MX2009002859A - Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. - Google Patents
Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos.Info
- Publication number
- MX2009002859A MX2009002859A MX2009002859A MX2009002859A MX2009002859A MX 2009002859 A MX2009002859 A MX 2009002859A MX 2009002859 A MX2009002859 A MX 2009002859A MX 2009002859 A MX2009002859 A MX 2009002859A MX 2009002859 A MX2009002859 A MX 2009002859A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- compound according
- further characterized
- independently
- group
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Microbiology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84502806P | 2006-09-15 | 2006-09-15 | |
| PCT/US2007/078597 WO2008034122A2 (fr) | 2006-09-15 | 2007-09-15 | Segments de liaison biodégradables à base d'ester encombré pour distribution d'oligonuclotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009002859A true MX2009002859A (es) | 2009-03-30 |
Family
ID=39184642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009002859A MX2009002859A (es) | 2006-09-15 | 2007-09-15 | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2063709A2 (fr) |
| JP (1) | JP2010503707A (fr) |
| KR (1) | KR20090055623A (fr) |
| CN (1) | CN101534643A (fr) |
| AU (1) | AU2007296054B2 (fr) |
| CA (1) | CA2662978A1 (fr) |
| IL (1) | IL197516A0 (fr) |
| MX (1) | MX2009002859A (fr) |
| WO (1) | WO2008034122A2 (fr) |
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| US20100279408A1 (en) * | 2006-11-27 | 2010-11-04 | Enzon Pharmaceuticals, Inc. | Polymeric short interfering rna conjugates |
| WO2008113832A2 (fr) | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | Composés arn antagonistes courts pour la modulation de l'arnm cible |
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| WO2008132234A2 (fr) | 2007-05-01 | 2008-11-06 | Santaris Pharma A/S | Composés antagonistes de l'arn pour la modulation de la béta caténine |
| AU2008250033A1 (en) | 2007-05-11 | 2008-11-20 | Enzon Pharmaceuticals, Inc. | RNA antagonist compounds for the modulation of HER3 |
| KR20100072185A (ko) | 2007-09-24 | 2010-06-30 | 녹손 파르마 아게 | 씨파이브에이 결합형 핵산 |
| AU2008306327B2 (en) | 2007-10-04 | 2014-05-15 | Roche Innovation Center Copenhagen A/S | Micromirs |
| US8450290B2 (en) | 2007-11-26 | 2013-05-28 | Enzon Pharmaceuticals, Inc. | Methods for treating androgen receptor dependent disorders including cancers |
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| ES2541442T3 (es) | 2008-08-01 | 2015-07-20 | Roche Innovation Center Copenhagen A/S | Modulación mediada por microARN de factores estimulantes de colonias |
| DK2328619T3 (en) * | 2008-08-22 | 2017-03-13 | Baxalta GmbH | POLYMER BENZYL CARBONATE DERIVATES |
| US20120065254A1 (en) | 2009-03-23 | 2012-03-15 | Noxxon Pharma Ag | C5A binding nucleic acids and the use thereof |
| WO2010122538A1 (fr) | 2009-04-24 | 2010-10-28 | Santaris Pharma A/S | Compositions pharmaceutiques pour le traitement de patients souffrant du vhc ne réagissant pas aux interférons |
| CN102802637A (zh) | 2009-06-12 | 2012-11-28 | 桑塔里斯制药公司 | 新的有力的抗apob反义化合物 |
| EP2456870A1 (fr) | 2009-07-21 | 2012-05-30 | Santaris Pharma A/S | Oligomères anti-sens ciblant pcsk9 |
| UA108475C2 (uk) | 2009-07-31 | 2015-05-12 | Санофі-Авентіс Дойчланд Гмбх | Композиція інсуліну тривалої дії |
| KR20120089843A (ko) | 2009-07-31 | 2012-08-14 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린 링커 접합체를 포함한 프로드럭 |
| LT2459220T (lt) | 2009-07-31 | 2020-12-28 | Ascendis Pharma A/S | Biologiškai suyrantys vandenyje netirpūs hidrogeliai polietilenglikolio pagrindu |
| US9364495B2 (en) | 2009-10-20 | 2016-06-14 | Roche Innovation Center Copenhagen A/S | Oral delivery of therapeutically effective LNA oligonucleotides |
| WO2011054811A1 (fr) | 2009-11-03 | 2011-05-12 | Santaris Pharma A/S | Traitement combiné par des antagonistes d'arn ciblant hsp-27 |
| JP5941904B2 (ja) | 2010-04-21 | 2016-06-29 | ノクソン ファーマ エージー | 脂質に結合する核酸 |
| WO2012007477A1 (fr) | 2010-07-12 | 2012-01-19 | Santaris Pharma A/S | Oligomères anti-vhc |
| WO2012025251A1 (fr) | 2010-08-27 | 2012-03-01 | Noxxon Pharma Ag | Acides nucléiques destinés au traitement de complications chroniques du diabète |
| US20130310442A1 (en) | 2010-09-09 | 2013-11-21 | Noxxon Pharma Ag | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment |
| WO2012034942A1 (fr) | 2010-09-13 | 2012-03-22 | Santaris Pharma A/S | Composés pour la modulation de l'expression de la kinase aurora b |
| EP2438930A1 (fr) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Promédicaments comprenant un conjugué de liaison d'exendine |
| EP2633053A1 (fr) | 2010-10-29 | 2013-09-04 | Noxxon Pharma AG | Utilisation d'acides nucléiques capables de se lier à l'hepcidine afin d'entraîner une diminution du niveau d'hepcidine dans l'organisme |
| AU2011326034B2 (en) | 2010-11-12 | 2016-02-04 | Roche Innovation Center Copenhagen A/S | Compositions and methods for treating androgen receptor dependent disorders including cancers |
| WO2012066093A1 (fr) | 2010-11-19 | 2012-05-24 | Santaris Pharma A/S | Composés pour la modulation de l'expression de la protéine kinase pbk à liaison avec pdz |
| WO2012066092A1 (fr) | 2010-11-19 | 2012-05-24 | Santaris Pharma A/S | Composés de modulation de l'expression de l'aurora kinase a |
| AU2012206750A1 (en) | 2011-01-10 | 2013-07-18 | Noxxon Pharma Ag | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same |
| WO2012110457A2 (fr) | 2011-02-14 | 2012-08-23 | Santaris Pharma A/S | Composés pour la modulation de l'expression de l'ostéopontine |
| WO2012143427A1 (fr) | 2011-04-19 | 2012-10-26 | Santaris Pharma A/S | Composés anti-polyomavirus |
| US20140127159A1 (en) | 2011-06-23 | 2014-05-08 | Stella Aps | HCV Combination Therapy |
| KR20140058536A (ko) | 2011-06-30 | 2014-05-14 | 스텔라 에이피에스 | Hcv 조합 치료 |
| EP2726610A1 (fr) | 2011-06-30 | 2014-05-07 | Stella ApS | Polythérapie anti-vhc |
| PT2581448E (pt) * | 2011-10-13 | 2015-05-21 | Institut National De La Santé Et De La Rech Médicale (Inserm) | Dna triciclo-fosforotioato |
| BR112014009104A2 (pt) | 2011-10-21 | 2017-04-18 | Noxxon Pharma Ag | ácidos nucleicos que se ligam ao glucagon |
| ES2607681T3 (es) | 2011-11-07 | 2017-04-03 | Roche Innovation Center Copenhagen A/S | Método de pronóstico para comprobar la eficacia de inhibidores de micro ARN-122 en pacientes VHC+ |
| CA2855241A1 (fr) | 2011-11-11 | 2013-05-16 | Santaris Pharma A/S | Composes pour la modulation de l'epissage de smn2 |
| MX2014008456A (es) | 2012-01-10 | 2014-11-25 | Noxxon Pharma Ag | Acidos nucleicos que enlazan especificamente a cgrp. |
| DK2802660T3 (da) | 2012-01-10 | 2020-05-18 | Aptarion Biotech Ag | Nye C5A-bindende nucleinsyrer |
| RU2704833C2 (ru) | 2012-05-16 | 2019-10-31 | Аптарион Биотек Аг | Ферментативный синтез l-нуклеиновых кислот |
| CA2889044A1 (fr) | 2012-11-15 | 2014-05-22 | Roche Innovation Center Copenhagen A/S | Composes conjugues antisens anti-apob |
| WO2014080004A1 (fr) | 2012-11-26 | 2014-05-30 | Santaris Pharma A/S | Compositions et méthodes pour la modulation de l'expression de fgfr3 |
| MX391977B (es) | 2013-06-27 | 2025-03-21 | Roche Innovation Ct Copenhagen As | Oligómeros antisentido y conjugados con diana en la proteína-convertasa subtilisina/kexina tipo 9(pcsk9). |
| JP2017502075A (ja) | 2013-11-04 | 2017-01-19 | ノクソン ファーマ エージー | 腎障害治療の手段および方法 |
| GB201408623D0 (en) | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
| GB201414098D0 (en) * | 2014-08-08 | 2014-09-24 | Illumina Cambridge Ltd | Modified nucleotide linkers |
| US10815481B2 (en) | 2014-12-16 | 2020-10-27 | Roche Innovation Center Copenhagen A/S | Chiral library screen |
| WO2017118704A1 (fr) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Agonistes de cnp à libération contrôlée présentant une faible liaison à npr-c |
| CA3008017C (fr) | 2016-01-08 | 2024-01-02 | Ascendis Pharma Growth Disorders A/S | Agonistes de cnp a liberation controlee presentant des effets secondaires reduits |
| WO2017118693A1 (fr) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Promédicaments du cnp possédant de grands fragments à rôle de transporteur |
| SMT202200466T1 (it) | 2016-01-08 | 2023-01-13 | Ascendis Pharma Growth Disorders As | Profarmaci di cnp con legame a supporto in corrispondenza del raggruppamento ciclico |
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| NZ743487A (en) | 2016-01-08 | 2023-02-24 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with increased nep stability |
| SMT202400423T1 (it) | 2016-03-01 | 2024-11-15 | Ascendis Pharma Bone Diseases As | Profarmaci di pth |
| WO2017178119A1 (fr) | 2016-04-15 | 2017-10-19 | Noxxon Pharma Ag | Procédé de modulation du nombre et de la répartition des leucocytes infiltrant les tumeurs dans les tumeurs |
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| NZ792622A (en) | 2016-09-29 | 2025-08-29 | Ascendis Pharma Bone Diseases As | Pth compounds with low peak-to-trough ratios |
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| IL321464A (en) | 2016-09-29 | 2025-08-01 | Ascendis Pharma Growth Disorders As | Combination therapy with controlled-release cnp agonists |
| AU2018240375C1 (en) | 2017-03-22 | 2024-02-01 | Ascendis Pharma A/S | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
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| CA3093083A1 (fr) | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugues |
| DK3793587T3 (da) | 2018-05-18 | 2025-07-21 | Ascendis Pharma Bone Diseases As | Startdosis af pth-konjugater |
| US20210220387A1 (en) | 2018-05-18 | 2021-07-22 | Hoffmann-La Roche, Inc. | Pharmaceutical compositions for treatment of microrna related diseases |
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| EP3856255A1 (fr) | 2018-09-26 | 2021-08-04 | Ascendis Pharma A/S | Traitement d'infections |
| EP3856256A1 (fr) | 2018-09-26 | 2021-08-04 | Ascendis Pharma A/S | Nouveaux conjugués d'hydrogel |
| US20220054476A1 (en) | 2019-01-04 | 2022-02-24 | Ascendis Pharma Oncology Division A/S | Sustained local drug levels for innate immune agonists |
| BR112021011592A2 (pt) | 2019-01-04 | 2021-10-26 | Ascendis Pharma Oncology Division A/S | Conjugados de agonistas de receptor de reconhecimento de padrão |
| WO2020141223A1 (fr) | 2019-01-04 | 2020-07-09 | Ascendis Pharma A/S | Induction d'une inflammation locale soutenue |
| CA3125541A1 (fr) | 2019-01-04 | 2020-07-09 | Ascendis Pharma Oncology Division A/S | Minimisation de l'inflammation systemique |
| EP3923905A1 (fr) | 2019-02-11 | 2021-12-22 | Ascendis Pharma Bone Diseases A/S | Formulations pharmaceutiques liquides de conjugués pth |
| US12377133B2 (en) | 2019-02-11 | 2025-08-05 | Ascendis Pharma Growth Disorders A/S | Dry pharmaceutical formulations of CNP conjugates |
| WO2020254612A1 (fr) | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés inhibiteurs de tyrosine kinases à libération contrôlée présentant des propriétés pharmacodynamiques localisées |
| EP3986478A1 (fr) | 2019-06-21 | 2022-04-27 | Ascendis Pharma Oncology Division A/S | Conjugués inhibiteur de tyrosine kinase |
| WO2020254613A1 (fr) | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés inhibiteurs de tyrosine kinase à libération contrôlée présentant des propriétés pharmacocinétiques localisées |
| WO2020254607A1 (fr) | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés anti-ctla4 à propriétés pd localisées |
| AU2020295725A1 (en) | 2019-06-21 | 2021-12-02 | Ascendis Pharma Oncology Division A/S | Anti-CTLA4 conjugates |
| WO2020254617A1 (fr) | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés anti-ctla4 présentant des propriétés pharmacocinétiques localisées |
| IL294357A (en) | 2020-01-13 | 2022-08-01 | Ascendis Pharma Bone Diseases As | Hypoparathyroidism treatment |
| WO2021224169A1 (fr) | 2020-05-04 | 2021-11-11 | Ascendis Pharma A/S | Irradiation d'hydrogel |
| JP2023527919A (ja) | 2020-06-03 | 2023-06-30 | アセンディス ファーマ オンコロジー ディヴィジョン エー/エス | Il-2配列及びその使用 |
| TW202219060A (zh) | 2020-08-28 | 2022-05-16 | 丹麥商阿森迪斯腫瘤製藥有限公司 | 醣基化il-2蛋白及其用途 |
| CN112047840A (zh) * | 2020-08-31 | 2020-12-08 | 山东药品食品职业学院 | 一种7-溴-2,2-二甲基庚酸乙酯的合成方法及合成得到的产品 |
| IL301411A (en) | 2020-09-28 | 2023-05-01 | Ascendis Pharma Bone Diseases As | Improvement of physical and mental well-being of patients with hypoparathyroidism |
| MX2023011059A (es) | 2021-04-01 | 2023-09-29 | Ascendis Pharma As | Uso de hormona del crecimiento de accion prolongada para tratamiento de enfermedades inducidas por inflamacion. |
| WO2022230990A1 (fr) * | 2021-04-28 | 2022-11-03 | 国立研究開発法人科学技術振興機構 | Acide nucléique artificiel et procédé d'administration d'acide nucléique l'utilisant |
| WO2023046732A1 (fr) | 2021-09-22 | 2023-03-30 | Ascendis Pharma Bone Diseases A/S | Traitements avec des composés pth à action prolongée |
| AU2022409306A1 (en) | 2021-12-13 | 2024-06-06 | Ascendis Pharma Oncology Division A/S | Cancer treatments with tlr7/8 agonists |
| WO2023110758A1 (fr) | 2021-12-13 | 2023-06-22 | Ascendis Pharma Growth Disorders A/S | Doses efficaces de conjugués cnp |
| JP2025522281A (ja) | 2022-05-23 | 2025-07-15 | アセンディス ファーマ グロース ディスオーダーズ エー/エス | Cnp化合物の液体医薬製剤 |
| EP4306640A1 (fr) | 2022-06-21 | 2024-01-17 | TME Pharma AG | Procédé de traitement d'une tumeur chez un sujet |
| KR20250025627A (ko) | 2022-06-21 | 2025-02-24 | 티엠이 파마 아게 | 대상체의 종양을 치료하는 방법 |
| AU2023374533A1 (en) | 2022-11-02 | 2025-04-10 | Ascendis Pharma Bone Diseases A/S | Pth treatment regimen comprising two pth compounds |
| WO2024104922A1 (fr) | 2022-11-14 | 2024-05-23 | Ascendis Pharma Growth Disorders A/S | Procédé d'amélioration de la fonction musculaire squelettique |
| TW202434299A (zh) | 2023-01-05 | 2024-09-01 | 丹麥商阿仙帝斯製藥公司 | 製造水凝膠微球之方法 |
| TW202430223A (zh) | 2023-01-05 | 2024-08-01 | 丹麥商阿仙帝斯眼科製藥有限公司 | 用於治療眼部病症之藥物結合物 |
| WO2024184352A1 (fr) | 2023-03-06 | 2024-09-12 | Ascendis Pharma A/S | Composés médicamenteux comprenant des fractions de liaison à l'albumine |
| TW202440150A (zh) | 2023-03-06 | 2024-10-16 | 丹麥商阿仙帝斯製藥公司 | 具白蛋白結合部分之藥物化合物 |
| WO2024184354A1 (fr) | 2023-03-06 | 2024-09-12 | Ascendis Pharma A/S | Composés de liaison à plusieurs albumines |
| AU2024240722A1 (en) | 2023-03-20 | 2025-09-18 | Ascendis Pharma Growth Disorders A/S | Method of treatment of a thoracolumbar deformity in a human subject with achondroplasia |
| AU2024270185A1 (en) | 2023-05-09 | 2025-11-06 | Ascendis Pharma Oncology Division A/S | Novel cancer treatments with il-2 conjugates |
| WO2025051711A1 (fr) | 2023-09-04 | 2025-03-13 | Ascendis Pharma Bone Diseases A/S | Traitement par pth d'une maladie rénale chronique |
| WO2025196240A1 (fr) | 2024-03-20 | 2025-09-25 | Aptarion Biotech Ag | Méthode de traitement d'un trouble avec un inhibiteur de c5a |
| EP4620474A1 (fr) | 2024-03-20 | 2025-09-24 | APTARION biotech AG | Procédé de traitement d'un trouble avec un inhibiteur de c5a |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904582A (en) * | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| US5606045A (en) * | 1990-05-15 | 1997-02-25 | Diatron Corporation | Nucleic acid probes and methods |
| JP2002510319A (ja) * | 1997-07-01 | 2002-04-02 | アイシス・ファーマシューティカルス・インコーポレーテッド | オリゴヌクレオチドの消化管を介したデリバリーのための組成物及び方法 |
| EP1037649B1 (fr) * | 1997-12-17 | 2009-09-30 | Enzon, Inc. | Prodrogues polymeriques d'agents bioactifs contenant amine ou hydroxy |
| US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| ATE268609T1 (de) * | 1998-03-12 | 2004-06-15 | Nektar Therapeutics Al Corp | Polyethylenglycolderivate mit benachbarten reaktiven gruppen |
| JP3485023B2 (ja) * | 1999-05-20 | 2004-01-13 | 東亞合成株式会社 | ヌクレオシド化合物 |
| CA2382202A1 (fr) * | 1999-08-26 | 2001-03-01 | Sydney Brenner | Conjugues de medicaments et leurs procedes de preparation |
| KR100406739B1 (ko) * | 2000-04-15 | 2003-11-20 | 주식회사 코오롱 | 파클리탁셀 또는 이의 유도체의 잔기를 포함하는 수용성프로드럭 화합물, 그의 제조 방법 및 그를 포함하는 약제조성물 |
| WO2002043663A2 (fr) * | 2000-12-01 | 2002-06-06 | Enzon, Inc. | Promedicaments tetrapartates |
| US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| KR20060015505A (ko) * | 2003-04-13 | 2006-02-17 | 엔존 파마슈티컬즈, 인코포레이티드 | 올리고뉴클레오타이드 전구약물 |
| EP2063912A4 (fr) * | 2006-09-15 | 2010-07-28 | Enzon Pharmaceuticals Inc | Polyalkylène oxydes présentant des segments de liaison biodégradables à base d'ester encombré |
-
2007
- 2007-09-15 MX MX2009002859A patent/MX2009002859A/es not_active Application Discontinuation
- 2007-09-15 KR KR1020097007157A patent/KR20090055623A/ko not_active Withdrawn
- 2007-09-15 EP EP07842576A patent/EP2063709A2/fr not_active Withdrawn
- 2007-09-15 CA CA002662978A patent/CA2662978A1/fr not_active Abandoned
- 2007-09-15 AU AU2007296054A patent/AU2007296054B2/en not_active Ceased
- 2007-09-15 CN CNA2007800419367A patent/CN101534643A/zh active Pending
- 2007-09-15 WO PCT/US2007/078597 patent/WO2008034122A2/fr not_active Ceased
- 2007-09-15 JP JP2009528517A patent/JP2010503707A/ja active Pending
-
2009
- 2009-03-10 IL IL197516A patent/IL197516A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010503707A (ja) | 2010-02-04 |
| AU2007296054A1 (en) | 2008-03-20 |
| AU2007296054B2 (en) | 2013-03-28 |
| WO2008034122A3 (fr) | 2008-10-30 |
| CN101534643A (zh) | 2009-09-16 |
| EP2063709A2 (fr) | 2009-06-03 |
| CA2662978A1 (fr) | 2008-03-20 |
| WO2008034122A2 (fr) | 2008-03-20 |
| IL197516A0 (en) | 2009-12-24 |
| KR20090055623A (ko) | 2009-06-02 |
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| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |