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MX2009009526A - PROCESO PARA LA PREPARACION DE COMPUESTOS DE ß-LACTAMA. - Google Patents

PROCESO PARA LA PREPARACION DE COMPUESTOS DE ß-LACTAMA.

Info

Publication number
MX2009009526A
MX2009009526A MX2009009526A MX2009009526A MX2009009526A MX 2009009526 A MX2009009526 A MX 2009009526A MX 2009009526 A MX2009009526 A MX 2009009526A MX 2009009526 A MX2009009526 A MX 2009009526A MX 2009009526 A MX2009009526 A MX 2009009526A
Authority
MX
Mexico
Prior art keywords
side chain
beta
preparation
lactam compounds
chain ester
Prior art date
Application number
MX2009009526A
Other languages
English (en)
Inventor
Harold Monro Moody
Van Der Thomas Does
Van Theodorus Johannes Godfried Maria Dooren
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2009009526A publication Critical patent/MX2009009526A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención describe un proceso para la síntesis de un compuesto ß-lactama semisintético de un núcleo y una cadena lateral seleccionada del grupo que consiste de D-fenilglicina y D-dihidro-fenilglicina en la forma de un éster de cadena lateral y una enzima que cataliza el acoplamiento del éster de cadena lateral al núcleo caracterizado porque el éster de cadena lateral no se aísla como un intermediario sólido.
MX2009009526A 2007-03-09 2008-03-10 PROCESO PARA LA PREPARACION DE COMPUESTOS DE ß-LACTAMA. MX2009009526A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07103850 2007-03-09
PCT/EP2008/052809 WO2008110527A1 (en) 2007-03-09 2008-03-10 Process for the preparation of beta-lactam compounds

Publications (1)

Publication Number Publication Date
MX2009009526A true MX2009009526A (es) 2009-09-16

Family

ID=38325288

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009526A MX2009009526A (es) 2007-03-09 2008-03-10 PROCESO PARA LA PREPARACION DE COMPUESTOS DE ß-LACTAMA.

Country Status (10)

Country Link
US (1) US8497088B2 (es)
EP (1) EP2121960B1 (es)
JP (1) JP2010520752A (es)
KR (1) KR101444492B1 (es)
CN (1) CN101631872B (es)
AT (1) ATE511547T1 (es)
BR (1) BRPI0808685A2 (es)
ES (1) ES2365831T3 (es)
MX (1) MX2009009526A (es)
WO (1) WO2008110527A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20180318T1 (hr) 2008-12-23 2018-03-23 Dsm Sinochem Pharmaceuticals Netherlands B.V. Mutant penicilin g acilaze
CN102656274B (zh) 2009-12-14 2014-10-15 中化帝斯曼制药有限公司荷兰公司 生产头孢拉定的方法
WO2012175585A1 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
EP2723881A2 (en) 2011-06-23 2014-04-30 DSM Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
RU2537845C2 (ru) * 2012-04-25 2015-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессиональногообразования "Московский государственный университет имени М.В. Ломоносова " (МГУ) Способ синтеза пептидов, в том числе бета-лактамных антибиотиков, при использовании варианта пенициллинацилазы
CN103805671B (zh) * 2013-11-11 2015-08-26 华北制药河北华民药业有限责任公司 一种制备头孢氨苄的方法
CN103757085B (zh) * 2013-11-28 2016-06-15 湖南福来格生物技术有限公司 头孢克洛及其合成方法
CN103805672B (zh) * 2014-02-25 2016-05-25 华北制药集团先泰药业有限公司 一种酶法制备氨苄西林的工艺
CN103937866B (zh) * 2014-05-12 2016-07-06 联邦制药(内蒙古)有限公司 一种改进的氨苄西林的制备方法
WO2016046055A1 (en) * 2014-09-22 2016-03-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Salt of phenylglycine methyl ester
CN106187795A (zh) * 2016-07-05 2016-12-07 南京红杉生物科技有限公司 一种d‑苯甘氨酸甲酯的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI925988A0 (fi) * 1990-07-04 1992-12-31 Novo Nordisk As Foerfarande foer framstaellning av b-laktamer
JPH05148199A (ja) * 1991-11-28 1993-06-15 Ajinomoto Co Inc アミノ酸エステルの製造法
CN1034177C (zh) * 1993-12-02 1997-03-05 山东新华制药厂 头孢氨苄的制备方法
US6060268A (en) * 1995-07-18 2000-05-09 Gist-Brocades B.V. Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer
DE69637771D1 (de) * 1995-07-18 2009-01-22 Dsm Ip Assets Bv Eine verbesserte immobilisierte penicillin g acylase
TW555855B (en) 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
ZA983387B (en) * 1997-04-22 1999-01-26 Gist Brocades Bv A method for preparing a beta-lactam antibiotic
EP1333278B1 (en) * 2002-02-01 2004-03-10 MTM molecular tools in medicine Methods for monitoring and prognosis of disease course of gastrointestinal tumors
WO2006003671A1 (en) * 2004-07-02 2006-01-12 Srinivasa Reddy Battula A process for resolution of methylamino(2-chlorophenyl)acetate

Also Published As

Publication number Publication date
WO2008110527A1 (en) 2008-09-18
ATE511547T1 (de) 2011-06-15
US20110104748A1 (en) 2011-05-05
EP2121960A1 (en) 2009-11-25
KR101444492B1 (ko) 2014-09-24
JP2010520752A (ja) 2010-06-17
BRPI0808685A2 (pt) 2014-08-19
US8497088B2 (en) 2013-07-30
ES2365831T3 (es) 2011-10-11
CN101631872B (zh) 2014-07-16
EP2121960B1 (en) 2011-06-01
CN101631872A (zh) 2010-01-20
HK1138623A1 (en) 2010-08-27
KR20090121310A (ko) 2009-11-25

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