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MX2009000254A - Nuevos derivados de 1h-indol-1-il-urea, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de 1h-indol-1-il-urea, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
MX2009000254A
MX2009000254A MX2009000254A MX2009000254A MX2009000254A MX 2009000254 A MX2009000254 A MX 2009000254A MX 2009000254 A MX2009000254 A MX 2009000254A MX 2009000254 A MX2009000254 A MX 2009000254A MX 2009000254 A MX2009000254 A MX 2009000254A
Authority
MX
Mexico
Prior art keywords
branched
linear
indol
urea
pharmaceutical compositions
Prior art date
Application number
MX2009000254A
Other languages
English (en)
Inventor
Jean-Daniel Brion
Alain Le Ridant
Catherine Harpey
Abdallah Deyine
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MX2009000254A publication Critical patent/MX2009000254A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Compuestos de fórmula (1): en la que: -Rl y R2, idénticos o diferentes, representan un átomo de hidrógeno o un grupo alquilo (C1-C6) lineal o ramificado, -R3 representa un átomo de hidrógeno o de halógeno, un grupo alquilo (C1-C6) lineal o ramificado, o un grupo alcoxi (Cl-C6) lineal o ramificado, -Het representa un grupo piridilo, pirimidilo o piperidilo, sustituidos opcionalmente con uno o varios grupos elegidos entre halógeno, alquilo (Cl-C6) lineal o ramificado, alcoxi (Cl-C6) lineal o ramificado, representa un enlace sencillo o un enlace doble, sus enantiómeros y diastereoisómeros, así como sus sales de adición a un ácido o a una base aceptable farmacéuticamente.
MX2009000254A 2008-01-04 2009-01-07 Nuevos derivados de 1h-indol-1-il-urea, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. MX2009000254A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0800043A FR2926077A1 (fr) 2008-01-04 2008-01-04 Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
MX2009000254A true MX2009000254A (es) 2009-08-12

Family

ID=39427563

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009000254A MX2009000254A (es) 2008-01-04 2009-01-07 Nuevos derivados de 1h-indol-1-il-urea, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (17)

Country Link
US (1) US20090176794A1 (es)
EP (1) EP2078716A1 (es)
JP (1) JP2009196976A (es)
KR (1) KR20090075632A (es)
CN (1) CN101475560A (es)
AR (1) AR070070A1 (es)
AU (1) AU2009200010A1 (es)
BR (1) BRPI0900030A2 (es)
CA (1) CA2648836A1 (es)
EA (1) EA200802427A1 (es)
FR (1) FR2926077A1 (es)
MA (1) MA30619B1 (es)
MX (1) MX2009000254A (es)
NZ (1) NZ573976A (es)
SG (1) SG153774A1 (es)
WO (1) WO2009106753A1 (es)
ZA (1) ZA200810841B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11446268B2 (en) * 2019-02-01 2022-09-20 Yamo Pharmaceuticals Llc Compositions and methods for treating anxiety-related disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3454583A (en) 1965-07-19 1969-07-08 Us Health Education & Welfare Synthesis of vincamine
FR2381048A1 (fr) 1977-02-22 1978-09-15 Roussel Uclaf Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments
FR2433528A2 (fr) 1978-08-16 1980-03-14 Roussel Uclaf Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments
FR2614022B1 (fr) 1987-04-15 1989-12-01 Roussel Uclaf Nouveaux derives 17-aza de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et ces compositions les renfermant
WO1993018026A1 (en) * 1992-03-04 1993-09-16 Beecham Group Plc Indole ureas as 5-ht1c receptor antogonists
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
FR2713644B1 (fr) 1993-12-14 1996-02-09 Adir Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AUPO390996A0 (en) * 1996-11-29 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911143A1 (fr) * 2007-01-05 2008-07-11 Servier Lab Utilisation de composes neuroprotecteurs pour l'obtention de medicaments destines au traitement de maladies neurodegeneratives.

Also Published As

Publication number Publication date
AR070070A1 (es) 2010-03-10
ZA200810841B (en) 2009-12-30
SG153774A1 (en) 2009-07-29
WO2009106753A1 (fr) 2009-09-03
JP2009196976A (ja) 2009-09-03
EP2078716A1 (fr) 2009-07-15
CN101475560A (zh) 2009-07-08
EA200802427A1 (ru) 2009-06-30
CA2648836A1 (fr) 2009-07-04
AU2009200010A1 (en) 2009-07-23
FR2926077A1 (fr) 2009-07-10
KR20090075632A (ko) 2009-07-08
NZ573976A (en) 2010-05-28
US20090176794A1 (en) 2009-07-09
MA30619B1 (fr) 2009-08-03
BRPI0900030A2 (pt) 2009-09-15

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal