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MX2009009384A - Malonamidas como antagonistas de orexina. - Google Patents

Malonamidas como antagonistas de orexina.

Info

Publication number
MX2009009384A
MX2009009384A MX2009009384A MX2009009384A MX2009009384A MX 2009009384 A MX2009009384 A MX 2009009384A MX 2009009384 A MX2009009384 A MX 2009009384A MX 2009009384 A MX2009009384 A MX 2009009384A MX 2009009384 A MX2009009384 A MX 2009009384A
Authority
MX
Mexico
Prior art keywords
lower alkyl
substituted
halogen
compounds
heteroaryl
Prior art date
Application number
MX2009009384A
Other languages
English (en)
Inventor
Mark Rogers-Evans
Emmanuel Pinard
Olivier Roche
Henner Knust
Parichehr Malherbe
Matthias Nettekoven
Luca Gobbi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009009384A publication Critical patent/MX2009009384A/es

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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a compuestos de la fórmula (ver fórmula I) en donde Ar1 y Ar2 con independencia entre sí son arilo o heteroarilo sustituido o sin sustituir; R1/R2 con independencia entre sí son hidrógeno, alquilo inferior, alquilo inferior sustituido por halógeno, -(CH2)o-O-alquilo inferior, -(CH2)o-N-(alquilo inferior)2, (CH2)p-cicloalquilo, (CH2)p-heterocicloalquilo, (CH2)p-arilo, (CH2)p-heteroarilo, los anillos pueden estar sustituidos por R, o R1 y R2 junto con el átomo de N al que están unidos pueden formar un anillo heterocíclico, opcionalmente con otros heteroátomos en el anillo seleccionados entre N, O y S, el anillo puede estar sustituido por R; R es halógeno, alquilo inferior, alquilo inferior sustituido por halógeno, alcoxi inferior o alcoxi inferior sustituido por halógeno; R3 es hidrógeno o alquilo inferior; n es el número 0, 1, 2, 3 ó 4; o es el número 1, 2 ó 3; p es el número 0, 1 ó 2; o a las sales de adición de ácido farmacéuticamente idóneas, enantiómeros ópticamente puros, racematos o mezclas diaestereoméricas de los mismos. Se ha encontrado que los compuestos de la fórmula I son antagonistas de receptores de orexina y los compuestos afines son útiles para el tratamiento de trastornos, en los que intervienen los mecanismos de la orexina, por ejemplo los trastornos del sueño.
MX2009009384A 2007-03-15 2008-03-05 Malonamidas como antagonistas de orexina. MX2009009384A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07104232 2007-03-15
PCT/EP2008/052639 WO2008110488A1 (en) 2007-03-15 2008-03-05 Malonamides as orexin antagonists

Publications (1)

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MX2009009384A true MX2009009384A (es) 2009-09-14

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MX2009009384A MX2009009384A (es) 2007-03-15 2008-03-05 Malonamidas como antagonistas de orexina.

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US (1) US7501541B2 (es)
EP (1) EP2121579B1 (es)
JP (1) JP5148636B2 (es)
CN (1) CN101636378A (es)
AR (1) AR071925A1 (es)
AT (1) ATE506343T1 (es)
AU (1) AU2008225922B2 (es)
BR (1) BRPI0808737A2 (es)
CA (1) CA2679985A1 (es)
CL (1) CL2008000738A1 (es)
DE (1) DE602008006368D1 (es)
ES (1) ES2361453T3 (es)
IL (1) IL200438A0 (es)
MX (1) MX2009009384A (es)
PE (1) PE20090521A1 (es)
TW (1) TW200843727A (es)
WO (1) WO2008110488A1 (es)

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PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
CA2726703A1 (en) 2008-06-16 2009-12-23 F. Hoffmann-La Roche Ag Heteroaromatic monoamides as orexinin receptor antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
JP5785045B2 (ja) * 2011-10-06 2015-09-24 エヌ・イーケムキャット株式会社 選択的脱ベンジル化方法およびこれに用いる選択水素化触媒
US9029364B2 (en) 2011-10-21 2015-05-12 Merck Sharp & Dohme Corp. 2,5-disubstituted thiomorpholine orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
NZ628491A (en) 2012-02-07 2016-06-24 Eolas Therapeutics Inc Substituted prolines / piperidines as orexin receptor antagonists
BR112016030690B1 (pt) * 2014-06-27 2023-11-14 Nogra Pharma Limited Compostos moduladores do receptor de arila, composição farmacêutica compreendendo os mesmos e usos terapêuticos dos ditos compostos
JP6663909B2 (ja) 2014-08-13 2020-03-13 エオラス セラピューティクス， インコーポレイテッド オレキシンレセプターモジュレーターとしてのジフルオロピロリジン
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