FR2433528A2 - Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments - Google Patents
Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicamentsInfo
- Publication number
- FR2433528A2 FR2433528A2 FR7823850A FR7823850A FR2433528A2 FR 2433528 A2 FR2433528 A2 FR 2433528A2 FR 7823850 A FR7823850 A FR 7823850A FR 7823850 A FR7823850 A FR 7823850A FR 2433528 A2 FR2433528 A2 FR 2433528A2
- Authority
- FR
- France
- Prior art keywords
- beta
- alpha
- eburnamenine
- cerebral
- prepn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 title abstract 9
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 title 1
- YCNZFPXXIWEFCF-UHFFFAOYSA-N alumane;sodium Chemical compound [Na].[AlH3] YCNZFPXXIWEFCF-UHFFFAOYSA-N 0.000 title 1
- 230000002490 cerebral effect Effects 0.000 abstract 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 abstract 1
- 208000032843 Hemorrhage Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 abstract 1
- 230000004089 microcirculation Effects 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'addition a pour objet un procédé de préparation d'un produit de formule I du brevet principal, l'isomère B du (3 beta , 16 alpha ) ( +- )14,15-dihydro 20,21-dinoréburnaménin-14.ol, à partir du chlorhydrate de (3 beta ,16 alpha ) ( +- ) 20,21-dinoréburnaménin-14-(l5H)-one, le produit tel qu'obtenu par ce procédé et son application comme médicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7823850A FR2433528A2 (fr) | 1978-08-16 | 1978-08-16 | Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7823850A FR2433528A2 (fr) | 1978-08-16 | 1978-08-16 | Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2433528A2 true FR2433528A2 (fr) | 1980-03-14 |
| FR2433528B2 FR2433528B2 (fr) | 1981-07-24 |
Family
ID=9211826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7823850A Granted FR2433528A2 (fr) | 1978-08-16 | 1978-08-16 | Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2433528A2 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3322686A1 (de) * | 1982-06-30 | 1984-02-16 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | Neue eburnanderivate, verfahren zur herstellung derselben und diese enthaltende pharmazeutische praeparate |
| EP0317426A1 (fr) * | 1987-11-19 | 1989-05-24 | Roussel-Uclaf | Produits optiquement actifs de dérivés de 20,21-dinoréburnaménine, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant |
| US7354918B2 (en) | 2004-04-14 | 2008-04-08 | Biocortech | Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof |
| EP2078716A1 (fr) | 2008-01-04 | 2009-07-15 | Les Laboratoires Servier | Nouveaux dérivés d'1H-indol-1-yl urée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1586697A (fr) * | 1967-08-23 | 1970-02-27 | ||
| FR2381048A1 (fr) * | 1977-02-22 | 1978-09-15 | Roussel Uclaf | Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments |
-
1978
- 1978-08-16 FR FR7823850A patent/FR2433528A2/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1586697A (fr) * | 1967-08-23 | 1970-02-27 | ||
| FR2381048A1 (fr) * | 1977-02-22 | 1978-09-15 | Roussel Uclaf | Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3322686A1 (de) * | 1982-06-30 | 1984-02-16 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | Neue eburnanderivate, verfahren zur herstellung derselben und diese enthaltende pharmazeutische praeparate |
| EP0317426A1 (fr) * | 1987-11-19 | 1989-05-24 | Roussel-Uclaf | Produits optiquement actifs de dérivés de 20,21-dinoréburnaménine, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant |
| FR2623503A1 (fr) * | 1987-11-19 | 1989-05-26 | Roussel Uclaf | |
| US7354918B2 (en) | 2004-04-14 | 2008-04-08 | Biocortech | Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof |
| EP2078716A1 (fr) | 2008-01-04 | 2009-07-15 | Les Laboratoires Servier | Nouveaux dérivés d'1H-indol-1-yl urée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2433528B2 (fr) | 1981-07-24 |
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