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MX2009011348A - Derivados novedosos de tetrahidrocarbazol como ligandos de receptores acoplados a proteina g. - Google Patents

Derivados novedosos de tetrahidrocarbazol como ligandos de receptores acoplados a proteina g.

Info

Publication number
MX2009011348A
MX2009011348A MX2009011348A MX2009011348A MX2009011348A MX 2009011348 A MX2009011348 A MX 2009011348A MX 2009011348 A MX2009011348 A MX 2009011348A MX 2009011348 A MX2009011348 A MX 2009011348A MX 2009011348 A MX2009011348 A MX 2009011348A
Authority
MX
Mexico
Prior art keywords
cancer
uterine
receptors
ligands
protein coupled
Prior art date
Application number
MX2009011348A
Other languages
English (en)
Inventor
Eckhard Guenther
Tilmann Schuster
Peter Schmidt
Klaus Paulini
Emmanuel Polymeropoulos
Silke Baasner
Michael Teifel
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of MX2009011348A publication Critical patent/MX2009011348A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

La presente invención proporciona derivados novedosos de tetrahidrocarbazol de acuerdo con la fórmula (1) corno ligandos de receptores acoplados a proteína G (GPCR). Los compuestos de la invención son útiles en tratamiento y/o profilaxis de condiciones fisiológicas y/o patológicas en mamíferos, preferiblemente humanos, los cuales son mediadas por GPCR o condiciones fisiológicas y/o patológicas las cuales pueden ser tratadas por modulación de estos receptores. La presente invención proporciona además antagonistas de receptor de LHRH que pueden ser utilizados para la modulación de estos receptores y que sean útiles para tratar las condiciones anteriores, en particular cáncer de próstata, cáncer de mama, cáncer uterino, cáncer endometrial, cáncer cervical, cáncer de ovario, hiperplasia prostática benigna (BPH), endometriosis, fibroides uterinos, miomas uterinos, hiperplasia del endometrio, dismenorrea, hemorragia uterina disfuncional (menorragia, metrorragia), pubertad precoz, hirsutismo, síndrome de ovario poliquístico, enfermedades de tumores que dependen de hormonas, infecciones por VIH o SIDA, trastornos neurológicos o neurodegenerativos, ARC (complejo relacionado con SIDA, sarcoma de Kaposi, tumores que se originan del cerebro y/o sistema nervioso y/o meninges, demencia, enfermedad de Alzheimer, náusea y vómito, dolor, inflamaciones, y estados patológicos reumáticos y artríticos.
MX2009011348A 2007-04-27 2008-04-25 Derivados novedosos de tetrahidrocarbazol como ligandos de receptores acoplados a proteina g. MX2009011348A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91442407P 2007-04-27 2007-04-27
EP07107094A EP1988098A1 (en) 2007-04-27 2007-04-27 Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
PCT/EP2008/055039 WO2008132153A1 (en) 2007-04-27 2008-04-25 Novel tetrahydrocarbazole derivatives as ligands of g-protein coupled receptors

Publications (1)

Publication Number Publication Date
MX2009011348A true MX2009011348A (es) 2009-11-05

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MX2009011348A MX2009011348A (es) 2007-04-27 2008-04-25 Derivados novedosos de tetrahidrocarbazol como ligandos de receptores acoplados a proteina g.

Country Status (17)

Country Link
US (2) US8148546B2 (es)
EP (2) EP1988098A1 (es)
JP (1) JP5371956B2 (es)
KR (1) KR20100015967A (es)
CN (1) CN101668769B (es)
AR (1) AR066145A1 (es)
AU (1) AU2008244305B2 (es)
BR (1) BRPI0810613A2 (es)
CA (1) CA2685428A1 (es)
IL (1) IL200851A0 (es)
MX (1) MX2009011348A (es)
NZ (1) NZ579671A (es)
RU (1) RU2497806C9 (es)
TW (1) TWI432454B (es)
UA (1) UA99618C2 (es)
WO (1) WO2008132153A1 (es)
ZA (1) ZA200906241B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2095818A1 (en) * 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
WO2012093101A1 (en) 2011-01-04 2012-07-12 Novartis Ag Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (amd)
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