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MA46827A - Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj - Google Patents

Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj

Info

Publication number
MA46827A
MA46827A MA046827A MA46827A MA46827A MA 46827 A MA46827 A MA 46827A MA 046827 A MA046827 A MA 046827A MA 46827 A MA46827 A MA 46827A MA 46827 A MA46827 A MA 46827A
Authority
MA
Morocco
Prior art keywords
receptor agonists
triazole compounds
apj receptor
cycloalkyl substitute
cycloalkyl
Prior art date
Application number
MA046827A
Other languages
English (en)
Inventor
Yinhong Chen
Paul John Dransfield
James S Harvey
Julie Anne Heath
Jonathan Houze
Aarif Yusuf Khakoo
David J Kopecky
Su-Jen Lai
Zhihua Ma
Nobuko Nishimura
Vatee Pattaropong
Philip Dean Ramsden
Gayathri Swaminath
Wen-Chen Yeh
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA46827A publication Critical patent/MA46827A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA046827A 2016-11-16 2017-11-03 Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj MA46827A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662422901P 2016-11-16 2016-11-16

Publications (1)

Publication Number Publication Date
MA46827A true MA46827A (fr) 2019-09-25

Family

ID=60409387

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046827A MA46827A (fr) 2016-11-16 2017-11-03 Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj

Country Status (4)

Country Link
US (1) US11020395B2 (fr)
EP (1) EP3541804B1 (fr)
MA (1) MA46827A (fr)
WO (1) WO2018093577A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
EP3541810B1 (fr) 2016-11-16 2020-12-23 Amgen Inc. Composés phényle triazole en tant qu'agonistes du récepteur apj
EP3541803B1 (fr) * 2016-11-16 2020-12-23 Amgen Inc. Composés de triazole pyridyle en tant qu'agonistes du récepteur apj
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
MA46824A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
BR112020002906A2 (pt) * 2017-08-15 2020-08-04 Inflazome Limited novos compostos de sulfonamida-carboxamida
US11149040B2 (en) 2017-11-03 2021-10-19 Amgen Inc. Fused triazole agonists of the APJ receptor
WO2019213006A1 (fr) 2018-05-01 2019-11-07 Amgen Inc. Pyrimidinones substituées en tant qu'agonistes du récepteur apj
WO2019241244A1 (fr) * 2018-06-13 2019-12-19 Board Of Regents, The University Of Texas System Inhibiteurs de sels de bicyclo[1.1.1]pentane de la double fermeture à glissière de leucine kinase (dlk) destinés au traitement de maladie
US11560366B2 (en) 2019-10-21 2023-01-24 Board Of Regents, The University Of Texas System Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
CN113105318B (zh) * 2021-02-23 2022-05-20 中山大学 一种2,2-二氟环丁烷-1-羧酸的制备方法及应用

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
DE3334455A1 (de) * 1983-03-04 1984-09-06 Bayer Ag, 5090 Leverkusen Guanidin - derivate
DE3825867A1 (de) 1988-03-04 1989-09-14 Bayer Ag Heterocyclisch substituierte sulfonylaminoazole und ihre verwendung als herbizide
EP0409332A3 (en) 1989-07-19 1991-08-07 Merck & Co. Inc. Substituted triazoles as angiotensin ii antagonists
DE3928605A1 (de) 1989-08-30 1991-03-07 Bayer Ag Substituierte sulfonylaminoazole
CA2075639A1 (fr) 1990-02-13 1991-08-14 William J. Greenlee Antagonistes de la trizole-angiotensine ii incorporant un element benzyle substitue
JPH0511439A (ja) 1990-09-13 1993-01-22 Fuji Photo Film Co Ltd 光重合性組成物
DE4035141A1 (de) 1990-11-06 1992-05-07 Bayer Ag Substituierte sulfonylaminotriazolylpyrimidine
CZ283018B6 (cs) 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
SE9103397D0 (sv) 1991-11-18 1991-11-18 Kabi Pharmacia Ab Nya substituerade salicylsyror
ATE205202T1 (de) 1992-03-13 2001-09-15 Merck Sharp & Dohme Imidazol-, triazol- und tetrazolderivate
US5411839A (en) 1993-01-15 1995-05-02 Eastman Kodak Company Image formation in color reversal materials using strong inhibitors
EP0807112B1 (fr) 1995-02-03 2001-09-05 PHARMACIA & UPJOHN COMPANY Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien
US5563026A (en) 1995-04-28 1996-10-08 Eastman Kodak Company Color negative element having improved green record printer compatibility
DE19725450A1 (de) 1997-06-16 1998-12-17 Hoechst Schering Agrevo Gmbh 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclylpyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
JP3788676B2 (ja) 1997-11-11 2006-06-21 富士写真フイルム株式会社 有機エレクトロルミネツセンス素子材料およびそれを使用した有機エレクトロルミネツセンス素子
CA2315735A1 (fr) 1998-02-13 1999-08-19 Michael R. Barbachyn Derives d'isoxazoline aminophenyle substitues utilises comme agents antimicrobiens
JP2002504550A (ja) 1998-02-25 2002-02-12 ファルマシア・アンド・アップジョン・カンパニー 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体
CA2384101A1 (fr) 1999-09-10 2001-03-15 Merck & Co., Inc. Inhibiteurs de tyrosine kinase
JP2003529609A (ja) 2000-03-16 2003-10-07 ジーンソフト インコーポレイティッド 核酸結合部分を含む荷電した化合物およびその利用法
DE60119714T2 (de) 2000-03-23 2006-09-07 Takeda Chemical Industries, Ltd. Peptidderivat
JP3873746B2 (ja) 2000-05-19 2007-01-24 アステラス製薬株式会社 トリアゾール誘導体
WO2002053160A1 (fr) 2000-12-29 2002-07-11 Alteon, Inc. Methode de traitement du glaucome ivb
WO2002053101A2 (fr) 2000-12-29 2002-07-11 Alteon, Inc. Procede de traitement de troubles fibrogenes et autres symptomes de type ivc
US6787555B2 (en) 2001-04-30 2004-09-07 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
US6727364B2 (en) 2001-04-30 2004-04-27 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
US6790846B2 (en) 2001-05-24 2004-09-14 The Procter & Gamble Company Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
JP2003005356A (ja) 2001-06-20 2003-01-08 Fuji Photo Film Co Ltd 電子線又はｘ線用ネガ型レジスト組成物
DE10138569A1 (de) 2001-08-06 2003-04-30 Bayer Ag Regulation des APJ-Rezeptors
JP2003321456A (ja) 2002-04-30 2003-11-11 Fuji Photo Film Co Ltd ５−アミノ−４−含窒素芳香族ヘテロ環置換ピラゾール類の製造方法
US20060135556A1 (en) 2002-08-23 2006-06-22 Jean-Luc Girardet Non-nucleoside reverse transcriptase inhibitors
US7084145B2 (en) 2002-10-25 2006-08-01 Pfizer Inc. Triazole compounds useful in therapy
US7361669B2 (en) 2003-01-02 2008-04-22 Millennium Pharmaceuticals, Inc. Compositions and method for inhibiting TGF-β
US7169797B2 (en) 2003-02-14 2007-01-30 Abbott Laboratories Protein-tyrosine phosphatase inhibitors and uses thereof
US20040167188A1 (en) 2003-02-14 2004-08-26 Zhili Xin Protein-tyrosine phosphatase inhibitors and uses thereof
JP2007524374A (ja) 2003-02-28 2007-08-30 プレキシコン，インコーポレーテッド Ｐｙｋ２結晶構造および使用
US20090048301A1 (en) 2003-07-09 2009-02-19 Imclone Systems Incorporated Heterocyclic compounds and their use as anticancer agents
ATE423122T1 (de) 2003-08-15 2009-03-15 Astrazeneca Ab Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)
EP1677786A1 (fr) 2003-10-18 2006-07-12 Bayer HealthCare AG Derives de 2-(phenylmethyl)thio-4-phenyl-4h-1,2,4-triazole substitues en 5 et composes associes utilises en tant que gaba-agonistes dans le traitement de l'incontinence urinaire et des maladies associees
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
US20050165015A1 (en) 2004-01-23 2005-07-28 Ncube Mghele V. Vanilloid receptor ligands and their use in treatments
US7297168B2 (en) 2004-02-02 2007-11-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
DE102004008141A1 (de) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
EP1730124A4 (fr) 2004-03-26 2009-04-01 Amphora Discovery Corp Composes et compositions a base de triazoles et leurs applications
WO2005123672A2 (fr) 2004-06-14 2005-12-29 Takeda San Diego, Inc. Inhibiteurs de kinase
US7399317B2 (en) 2004-08-26 2008-07-15 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
KR101214665B1 (ko) 2004-09-16 2012-12-21 아스텔라스세이야쿠 가부시키가이샤 트리아졸 유도체 또는 그의 염
CN101072759B (zh) 2004-11-18 2013-06-19 Synta医药公司 调节hsp90活性的三唑化合物
US20060156480A1 (en) 2005-01-14 2006-07-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
JPWO2006080533A1 (ja) 2005-01-31 2008-06-19 持田製薬株式会社 ３−アミノ−１，２，４−トリアゾール誘導体
CN101160291B (zh) 2005-03-09 2012-09-05 日本化药株式会社 作为hsp90抑制剂的三唑衍生物
US8399464B2 (en) 2005-03-09 2013-03-19 Nippon Kayaku Kabushiki Kaisha HSP90 inhibitor
CA2602383A1 (fr) 2005-03-21 2006-09-28 Pfizer Limited Derives de triazole substitues utilises en tant qu'antagonistes d'oxytocine
US8101618B2 (en) 2005-04-06 2012-01-24 Msd K.K. 1,4-substituted piperazine derivatives
WO2007007688A1 (fr) 2005-07-08 2007-01-18 Mochida Pharmaceutical Co., Ltd. Dérivé de 3,5-diamino-1,2,4-triazole
WO2007021941A2 (fr) 2005-08-16 2007-02-22 Icagen, Inc. Inhibiteurs des canaux sodium sensibles au voltage
EP2308852A1 (fr) 2005-08-21 2011-04-13 Abbott GmbH & Co. KG Composés 5-cycle-heteroaromates et leur utilisation en tant que partenaires de liaison des récepteurs 5-HT5
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
US8076486B2 (en) 2006-04-19 2011-12-13 Merck Serono S.A. Heteroaryl-substituted arylaminopyridine derivatives as MEK inhibitors
EP2026797A2 (fr) 2006-05-25 2009-02-25 Synta Pharmaceuticals Corporation Méthode pour traiter un lymphome non hodgkinien
TW200806637A (en) 2006-05-25 2008-02-01 Synta Pharmaceuticals Corp Synthesis of triazole compounds that modulate HSP90 activity
AU2012200157B2 (en) 2006-05-25 2014-08-21 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with protooncogene products
US8318790B2 (en) 2006-05-25 2012-11-27 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US8053456B2 (en) 2006-05-25 2011-11-08 Synta Pharmaceuticals Corp. Triazole compounds that modulate Hsp90 activity
CA2653217A1 (fr) 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Procede pour traiter des troubles proliferants associes a des produits protooncogenes
EP2038272B8 (fr) 2006-06-30 2013-10-23 Sunesis Pharmaceuticals, Inc. Inhibiteurs de pyridinonyle pdk1
US7718683B2 (en) 2006-07-14 2010-05-18 Chemocentryx, Inc. Triazolyl phenyl benzenesulfonamides
JP5320291B2 (ja) 2006-07-14 2013-10-23 ケモセントリックス， インコーポレイテッド トリアゾリルピリジルベンゼンスルホンアミド類
JP5480623B2 (ja) 2006-08-17 2014-04-23 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
US20110046125A1 (en) 2006-10-19 2011-02-24 Synta Pharmaceuticals Corp. Method for treating infections
WO2008057246A2 (fr) 2006-10-26 2008-05-15 Synta Pharmaceuticals Corp. Procédé de traitement de troubles inflammatoires
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
BRPI0807219A2 (pt) 2007-02-08 2015-05-26 Synta Pharmaceuticals Corp Composto de tiazol que modulam a atividade de hsp90
US7909187B2 (en) 2007-02-20 2011-03-22 Lonzell Montgomery Modular baby bottle system
WO2008112199A1 (fr) 2007-03-12 2008-09-18 Synta Pharmaceuticals Corp. Procédé d'inhibition de la topoisomérase ii
US8648104B2 (en) 2007-05-25 2014-02-11 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with mutations in c-Met
CN101801942B (zh) 2007-07-17 2013-03-27 美国艾森生物科学公司 杂环化合物和作为抗癌剂的用途
AU2008287367B2 (en) 2007-08-13 2012-02-23 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
WO2009075890A2 (fr) 2007-12-12 2009-06-18 Synta Pharmaceuticals Corp. Composés triazole qui modulent l'activité de hsp90
WO2009085230A1 (fr) 2007-12-19 2009-07-09 Amgen Inc. Inhibiteurs de la pi3 kinase
DE102008013587A1 (de) 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung
EP2103602A1 (fr) 2008-03-17 2009-09-23 AEterna Zentaris GmbH Nouveaux dérivés de triazole 1,2,4 et leur processus de fabrication
US9029376B2 (en) 2008-06-03 2015-05-12 Siga Technologies, Inc. Small molecule inhibitors for the treatment or prevention of dengue virus infection
PE20110570A1 (es) 2008-07-01 2011-08-26 Genentech Inc Heterociclos biciclicos sustituidos
CA2727252A1 (fr) 2008-07-01 2010-01-07 Genentech, Inc. Derives d'isoindolone utilises en tant qu'inhibiteurs de kinase mek et procedes d'utilisation correspondants
EP2323737A2 (fr) 2008-08-08 2011-05-25 Synta Pharmaceuticals Corp. Composés de triazole qui modulent l'activité hsp90
DE102008038221A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh 7-Azaindolderivate
WO2010062861A2 (fr) 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Inhibiteurs de recyclage de l'acide biliaire pour le traitement de l'obésité et du diabète
DE102008059702A1 (de) 2008-12-01 2010-06-02 Byk-Chemie Gmbh Verfahren zur Herstellung rheologisch wirksamer Harnstoffurethane in organischen Salzen
CA2764339A1 (fr) 2009-06-05 2010-12-09 Oslo University Hospital Hf Derives d'azole en tant qu'inhibiteurs de la voie wnt
CA2764785C (fr) 2009-06-08 2015-10-27 California Capital Equity, Llc Derives de triazine et leurs applications therapeutiques
CN102781922A (zh) 2009-12-11 2012-11-14 埃克塞利希斯股份有限公司 Tgr5激动剂
CN110269856A (zh) 2010-03-30 2019-09-24 维颂公司 多取代芳族化合物作为凝血酶的抑制剂
EP2560640A1 (fr) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Thérapie anticancéreuse à l'aide d'une combinaison d'un composé inhibiteur de hsp90 et d'un inhibiteur d'egfr
US20130156755A1 (en) 2010-04-19 2013-06-20 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor
US20130172333A1 (en) 2010-05-20 2013-07-04 Synta Pharmaceuticals Corp. Formulation and dosing of hsp90 inhibitory compounds
ES2552657T3 (es) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
JP5996532B2 (ja) 2010-07-15 2016-09-21 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 有害生物防除剤としての新規複素環式化合物
US20130266636A1 (en) 2010-08-12 2013-10-10 The Regents Of The University Of California Methods for blocking cell proliferation and treating diseases and conditions responsive to cell growth inhibition
WO2012076898A1 (fr) 2010-12-08 2012-06-14 Oslo University Hospital Hf Dérivés de triazole en tant qu'inhibiteurs de la voie de signalisation wnt
US20140045908A1 (en) 2011-02-25 2014-02-13 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
WO2013020108A2 (fr) 2011-08-04 2013-02-07 Lumena Pharmaceuticals, Inc. Inhibiteurs du recyclage de l'acide biliaire dans le traitement du pancréas
US9593109B2 (en) 2011-08-26 2017-03-14 Cymabay Therapeutics, Inc. Bicyclic agonists of GPR131 and uses thereof
SG10201406155QA (en) 2011-10-28 2014-11-27 Lumena Pharmaceuticals Inc Bile Acid Recycling Inhibitors For Treatment Of Pediatric Cholestatic Liver Diseases
SG11201401849QA (en) 2011-10-28 2014-05-29 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
JP2014532712A (ja) 2011-11-02 2014-12-08 シンタ ファーマシューティカルズ コーポレーション トポイソメラーゼｉ阻害剤とｈｓｐ９０阻害剤の組合せを使用する癌療法
AU2012339679A1 (en) 2011-11-14 2014-06-12 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with BRAF inhibitors
CA2860740A1 (fr) 2012-01-09 2013-07-18 Anchor Therapeutics, Inc. Composes de recepteurs apj
WO2013106614A1 (fr) 2012-01-13 2013-07-18 Bristol-Myers Squibb Company Composés pyridyles à substitution triazolyle utiles comme inhibiteurs de kinases
WO2013148857A1 (fr) 2012-03-28 2013-10-03 Synta Pharmaceuticals Corp. Dérivés de triazole comme inhibiteurs de hsp90
WO2013184755A2 (fr) 2012-06-07 2013-12-12 Georgia State University Research Foundation, Inc. Inhibiteurs de seca et leurs procédés de fabrication et d'utilisation
US20140005181A1 (en) 2012-06-21 2014-01-02 Sanford-Burnham Medical Research Institute Small molecule antagonists of the apelin receptor for the treatment of disease
KR20150058284A (ko) 2012-09-21 2015-05-28 사노피 Apj 수용체 조절자로서의 벤조이미다졸-카르복시산 아미드 유도체
EP3907237A1 (fr) 2012-12-20 2021-11-10 Amgen Inc. Agonistes du récepteur apj et leurs utilisations
BR112015023294A2 (pt) 2013-03-15 2017-07-18 Shifa Biomedical Corp método para tratamento ou prevenção de uma doença
UY35517A (es) 2013-04-04 2014-10-31 Mabxience S A Un procedimiento para aumentar la formación de ácido piroglutamico de una proteína
EP3003322B1 (fr) 2013-05-30 2023-09-13 Washington University Dérivés du mannose et leur utilisation dans le traitement d'infections bactériennes
JP2017516490A (ja) 2014-03-20 2017-06-22 セントル ナショナル デ ラ ルシュルシュ サイエンティフィーク（シーエヌアールエス） 癌を治療するためのアペリン／ａｐｊ／ｇｐ１３０シグナル伝達を阻害する化合物の使用
WO2015163818A1 (fr) 2014-04-24 2015-10-29 Nanyang Technological University Protéine ligase spécifique de asx
US10570128B2 (en) 2014-05-28 2020-02-25 Sanford Burnham Prebys Medical Discovery Institute Agonists of the apelin receptor and methods of use thereof
MA39999A (fr) 2014-06-06 2015-12-10 Res Triangle Inst Agonistes du récepteur de l'apeline (apj) et leurs utilisations
US20160058705A1 (en) 2014-08-28 2016-03-03 Jayakumar Rajadas Compositions and methods for treating cardiovascular and pulmonary diseases and disorders with apelin
US20170355734A1 (en) 2014-12-23 2017-12-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Metabolically Stable Apelin Analogs in the Treatment of Disease Mediated by the Apelin Receptor
WO2016151018A1 (fr) 2015-03-24 2016-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthode et composition pharmaceutique destinées à être utilisées dans le traitement du diabète
WO2016176473A1 (fr) 2015-04-28 2016-11-03 Sanford-Burnham Medical Researc Institute Agonistes du récepteur de l'apéline et leurs méthodes d'utilisation
JP6356364B1 (ja) 2015-05-20 2018-07-11 アムジエン・インコーポレーテツド Ａｐｊ受容体のトリアゾールアゴニスト
PH12017502158B1 (en) 2015-06-03 2022-04-27 Bristol Meyers Squibb Co 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders
WO2017066402A1 (fr) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company 2,4-dihydroxy-nicotinamides utilisés en tant qu'agonistes d'apj
US10626096B2 (en) 2015-11-24 2020-04-21 Sanford Burnham Prebys Medical Discovery Institute Azole derivatives as apelin receptor agonist
PE20181269A1 (es) 2015-12-04 2018-08-03 Bristol Myers Squibb Co Agonistas del receptor de apelina y metodos de uso
EP3386976A1 (fr) 2015-12-09 2018-10-17 Research Triangle Institute, International Agonistes améliorés du récepteur de l'apéline (apj) et leurs utilisations
SG11201804674UA (en) 2015-12-16 2018-06-28 Bristol Myers Squibb Co Heteroarylhydroxypyrimidinones as agonists of the apj receptor
CN109195963B (zh) 2016-03-24 2021-04-23 百时美施贵宝公司 作为apj激动剂的6-羟基-4-氧代-1，4-二氢嘧啶-5-甲酰胺
EP3228630A1 (fr) 2016-04-07 2017-10-11 IMBA-Institut für Molekulare Biotechnologie GmbH Combinaison d'un antagoniste d'apeline et inhibiteur de l'angiogenèse pour le traitement du cancer
WO2017192485A1 (fr) 2016-05-03 2017-11-09 Amgen Inc. Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj
WO2017218633A1 (fr) 2016-06-14 2017-12-21 Bristol-Myers Squibb Company 6-hydroxy-5-(phényl/hétéroarylsulfonyl) pyrimidin-4(1h)-one utilisée en tant qu'agonistes de l'apj
WO2017218617A1 (fr) 2016-06-14 2017-12-21 Bristol-Myers Squibb Company 4-hydroxy-3-sulfonylpyridin-2(1h)-ones utilisés en tant qu'agonistes du récepteur apj
RU2764039C2 (ru) 2016-10-12 2022-01-14 Рисерч Трайэнгл Инститьют Гетероциклические агонисты рецептора апелина (apj) и их применение
JP7037558B2 (ja) 2016-10-14 2022-03-16 ブリストル－マイヤーズ スクイブ カンパニー ３－スルホニル－５－アミノピリジン－２，４－ジオール ａｐｊアゴニスト
EP3541810B1 (fr) 2016-11-16 2020-12-23 Amgen Inc. Composés phényle triazole en tant qu'agonistes du récepteur apj
EP3541803B1 (fr) 2016-11-16 2020-12-23 Amgen Inc. Composés de triazole pyridyle en tant qu'agonistes du récepteur apj
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
MA46824A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj

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US20190290648A1 (en) 2019-09-26
WO2018093577A1 (fr) 2018-05-24

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