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MX2010009644A - Derivados piridin-2-ilo como agentes inmunomoduladores. - Google Patents

Derivados piridin-2-ilo como agentes inmunomoduladores.

Info

Publication number
MX2010009644A
MX2010009644A MX2010009644A MX2010009644A MX2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A MX 2010009644 A MX2010009644 A MX 2010009644A
Authority
MX
Mexico
Prior art keywords
derivatives
pyridin
immunomodulating agents
immunomodulating
agents
Prior art date
Application number
MX2010009644A
Other languages
English (en)
Inventor
Beat Steiner
Boris Mathys
Claus Mueller
Oliver Nayler
Martin Bolli
Cyrille Lescop
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010009644(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2010009644A publication Critical patent/MX2010009644A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención se refiere a derivados piridina de Fórmula (I) (ver fórmula (I) donde A, R1, R2, R3, R4, R5, R6 y R7 son tal como se han descrito en la descripción, su preparación y su uso como compuestos farmacéuticamente activos. Los compuestos actúan particularmente como agentes inmunomoduladores.
MX2010009644A 2008-03-07 2009-02-25 Derivados piridin-2-ilo como agentes inmunomoduladores. MX2010009644A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008050848 2008-03-07
PCT/IB2009/050749 WO2009109872A1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents

Publications (1)

Publication Number Publication Date
MX2010009644A true MX2010009644A (es) 2010-09-22

Family

ID=40584746

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009644A MX2010009644A (es) 2008-03-07 2009-02-25 Derivados piridin-2-ilo como agentes inmunomoduladores.

Country Status (26)

Country Link
US (1) US8575200B2 (es)
EP (1) EP2252609B1 (es)
JP (1) JP5435745B2 (es)
KR (1) KR101615779B1 (es)
CN (1) CN102015695B (es)
AR (1) AR070858A1 (es)
AU (1) AU2009220861B2 (es)
BR (1) BRPI0909055A2 (es)
CA (1) CA2715437C (es)
CL (1) CL2009000532A1 (es)
CY (1) CY1114096T1 (es)
DK (1) DK2252609T3 (es)
ES (1) ES2414533T3 (es)
HR (1) HRP20130641T1 (es)
IL (1) IL207972A (es)
MA (1) MA32173B1 (es)
MX (1) MX2010009644A (es)
MY (1) MY183039A (es)
NZ (1) NZ588438A (es)
PL (1) PL2252609T3 (es)
PT (1) PT2252609E (es)
RU (1) RU2494099C2 (es)
SI (1) SI2252609T1 (es)
TW (1) TWI444377B (es)
WO (1) WO2009109872A1 (es)
ZA (1) ZA201007136B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101470659B1 (ko) * 2006-09-07 2014-12-08 액테리온 파마슈티칼 리미티드 면역조절제로서 피리딘-4-일 유도체
US8288554B2 (en) * 2006-09-08 2012-10-16 Actelion Pharmaceuticals Ltd. Pyridin-3-yl derivatives as immunomodulating agents
EP2069318B1 (en) * 2006-09-21 2012-09-12 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
MX2009009597A (es) * 2007-03-16 2009-09-16 Actelion Pharmaceuticals Ltd Derivados de amino-piridina como agonistas del receptor s1p1/edg1.
CN102648198B (zh) * 2007-08-17 2015-04-01 埃科特莱茵药品有限公司 作为s1p1/edg1受体调节剂的吡啶衍生物
BRPI0818804A2 (pt) * 2007-11-01 2015-04-22 Actelion Pharmaceuticals Ltd Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.
AR077413A1 (es) 2009-07-16 2011-08-24 Actelion Pharmaceuticals Ltd Derivados piridin-4-ilo
EP2558433B1 (en) * 2010-04-15 2014-06-18 Merck Patent GmbH Process for the preparation of hydroquinones
ES2544086T3 (es) 2011-01-19 2015-08-27 Actelion Pharmaceuticals Ltd. Derivados de 2-metoxi-piridin-4-ilo
HUE035154T2 (en) * 2013-03-15 2018-05-02 Idorsia Pharmaceuticals Ltd Pyridin-4-yl derivatives
US10385043B2 (en) 2015-05-20 2019-08-20 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

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JP2003034684A (ja) * 2001-06-29 2003-02-07 Biofor Inc 新規な種類の抗真菌剤
AU2003276043A1 (en) * 2002-06-17 2003-12-31 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
DE10237883A1 (de) 2002-08-19 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
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PT1826197E (pt) 2004-12-13 2012-03-06 Ono Pharmaceutical Co Derivado de ácido aminocarboxílico e sua utilização medicinal
BRPI0609515A8 (pt) 2005-03-23 2017-12-26 Actelion Pharmaceuticals Ltd Composto, composição farmacêutica, e, uso de um composto
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CN101370805B (zh) 2006-01-24 2011-04-27 埃科特莱茵药品有限公司 吡啶衍生物
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KR101470659B1 (ko) * 2006-09-07 2014-12-08 액테리온 파마슈티칼 리미티드 면역조절제로서 피리딘-4-일 유도체
AR061841A1 (es) 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
US8288554B2 (en) 2006-09-08 2012-10-16 Actelion Pharmaceuticals Ltd. Pyridin-3-yl derivatives as immunomodulating agents
EP2069318B1 (en) 2006-09-21 2012-09-12 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
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CN102648198B (zh) 2007-08-17 2015-04-01 埃科特莱茵药品有限公司 作为s1p1/edg1受体调节剂的吡啶衍生物
BRPI0818804A2 (pt) 2007-11-01 2015-04-22 Actelion Pharmaceuticals Ltd Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.
RU2010128006A (ru) 2007-12-10 2012-01-20 Актелион Фармасьютиклз Лтд (Ch) Производные тиофена в качестве агонистов sipi/edgi
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Also Published As

Publication number Publication date
EP2252609A1 (en) 2010-11-24
IL207972A0 (en) 2010-12-30
ZA201007136B (en) 2014-03-26
KR101615779B1 (ko) 2016-04-26
AU2009220861A1 (en) 2009-09-11
CY1114096T1 (el) 2016-07-27
TW200940532A (en) 2009-10-01
BRPI0909055A2 (pt) 2019-02-26
ES2414533T3 (es) 2013-07-19
CA2715437C (en) 2016-05-24
US8575200B2 (en) 2013-11-05
WO2009109872A1 (en) 2009-09-11
MY183039A (en) 2021-02-08
DK2252609T3 (da) 2013-06-24
PL2252609T3 (pl) 2013-09-30
RU2010140854A (ru) 2012-04-20
KR20100137493A (ko) 2010-12-30
CN102015695B (zh) 2014-08-27
HK1150601A1 (en) 2012-01-06
TWI444377B (zh) 2014-07-11
CL2009000532A1 (es) 2010-04-09
SI2252609T1 (sl) 2013-07-31
PT2252609E (pt) 2013-06-24
NZ588438A (en) 2012-05-25
AR070858A1 (es) 2010-05-12
HRP20130641T1 (en) 2013-08-31
RU2494099C2 (ru) 2013-09-27
CA2715437A1 (en) 2009-09-11
CN102015695A (zh) 2011-04-13
EP2252609B1 (en) 2013-04-17
AU2009220861B2 (en) 2014-05-29
US20100331372A1 (en) 2010-12-30
MA32173B1 (fr) 2011-03-01
IL207972A (en) 2016-03-31
JP2011513381A (ja) 2011-04-28
JP5435745B2 (ja) 2014-03-05

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