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MX2018004777A - Compuestos oxa-diazaspiro que tienen actividad contra el dolor. - Google Patents

Compuestos oxa-diazaspiro que tienen actividad contra el dolor.

Info

Publication number
MX2018004777A
MX2018004777A MX2018004777A MX2018004777A MX2018004777A MX 2018004777 A MX2018004777 A MX 2018004777A MX 2018004777 A MX2018004777 A MX 2018004777A MX 2018004777 A MX2018004777 A MX 2018004777A MX 2018004777 A MX2018004777 A MX 2018004777A
Authority
MX
Mexico
Prior art keywords
oxa
activity against
compounds
against pain
diazaspiro
Prior art date
Application number
MX2018004777A
Other languages
English (en)
Inventor
Virgili-Bernado Marina
ALEGRET-MOLINA Carlos
Almansa-Rosales Carmen
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of MX2018004777A publication Critical patent/MX2018004777A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos oxadiazaespíricos con actividad farmacológica contra el receptor sigma (s), a procesos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor.
MX2018004777A 2015-10-23 2016-10-21 Compuestos oxa-diazaspiro que tienen actividad contra el dolor. MX2018004777A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15382523 2015-10-23
PCT/EP2016/001742 WO2017067664A1 (en) 2015-10-23 2016-10-21 Oxa-diazaspiro compounds having activity against pain

Publications (1)

Publication Number Publication Date
MX2018004777A true MX2018004777A (es) 2018-06-19

Family

ID=54364221

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004777A MX2018004777A (es) 2015-10-23 2016-10-21 Compuestos oxa-diazaspiro que tienen actividad contra el dolor.

Country Status (31)

Country Link
US (1) US10689398B2 (es)
EP (1) EP3365346B1 (es)
JP (1) JP6884973B2 (es)
KR (1) KR20180073638A (es)
CN (1) CN108349998B (es)
AR (1) AR106448A1 (es)
AU (1) AU2016343551A1 (es)
BR (1) BR112018007269A2 (es)
CA (1) CA2999925A1 (es)
CO (1) CO2018004803A2 (es)
CY (1) CY1122708T1 (es)
DK (1) DK3365346T3 (es)
ES (1) ES2775522T3 (es)
HR (1) HRP20200309T1 (es)
HU (1) HUE047997T2 (es)
IL (1) IL258370A (es)
LT (1) LT3365346T (es)
MA (1) MA43158B1 (es)
ME (1) ME03636B (es)
MX (1) MX2018004777A (es)
PH (1) PH12018500682A1 (es)
PL (1) PL3365346T3 (es)
PT (1) PT3365346T (es)
RS (1) RS59956B1 (es)
RU (1) RU2018118399A (es)
SG (1) SG11201802988XA (es)
SI (1) SI3365346T1 (es)
SM (1) SMT202000128T1 (es)
TN (1) TN2018000091A1 (es)
TW (1) TW201731853A (es)
WO (1) WO2017067664A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
SI3365346T1 (sl) 2015-10-23 2020-04-30 Esteve Pharmaceuticals, S.A. Spojine oksa diazaspiro s protibolečinskim delovanjem

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481942A (en) 1968-09-06 1969-12-02 Smithkline Corp Oxa-diazaspiro(4.5)decane compounds
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
WO1993013101A1 (fr) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Compose de pyridonecarboxylate, son utilisation pharmaceutique et compose spiro
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
ATE466014T1 (de) 2001-12-28 2010-05-15 Acadia Pharm Inc Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
KR101167573B1 (ko) * 2003-11-07 2012-07-30 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 개선된 약학적 성질을 갖는 퀴놀리논 화합물의 약학적으로허용가능한 염
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
PL1961744T3 (pl) 2005-11-18 2013-09-30 Ono Pharmaceutical Co Związek zawierający grupę zasadową oraz jego zastosowanie
EP1829869A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
WO2007124136A1 (en) 2006-04-19 2007-11-01 Acadia Pharmaceuticals, Inc. Use of 4-amino-piperidines for treating sleep disorders
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
US8877779B2 (en) 2007-03-01 2014-11-04 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
EP1982714A1 (en) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
EP2197876A1 (en) 2007-08-29 2010-06-23 Glaxosmithkline LLC Thiazole and oxazole kinase inhibitors
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
PL2242759T3 (pl) 2008-02-06 2013-06-28 Astrazeneca Ab Związki
EP2460347A4 (en) 2009-10-25 2014-03-12 Lg Electronics Inc METHOD FOR PROCESSING BROADCAST AND BROADCAST RECEIVER PROGRAM INFORMATION
EP2686325B1 (en) * 2011-03-14 2016-12-14 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
US8940085B2 (en) 2011-03-16 2015-01-27 Access Business Group International Llc Humidifier with ultraviolet disinfection
EP2744333B1 (en) 2011-08-19 2016-10-05 Glaxosmithkline Intellectual Property (No. 2) Limited Fatty acid synthase inhibitors
EP3027625B1 (en) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure
JP2017100951A (ja) 2014-04-04 2017-06-08 大正製薬株式会社 オキサゾリジノン及びオキサジナノン誘導体
TW201615643A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
CN107001368B (zh) 2014-11-21 2019-05-31 埃斯特韦制药股份公司 具有多重模式抗疼痛活性的1,9-二氮杂螺环十一烷化合物
SI3365346T1 (sl) 2015-10-23 2020-04-30 Esteve Pharmaceuticals, S.A. Spojine oksa diazaspiro s protibolečinskim delovanjem

Also Published As

Publication number Publication date
PL3365346T3 (pl) 2020-06-01
IL258370A (en) 2018-05-31
BR112018007269A2 (pt) 2018-10-30
RU2018118399A (ru) 2019-11-25
CY1122708T1 (el) 2021-03-12
US10689398B2 (en) 2020-06-23
HRP20200309T1 (hr) 2020-06-12
WO2017067664A9 (en) 2017-06-29
HUE047997T2 (hu) 2020-05-28
RU2018118399A3 (es) 2020-01-31
RS59956B1 (sr) 2020-03-31
JP2018531263A (ja) 2018-10-25
CN108349998B (zh) 2021-10-29
ME03636B (me) 2020-07-20
PH12018500682A1 (en) 2018-10-01
KR20180073638A (ko) 2018-07-02
WO2017067664A1 (en) 2017-04-27
SG11201802988XA (en) 2018-05-30
AR106448A1 (es) 2018-01-17
TN2018000091A1 (en) 2019-07-08
CA2999925A1 (en) 2017-04-27
TW201731853A (zh) 2017-09-16
MA43158B1 (fr) 2020-03-31
US20190002475A1 (en) 2019-01-03
EP3365346A1 (en) 2018-08-29
LT3365346T (lt) 2020-04-10
CO2018004803A2 (es) 2018-07-19
AU2016343551A1 (en) 2018-04-19
CN108349998A (zh) 2018-07-31
SI3365346T1 (sl) 2020-04-30
EP3365346B1 (en) 2019-12-04
DK3365346T3 (da) 2020-03-09
ES2775522T3 (es) 2020-07-27
JP6884973B2 (ja) 2021-06-09
PT3365346T (pt) 2020-03-05
SMT202000128T1 (it) 2020-05-08

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