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MX2007003913A - Alquil-piridinas como inhibidores de 11 beta para diabetes. - Google Patents

Alquil-piridinas como inhibidores de 11 beta para diabetes.

Info

Publication number
MX2007003913A
MX2007003913A MX2007003913A MX2007003913A MX2007003913A MX 2007003913 A MX2007003913 A MX 2007003913A MX 2007003913 A MX2007003913 A MX 2007003913A MX 2007003913 A MX2007003913 A MX 2007003913A MX 2007003913 A MX2007003913 A MX 2007003913A
Authority
MX
Mexico
Prior art keywords
alkil
pyridines
diabetes
beta inhibitors
inhibitors
Prior art date
Application number
MX2007003913A
Other languages
English (en)
Inventor
Werner Neidhart
Bernd Kuhn
Daniel Hunziker
Alexander Mayweg
Kurt Amrein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35276680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2007003913(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2007003913A publication Critical patent/MX2007003913A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Se describen compuestos de formula (1) asi como las sales y esteres farmaceuticamente aceptables de los mismos, en donde R1 a R6 tienen los valores definidos en la reivindicacion 1, los cuales pueden utilizarse en forma de composiciones farmaceuticas. (ver formula).
MX2007003913A 2004-10-04 2005-09-26 Alquil-piridinas como inhibidores de 11 beta para diabetes. MX2007003913A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04104856 2004-10-04
PCT/EP2005/010372 WO2006037501A1 (en) 2004-10-04 2005-09-26 Alkil-pyridines as 11-beta inhibitors for diabetes

Publications (1)

Publication Number Publication Date
MX2007003913A true MX2007003913A (es) 2007-05-21

Family

ID=35276680

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007003913A MX2007003913A (es) 2004-10-04 2005-09-26 Alquil-piridinas como inhibidores de 11 beta para diabetes.

Country Status (18)

Country Link
US (1) US7482341B2 (es)
EP (1) EP1799647A1 (es)
JP (2) JP5414990B2 (es)
KR (1) KR100874313B1 (es)
CN (1) CN101035762B (es)
AR (1) AR054688A1 (es)
AU (1) AU2005291561B2 (es)
BR (1) BRPI0516454A (es)
CA (1) CA2582276C (es)
IL (1) IL182310A0 (es)
MX (1) MX2007003913A (es)
MY (1) MY139522A (es)
NO (1) NO20071658L (es)
NZ (1) NZ554014A (es)
RU (1) RU2383533C2 (es)
TW (1) TWI298721B (es)
WO (1) WO2006037501A1 (es)
ZA (1) ZA200702716B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101035762B (zh) * 2004-10-04 2010-09-29 霍夫曼-拉罗奇有限公司 用于糖尿病的作为11-β抑制剂的烷基(alkil)-吡啶类
WO2006106423A2 (en) * 2005-04-07 2006-10-12 Pfizer Inc. Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase
ZA200709961B (en) 2005-05-10 2009-07-29 Vertex Pharma Bicyclic derivatives as modulators of ion channels
DE602006010546D1 (de) * 2005-06-16 2009-12-31 Pfizer N-(pyridin-2-yl)sulfonamidderivate
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
US8269010B2 (en) * 2006-09-21 2012-09-18 Piramal Healthcare Limited 3-amino-pyridine derivatives for the treatment of metabolic disorders
CA2734710A1 (en) * 2007-08-22 2009-02-26 Proteologics Ltd. Pyrimidine and pyridine derivatives as posh and posh-ap inhibitors
KR20110050459A (ko) * 2008-07-25 2011-05-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
WO2011068927A2 (en) * 2009-12-04 2011-06-09 Abbott Laboratories 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF
JP2013536241A (ja) * 2010-08-24 2013-09-19 ブリガム・ヤング・ユニバーシティ 抗転移化合物
WO2012124744A1 (ja) * 2011-03-14 2012-09-20 大正製薬株式会社 含窒素縮合複素環化合物
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
CN104974084A (zh) * 2015-07-19 2015-10-14 佛山市赛维斯医药科技有限公司 一类胺基二吡啶叔醇结构的11β-HSD1抑制剂及其用途
TW201811766A (zh) 2016-08-29 2018-04-01 瑞士商諾華公司 N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途
RU2652993C1 (ru) * 2017-06-07 2018-05-04 федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации Новое 2-стирилпроизводное 4-(2,6-диметил-4-оксо-5-фенил-4н-пиримидин-1-ил)-бензсульфамида, обладающее эндотелеопротекторной активностью
CA3184471A1 (en) 2020-05-27 2021-12-02 The Penn State Research Foundation Antibacterial compounds
US20240132431A1 (en) * 2021-01-06 2024-04-25 Chugai Seiyaku Kabushiki Kaisha Method for alkylating acidic functional group
WO2022266794A1 (zh) * 2021-06-21 2022-12-29 武汉睿健医药科技有限公司 Oct4高选择性活化剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0174752B1 (ko) * 1993-09-10 1999-02-01 나이토 하루오 이환식 헤테로환 함유 술폰아미드 유도체 및 그 제조방법
SE0001899D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
PL370275A1 (en) * 2001-11-22 2005-05-16 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
AU2002353717B2 (en) * 2001-11-22 2006-08-03 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
DE602004017703D1 (de) * 2003-02-24 2008-12-24 Arena Pharm Inc Phenyl- und pyridylpiperidinderivate als modulatoren des glucose-metabolismus
US20070099938A1 (en) * 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
JP2007514731A (ja) * 2003-12-19 2007-06-07 ファイザー インコーポレイテッド 糖尿病及び肥満症の治療のための１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１型（１１−β−ｈｓｄ−１）の阻害剤としてのベンゼンスルホニルアミノ−ピリジン−２−イル誘導体及び関連化合物
CN1897944A (zh) * 2003-12-19 2007-01-17 辉瑞有限公司 用于治疗糖尿病和肥胖症的11－β－羟基类固醇脱氢酶－1型(11－β－HSD－1 ) 抑制剂苯磺酰胺基－吡啶－2－基衍生物和相关化合物
CN101035762B (zh) * 2004-10-04 2010-09-29 霍夫曼-拉罗奇有限公司 用于糖尿病的作为11-β抑制剂的烷基(alkil)-吡啶类

Also Published As

Publication number Publication date
CA2582276A1 (en) 2006-04-13
CA2582276C (en) 2011-09-13
NZ554014A (en) 2010-06-25
BRPI0516454A (pt) 2008-09-02
RU2007116431A (ru) 2008-11-10
CN101035762A (zh) 2007-09-12
CN101035762B (zh) 2010-09-29
TWI298721B (en) 2008-07-11
JP5414990B2 (ja) 2014-02-12
NO20071658L (no) 2007-05-03
RU2383533C2 (ru) 2010-03-10
ZA200702716B (en) 2008-07-30
AU2005291561A1 (en) 2006-04-13
AR054688A1 (es) 2007-07-11
AU2005291561B2 (en) 2010-02-25
TW200616958A (en) 2006-06-01
JP2008515826A (ja) 2008-05-15
IL182310A0 (en) 2007-07-24
KR20070063527A (ko) 2007-06-19
HK1108283A1 (zh) 2008-05-02
JP2011157373A (ja) 2011-08-18
JP5351199B2 (ja) 2013-11-27
EP1799647A1 (en) 2007-06-27
WO2006037501A9 (en) 2007-08-02
US7482341B2 (en) 2009-01-27
US20060074237A1 (en) 2006-04-06
KR100874313B1 (ko) 2008-12-18
MY139522A (en) 2009-10-30
WO2006037501A1 (en) 2006-04-13

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