MX2019007073A - Inhibidores de moléculas pequeñas de la familia de quinasas jak. - Google Patents
Inhibidores de moléculas pequeñas de la familia de quinasas jak.Info
- Publication number
- MX2019007073A MX2019007073A MX2019007073A MX2019007073A MX2019007073A MX 2019007073 A MX2019007073 A MX 2019007073A MX 2019007073 A MX2019007073 A MX 2019007073A MX 2019007073 A MX2019007073 A MX 2019007073A MX 2019007073 A MX2019007073 A MX 2019007073A
- Authority
- MX
- Mexico
- Prior art keywords
- kinases
- small molecule
- molecule inhibitors
- jak family
- methods
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000003384 small molecules Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 150000007960 acetonitrile Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de 2-((1r,4r)-4-(imidazo[4,5-d]pirrolo[2,3-b]piridina-1 (6H)- il)ciclohexil)acetonitrilo, composiciones farmaceuticas que los contienen, metodos de elaboración, y metodos para utilizarlos que incluyen metodos para tratar enfermedades, desordenes y condiciones mediadas por JAK, tales como la enfermedad inflamatoria del intestino.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435609P | 2016-12-16 | 2016-12-16 | |
| US201762592680P | 2017-11-30 | 2017-11-30 | |
| US201762596607P | 2017-12-08 | 2017-12-08 | |
| PCT/US2017/066744 WO2018112379A1 (en) | 2016-12-16 | 2017-12-15 | Small molecule inhibitors of the jak family of kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019007073A true MX2019007073A (es) | 2019-10-15 |
| MX391936B MX391936B (es) | 2025-03-21 |
Family
ID=61692222
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007073A MX391936B (es) | 2016-12-16 | 2017-12-15 | Inhibidores de moléculas pequeñas de la familia de quinasas jak |
| MX2022004474A MX2022004474A (es) | 2016-12-16 | 2017-12-15 | Inhibidores de moléculas pequeñas de la familia de quinasas jak. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022004474A MX2022004474A (es) | 2016-12-16 | 2017-12-15 | Inhibidores de moléculas pequeñas de la familia de quinasas jak. |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US10294226B2 (es) |
| EP (2) | EP4086256A1 (es) |
| JP (2) | JP7291077B2 (es) |
| KR (1) | KR102352462B1 (es) |
| CN (1) | CN110088105B (es) |
| AU (3) | AU2017377069B2 (es) |
| CL (1) | CL2019001626A1 (es) |
| CO (1) | CO2019006200A2 (es) |
| CR (1) | CR20190282A (es) |
| CY (1) | CY1125460T1 (es) |
| DK (1) | DK3555097T3 (es) |
| EC (1) | ECSP19042688A (es) |
| ES (1) | ES2922379T3 (es) |
| HR (1) | HRP20220885T1 (es) |
| HU (1) | HUE059274T2 (es) |
| IL (1) | IL267275B (es) |
| JO (1) | JOP20190143B1 (es) |
| LT (1) | LT3555097T (es) |
| MD (1) | MD3555097T2 (es) |
| MX (2) | MX391936B (es) |
| MY (1) | MY196260A (es) |
| NI (1) | NI201900060A (es) |
| NZ (1) | NZ795615A (es) |
| PE (1) | PE20191105A1 (es) |
| PH (1) | PH12019501254A1 (es) |
| PL (1) | PL3555097T3 (es) |
| PT (1) | PT3555097T (es) |
| RS (1) | RS63500B1 (es) |
| SA (1) | SA519402216B1 (es) |
| SI (1) | SI3555097T1 (es) |
| SM (1) | SMT202200326T1 (es) |
| TW (1) | TWI777997B (es) |
| UA (1) | UA125042C2 (es) |
| WO (1) | WO2018112379A1 (es) |
| ZA (1) | ZA201904615B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3433256T3 (da) | 2016-10-24 | 2019-10-28 | Astrazeneca | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinolinderivat, der er anvendeligt til behandling af cancer |
| JOP20190144A1 (ar) * | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| ES2922379T3 (es) | 2016-12-16 | 2022-09-14 | Janssen Pharmaceutica Nv | Compuestos de imidazo[4,5,D]pirrolo[2,3,B]piridina como inhibidores de Janus quinasas |
| ES2766249T3 (es) | 2017-01-30 | 2020-06-12 | Astrazeneca Ab | Moduladores del receptor de estrógeno |
| CN119552120A (zh) | 2018-06-15 | 2025-03-04 | 里亚塔医药公司 | 用于抑制IL-17和RORγ的吡唑和咪唑化合物 |
| TW202016110A (zh) * | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| WO2019246461A1 (en) | 2018-06-20 | 2019-12-26 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| WO2020216936A1 (en) | 2019-04-24 | 2020-10-29 | Janssen Pharmaceutica Nv | Non-clinical liquid formulations of pan-jak inhibitor |
| KR102785014B1 (ko) | 2019-06-06 | 2025-03-20 | 항저우 하이라이트엘엘 파마슈티컬 씨오., 엘티디. | 푸로이미다조피리딘 화합물의 합성 방법, 푸로이미다조피리딘 화합물의 결정 형태, 및 그의 염의 결정 형태 |
| CN110483514B (zh) * | 2019-09-16 | 2022-06-14 | 启元生物(杭州)有限公司 | 一种氰基取代的环肼衍生物及其应用 |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| ES3037893T3 (en) * | 2020-02-21 | 2025-10-07 | Zhuhai United Laboratories Co Ltd | Crystalline form of jak inhibitor and application thereof |
| KR20230005270A (ko) | 2020-04-24 | 2023-01-09 | 아스트라제네카 아베 | 약학적 제형 |
| IL297216A (en) | 2020-04-24 | 2022-12-01 | Astrazeneca Ab | Dosage regimen for the treatment of cancer |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| CN116925077A (zh) * | 2020-09-08 | 2023-10-24 | 一又生物(上海)有限公司 | 吡啶并环类化合物及其制备方法、中间体、组合物和应用 |
| JP2024509587A (ja) | 2021-03-11 | 2024-03-04 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｊａｋ媒介性障害の治療に使用するためのｌｏｒｐｕｃｉｔｉｎｉｂ |
| CN113292561A (zh) * | 2021-05-22 | 2021-08-24 | 中国药科大学 | 一种二吡咯并吡啶结构的化合物、制备方法和医药用途 |
| CN114432317A (zh) * | 2021-05-31 | 2022-05-06 | 广州嘉越医药科技有限公司 | 吡咯并嘧啶类化合物的用途 |
| CN113861194B (zh) * | 2021-11-10 | 2022-07-05 | 英维沃化工科技(广州)有限公司 | 一种含吡咯并吡啶双酰胺咪唑类化合物及其制备方法和应用 |
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| US6080747A (en) | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
| AR023561A1 (es) | 1999-04-23 | 2002-09-04 | Smithkline Beecham Corp | Una forma polimorfica del acido maleico de un derivado de tiazolidin-2, 4 diona, una composicion farmaceutica y el uso de dicho polimorfo para lafabricacion de un medicamento |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| AR040233A1 (es) | 2002-05-31 | 2005-03-23 | Schering Corp | Polimorfos inhibidores de xantina fosfodiesterasa v |
| GB0319935D0 (en) | 2003-08-26 | 2003-09-24 | Cipla Ltd | Polymorphs |
| US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
| RU2007148072A (ru) | 2005-07-01 | 2009-08-10 | Вайет (Us) | Кристаллические формы 4-[(2,4-дихлор-5-метоксифинил)амино]-6- меокси-7-[3-(4-метил-1-пиперазинил)пропокси]-3-хиналинкарбонитрил и способы их получения |
| EP2251341A1 (en) * | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| EP1910358A2 (en) | 2005-07-14 | 2008-04-16 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
| SI2299821T1 (sl) | 2008-06-10 | 2016-03-31 | Abbvie Inc. | Triciklične spojine |
| KR101669311B1 (ko) | 2009-09-03 | 2016-10-25 | 브리스톨-마이어스 스큅 컴퍼니 | Ｊａｋ２ 억제제, 및 골수증식성 질환 및 암의 치료를 위한 그의 용도 |
| JP2011066747A (ja) * | 2009-09-18 | 2011-03-31 | Panasonic Corp | 弾性波フィルタ |
| PL2506716T3 (pl) | 2009-12-01 | 2017-10-31 | Abbvie Inc | Nowe związki tricykliczne |
| US8785639B2 (en) | 2009-12-01 | 2014-07-22 | Abbvie Inc. | Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof |
| CN102712640A (zh) * | 2010-01-12 | 2012-10-03 | 弗·哈夫曼-拉罗切有限公司 | 三环杂环化合物、其组合物和应用方法 |
| US8841078B2 (en) | 2010-02-10 | 2014-09-23 | Genon Biotechnologies Oy | Dual activity kinase domains and uses thereof |
| WO2013007765A1 (en) * | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Fused tricyclic compounds for use as inhibitors of janus kinases |
| GB201212081D0 (en) | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
| EP2955181B1 (en) | 2013-02-08 | 2019-10-30 | Nissan Chemical Corporation | Tricyclic pyrrolopyridine compound, and jak inhibitor |
| EP2924026A1 (en) * | 2014-03-28 | 2015-09-30 | Novartis Tiergesundheit AG | Aminosulfonylmethylcyclohexanes as JAK inhibitors |
| RU2674262C2 (ru) | 2014-05-14 | 2018-12-06 | Ниссан Кемикал Индастриз, Лтд. | Трициклическое соединение и ингибитор jak |
| DK3303348T3 (da) | 2015-05-28 | 2019-11-11 | Theravance Biopharma R&D Ip Llc | Naphthyridinforbindelser som JAK-kinaseinhibitorer |
| EP3371332A4 (en) | 2015-11-04 | 2019-04-03 | Mayo Foundation for Medical Education and Research | METHOD AND MATERIALS FOR TREATING AUTOIMMUNE DISEASES |
| JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
| DK3433256T3 (da) | 2016-10-24 | 2019-10-28 | Astrazeneca | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinolinderivat, der er anvendeligt til behandling af cancer |
| MA56480B1 (fr) | 2016-12-16 | 2022-12-30 | Pfizer | Agonistes du récepteur glp-1 et leurs utilisations |
| JOP20190144A1 (ar) * | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| ES2922379T3 (es) | 2016-12-16 | 2022-09-14 | Janssen Pharmaceutica Nv | Compuestos de imidazo[4,5,D]pirrolo[2,3,B]piridina como inhibidores de Janus quinasas |
| AU2017374992A1 (en) | 2016-12-16 | 2019-06-20 | Basf Se | Pesticidal compounds |
| RU2765752C2 (ru) | 2016-12-16 | 2022-02-02 | Сосьете Де Продюи Нестле С.А. | Олигосахариды для создания вкусоароматических свойств |
| ES2835281T3 (es) | 2016-12-16 | 2021-06-22 | Lilly Co Eli | Compuestos de 7-feniletilamino-4H-pirimido[4,5-d][1,3]oxazin-2-ona como inhibidores de IDH1 e IDH2 mutantes |
| PL3568396T3 (pl) | 2017-01-11 | 2021-05-31 | Leo Pharma A/S | Nowe pochodne aminoimidazopirydyny jako inhibitory kinaz janusowych i ich zastosowanie farmaceutyczne |
| ES2766249T3 (es) | 2017-01-30 | 2020-06-12 | Astrazeneca Ab | Moduladores del receptor de estrógeno |
| CA3059939A1 (en) | 2017-04-21 | 2018-10-25 | Kyn Therapeutics | Indole ahr inhibitors and uses thereof |
| CN106881892B (zh) | 2017-04-27 | 2020-10-16 | 双钱集团（江苏）轮胎有限公司 | 一种轮胎生产用生胎转移系统 |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| WO2020216936A1 (en) | 2019-04-24 | 2020-10-29 | Janssen Pharmaceutica Nv | Non-clinical liquid formulations of pan-jak inhibitor |
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2017
- 2017-12-15 ES ES17854175T patent/ES2922379T3/es active Active
- 2017-12-15 TW TW106144095A patent/TWI777997B/zh active
- 2017-12-15 CR CR20190282A patent/CR20190282A/es unknown
- 2017-12-15 SM SM20220326T patent/SMT202200326T1/it unknown
- 2017-12-15 EP EP22178880.5A patent/EP4086256A1/en active Pending
- 2017-12-15 JO JOP/2019/0143A patent/JOP20190143B1/ar active
- 2017-12-15 HR HRP20220885TT patent/HRP20220885T1/hr unknown
- 2017-12-15 RS RS20220753A patent/RS63500B1/sr unknown
- 2017-12-15 JP JP2019531668A patent/JP7291077B2/ja active Active
- 2017-12-15 PL PL17854175.1T patent/PL3555097T3/pl unknown
- 2017-12-15 LT LTEPPCT/US2017/066744T patent/LT3555097T/lt unknown
- 2017-12-15 MD MDE20191212T patent/MD3555097T2/ro unknown
- 2017-12-15 KR KR1020197020121A patent/KR102352462B1/ko active Active
- 2017-12-15 UA UAA201908086A patent/UA125042C2/uk unknown
- 2017-12-15 MX MX2019007073A patent/MX391936B/es unknown
- 2017-12-15 NZ NZ795615A patent/NZ795615A/en unknown
- 2017-12-15 MX MX2022004474A patent/MX2022004474A/es unknown
- 2017-12-15 PT PT178541751T patent/PT3555097T/pt unknown
- 2017-12-15 EP EP17854175.1A patent/EP3555097B1/en active Active
- 2017-12-15 US US15/843,642 patent/US10294226B2/en active Active
- 2017-12-15 PE PE2019001252A patent/PE20191105A1/es unknown
- 2017-12-15 SI SI201731186T patent/SI3555097T1/sl unknown
- 2017-12-15 CN CN201780077753.4A patent/CN110088105B/zh active Active
- 2017-12-15 MY MYPI2019003389A patent/MY196260A/en unknown
- 2017-12-15 HU HUE17854175A patent/HUE059274T2/hu unknown
- 2017-12-15 WO PCT/US2017/066744 patent/WO2018112379A1/en not_active Ceased
- 2017-12-15 AU AU2017377069A patent/AU2017377069B2/en active Active
- 2017-12-15 DK DK17854175.1T patent/DK3555097T3/da active
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2019
- 2019-01-09 US US16/243,874 patent/US10364246B2/en active Active
- 2019-02-12 US US16/274,142 patent/US11059823B2/en active Active
- 2019-02-13 US US16/275,045 patent/US10487083B2/en active Active
- 2019-06-06 PH PH12019501254A patent/PH12019501254A1/en unknown
- 2019-06-12 CL CL2019001626A patent/CL2019001626A1/es unknown
- 2019-06-12 IL IL267275A patent/IL267275B/en unknown
- 2019-06-13 SA SA519402216A patent/SA519402216B1/ar unknown
- 2019-06-14 EC ECSENADI201942688A patent/ECSP19042688A/es unknown
- 2019-06-14 CO CONC2019/0006200A patent/CO2019006200A2/es unknown
- 2019-06-14 NI NI201900060A patent/NI201900060A/es unknown
- 2019-07-15 ZA ZA2019/04615A patent/ZA201904615B/en unknown
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2020
- 2020-10-21 AU AU2020257068A patent/AU2020257068A1/en not_active Abandoned
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2021
- 2021-06-23 US US17/355,472 patent/US12202831B2/en active Active
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2022
- 2022-06-17 AU AU2022204240A patent/AU2022204240B2/en active Active
- 2022-08-02 CY CY20221100530T patent/CY1125460T1/el unknown
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2023
- 2023-02-13 JP JP2023019626A patent/JP7493068B2/ja active Active
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