[go: up one dir, main page]

MX2007003171A - Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico. - Google Patents

Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico.

Info

Publication number
MX2007003171A
MX2007003171A MX2007003171A MX2007003171A MX2007003171A MX 2007003171 A MX2007003171 A MX 2007003171A MX 2007003171 A MX2007003171 A MX 2007003171A MX 2007003171 A MX2007003171 A MX 2007003171A MX 2007003171 A MX2007003171 A MX 2007003171A
Authority
MX
Mexico
Prior art keywords
present
vlp
virus
particles
modified
Prior art date
Application number
MX2007003171A
Other languages
English (en)
Inventor
Martin Bachmann
Alain Tissot
Gary Jennings
Regina Renhofa
Paul Pumpens
Indulis Cielens
Original Assignee
Cytos Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytos Biotechnology Ag filed Critical Cytos Biotechnology Ag
Publication of MX2007003171A publication Critical patent/MX2007003171A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18123—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invencion esta en el campo de la medicina, inmunologia, virologia y biologia molecular. La presente invencion proporciona una composicion que comprende una particula tipo virus (VLP) modificada, derivada del bacteriofago AP205 de ARN. La invencion tambien proporciona un proceso para producir la VLP mencionada anteriormente: La VLP modificada descrita en al presente invencion es util en la produccion de composiciones para inducir respuestas inmunitarias para la prevencion o tratamiento en enfermedades, trastornos que incluyen enfermedades infecciosas, alergias, canceres y adiccion a drogas. Ademas, la VLP modificada descrita en la presente invencion es, en particular, util para inducir de forma eficiente respuestas inmunitarias auto-especificas, en particular respuestas de anticuerpos.
MX2007003171A 2004-09-21 2005-09-21 Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico. MX2007003171A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61130804P 2004-09-21 2004-09-21
EP05105229 2005-06-14
PCT/EP2005/054721 WO2006032674A1 (en) 2004-09-21 2005-09-21 Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide

Publications (1)

Publication Number Publication Date
MX2007003171A true MX2007003171A (es) 2007-05-23

Family

ID=46307785

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007003171A MX2007003171A (es) 2004-09-21 2005-09-21 Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico.

Country Status (10)

Country Link
US (1) US20080292652A1 (es)
EP (1) EP1791870A1 (es)
JP (1) JP2008513035A (es)
AU (1) AU2005286475A1 (es)
BR (1) BRPI0516953A (es)
CA (1) CA2580208A1 (es)
MX (1) MX2007003171A (es)
NZ (1) NZ554387A (es)
RU (1) RU2409667C2 (es)
WO (1) WO2006032674A1 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
ATE447967T1 (de) * 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
RU2450827C2 (ru) * 2002-07-19 2012-05-20 Цитос Биотехнологи Аг Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6
MXPA05004588A (es) 2002-10-29 2005-12-14 Coley Pharmaceutical Group Ltd Metodos y productos relacionados con el tratamiento y prevencion de infeccion de virus de hepatitis c.
JP5022028B2 (ja) * 2003-03-26 2012-09-12 サイトス・バイオテクノロジー・アクチェンゲゼルシャフト メラン−ａペプチドアナログ−ウイルス様粒子コンジュゲート
AU2005291231B2 (en) 2004-10-05 2010-12-23 Cytos Biotechnology Ag VLP-antigen conjugates and their uses as vaccines
CA2580919A1 (en) 2004-10-25 2006-05-04 Cytos Biotechnology Ag Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof
CN101193654A (zh) * 2005-06-14 2008-06-04 赛托斯生物技术公司 抗原偶联物及其用途
ES2310062B1 (es) 2005-07-15 2009-11-13 Bionostra, S.L. Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones.
KR20080047564A (ko) 2005-09-28 2008-05-29 사이토스 바이오테크놀로지 아게 인터루킨-1 컨쥬게이트 및 그의 용도
EP1973608A1 (en) * 2005-12-14 2008-10-01 Cytos Biotechnology AG Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
AU2013204383B2 (en) * 2006-06-12 2016-09-22 Kuros Us Llc Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages
NZ573622A (en) 2006-06-12 2011-12-22 Cytos Biotechnology Ag Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages
US20090142362A1 (en) * 2006-11-06 2009-06-04 Avant Immunotherapeutics, Inc. Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (CETP)
CA2671873C (en) 2006-12-12 2018-10-09 Brian Stephen Sproat Oligonucleotides containing high concentrations of guanine monomers
AU2007336132A1 (en) * 2006-12-21 2008-06-26 Cytos Biotechnology Ag Circular CCR5 peptide conjugates and uses thereof
CN101245110B (zh) * 2007-02-16 2010-09-15 鲁南制药集团股份有限公司 重组中性粒细胞抑制因子和水蛭原嵌合蛋白及其药物组合物
CA2721657A1 (en) * 2008-04-22 2009-10-29 Cytos Biotechnology Ag Vaccine compositions for the treatment of dengue fever and uses thereof
WO2010122164A1 (en) 2009-04-23 2010-10-28 Cytos Biotechnology Ag VIRUS-LIKE PARTICLES OF BACTERIOPHAGE φCB5
US20120263743A1 (en) * 2009-04-30 2012-10-18 Cytos Biotechnology Ag Influenza hemagglutinin compositions and uses thereof
CN104436212A (zh) * 2010-03-29 2015-03-25 诺华股份有限公司 包含与病毒样颗粒偶联的淀粉样β1-6肽及佐剂的组合物
GB201121571D0 (en) * 2011-12-15 2012-01-25 Astrimmune Ltd Compounds and uses thereof
EP2794662A1 (en) 2011-12-22 2014-10-29 F.Hoffmann-La Roche Ag Full length antibody display system for eukaryotic cells and its use
AU2013221187B9 (en) * 2012-02-16 2018-01-04 Vlp Therapeutics, Inc. Virus like particle composition
EP3158058B1 (en) 2014-06-18 2019-04-17 MorphoSys AG Fusion proteins and uses thereof
CN104255335B (zh) * 2014-08-24 2016-08-31 苗建军 一种吊放蔓用钳
RU2568872C1 (ru) * 2014-10-15 2015-11-20 Игорь Геннадьевич Сивов Лекарственное средство для лечения вирусного гепатита с
MA40824A (fr) 2014-10-22 2017-08-29 Saiba Gmbh Particules de cmv de type virus modifié
WO2016112921A1 (en) 2015-01-15 2016-07-21 University Of Copenhagen Virus-like particle with efficient epitope display
WO2017071713A1 (en) 2015-10-30 2017-05-04 University Of Copenhagen Virus like particle with efficient epitope display
EP3389693A4 (en) 2015-12-18 2019-08-21 Agilvax, Inc. COMPOSITIONS AND METHODS RELATED TO XCT PEPTIDES
MX394254B (es) * 2016-04-27 2025-03-24 Benchmark Animal Health Ltd Composiciones para el tratamiento de dermatitis atópica canina y sus usos.
CN112500456B (zh) * 2020-12-02 2022-10-28 深圳赫兹生命科学技术有限公司 一种去势ap205病毒样颗粒亚单位疫苗
CN117202926A (zh) * 2021-02-02 2023-12-08 普罗瓦克萨斯股份有限公司 新型免疫调节平台及其使用方法
US20240189407A1 (en) 2021-04-12 2024-06-13 Saiba AG Modified virus-like particles of bacteriophage ap205
US20240156937A1 (en) * 2021-04-23 2024-05-16 Unm Rainforest Innovations Baceriophage virus-like particles vaccines for chlamydia trachomatis infections
CN114933639B (zh) * 2022-05-05 2023-12-29 中国农业科学院兰州兽医研究所 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途
CN115819623A (zh) * 2022-12-12 2023-03-21 长春百克生物科技股份公司 一种重组病毒样颗粒疫苗组合物的制备及应用
CN118684781A (zh) * 2023-03-21 2024-09-24 深圳赫兹生命科学技术有限公司 GnRH-VLP重组去势疫苗及其制备方法
WO2025000310A1 (zh) * 2023-06-29 2025-01-02 深圳赫兹生命科学技术有限公司 去势ap205病毒样颗粒亚单位疫苗的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020193565A1 (en) * 1998-03-27 2002-12-19 Stanley Margaret Anne Antigen preparation and use
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7128911B2 (en) * 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
ATE447967T1 (de) * 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
EP1425040A2 (en) * 2001-09-14 2004-06-09 Cytos Biotechnology AG In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
AU2002362696B2 (en) * 2001-10-05 2008-05-29 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
PL369863A1 (en) * 2001-11-07 2005-05-02 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
KR20050044316A (ko) * 2001-11-07 2005-05-12 사이토스 바이오테크놀로지 아게 호산구성 알레르기 질환 치료용의 ｉｌ-5, ｉｌ-13 또는에오탁신을 제시하는 항원 어레이
ATE489969T1 (de) * 2002-06-20 2010-12-15 Cytos Biotechnology Ag Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung
MXPA05000287A (es) * 2002-07-05 2005-09-08 Leclerc Denis Particula viral adyuvante.
RU2324704C2 (ru) * 2002-07-17 2008-05-20 Цитос Байотекнолоджи Аг Молекулярные массивы антигенов

Also Published As

Publication number Publication date
JP2008513035A (ja) 2008-05-01
US20080292652A1 (en) 2008-11-27
EP1791870A1 (en) 2007-06-06
BRPI0516953A (pt) 2008-09-30
WO2006032674A1 (en) 2006-03-30
RU2007114956A (ru) 2008-10-27
RU2409667C2 (ru) 2011-01-20
CA2580208A1 (en) 2006-03-30
AU2005286475A1 (en) 2006-03-30
NZ554387A (en) 2009-09-25

Similar Documents

Publication Publication Date Title
MX2007003171A (es) Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico.
WO2004007538A3 (en) Molecular antigen arrays using a virus like particle derived from the ap205 coat protein
Lebel et al. Plant viruses as nanoparticle-based vaccines and adjuvants
CN100518823C (zh) 半抗原-载体偶联物及其用途
WO2006097530A3 (en) Cat allergen fusion proteins and uses thereof
WO2002056905A3 (en) Molecular antigen array
MX2010006610A (es) Conjugados de factor de crecimiento de nervios y usos de los mismos.
ATE489969T1 (de) Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung
WO2004084939A3 (en) Hiv-peptide-carrier-conjugates
IL165003A0 (en) Ghrelin-carrier conjugates
IL166227A0 (en) Vaccine compositions containing amyloid beta1-6 antigen arrays
PL369863A1 (en) Antigen arrays for treatment of allergic eosinophilic diseases
WO2006063974A3 (en) Il-15 antigen arrays and uses thereof
WO2005117983A3 (en) Carrier conjugates of tnf-peptides
IL161146A0 (en) Antigen arrays for treatment of bone disease
JP2010508857A5 (es)
WO2006027300A3 (en) Carrier conjugates of gnrh-peptides
WO2003090687A3 (en) Using heat shock proteins to increase immune response
WO2008109686A3 (en) Non- infectious recombinant virus-like particles and their pharmaceutical applications
WO2008082719A3 (en) Combined human papillomavirus vlp/gene delivery system and use thereof as a vaccine for prophylaxis and immunotherapy of infectious diseases and tumors
WO2003059386A3 (en) Prion protein carrier-conjugates
Sobczak et al. Identifying key drivers of efficient B cell responses: on the role of T help, antigen-organization, and toll-like receptor stimulation for generating a neutralizing anti-dengue virus response
WO2007039458A3 (en) Hiv peptide conjugates and uses thereof
MXPA04003901A (es) Disposiciones de antigenos para el tratamiento de enfermedades eosinofilicas alergicas.
WO2007008093A3 (en) A method of manufacturing a recombinant vaccine against viral rabbit haemorrhagic disease, the vaccine, the application of a recombinant antigen in the manufacture of the vaccine

Legal Events

Date Code Title Description
FA Abandonment or withdrawal