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MX2008000070A - Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona. - Google Patents

Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona.

Info

Publication number
MX2008000070A
MX2008000070A MX2008000070A MX2008000070A MX2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A
Authority
MX
Mexico
Prior art keywords
receptor modulators
progesterone receptor
well
therapy
benzofuranone derivatives
Prior art date
Application number
MX2008000070A
Other languages
English (en)
Inventor
Norbert Schmees
Wolfgang Schwede
Ulrike Fuhrmann
Carsten Moeller
Anja Schmidt
Ulrich Bothe
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MX2008000070A publication Critical patent/MX2008000070A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

La presente invencion se refiere a moduladores no esteroides del receptor de progesterona de la formula general I, (ver formula) al proceso para su produccion, al uso de los moduladores del receptor de progesterona para la preparacion de agentes farmaceuticos asi como tambien composiciones farmaceuticas que contienen estos compuestos. Los compuestos segun la invencion son apropiados para la terapia y la prevencion de enfermedades ginecologicas tales como endometriosis, leiomiomas de utero, hemorragias disfuncionales y dismenorrea y para la terapia y la prevencion de tumores dependientes de hormonas y parta el uso para el control de la fertilidad femenina y para la terapia de reemplazo hormonal.
MX2008000070A 2005-06-24 2006-06-22 Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona. MX2008000070A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030294A DE102005030294A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren
PCT/EP2006/006532 WO2006136462A1 (en) 2005-06-24 2006-06-22 Benzofuranone derivatives as nonsteroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
MX2008000070A true MX2008000070A (es) 2008-03-19

Family

ID=36716643

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008000070A MX2008000070A (es) 2005-06-24 2006-06-22 Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona.

Country Status (22)

Country Link
EP (1) EP1899315A1 (es)
JP (1) JP2008543911A (es)
KR (1) KR20080018275A (es)
CN (1) CN101248056A (es)
AR (1) AR057409A1 (es)
AU (1) AU2006261049A1 (es)
BR (1) BRPI0612305A2 (es)
CA (1) CA2611900A1 (es)
CR (1) CR9595A (es)
DE (1) DE102005030294A1 (es)
DO (1) DOP2006000150A (es)
EA (1) EA200702604A1 (es)
EC (1) ECSP078043A (es)
GT (1) GT200600272A (es)
IL (1) IL188022A0 (es)
MX (1) MX2008000070A (es)
NO (1) NO20080441L (es)
PE (1) PE20070170A1 (es)
TW (1) TW200738665A (es)
UY (1) UY29626A1 (es)
WO (1) WO2006136462A1 (es)
ZA (1) ZA200800689B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
IN2014DN10548A (es) 2012-05-31 2015-08-21 Repros Therapeutics Inc
AU2013338305B2 (en) 2012-11-02 2018-06-07 Allergan pharmaceuticals International Ltd. Methods and compositions for treating progesterone-dependent conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723722A1 (de) * 1997-05-30 1998-12-10 Schering Ag Nichtsteroidale Gestagene
HK1043788A1 (zh) * 1999-05-04 2002-09-27 American Home Products Corporation 四環黃體酮受體調節劑化合物及方法
US6358948B1 (en) * 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
WO2003059899A1 (en) * 2002-01-14 2003-07-24 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
BR0308394A (pt) * 2002-03-11 2005-01-25 Schering Ag 5-{2-hidróxi-3-[1-(3-trifluormetilfenil)-ciclopropil]-pr oprionilamino}-ftaleto e compostos relacionados com atividade moduladora de receptores de progesterona para uso em controle da fertilidade e terapia de reposição hormonal
DE10346939A1 (de) * 2003-10-06 2005-05-19 Schering Ag Heterocyclisch substituierte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Also Published As

Publication number Publication date
CR9595A (es) 2008-05-05
TW200738665A (en) 2007-10-16
ZA200800689B (en) 2009-07-29
AR057409A1 (es) 2007-12-05
ECSP078043A (es) 2008-01-23
EP1899315A1 (en) 2008-03-19
IL188022A0 (en) 2008-03-20
DE102005030294A1 (de) 2007-01-04
AU2006261049A1 (en) 2006-12-28
PE20070170A1 (es) 2007-03-02
CN101248056A (zh) 2008-08-20
DOP2006000150A (es) 2006-12-31
KR20080018275A (ko) 2008-02-27
EA200702604A1 (ru) 2008-06-30
NO20080441L (no) 2008-03-07
CA2611900A1 (en) 2006-12-28
WO2006136462A1 (en) 2006-12-28
JP2008543911A (ja) 2008-12-04
GT200600272A (es) 2007-08-20
UY29626A1 (es) 2007-01-31
BRPI0612305A2 (pt) 2010-11-03

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