
chloropyridin
bromo
carboxylic acid
methods
Prior art date
Application number
MX2022004627A
Other languages
English (en)
Inventor
Xin Liu
Jianhua Mao
Yanchun Cao
Zhijian Xu
Original Assignee
Fmc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp filed Critical Fmc Corp
Publication of MX2022004627A publication Critical patent/MX2022004627A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente, se describen métodos novedosos para sintetizar el ácido 5-bromo-2-(3-cloropiridin-2-il)-2H-pirazol-3-carboxílico a partir de pirazol o derivados de pirazol. En la presente, también se describen productos intermedios de reacción novedosos.
MX2022004627A 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico. MX2022004627A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962916840P 2019-10-18 2019-10-18
US202062982248P 2020-02-27 2020-02-27
PCT/US2020/055897 WO2021076839A1 (en) 2019-10-18 2020-10-16 Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid

Publications (1)

Publication Number Publication Date
MX2022004627A true MX2022004627A (es) 2022-05-26

Family

ID=73198483

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2022004631A MX2022004631A (es) 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.
MX2022004627A MX2022004627A (es) 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2022004631A MX2022004631A (es) 2019-10-18 2020-10-16 Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.

Country Status (16)

Country Link
US (2) US20220396560A1 (es)
EP (5) EP4043451B1 (es)
JP (2) JP2022552273A (es)
KR (2) KR20220086612A (es)
CN (3) CN114641471B (es)
AU (2) AU2020366037A1 (es)
BR (2) BR112022007215A2 (es)
HU (4) HUE062047T2 (es)
IL (5) IL291939B2 (es)
MA (2) MA56055A (es)
MX (2) MX2022004631A (es)
PL (4) PL4043451T3 (es)
TW (3) TWI875840B (es)
UY (1) UY38925A (es)
WO (2) WO2021076839A1 (es)
ZA (2) ZA202204278B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022007294A2 (pt) * 2019-10-18 2022-07-05 Fmc Corp Métodos para a preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico
PL4043451T3 (pl) * 2019-10-18 2024-06-10 Fmc Corporation Sposoby wytwarzania związku pośredniego w syntezie kwasu 5-bromo-2-(3-chloropirydyn-2-ylo)-2h-pirazolo-3-karboksylowego
CN115557931B (zh) * 2022-10-20 2024-05-14 浙江新安化工集团股份有限公司 一种3-溴-1-(3-氯-2-吡啶基)-1h-吡唑-5-甲酸的合成方法
CN117024374A (zh) * 2023-08-08 2023-11-10 安庆百谊生物科技有限公司 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE3011084A1 (de) * 1980-03-22 1981-10-01 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von substituierten n-azolylmethyl-halogenacetaniliden
JPH07110867B2 (ja) * 1987-04-04 1995-11-29 株式会社トクヤマ ハロゲン化複素環式化合物の製造方法
MY142967A (en) 2001-08-13 2011-01-31 Du Pont Method for controlling particular insect pests by applying anthranilamide compounds
MD3864C2 (ro) * 2003-01-28 2009-11-30 E.I. Du Pont De Nemours And Company Compuşi ai cianoantranilamidei, compoziţii pe baza ei şi procedeu de combatere a dăunătorilor nevertebraţi
PE20060285A1 (es) * 2004-03-30 2006-05-08 Aventis Pharma Inc Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
MY140912A (en) * 2004-07-26 2010-01-29 Du Pont Mixtures of anthranilamide invertebrate pest control agents
US7087755B1 (en) * 2004-11-12 2006-08-08 Frontier Scientific, Inc. Substituted pyridines
CN101611006A (zh) * 2006-12-13 2009-12-23 辉瑞产品公司 3-(4-(2,4-二氟苄氧基)-3-溴-6-甲基-2-氧代吡啶-1(2h)-基)-n,4-二甲基苯甲酰胺的制备方法
CL2008000979A1 (es) * 2007-04-11 2008-10-17 Sumitomo Chemical Co Proceso para producir un compuesto derivado de 2-piridin-2-il-2h-pirazol-3-fenilamida; compuestos intermediarios; el compuesto en si; composicion plaguicida que contiene a dicho compuesto; uso de dicho compuesto como plaguicida; y metodo para control
JP2008280340A (ja) * 2007-04-12 2008-11-20 Sumitomo Chemical Co Ltd ヒドラジド化合物及びそれを含有する有害節足動物防除剤
JP2009023991A (ja) * 2007-06-20 2009-02-05 Ishihara Sangyo Kaisha Ltd アントラニルアミド系化合物の製造方法
CN102746327A (zh) * 2007-08-14 2012-10-24 住友化学株式会社 肼化合物的制造方法、以及肼化合物的制造中间体及其制造方法
TW201245155A (en) * 2010-09-01 2012-11-16 Du Pont Fungicidal pyrazoles
CN102651485B (zh) * 2011-02-28 2016-03-30 丰田自动车株式会社 可充镁电池、电解液在可充镁电池中的应用、以及用于可充镁电池的电解液
EP2719697B1 (en) * 2011-06-04 2018-08-01 Xuanzhu Pharma Co., Ltd. Pyridonaphthyridine pi3k/mtor dual inhibitors and preparation and use thereof
WO2013105100A1 (en) * 2012-01-09 2013-07-18 Symed Labs Limited Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
UA115881C2 (uk) * 2012-09-07 2018-01-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Алкоксипіразоли як активатори розчинної гуанілатциклази
CN105669643A (zh) * 2013-12-05 2016-06-15 江西天人生态股份有限公司 一类基于鱼泥丁受体的邻甲酰氨基苯甲酰胺衍生物及其制备方法和用途
BR112016023860A2 (pt) * 2014-04-14 2017-08-15 Gruenenthal Gmbh heterociclil sulfonas substituídas por heteroaril
TW201726128A (zh) * 2015-10-08 2017-08-01 歌林達有限公司 經吡唑基取代之四氫哌喃基碸
EP3371176A4 (en) * 2015-10-16 2019-09-04 William Marsh Rice University EPOTHILON ANALOGUE, SYNTHESIS METHOD, TREATMENT METHOD AND MEDICAMENT CONJUGATE THEREFOR
DK3558945T3 (da) * 2016-12-21 2021-07-26 Bayer Cropscience Ag Fremgangsmåde til fremstilling af et n-[2-(2-pyridinyl)ethyl]carboxamidderivat
GB201721969D0 (en) * 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
CN111825653A (zh) * 2019-04-19 2020-10-27 安道麦马克西姆有限公司 取代吡唑类化合物的制备及其作为邻氨基苯甲酰胺前体的用途
PL4043451T3 (pl) 2019-10-18 2024-06-10 Fmc Corporation Sposoby wytwarzania związku pośredniego w syntezie kwasu 5-bromo-2-(3-chloropirydyn-2-ylo)-2h-pirazolo-3-karboksylowego

Also Published As

Publication number Publication date
ZA202204278B (en) 2024-08-28
UY38925A (es) 2021-05-31
PL3976589T3 (pl) 2023-07-31
KR20220086612A (ko) 2022-06-23
PL4043451T3 (pl) 2024-06-10
EP4219455A1 (en) 2023-08-02
TW202128631A (zh) 2021-08-01
CN119039270A (zh) 2024-11-29
IL299818B2 (en) 2025-02-01
JP2022552272A (ja) 2022-12-15
CN114641471A (zh) 2022-06-17
IL294551A (en) 2022-09-01
TW202517625A (zh) 2025-05-01
HUE066520T2 (hu) 2024-08-28
IL298694A (en) 2023-02-01
EP3976589B1 (en) 2023-04-12
WO2021076839A1 (en) 2021-04-22
CN114650987A (zh) 2022-06-21
EP4043451A1 (en) 2022-08-17
HUE062237T2 (hu) 2023-10-28
WO2021076835A1 (en) 2021-04-22
EP3976591A1 (en) 2022-04-06
KR20220084347A (ko) 2022-06-21
IL291939A (en) 2022-06-01
EP4219455B1 (en) 2024-12-11
EP4253380A2 (en) 2023-10-04
EP4043451B1 (en) 2024-02-28
PL3976591T3 (pl) 2023-07-31
CN114650987B (zh) 2024-09-06
TWI875840B (zh) 2025-03-11
IL294551B1 (en) 2023-01-01
IL292090A (en) 2022-06-01
MX2022004631A (es) 2022-05-24
WO2021076835A8 (en) 2021-11-04
PL4219455T3 (pl) 2025-04-14
AU2020366037A1 (en) 2022-04-21
HUE070680T2 (hu) 2025-06-28
BR112022007102A2 (pt) 2022-07-05
US20220396560A1 (en) 2022-12-15
ZA202204277B (en) 2024-08-28
JP7667144B2 (ja) 2025-04-22
MA56053A (fr) 2022-04-20
IL292090B2 (en) 2023-06-01
EP3976589A1 (en) 2022-04-06
EP4253380A3 (en) 2023-11-15
IL299818B1 (en) 2024-10-01
MA56055A (fr) 2022-04-06
BR112022007215A2 (pt) 2022-07-05
JP2022552273A (ja) 2022-12-15
TW202116748A (zh) 2021-05-01
IL298694B2 (en) 2025-05-01
IL291939B (en) 2022-12-01
IL291939B2 (en) 2023-04-01
TWI884994B (zh) 2025-06-01
CN114641471B (zh) 2025-05-23
EP3976591B1 (en) 2023-04-19
AU2020366212A1 (en) 2022-04-21
US20220259178A1 (en) 2022-08-18
IL299818A (en) 2023-03-01
HUE062047T2 (hu) 2023-09-28
IL294551B2 (en) 2023-05-01
IL298694B1 (en) 2025-01-01

Similar Documents

Publication Publication Date Title
MX2022004627A (es) Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.
MX2020006315A (es) Acidos carbamoil ciclohexilicos ligados a n triazol como antagonistas de acido lisofosfatidico (lpa).
MX2015000082A (es) Fabricacion de acido 2- (5-bromo-4- (4-ciclopropilnaftalen-1-il) -4h-1,2,4-triazol-3-iltio) acetico.
MX2021000348A (es) 2-fluoro-3-nitrotolueno cristalino y procedimiento para la preparacion del mismo.
ZA202403308B (en) An efficient new process for synthesis of 2-amino-5-chloro-n-,3-dimethylbenzamide
AR116790A1 (es) PROCEDIMIENTO PARA LA PREPARACIÓN DE 3a-HIDROXI-5a-PREGNAN-20-ONA (BREXANOLONA)
BR112014032229A2 (pt) método para produção de 4-[5-(piridin-4-il)-1h-1,2,4-triazol-3-il) piridina-2-carbonitrila, e intermediários da mesma
MX2017001459A (es) Sintesis de fosforamidatos.
MX2021013507A (es) Proceso para la preparacion de inhibidores del canal de cloruro ciec-1.
MX2022001549A (es) Nuevas sintesis telescopicas de 2-metoximetil-p-fenilendiamina.
PH12017501404A1 (en) Diaza-benzofluoranthrene compounds
MX376203B (es) Un proceso novedoso para la sintesis de 1-aril-1-trifluoro-metil-ciclopropanos.
ZA202204280B (en) Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid
MX2021004996A (es) Preparacion de 4-metiltetrahidropiranos 2-sustituidos a partir de 4-hidroxi-4-metiltetrahidropiranos 2-sustituidos como materiales de partida.
BR112022007172A2 (pt) Métodos para a preparação de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico
MX2022004630A (es) Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.
ZA202204275B (en) Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid
MX2021001530A (es) Metodo de produccion de esteres carbonicos.
MX379453B (es) Método para producir una forma polimórfica de 3-[5-amino-4-(3-cianobenzoilo)-pirazol-1-il]-n-ciclopropil-4-metilbenzamida.
EA201791098A1 (ru) Способ синтеза производных бензазепина
ZA202307488B (en) Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid
MX2022005604A (es) Metodos para la preparacion de 3-bromo-1-(3-cloropiridin-2-il)-1h- pirazol-5-carboxilato de etilo.
MX2022000651A (es) Proceso mejorado para preparar ozanimod.
AR120240A1 (es) Métodos para la preparación de ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico
AR120241A1 (es) Procedimiento para la preparación del ácido 5-bromo-2-(3-cloro-piridin-2-il)-2h-pirazol-3-carboxílico