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MX2018007841A - Composicion de celula dendritica. - Google Patents

Composicion de celula dendritica.

Info

Publication number
MX2018007841A
MX2018007841A MX2018007841A MX2018007841A MX2018007841A MX 2018007841 A MX2018007841 A MX 2018007841A MX 2018007841 A MX2018007841 A MX 2018007841A MX 2018007841 A MX2018007841 A MX 2018007841A MX 2018007841 A MX2018007841 A MX 2018007841A
Authority
MX
Mexico
Prior art keywords
dendritic cell
antigen
fragment
cell composition
mhc class
Prior art date
Application number
MX2018007841A
Other languages
English (en)
Inventor
Schendel Dolores
Milosevic Slavoljub
Ellinger Christian
Wehner Carina
Original Assignee
Medigene Immunotherapies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Immunotherapies Gmbh filed Critical Medigene Immunotherapies Gmbh
Publication of MX2018007841A publication Critical patent/MX2018007841A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4269—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A61K40/4272—Melan-A/MART
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2121/00—Preparations for use in therapy
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
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Abstract

La presente invencion contempla composiciones de celulas dendriticas. Las composiciones de celulas dendriticas emplean senales de direccionamiento MHC de clase II fusionadas a un antígeno o fragmento de este para obtener la presentacion de MHC II del antigeno o el fragmento de este. En particular, la invencion se refiere a una vacuna de celulas dendriticas que comprende celulas dendriticas que expresan una senal de direccionamiento MHC de clase II fusionada a un antigeno o fragmento de este. Tambien se describen vacunas de celulas dendriticas para la estimulacion de una respuesta inmune contra el antigeno asociado al melanoma.
MX2018007841A 2015-12-23 2016-12-22 Composicion de celula dendritica. MX2018007841A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15202329 2015-12-23
EP16190399 2016-09-23
PCT/EP2016/082445 WO2017109110A1 (en) 2015-12-23 2016-12-22 Dendritic cell composition

Publications (1)

Publication Number Publication Date
MX2018007841A true MX2018007841A (es) 2018-11-09

Family

ID=57794260

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018007841A MX2018007841A (es) 2015-12-23 2016-12-22 Composicion de celula dendritica.
MX2018007842A MX2018007842A (es) 2015-12-23 2016-12-22 Nueva generacion de tcr especificos de antigeno.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018007842A MX2018007842A (es) 2015-12-23 2016-12-22 Nueva generacion de tcr especificos de antigeno.

Country Status (17)

Country Link
US (2) US10882891B2 (es)
EP (4) EP3394248B1 (es)
JP (3) JP6697562B2 (es)
KR (4) KR20180089446A (es)
CN (2) CN108473960A (es)
AU (2) AU2016374874B2 (es)
BR (2) BR112018012826A2 (es)
CA (2) CA3009564C (es)
DK (2) DK3394248T3 (es)
EA (2) EA201891460A1 (es)
ES (2) ES2863733T3 (es)
HU (1) HUE053674T2 (es)
MX (2) MX2018007841A (es)
PH (2) PH12018501336A1 (es)
PL (2) PL3394247T3 (es)
TW (2) TWI772282B (es)
WO (2) WO2017109110A1 (es)

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