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MX2018007155A - Heteroarilhidroxipirimidinonas como agonistas del receptor de apelina (apj). - Google Patents

Heteroarilhidroxipirimidinonas como agonistas del receptor de apelina (apj).

Info

Publication number
MX2018007155A
MX2018007155A MX2018007155A MX2018007155A MX2018007155A MX 2018007155 A MX2018007155 A MX 2018007155A MX 2018007155 A MX2018007155 A MX 2018007155A MX 2018007155 A MX2018007155 A MX 2018007155A MX 2018007155 A MX2018007155 A MX 2018007155A
Authority
MX
Mexico
Prior art keywords
agonists
heteroarylhydroxypyrimidinones
apj receptor
formula
apj
Prior art date
Application number
MX2018007155A
Other languages
English (en)
Other versions
MX380669B (es
Inventor
Michael Lawrence R
Meng Wei
C Myers Michael
Finlay Heather
M Bilder Donna
Pi Zulan
Paul Brigance Robert
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of MX2018007155A publication Critical patent/MX2018007155A/es
Publication of MX380669B publication Critical patent/MX380669B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención proporciona compuestos de la Fórmula (I): (ver Fórmula) en donde todas las variables son como se definen en la descripción, y composiciones que comprenden cualquiera de tales compuestos novedosos. Estos compuestos son agonistas de APJ que se pueden usar como medicamentos.
MX2018007155A 2015-12-16 2016-12-15 Heteroarilhidroxipirimidinonas como agonistas del receptor de apelina (apj). MX380669B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562267997P 2015-12-16 2015-12-16
PCT/US2016/066750 WO2017106396A1 (en) 2015-12-16 2016-12-15 Heteroarylhydroxypyrimidinones as agonists of the apj receptor

Publications (2)

Publication Number Publication Date
MX2018007155A true MX2018007155A (es) 2018-08-15
MX380669B MX380669B (es) 2025-03-12

Family

ID=57708840

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007155A MX380669B (es) 2015-12-16 2016-12-15 Heteroarilhidroxipirimidinonas como agonistas del receptor de apelina (apj).

Country Status (21)

Country Link
US (1) US10669261B2 (es)
EP (1) EP3390400B1 (es)
JP (1) JP6948322B2 (es)
KR (1) KR102742744B1 (es)
CN (1) CN108602813B (es)
AR (1) AR107061A1 (es)
AU (1) AU2016372048B2 (es)
BR (1) BR112018012112A2 (es)
CA (1) CA3008630A1 (es)
CL (1) CL2018001621A1 (es)
CO (1) CO2018007221A2 (es)
EA (1) EA036736B1 (es)
ES (1) ES2854733T3 (es)
HK (1) HK1255163A1 (es)
IL (1) IL259947B (es)
MX (1) MX380669B (es)
PE (1) PE20181487A1 (es)
SG (1) SG11201804674UA (es)
TW (1) TW201725203A (es)
UY (1) UY37026A (es)
WO (1) WO2017106396A1 (es)

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WO2017066402A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides as apj agonists
PE20181269A1 (es) 2015-12-04 2018-08-03 Bristol Myers Squibb Co Agonistas del receptor de apelina y metodos de uso
MA55064A (fr) 2015-12-16 2021-09-29 Loxo Oncology Inc Composés utilisés comme inhibiteurs de kinase
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WO2017192485A1 (en) 2016-05-03 2017-11-09 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
WO2017218633A1 (en) 2016-06-14 2017-12-21 Bristol-Myers Squibb Company 6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1h)-one as apj agonists
WO2017218617A1 (en) 2016-06-14 2017-12-21 Bristol-Myers Squibb Company 4-hydroxy-3-sulfonylpyridin-2(1h)-ones as apj receptor agonists
JP7037558B2 (ja) 2016-10-14 2022-03-16 ブリストル－マイヤーズ スクイブ カンパニー ３－スルホニル－５－アミノピリジン－２，４－ジオール ａｐｊアゴニスト
EP3541810B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole phenyl compounds as agonists of the apj receptor
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
MA46827A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
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WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor

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JP7037558B2 (ja) 2016-10-14 2022-03-16 ブリストル－マイヤーズ スクイブ カンパニー ３－スルホニル－５－アミノピリジン－２，４－ジオール ａｐｊアゴニスト

Also Published As

Publication number Publication date
PE20181487A1 (es) 2018-09-18
MX380669B (es) 2025-03-12
AU2016372048B2 (en) 2021-02-04
HK1255163A1 (zh) 2019-08-09
ES2854733T3 (es) 2021-09-22
TW201725203A (zh) 2017-07-16
AU2016372048A1 (en) 2018-08-02
AR107061A1 (es) 2018-03-14
KR20180095577A (ko) 2018-08-27
US10669261B2 (en) 2020-06-02
CA3008630A1 (en) 2017-06-22
JP2018538304A (ja) 2018-12-27
SG11201804674UA (en) 2018-06-28
CL2018001621A1 (es) 2018-08-03
JP6948322B2 (ja) 2021-10-13
CN108602813A (zh) 2018-09-28
CO2018007221A2 (es) 2018-07-19
IL259947A (en) 2018-07-31
CN108602813B (zh) 2021-10-29
WO2017106396A1 (en) 2017-06-22
UY37026A (es) 2017-06-30
EA036736B1 (ru) 2020-12-14
EP3390400A1 (en) 2018-10-24
BR112018012112A2 (pt) 2018-12-04
IL259947B (en) 2020-10-29
US20180362508A1 (en) 2018-12-20
KR102742744B1 (ko) 2024-12-12
EP3390400B1 (en) 2021-01-20
EA201891336A1 (ru) 2019-01-31

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