MX2017009714A - Metodos para producir compuesto de pirazin carboxamida e intermediario sintetico del mismo. - Google Patents
Metodos para producir compuesto de pirazin carboxamida e intermediario sintetico del mismo.Info
- Publication number
- MX2017009714A MX2017009714A MX2017009714A MX2017009714A MX2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A
- Authority
- MX
- Mexico
- Prior art keywords
- carboxamide compound
- synthetic intermediate
- pyrazine carboxamide
- production
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 5
- 229960005206 pyrazinamide Drugs 0.000 title abstract 4
- -1 pyrazine carboxamide compound Chemical class 0.000 title abstract 4
- 239000000463 material Substances 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 229940127557 pharmaceutical product Drugs 0.000 abstract 2
- 238000009776 industrial production Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000010898 silica gel chromatography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
[Problema] Se proporciona un método novedoso para producir un compuesto de pirazin carboxamida como un material de producción de preparación de farmacéuticos, etc.; y un intermediario sintético que es útil en dicho método de producción. [Solución] Como un resultado de la investigación cuidadosa en los métodos de producción para producir industrialmente un compuesto de pirazincarboxamida, los inventores ha encontrado que, al usar un material e intermediario sintético predeterminados, el compuesto de pirazin carboxamida puede ser producido de acuerdo a un método que es apropiado para producción industrial como un producto farmacéutico, sin requerir la purificación por cromatografía de columna en gel de sílice, y en el cual el rendimiento total es mejorado considerablemente, por ello completando la invención actual.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015014533 | 2015-01-28 | ||
| PCT/JP2016/052229 WO2016121777A1 (ja) | 2015-01-28 | 2016-01-27 | ピラジンカルボキサミド化合物の製造方法及びその合成中間体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017009714A true MX2017009714A (es) | 2017-11-17 |
Family
ID=56543388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017009714A MX2017009714A (es) | 2015-01-28 | 2016-01-27 | Metodos para producir compuesto de pirazin carboxamida e intermediario sintetico del mismo. |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPWO2016121777A1 (es) |
| KR (1) | KR20170105021A (es) |
| CN (1) | CN107207468A (es) |
| CA (1) | CA2975072A1 (es) |
| MX (1) | MX2017009714A (es) |
| WO (1) | WO2016121777A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190282569A1 (en) * | 2016-10-26 | 2019-09-19 | Astellas Pharma Inc. | Stable pharmaceutical composition |
| EP4159731A4 (en) * | 2020-06-01 | 2024-06-26 | Wigen Biomedicine Technology (Shanghai) Co., Ltd. | New pyrazine compound |
| AU2022426699A1 (en) | 2021-12-30 | 2024-07-11 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
| IL317645A (en) * | 2022-06-14 | 2025-02-01 | Principia Biopharma Inc | Methods for preparing tolbrutinib |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5754177A (ja) * | 1980-09-19 | 1982-03-31 | Teikoku Hormone Mfg Co Ltd | Chikanchiazoorujudotai |
| JP3534903B2 (ja) * | 1995-06-09 | 2004-06-07 | 鐘淵化学工業株式会社 | １−［３−クロロ−（２ｓ）−メチルプロピオニル］−ピロリジン−（２ｓ）−カルボン酸の製造方法 |
| ME02648B (me) * | 2012-01-17 | 2017-06-20 | Astellas Pharma Inc | Jedinjenje pirazin karboksamida |
-
2016
- 2016-01-27 JP JP2016572078A patent/JPWO2016121777A1/ja active Pending
- 2016-01-27 KR KR1020177020729A patent/KR20170105021A/ko not_active Withdrawn
- 2016-01-27 WO PCT/JP2016/052229 patent/WO2016121777A1/ja not_active Ceased
- 2016-01-27 CN CN201680007743.9A patent/CN107207468A/zh active Pending
- 2016-01-27 MX MX2017009714A patent/MX2017009714A/es unknown
- 2016-01-27 CA CA2975072A patent/CA2975072A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2016121777A1 (ja) | 2017-11-02 |
| CA2975072A1 (en) | 2016-08-04 |
| WO2016121777A1 (ja) | 2016-08-04 |
| CN107207468A (zh) | 2017-09-26 |
| KR20170105021A (ko) | 2017-09-18 |
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