[go: up one dir, main page]

MX2016002218A - Ensayos para la deteccion de una sola molecula y uso de los mismos. - Google Patents

Ensayos para la deteccion de una sola molecula y uso de los mismos.

Info

Publication number
MX2016002218A
MX2016002218A MX2016002218A MX2016002218A MX2016002218A MX 2016002218 A MX2016002218 A MX 2016002218A MX 2016002218 A MX2016002218 A MX 2016002218A MX 2016002218 A MX2016002218 A MX 2016002218A MX 2016002218 A MX2016002218 A MX 2016002218A
Authority
MX
Mexico
Prior art keywords
assays
single molecule
molecule detection
probes
genetic
Prior art date
Application number
MX2016002218A
Other languages
English (en)
Other versions
MX371428B (es
Inventor
Nielsen Fehr Adrian
James Collins Patrick
Lyndon Herschleb Jill
Bowden JONES Hywel
Original Assignee
Singular Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singular Bio Inc filed Critical Singular Bio Inc
Publication of MX2016002218A publication Critical patent/MX2016002218A/es
Publication of MX371428B publication Critical patent/MX371428B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Métodos para detectar una variación genética en una muestra genética proveniente de un sujeto usando sondas marcadas y contar el número de marcadores en las sondas.
MX2016002218A 2013-08-19 2014-08-19 Ensayos para la deteccion de una sola molecula y uso de los mismos. MX371428B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361867559P 2013-08-19 2013-08-19
US201361867554P 2013-08-19 2013-08-19
PCT/US2014/051763 WO2015026873A1 (en) 2013-08-19 2014-08-19 Assays for single molecule detection and use thereof

Publications (2)

Publication Number Publication Date
MX2016002218A true MX2016002218A (es) 2016-11-18
MX371428B MX371428B (es) 2020-01-30

Family

ID=52484110

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016002218A MX371428B (es) 2013-08-19 2014-08-19 Ensayos para la deteccion de una sola molecula y uso de los mismos.
MX2019015016A MX2019015016A (es) 2013-08-19 2016-02-19 Ensayos para la deteccion de una sola molecula y uso de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019015016A MX2019015016A (es) 2013-08-19 2016-02-19 Ensayos para la deteccion de una sola molecula y uso de los mismos.

Country Status (13)

Country Link
US (5) US9212394B2 (es)
EP (3) EP3036545B1 (es)
JP (2) JP6088710B2 (es)
CN (2) CN105659091A (es)
AU (2) AU2014308980C1 (es)
BR (1) BR112016003480B1 (es)
CA (1) CA2921628A1 (es)
ES (1) ES2739430T3 (es)
IL (3) IL285521B2 (es)
MX (2) MX371428B (es)
SG (1) SG11201601201VA (es)
WO (1) WO2015026873A1 (es)
ZA (1) ZA201601029B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
WO2013106807A1 (en) 2012-01-13 2013-07-18 Curry John D Scalable characterization of nucleic acids by parallel sequencing
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US10378053B2 (en) * 2017-03-17 2019-08-13 Apton Biosystems, Inc. Sequencing and high resolution imaging
EP3036545B1 (en) 2013-08-19 2019-07-03 Singular Bio Inc. Assays for single molecule detection and use thereof
JP6659575B2 (ja) 2014-04-21 2020-03-04 ナテラ， インコーポレイテッド 変異の検出および染色体分節の倍数性
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
WO2016008451A1 (en) 2014-07-18 2016-01-21 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
KR20170116157A (ko) 2015-02-18 2017-10-18 싱귤러 바이오, 인코포레이티드 단일분자 검출용 분석 및 그의 용도
US10221448B2 (en) 2015-03-06 2019-03-05 Pillar Biosciences Inc. Selective amplification of overlapping amplicons
JP6588560B2 (ja) * 2015-03-06 2019-10-09 ピラー バイオサイエンシズ インコーポレイティド オーバーラップするアンプリコンの選択的増幅
DK3294906T3 (en) 2015-05-11 2024-08-05 Natera Inc Methods for determining ploidy
CN106795569B (zh) 2015-07-07 2017-12-05 上海真固生物科技有限公司 减少引物二聚体扩增的方法
US11118216B2 (en) 2015-09-08 2021-09-14 Affymetrix, Inc. Nucleic acid analysis by joining barcoded polynucleotide probes
CN109477138A (zh) 2016-04-15 2019-03-15 纳特拉公司 肺癌检测方法
CN106053405B (zh) * 2016-05-10 2018-10-02 东南大学 一种基于单分子定位法的超分辨光学成像方法
WO2017205827A1 (en) * 2016-05-26 2017-11-30 Singular Bio, Inc. Arrays for single molecule detection and uses thereof
EP3507769B1 (en) 2016-09-02 2023-11-01 Invitae Corporation Systems and methods for single molecule quantification
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
AU2017369018B2 (en) 2016-11-30 2021-02-25 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine and other samples
US11093307B2 (en) * 2016-12-08 2021-08-17 Accenture Global Solutions Limited Platform for supporting multiple virtual agent applications
EP3642353B1 (en) 2017-06-20 2025-03-05 The Medical College of Wisconsin, Inc. Assessing transplant complication risk with total cell-free dna
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN112236535A (zh) 2018-04-14 2021-01-15 纳特拉公司 用于借助于循环肿瘤dna的个人化检测的癌症检测和监测的方法
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3591401A1 (de) 2018-07-06 2020-01-08 Euroimmun Medizinische Labordiagnostika AG Verfahren zum automatisierten detektieren von antikörpern in einer flüssigen biologischen probe unter verwendung eines antigen-chips und antigen-chip hierfür
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
JPWO2021117667A1 (es) * 2019-12-09 2021-06-17
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN112345766B (zh) * 2020-10-22 2024-02-02 中国工程物理研究院核物理与化学研究所 一种荧光-放射性联用的体外靶向筛选方法
CN112419235B (zh) * 2020-10-22 2024-07-23 南京大学 一种精子活性检测系统及方法
WO2022182682A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
EP4092136B8 (en) * 2021-05-20 2024-03-13 Sophia Genetics S.A. Capture probes and uses thereof
EP4441277A2 (en) * 2021-12-01 2024-10-09 Siscapa Assay Technologies, Inc. Enriched peptide detection by single molecule sequencing
EP4581367A1 (en) * 2022-09-01 2025-07-09 The Johns Hopkins University Methods for measuring telomere length

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5256536A (en) 1990-11-09 1993-10-26 Syntex (U.S.A.) Inc. Nucleotide probe for Neisseria gonrrhoeae
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
EP0562025B1 (en) 1990-12-06 2001-02-07 Affymetrix, Inc. (a Delaware Corporation) Compounds and their use in a binary synthesis strategy
WO1992011390A1 (en) 1990-12-17 1992-07-09 Idexx Laboratories, Inc. Nucleic acid sequence detection by triple helix formation
EP0675966B1 (en) 1992-02-19 2004-10-06 The Public Health Research Institute Of The City Of New York, Inc. Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
US5670330A (en) 1992-09-29 1997-09-23 Mcgill University Anti-tumor agent assay using PKR
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
WO1997014028A2 (en) 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
EP2332958B1 (en) * 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detection of nucleic and sequence differences using the ligase detection reaction with addressable arrays
AU730633B2 (en) * 1996-05-29 2001-03-08 Phillip Belgrader Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US6028189A (en) 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
EP0975802B1 (en) 1997-04-01 2004-06-23 Manteia S.A. Method of nucleic acid sequencing
CA2243985C (en) 1997-09-11 2004-08-10 F. Hoffmann-La Roche Ag Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US6284497B1 (en) 1998-04-09 2001-09-04 Trustees Of Boston University Nucleic acid arrays and methods of synthesis
CA2339121A1 (en) 1998-07-30 2000-02-10 Shankar Balasubramanian Arrayed biomolecules and their use in sequencing
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
AU772281B2 (en) 1998-12-14 2004-04-22 Li-Cor Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
US6432642B1 (en) 1999-01-15 2002-08-13 Pe Corporation (Ny) Binary probe and clamp composition and methods for a target hybridization detection
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6238868B1 (en) 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20020086289A1 (en) 1999-06-15 2002-07-04 Don Straus Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6495320B1 (en) 1999-07-21 2002-12-17 Affymetrix, Inc. Even length proportional amplification of nucleic acids
AU7537200A (en) 1999-09-29 2001-04-30 Solexa Ltd. Polynucleotide sequencing
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP1990428B1 (en) 2000-02-07 2010-12-22 Illumina, Inc. Nucleic acid detection methods using universal priming
JP5508654B2 (ja) 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
CA2410950A1 (en) * 2000-05-30 2001-12-06 Hans-Michael Wenz Methods for detecting target nucleic acids using coupled ligation and amplification
US6635425B2 (en) 2001-01-05 2003-10-21 Molecular Staging, Inc. 5′-thio phosphate directed ligation of oligonucleotides and use in detection of single nucleotide polymorphisms
EP2801624B1 (en) 2001-03-16 2019-03-06 Singular Bio, Inc Arrays and methods of use
US20020197630A1 (en) 2001-04-12 2002-12-26 Knapp Michael R. Systems and methods for high throughput genetic analysis
CA2492048A1 (en) 2002-07-18 2004-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of chemical ligation using fluorescence quenching leaving groups
EP1556506A1 (en) * 2002-09-19 2005-07-27 The Chancellor, Masters And Scholars Of The University Of Oxford Molecular arrays and single molecule detection
WO2004027082A2 (en) 2002-09-19 2004-04-01 Applera Corporation Methods and compositions for detecting targets
US8105771B2 (en) 2003-02-26 2012-01-31 Callida Genomics, Inc. Random array DNA analysis by hybridization
US7105024B2 (en) 2003-05-06 2006-09-12 Aesculap Ii, Inc. Artificial intervertebral disc
EP1602733A1 (en) 2004-06-02 2005-12-07 Keygene N.V. Detection of target nucleotide sequences using an asymmetric oligonucleotide ligation assay
WO2005026329A2 (en) * 2003-09-12 2005-03-24 Cornell Research Foundation, Inc. Methods for identifying target nucleic acid molecules
DE60328193D1 (de) 2003-10-16 2009-08-13 Sequenom Inc Nicht invasiver Nachweis fötaler genetischer Merkmale
US8192937B2 (en) 2004-04-07 2012-06-05 Exiqon A/S Methods for quantification of microRNAs and small interfering RNAs
US20060019304A1 (en) * 2004-07-26 2006-01-26 Paul Hardenbol Simultaneous analysis of multiple genomes
TWI367260B (en) * 2005-03-18 2012-07-01 Univ Hong Kong Chinese Method for detecting the presence of a fetus with trisomy 21 in a pregnant woman and kit thereof
CN1824786A (zh) * 2005-12-23 2006-08-30 上海生物芯片有限公司 基于连接的选择性扩增方法
WO2007112418A2 (en) 2006-03-28 2007-10-04 Baylor College Of Medicine Screening for down syndrome
US8137912B2 (en) * 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
WO2007147074A2 (en) * 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
JP5165933B2 (ja) * 2007-06-12 2013-03-21 日本碍子株式会社 標的核酸中の特定部分配列の検出方法及びアレイ
CA2693438A1 (en) 2007-07-11 2009-01-15 Universite Laval Nucleic acid sequences and combination thereof for sensitive amplification and detection of bacterial and fungal sepsis pathogens
US20100297585A1 (en) 2008-01-29 2010-11-25 Uriel Yarovesky Process for making a dental restoration and resultant apparatus
JP5319148B2 (ja) * 2008-03-27 2013-10-16 日本碍子株式会社 標的核酸中の変異の検出方法及びアレイ
US20120252015A1 (en) 2011-02-18 2012-10-04 Bio-Rad Laboratories Methods and compositions for detecting genetic material
JP2012507306A (ja) 2008-11-05 2012-03-29 シュティッヒティング・サンコン・ブロードフォールジーニング 核酸配列を調査するための手段および方法
US20100273164A1 (en) 2009-03-24 2010-10-28 President And Fellows Of Harvard College Targeted and Whole-Genome Technologies to Profile DNA Cytosine Methylation
EP2443457A4 (en) 2009-06-18 2012-10-31 Penn State Res Found METHODS, SYSTEMS AND KITS FOR DETECTING PROTEIN NUCLEIC ACID INTERACTIONS
US20120196765A1 (en) * 2009-07-09 2012-08-02 Mitsuo Kawase Method for detection or analysis of target sequence in genomic dna
CN101864482A (zh) * 2010-02-10 2010-10-20 深圳出入境检验检疫局动植物检验检疫技术中心 Mlcr探针、二步反应模式和悬浮芯片检测用捕获探针
EP2569447A4 (en) * 2010-05-14 2013-11-27 Fluidigm Corp ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY
CA2801039A1 (en) 2010-06-07 2011-12-15 Esoterix Genetic Laboratories, Llc Enumeration of nucleic acids
EP2596127A2 (en) * 2010-07-23 2013-05-29 Esoterix Genetic Laboratories, LLC Identification of differentially represented fetal or maternal genomic regions and uses thereof
US20120077185A1 (en) 2010-08-06 2012-03-29 Tandem Diagnostics, Inc. Detection of genetic abnormalities and infectious disease
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20140342940A1 (en) * 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20120190557A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Risk calculation for evaluation of fetal aneuploidy
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
CN103228796B (zh) * 2010-08-11 2016-06-01 赛路拉公司 基因分型dna
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US20120190020A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US20120219950A1 (en) 2011-02-28 2012-08-30 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
US8759036B2 (en) * 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
WO2012135658A2 (en) 2011-03-30 2012-10-04 Noblegen Biosciences, Inc. Sequence preserved dna conversion for optical nanopore sequencing
WO2013009175A1 (en) 2011-07-08 2013-01-17 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
JP2015508655A (ja) 2012-02-14 2015-03-23 コーネル ユニバーシティー 組み合わせたヌクレアーゼ反応、連結反応、およびポリメラーゼ反応を用いて核酸配列、発現、またはコピー変化を相対的に定量するための方法
US20130310262A1 (en) 2012-05-21 2013-11-21 Ariosa Diagnostics, Inc. Noninvasive detection of robertsonian translocations
AU2013292287A1 (en) 2012-07-19 2015-02-19 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
CN102936755B (zh) * 2012-10-19 2015-01-21 上海交通大学 一种单分子核酸芯片的制作方法
HK1216653A1 (zh) 2012-12-07 2016-11-25 因维蒂公司 多重核酸檢測方法
US20140242582A1 (en) 2013-02-28 2014-08-28 Ariosa Diagnostics, Inc. Detection of genetic abnormalities using ligation-based detection and digital pcr
JP6441893B2 (ja) 2013-03-19 2018-12-19 ディレクティド・ジェノミクス・エル・エル・シー 標的配列の濃縮
EP3030682B1 (en) 2013-08-05 2020-06-03 Twist Bioscience Corporation De novo synthesized gene libraries
EP3036545B1 (en) * 2013-08-19 2019-07-03 Singular Bio Inc. Assays for single molecule detection and use thereof
CA2955740A1 (en) 2014-08-01 2016-02-04 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
WO2016070164A1 (en) 2014-11-01 2016-05-06 Singular Bio, Inc. Assays for single molecule detection and use thereof
KR20170116157A (ko) 2015-02-18 2017-10-18 싱귤러 바이오, 인코포레이티드 단일분자 검출용 분석 및 그의 용도

Also Published As

Publication number Publication date
US20180179586A1 (en) 2018-06-28
AU2014308980A1 (en) 2016-03-10
IL244190B (en) 2019-11-28
CN110283888B (zh) 2021-06-22
AU2014308980C1 (en) 2021-09-30
US20200325528A1 (en) 2020-10-15
JP6088710B2 (ja) 2017-03-01
ES2739430T3 (es) 2020-01-31
US20160076087A1 (en) 2016-03-17
IL285521A (en) 2021-09-30
AU2021200925A1 (en) 2021-03-04
EP3968023A1 (en) 2022-03-16
IL285521B (en) 2022-11-01
EP3968023C0 (en) 2025-10-08
BR112016003480B1 (pt) 2022-08-16
JP6397065B2 (ja) 2018-09-26
EP3036545B1 (en) 2019-07-03
EP3968023B1 (en) 2025-10-08
EP3036545A4 (en) 2017-03-29
US9212394B2 (en) 2015-12-15
MX2019015016A (es) 2020-02-26
CA2921628A1 (en) 2015-02-26
AU2014308980B2 (en) 2020-11-26
BR112016003480A2 (pt) 2018-04-17
CN110283888A (zh) 2019-09-27
CN105659091A (zh) 2016-06-08
IL285521B2 (en) 2023-03-01
IL270651B (en) 2021-08-31
SG11201601201VA (en) 2016-03-30
JP2016527918A (ja) 2016-09-15
US20150167077A1 (en) 2015-06-18
US9758814B2 (en) 2017-09-12
US11326204B2 (en) 2022-05-10
WO2015026873A1 (en) 2015-02-26
US10626450B2 (en) 2020-04-21
EP3036545A1 (en) 2016-06-29
MX371428B (es) 2020-01-30
US20220340958A1 (en) 2022-10-27
EP3726213A1 (en) 2020-10-21
HK1222449A1 (en) 2017-06-30
IL244190A0 (en) 2016-04-21
JP2017108748A (ja) 2017-06-22
ZA201601029B (en) 2019-09-25
AU2021200925B2 (en) 2023-09-07

Similar Documents

Publication Publication Date Title
MX2016002218A (es) Ensayos para la deteccion de una sola molecula y uso de los mismos.
IL289514B1 (en) Assays for determining plasma kallikrein system biomarkers
EP2751567A4 (en) OLIGONUCLEOTIDE PROBES FOR DETECTION OF BACTERIAL NUCLEASES
MX2017003790A (es) Detección de secuencias diana por percepción de nanoporos de sondas sintéticas.
EP2824465A4 (en) Defect detection device
EP2994044A4 (en) ANALYSIS AND DETECTION OF ARRHYTHMEDIATORS
ME03512B (me) Cd47 antitijela i postupci za njihovu upotrebu
EP2755254A4 (en) MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE EMPLOYING THE MATERIAL
BR112014018566A2 (pt) artigo de fundo de poço seletivamente corrosível e método para sua remoção
EP2685271A4 (en) MAGNETIC DETECTION DEVICE
IL285831A (en) Low sample volume sensing device
DK2971064T3 (da) Nærhedsassay til in situ-påvisning af mål
EP2916768A4 (en) PERIDONTAL PROBE WITH TOUCH DETECTION
CO6940375A2 (es) Ensayo de lisiloxidasa-homólogo 2 y métodos de uso del mismo
HUE039925T2 (hu) Eljárás egy skála-inhibitor koncentrációjának meghatározására egy mintában
CL2015002572A1 (es) Marcadores asociados con inhibidores de wnt
IT201600073964A1 (it) Nanointerruttore basato su nucleotidi e metodi per la rilevazione di anticorpi e altri analiti
ITTO20120129A1 (it) Dispositivo di stima / rilevamento del rapporto aria-carburante.
FI20145267A7 (fi) Mittausjärjestely, laite mittausjärjestelyä varten ja menetelmät näytteen mittaamiseksi
BR112014006859A2 (pt) biossensor e seu dispositivo de medição
PL3152565T3 (pl) <div>Układy elektrod do sprawdzania integralności elementu testowego w odniesieniu do powiązanych zgłoszeń</div>
DE112014004412A5 (de) Abgasentnahmesonde
LT2972357T (lt) Molekulių aptikimo mėginyje būdai
DK3068894T3 (da) Fremgangsmåde til at detektere bakteriolytiske tilstande i en prøve
UA116372C2 (uk) Частинки резинату фенілефрину

Legal Events

Date Code Title Description
FG Grant or registration