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MX2017009714A - Method for producing pyrazine carboxamide compound, and synthetic intermediate thereof. - Google Patents

Method for producing pyrazine carboxamide compound, and synthetic intermediate thereof.

Info

Publication number
MX2017009714A
MX2017009714A MX2017009714A MX2017009714A MX2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A MX 2017009714 A MX2017009714 A MX 2017009714A
Authority
MX
Mexico
Prior art keywords
carboxamide compound
synthetic intermediate
pyrazine carboxamide
production
producing
Prior art date
Application number
MX2017009714A
Other languages
Spanish (es)
Inventor
Morinaga Yasuhiro
Shimada Itsuro
Akiba Takahiro
Hoshii Hiroaki
Komenoi Kousuke
Nishikawa Kentaro
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2017009714A publication Critical patent/MX2017009714A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

[Problem] To provide: a novel method for producing a pyrazine carboxamide compound as a production material of pharmaceutical products, etc.; and a synthetic intermediate that is useful in said production method. [Solution] As a result of diligent research on production methods in industrially producing a pyrazine carboxamide compound, the inventors have found that, by using a predetermined material and synthetic intermediate, a pyrazine carboxamide compound can be produced according to a method that is suitable for industrial production as a pharmaceutical product, does not require purification by silica gel column chromatography, and in which overall yield is greatly improved, thus accomplishing the present invention.
MX2017009714A 2015-01-28 2016-01-27 Method for producing pyrazine carboxamide compound, and synthetic intermediate thereof. MX2017009714A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015014533 2015-01-28
PCT/JP2016/052229 WO2016121777A1 (en) 2015-01-28 2016-01-27 Method for producing pyrazine carboxamide compound, and synthetic intermediate thereof

Publications (1)

Publication Number Publication Date
MX2017009714A true MX2017009714A (en) 2017-11-17

Family

ID=56543388

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017009714A MX2017009714A (en) 2015-01-28 2016-01-27 Method for producing pyrazine carboxamide compound, and synthetic intermediate thereof.

Country Status (6)

Country Link
JP (1) JPWO2016121777A1 (en)
KR (1) KR20170105021A (en)
CN (1) CN107207468A (en)
CA (1) CA2975072A1 (en)
MX (1) MX2017009714A (en)
WO (1) WO2016121777A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2018079570A1 (en) * 2016-10-26 2019-09-19 アステラス製薬株式会社 Stable pharmaceutical composition
US20230167099A1 (en) * 2020-06-01 2023-06-01 Wigen Biomedicine Technology (shanghai) Co., Ltd. New pyrazine compound
IL313670A (en) 2021-12-30 2024-08-01 Biomea Fusion Inc Pyrazine compounds as inhibitors of flt3
AU2023294689A1 (en) * 2022-06-14 2025-01-30 Principia Biopharma Inc. Methods of making tolebrutinib

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5754177A (en) * 1980-09-19 1982-03-31 Teikoku Hormone Mfg Co Ltd CHIKANCHIAZOORUJUDOTAI
JP3534903B2 (en) * 1995-06-09 2004-06-07 鐘淵化学工業株式会社 Method for producing 1- [3-chloro- (2S) -methylpropionyl] -pyrrolidine- (2S) -carboxylic acid
UA111010C2 (en) * 2012-01-17 2016-03-10 Астеллас Фарма Інк. PIRASINCARBOXAMID COMPOUND

Also Published As

Publication number Publication date
JPWO2016121777A1 (en) 2017-11-02
CA2975072A1 (en) 2016-08-04
WO2016121777A1 (en) 2016-08-04
KR20170105021A (en) 2017-09-18
CN107207468A (en) 2017-09-26

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