MX2020011910A - Compuestos de heteroarilo tetraciclicos. - Google Patents
Compuestos de heteroarilo tetraciclicos.Info
- Publication number
- MX2020011910A MX2020011910A MX2020011910A MX2020011910A MX2020011910A MX 2020011910 A MX2020011910 A MX 2020011910A MX 2020011910 A MX2020011910 A MX 2020011910A MX 2020011910 A MX2020011910 A MX 2020011910A MX 2020011910 A MX2020011910 A MX 2020011910A
- Authority
- MX
- Mexico
- Prior art keywords
- heteroaryl compounds
- tetracyclic heteroaryl
- tetracyclic
- relates
- compounds
- Prior art date
Links
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La memoria descriptiva se refiere a compuestos de Fórmula (I) (ver Fórmula) y sales farmacéuticamente aceptables de los mismos. La memoria descriptiva también se refiere a procesos e intermedios usados para su preparación, a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos proliferativos celulares.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862668321P | 2018-05-08 | 2018-05-08 | |
| US201862754814P | 2018-11-02 | 2018-11-02 | |
| PCT/EP2019/061754 WO2019215203A1 (en) | 2018-05-08 | 2019-05-07 | Tetracyclic heteroaryl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020011910A true MX2020011910A (es) | 2021-01-29 |
Family
ID=66484036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020011910A MX2020011910A (es) | 2018-05-08 | 2019-05-07 | Compuestos de heteroarilo tetraciclicos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11407765B2 (es) |
| EP (1) | EP3790884A1 (es) |
| JP (1) | JP7138724B2 (es) |
| KR (1) | KR20210006948A (es) |
| CN (1) | CN112074520A (es) |
| AU (1) | AU2019267008B2 (es) |
| BR (1) | BR112020021467A2 (es) |
| CA (1) | CA3098261A1 (es) |
| CL (1) | CL2020002866A1 (es) |
| CO (1) | CO2020013564A2 (es) |
| CR (1) | CR20200532A (es) |
| DO (1) | DOP2020000201A (es) |
| EC (1) | ECSP20070854A (es) |
| JO (1) | JOP20200281A1 (es) |
| MA (1) | MA52560A (es) |
| MX (1) | MX2020011910A (es) |
| NI (1) | NI202000078A (es) |
| PE (1) | PE20211795A1 (es) |
| PH (1) | PH12020551870A1 (es) |
| SG (1) | SG11202010953QA (es) |
| TW (1) | TW202012415A (es) |
| UY (1) | UY38221A (es) |
| WO (1) | WO2019215203A1 (es) |
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| US20200109153A1 (en) | 2017-05-11 | 2020-04-09 | Astrazeneca Ab | Heteroaryl compounds that inhibit g12c mutant ras proteins |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| CN110869357A (zh) | 2017-05-25 | 2020-03-06 | 亚瑞克西斯制药公司 | 化合物及其用于治疗癌症的使用方法 |
| US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
| AU2018271990A1 (en) | 2017-05-25 | 2019-12-12 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| EP4403175A3 (en) | 2017-09-08 | 2024-10-02 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| SI3710439T1 (sl) | 2017-11-15 | 2023-06-30 | Mirati Therapeutics, Inc., | Zaviralci mutacije kras g12c |
| TW201938561A (zh) | 2017-12-08 | 2019-10-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| TW201942115A (zh) | 2018-02-01 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物 |
| TW201942116A (zh) | 2018-02-09 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌劑之四氫喹唑啉衍生物 |
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2019
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- 2019-05-07 JP JP2020560800A patent/JP7138724B2/ja active Active
- 2019-05-07 MA MA052560A patent/MA52560A/fr unknown
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- 2019-05-07 SG SG11202010953QA patent/SG11202010953QA/en unknown
- 2019-05-07 KR KR1020207035034A patent/KR20210006948A/ko not_active Withdrawn
- 2019-05-07 US US17/053,400 patent/US11407765B2/en active Active
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- 2019-05-07 JO JOP/2020/0281A patent/JOP20200281A1/ar unknown
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- 2019-05-07 PE PE2020001766A patent/PE20211795A1/es unknown
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- 2019-05-08 UY UY38221A patent/UY38221A/es not_active Application Discontinuation
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2020
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| CL2020002866A1 (es) | 2021-02-12 |
| CA3098261A1 (en) | 2019-11-14 |
| JP7138724B2 (ja) | 2022-09-16 |
| JOP20200281A1 (ar) | 2020-11-05 |
| PH12020551870A1 (en) | 2021-07-26 |
| ECSP20070854A (es) | 2020-12-31 |
| AU2019267008B2 (en) | 2022-02-17 |
| KR20210006948A (ko) | 2021-01-19 |
| DOP2020000201A (es) | 2020-11-30 |
| UY38221A (es) | 2019-10-31 |
| CO2020013564A2 (es) | 2020-11-10 |
| WO2019215203A1 (en) | 2019-11-14 |
| CN112074520A (zh) | 2020-12-11 |
| US11407765B2 (en) | 2022-08-09 |
| PE20211795A1 (es) | 2021-09-09 |
| CR20200532A (es) | 2020-12-23 |
| EP3790884A1 (en) | 2021-03-17 |
| BR112020021467A2 (pt) | 2021-01-19 |
| NI202000078A (es) | 2021-02-16 |
| TW202012415A (zh) | 2020-04-01 |
| JP2021532061A (ja) | 2021-11-25 |
| MA52560A (fr) | 2021-03-17 |
| AU2019267008A1 (en) | 2021-01-07 |
| US20210221823A1 (en) | 2021-07-22 |
| SG11202010953QA (en) | 2020-12-30 |
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