DK2252609T3 - Pyridin-2-yl-derivater som immunomodulerende midler - Google Patents

Pyridin-2-yl-derivater som immunomodulerende midler

Info

Publication number: DK2252609T3
Authority: DK; Denmark
Prior art keywords: pyridin; derivatives; immuno modulators; immuno; modulators
Prior art date: 2008-03-07

Application number

DK09716943.7T

Other languages

English (en)

Inventor

Martin Bolli

Cyrille Lescop

Boris Mathys

Claus Mueller

Oliver Nayler

Beat Steiner

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-07

Filing date

2009-02-25

Publication date

2013-06-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2252609(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-02-25 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2013-06-24 Application granted granted Critical

2013-06-24 Publication of DK2252609T3 publication Critical patent/DK2252609T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Oncology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

DK09716943.7T 2008-03-07 2009-02-25 Pyridin-2-yl-derivater som immunomodulerende midler DK2252609T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2008050848		2008-03-07
PCT/IB2009/050749 WO2009109872A1 (en)	2008-03-07	2009-02-25	Pyridin-2-yl derivatives as immunomodulating agents

Publications (1)

Publication Number	Publication Date
DK2252609T3 true DK2252609T3 (da)	2013-06-24

Family

ID=40584746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09716943.7T DK2252609T3 (da)	2008-03-07	2009-02-25	Pyridin-2-yl-derivater som immunomodulerende midler

Country Status (26)

Country	Link
US (1)	US8575200B2 (da)
EP (1)	EP2252609B1 (da)
JP (1)	JP5435745B2 (da)
KR (1)	KR101615779B1 (da)
CN (1)	CN102015695B (da)
AR (1)	AR070858A1 (da)
AU (1)	AU2009220861B2 (da)
BR (1)	BRPI0909055A2 (da)
CA (1)	CA2715437C (da)
CL (1)	CL2009000532A1 (da)
CY (1)	CY1114096T1 (da)
DK (1)	DK2252609T3 (da)
ES (1)	ES2414533T3 (da)
HR (1)	HRP20130641T1 (da)
IL (1)	IL207972A (da)
MA (1)	MA32173B1 (da)
MX (1)	MX2010009644A (da)
MY (1)	MY183039A (da)
NZ (1)	NZ588438A (da)
PL (1)	PL2252609T3 (da)
PT (1)	PT2252609E (da)
RU (1)	RU2494099C2 (da)
SI (1)	SI2252609T1 (da)
TW (1)	TWI444377B (da)
WO (1)	WO2009109872A1 (da)
ZA (1)	ZA201007136B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY149853A (en) *	2006-09-07	2013-10-31	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives as immunomodulating agents
CL2007002594A1 (es) *	2006-09-08	2008-06-06	Actelion Pharmaceuticals Ltd	Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
KR20090051774A (ko) *	2006-09-21	2009-05-22	액테리온 파마슈티칼 리미티드	페닐 유도체 및 면역조절제로서 이들의 용도
DK2125797T3 (da) *	2007-03-16	2014-02-10	Actelion Pharmaceuticals Ltd	Aminopyridinderivater som s1p1/edg1-receptoragonister
KR101541558B1 (ko) *	2007-08-17	2015-08-03	액테리온 파마슈티칼 리미티드	Ｓ1ｐ1/ｅｄｇ1 수용체 조절제로서의 피리딘 유도체
CA2700917A1 (en) *	2007-11-01	2009-05-07	Actelion Pharmaceuticals Ltd	Novel pyrimidine derivatives
CA2767585C (en)	2009-07-16	2017-09-26	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives
JP5778755B2 (ja) *	2010-04-15	2015-09-16	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	ヒドロキノンの製造方法
MX350009B (es)	2011-01-19	2017-08-23	Idorsia Pharmaceuticals Ltd	Derivados de 2-metoxi-piridin-4-ilo.
CN105189487B (zh) *	2013-03-15	2017-12-26	爱杜西亚药品有限公司	吡啶‑4‑基衍生物
KR102220848B1 (ko)	2015-05-20	2021-02-26	이도르시아 파마슈티컬스 리미티드	화합물 (s)-3-｛4-[5-(2-시클로펜틸-6-메톡시-피리딘-4-일)-[1,2,4]옥사디아졸-3-일]-2-에틸-6-메틸-페녹시｝-프로판-1,2-디올의 결정형

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3647809A (en) *	1968-04-26	1972-03-07	Chinoin Gyogyszer Es Vegyeszet	Certain pyridyl-1 2 4-oxadiazole derivatives
AU653957B2 (en)	1990-09-20	1994-10-20	Merrell Dow Pharmaceuticals Inc.	1-aryl-3-pyridinyl-2-propene-1-ones
DE4429465A1 (de) *	1994-08-19	1996-02-22	Bayer Ag	Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
JP2003034684A (ja) *	2001-06-29	2003-02-07	Biofor Inc	新規な種類の抗真菌剤
AU2003276043A1 (en) *	2002-06-17	2003-12-31	Merck & Co., Inc.	1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
DE10237883A1 (de)	2002-08-19	2004-03-04	Merckle Gmbh Chem.-Pharm. Fabrik	Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
WO2004035538A1 (en) *	2002-10-15	2004-04-29	Merck & Co., Inc.	Process for making azetidine-3-carboxylic acid
CN1859908A (zh) *	2003-10-01	2006-11-08	默克公司	作为s1p受体激动剂的3,5－芳基、杂芳基或环烷基取代的－1,2,4－噁二唑类化合物
CA2547198A1 (en) *	2003-12-17	2005-06-30	Merck & Co., Inc.	(3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
EP1760071A4 (en) *	2004-06-23	2008-03-05	Ono Pharmaceutical Co	COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
WO2006010379A1 (en) *	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
EP2371811B1 (en) *	2004-12-13	2014-10-08	Ono Pharmaceutical Co., Ltd.	Azetidinecarboxylic acid derivative and medicinal use thereof
EP1863787B1 (en) *	2005-03-23	2011-05-25	Actelion Pharmaceuticals Ltd.	Hydogrenated benzo[c]thiophene derivatives as immunomodulators
CN101146529B (zh) *	2005-03-23	2012-08-29	埃科特莱茵药品有限公司	新颖噻吩衍生物作为鞘氨醇-1-磷酸酯-1受体激动剂
US7846964B2 (en) *	2005-03-23	2010-12-07	Actelion Pharmaceuticals Ltd.	Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists
KR20080013886A (ko) *	2005-04-05	2008-02-13	파마코페이아, 인코포레이티드	면역억제용 퓨린 및 이미다조피리딘 유도체
KR20070121013A (ko)	2005-04-22	2007-12-26	다이이찌 산쿄 가부시키가이샤	헤테로 고리 화합물
RU2007147940A (ru) *	2005-06-08	2009-07-20	Новартис АГ (CH)	Полициклические оксадиазолы или изоксазолы и их применение в качестве лигандов s1p рецептора
EP1893591A1 (en) *	2005-06-08	2008-03-05	Novartis AG	POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
US20070043104A1 (en) *	2005-06-10	2007-02-22	Luthman Ingrid K	UII-modulating compounds and their use
CA2612661A1 (en) *	2005-06-24	2006-12-28	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives
AR057894A1 (es) *	2005-11-23	2007-12-26	Actelion Pharmaceuticals Ltd	Derivados de tiofeno
TWI404706B (zh) *	2006-01-11	2013-08-11	Actelion Pharmaceuticals Ltd	新穎噻吩衍生物
JP5063615B2 (ja) *	2006-01-24	2012-10-31	アクテリオンファーマシューティカルズリミテッド	新規ピリジン誘導体
BRPI0711358A2 (pt) *	2006-05-09	2011-09-27	Pfizer Prod Inc	derivados do ácido cicloalquilamino e suas composições farmacêuticas
TWI408139B (zh) *	2006-09-07	2013-09-11	Actelion Pharmaceuticals Ltd	新穎噻吩衍生物
MY149853A (en) *	2006-09-07	2013-10-31	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives as immunomodulating agents
CL2007002594A1 (es) *	2006-09-08	2008-06-06	Actelion Pharmaceuticals Ltd	Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
KR20090051774A (ko) *	2006-09-21	2009-05-22	액테리온 파마슈티칼 리미티드	페닐 유도체 및 면역조절제로서 이들의 용도
CN101522646A (zh) *	2006-09-29	2009-09-02	诺瓦提斯公司	具有抗炎和免疫抑制特性的二唑衍生物
JP2008120794A (ja)	2006-10-16	2008-05-29	Daiichi Sankyo Co Ltd	ヘテロ環化合物を含有する医薬組成物
EP2109364A4 (en) *	2006-12-15	2010-04-14	Abbott Lab	NOVEL OXADIAZONE COMPOUNDS
DK2125797T3 (da) *	2007-03-16	2014-02-10	Actelion Pharmaceuticals Ltd	Aminopyridinderivater som s1p1/edg1-receptoragonister
KR101541558B1 (ko) *	2007-08-17	2015-08-03	액테리온 파마슈티칼 리미티드	Ｓ1ｐ1/ｅｄｇ1 수용체 조절제로서의 피리딘 유도체
CA2700917A1 (en) *	2007-11-01	2009-05-07	Actelion Pharmaceuticals Ltd	Novel pyrimidine derivatives
CA2706834A1 (en) *	2007-12-10	2009-06-18	Actelion Pharmaceuticals Ltd	Thiophene derivatives as agonists of s1p1/edg1
WO2009109906A1 (en) *	2008-03-06	2009-09-11	Actelion Pharmaceuticals Ltd	Pyridine compounds
US20110046170A1 (en) *	2008-03-06	2011-02-24	Martin Bolli	Novel pyrimidine-pyridine derivatives
EP2262782B1 (en) *	2008-03-07	2012-07-04	Actelion Pharmaceuticals Ltd.	Novel aminomethyl benzene derivatives
CA2767585C (en) *	2009-07-16	2017-09-26	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives

2009
- 2009-02-25 SI SI200930611T patent/SI2252609T1/sl unknown
- 2009-02-25 CA CA2715437A patent/CA2715437C/en active Active
- 2009-02-25 PL PL09716943T patent/PL2252609T3/pl unknown
- 2009-02-25 RU RU2010140854/04A patent/RU2494099C2/ru not_active IP Right Cessation
- 2009-02-25 MY MYPI2010004192A patent/MY183039A/en unknown
- 2009-02-25 NZ NZ588438A patent/NZ588438A/en not_active IP Right Cessation
- 2009-02-25 CN CN200980108360.0A patent/CN102015695B/zh not_active Expired - Fee Related
- 2009-02-25 ES ES09716943T patent/ES2414533T3/es active Active
- 2009-02-25 JP JP2010549213A patent/JP5435745B2/ja not_active Expired - Fee Related
- 2009-02-25 EP EP09716943.7A patent/EP2252609B1/en active Active
- 2009-02-25 DK DK09716943.7T patent/DK2252609T3/da active
- 2009-02-25 PT PT97169437T patent/PT2252609E/pt unknown
- 2009-02-25 US US12/920,656 patent/US8575200B2/en active Active
- 2009-02-25 WO PCT/IB2009/050749 patent/WO2009109872A1/en not_active Ceased
- 2009-02-25 BR BRPI0909055-0A patent/BRPI0909055A2/pt not_active Application Discontinuation
- 2009-02-25 MX MX2010009644A patent/MX2010009644A/es active IP Right Grant
- 2009-02-25 KR KR1020107021960A patent/KR101615779B1/ko not_active Expired - Fee Related
- 2009-02-25 AU AU2009220861A patent/AU2009220861B2/en not_active Ceased
- 2009-02-25 HR HRP20130641AT patent/HRP20130641T1/hr unknown
- 2009-03-06 TW TW098107431A patent/TWI444377B/zh not_active IP Right Cessation
- 2009-03-06 AR ARP090100812A patent/AR070858A1/es not_active Application Discontinuation
- 2009-03-06 CL CL2009000532A patent/CL2009000532A1/es unknown
2010
- 2010-09-05 IL IL207972A patent/IL207972A/en not_active IP Right Cessation
- 2010-09-29 MA MA33209A patent/MA32173B1/fr unknown
- 2010-10-06 ZA ZA2010/07136A patent/ZA201007136B/en unknown
2013
- 2013-07-02 CY CY20131100534T patent/CY1114096T1/el unknown

Also Published As

Publication number	Publication date
CA2715437C (en)	2016-05-24
PT2252609E (pt)	2013-06-24
HK1150601A1 (en)	2012-01-06
JP5435745B2 (ja)	2014-03-05
MY183039A (en)	2021-02-08
EP2252609A1 (en)	2010-11-24
US8575200B2 (en)	2013-11-05
CA2715437A1 (en)	2009-09-11
CN102015695A (zh)	2011-04-13
SI2252609T1 (sl)	2013-07-31
ES2414533T3 (es)	2013-07-19
BRPI0909055A2 (pt)	2019-02-26
KR20100137493A (ko)	2010-12-30
RU2494099C2 (ru)	2013-09-27
RU2010140854A (ru)	2012-04-20
CL2009000532A1 (es)	2010-04-09
ZA201007136B (en)	2014-03-26
TWI444377B (zh)	2014-07-11
CN102015695B (zh)	2014-08-27
PL2252609T3 (pl)	2013-09-30
MX2010009644A (es)	2010-09-22
WO2009109872A1 (en)	2009-09-11
HRP20130641T1 (en)	2013-08-31
CY1114096T1 (el)	2016-07-27
AU2009220861B2 (en)	2014-05-29
EP2252609B1 (en)	2013-04-17
US20100331372A1 (en)	2010-12-30
JP2011513381A (ja)	2011-04-28
IL207972A (en)	2016-03-31
KR101615779B1 (ko)	2016-04-26
MA32173B1 (fr)	2011-03-01
TW200940532A (en)	2009-10-01
AU2009220861A1 (en)	2009-09-11
IL207972A0 (en)	2010-12-30
AR070858A1 (es)	2010-05-12
NZ588438A (en)	2012-05-25

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DK2069336T3 (da)	2013-02-25	Pyridin-4-yl-derivater som immunomodulerende midler
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BRPI0813836A2 (pt)	2015-01-06	Derivados pirazólicos
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