MW390A1 - Antiviral or antibacterial compound and method of use - Google Patents
Antiviral or antibacterial compound and method of useInfo
- Publication number
- MW390A1 MW390A1 MW3/90A MW390A MW390A1 MW 390 A1 MW390 A1 MW 390A1 MW 3/90 A MW3/90 A MW 3/90A MW 390 A MW390 A MW 390A MW 390 A1 MW390 A1 MW 390A1
- Authority
- MW
- MALAWI
- Prior art keywords
- antiviral
- composition
- disclosed
- antibacterial compound
- forms
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 229940088598 enzyme Drugs 0.000 abstract 2
- 208000031295 Animal disease Diseases 0.000 abstract 1
- 102000016943 Muramidase Human genes 0.000 abstract 1
- 108010014251 Muramidase Proteins 0.000 abstract 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 102000006382 Ribonucleases Human genes 0.000 abstract 1
- 108010083644 Ribonucleases Proteins 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229960000274 lysozyme Drugs 0.000 abstract 1
- 235000010335 lysozyme Nutrition 0.000 abstract 1
- 239000004325 lysozyme Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
A composition having antiviral and antibacterial effects is disclosed which comprises the dimeric forms of enzymes selected from lysozyme and ribonuclease and a pharmaceutically acceptable carrier. These dimeric forms are more effective in treating a variety of human and animal diseases because they are much less cytotoxic than the monomeric forms of the enzyme. A method for the use of these compositions is also disclosed which comprises applying an effective amount of the composition to the infected area.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17858888A | 1988-05-26 | 1988-05-26 | |
| PCT/US1988/001785 WO1989011294A1 (en) | 1988-05-26 | 1988-05-26 | Antiviral or antibacterial compound and method of use |
| OA59731A OA09785A (en) | 1988-05-26 | 1990-01-26 | Antiviral or antibacterial compound and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MW390A1 true MW390A1 (en) | 1990-11-14 |
Family
ID=33162813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MW3/90A MW390A1 (en) | 1988-05-26 | 1990-01-22 | Antiviral or antibacterial compound and method of use |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US5200182A (en) |
| EP (1) | EP0380484B1 (en) |
| JP (1) | JPH0649659B2 (en) |
| AT (1) | ATE93143T1 (en) |
| AU (1) | AU624331B2 (en) |
| BG (1) | BG60544B1 (en) |
| CA (1) | CA1335425C (en) |
| CS (1) | CS277030B6 (en) |
| DK (1) | DK173078B1 (en) |
| ES (1) | ES2011577A6 (en) |
| FI (1) | FI900412A7 (en) |
| HK (1) | HK42394A (en) |
| HU (1) | HU204710B (en) |
| IL (1) | IL90092A (en) |
| LV (1) | LV10054B (en) |
| MA (1) | MA21560A1 (en) |
| MW (1) | MW390A1 (en) |
| OA (1) | OA09785A (en) |
| PH (1) | PH26284A (en) |
| RU (1) | RU2092183C1 (en) |
| WO (1) | WO1989011294A1 (en) |
| YU (1) | YU109289A (en) |
| ZA (1) | ZA893382B (en) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200182A (en) * | 1988-05-26 | 1993-04-06 | Nika Health Products, Ltd. | Antiviral or antibacterial composition and method of use |
| AU645252B2 (en) * | 1990-01-08 | 1994-01-13 | Nika Health Products Ltd. | Method of producing ribonuclease dimers |
| US5989880A (en) * | 1990-01-08 | 1999-11-23 | Nika Health Products Ltd. | Method of preparing lysozyme dimers |
| PL173978B1 (en) * | 1992-07-13 | 1998-05-29 | Nika Health Products Ltd | Method of obtaining a preparation capable to retard the synthesis of endogenous cytotoxic cytokinins |
| CH682541A5 (en) * | 1992-06-23 | 1993-10-15 | Urs Viktor Dr Wirth | Biochemical Inactivation of RNA viruses. |
| US6183742B1 (en) | 1992-07-13 | 2001-02-06 | Nika Health Products, Limited | Applications of lysozyme dimer |
| DZ1964A1 (en) * | 1995-01-13 | 2002-10-15 | Nika Health Products Ltd | New applications of a lysozyme dimer. |
| GB2304048A (en) * | 1995-08-12 | 1997-03-12 | John William Carson | Medicament containing saliva extract |
| US6123937A (en) * | 1997-03-14 | 2000-09-26 | Nika Health Products, Limited | Applications of lysozyme dimer |
| RU2157206C1 (en) * | 1999-03-10 | 2000-10-10 | Оренбургская государственная медицинская академия | Bactericidal otogel |
| RU2172179C2 (en) * | 1999-06-24 | 2001-08-20 | Сельков Сергей Алексеевич | Globuli "biosan" for treatment of patients with colpitis of different genesis and method of treatment of patients with colpitis of different genesis |
| RU2191576C2 (en) * | 1999-07-27 | 2002-10-27 | Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии | Method for treating subclinical form of female genital herpesvirus infection |
| RU2200550C2 (en) * | 1999-10-29 | 2003-03-20 | Научно-исследовательская лаборатория иммунохимиотерапии лепры и иммунотропных средств с клиникой и опытно-экспериментальным производством | Novel medicinal forms of dimocifon in leprosy therapy, itching and allergodermatosis, during's dermatitis herpetiformis |
| RU2163119C1 (en) * | 2000-04-26 | 2001-02-20 | Свистов Виталий Владимирович | Antiseptic agent |
| RU2180593C1 (en) * | 2000-11-08 | 2002-03-20 | Айламазян Эдуард Карпович | Pharmaceutical composition for treatment and prophylaxis of genital herpes, chronic papilloma of viral infection and prophylaxis of uterine cervix cancer (variants) |
| US7338936B2 (en) * | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| US6716813B2 (en) * | 2000-11-28 | 2004-04-06 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| RU2177781C1 (en) * | 2000-12-06 | 2002-01-10 | Научный Центр Здоровья детей РАМН | Vitamin complex-containing rectal suppositories |
| JP2002187853A (en) * | 2000-12-21 | 2002-07-05 | Shinei Ferumentekku:Kk | Disinfectiong agent for nipple of animal, and method for improving fungal environment |
| RU2195927C1 (en) * | 2001-07-13 | 2003-01-10 | ООО "Тенториум" | Candella-2 abies-candle |
| DE10210285A1 (en) * | 2002-03-08 | 2003-11-13 | Medigene Ag | Reversible toxin and its use |
| WO2005115477A2 (en) * | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
| US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
| US7348301B2 (en) * | 2006-02-16 | 2008-03-25 | Buckman Laboratories International, Inc. | Lysozyme-based method and composition to control the growth of microorganisms in aqueous systems |
| WO2007149594A2 (en) * | 2006-06-23 | 2007-12-27 | Quintessence Biosciences, Inc. | Modified ribonucleases |
| US8298801B2 (en) | 2006-07-17 | 2012-10-30 | Quintessence Biosciences, Inc. | Methods and compositions for the treatment of cancer |
| EP2134354A4 (en) * | 2007-03-02 | 2012-03-21 | Saint Simeon Lda | Composition and method for treating papilloma virus and equine sarcoids |
| WO2009036000A2 (en) * | 2007-09-11 | 2009-03-19 | University Of Maryland, Baltimore | Methods of treating a microbial infection by modulating rnase-l expression and/or activity |
| US8697062B2 (en) * | 2007-10-08 | 2014-04-15 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapeutics |
| CN102227443B (en) | 2008-10-01 | 2014-05-14 | 昆特森斯生物科学公司 | Therapeutic ribonucleases |
| US20100215707A1 (en) * | 2009-02-25 | 2010-08-26 | Mcdonald Thomas | Activated creatinine and precursors thereof as antibacterial agents, compositions and products containing such agents and uses thereof |
| NZ600269A (en) | 2009-05-20 | 2014-02-28 | Dec Int Nz Ltd | Delivery device for treatment of mastitis |
| PL2457576T3 (en) | 2010-11-29 | 2021-04-06 | Eurochit Danuta Kruszewska | Lactobacillus reuteri strain for use in the medical and veterinary prophylaxis and treatment of metabolic syndrome or infections |
| RU2548803C2 (en) * | 2011-11-28 | 2015-04-20 | Общество с ограниченной ответственностью " Фарматренд" | PHARMACEUTICAL COMPOSITION FOR TREATING EYE INFECTIONS P. Aeruginosa CONTAINING RECOMBINANT LYSOZYME |
| RU2509801C2 (en) * | 2012-03-22 | 2014-03-20 | Борис Михайлович Куриненко | METHOD OF USING Bacillus intermedius RIBONUCLEASE |
| EP2674162A1 (en) | 2012-05-29 | 2013-12-18 | Danuta Kruszewska | Nanoproduct comprising lactobacillus reuteri dan080 useful in prophylaxis and medicine, both human and veterinary and medical use of the same |
| JP2015520773A (en) | 2012-05-29 | 2015-07-23 | ダヌタ・クルセフスカDanutaKRUSZEWSKA | Nano products containing Lactobacillus reuteri DAN80 useful for prevention and medicine in humans and animals and their pharmaceutical use |
| RU2504397C1 (en) * | 2012-10-25 | 2014-01-20 | Леонид Леонидович Клопотенко | Pharmaceutical composition containing enzyme ribonuclease and glycyrrhizic acid or salts thereof: ammonium or dipotassium or trisodium glycyrrhizinate |
| WO2014152678A1 (en) | 2013-03-15 | 2014-09-25 | University Of Massachusetts | Compositions and methods for delivering agents to the central nervous system |
| US9573980B2 (en) | 2013-03-15 | 2017-02-21 | Spogen Biotech Inc. | Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots |
| WO2015125961A1 (en) | 2014-02-21 | 2015-08-27 | 国立大学法人東京海洋大学 | Norovirus inactivator and method for producing same, method for inactivating norovirus, method for producing lysozyme component for norovirus inactivation use, prophylactic or therapeutic agent for norovirus infection, and external preparation for skin for norovirus inactivation purposes |
| EP3175713A4 (en) * | 2014-07-31 | 2018-04-18 | Kewpie Corporation | Water-containing fluid composition, method for producing same, processed lysozyme and/or salt thereof, and method for producing same |
| IL315468A (en) | 2014-09-17 | 2024-11-01 | Spogen Biotech Inc | Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria |
| LV15071B (en) * | 2015-07-14 | 2016-02-20 | Rīgas Stradiņa Universitāte | Composition for treating subclinical mastitis in cows |
| RU2634264C1 (en) * | 2016-09-19 | 2017-10-24 | Александр Ливиевич Ураков | Cream-milk for zoster treatment |
| CN113861760B (en) | 2016-12-28 | 2023-05-05 | Dic株式会社 | Dispersion body |
| EP3684168A4 (en) | 2017-09-20 | 2021-10-27 | Spogen Biotech Inc. | FUSION PROTEINS, RECOMBINANT BACTERIA AND EXIN FRAGMENTS FOR PLANT HEALTH |
| WO2021021765A1 (en) * | 2019-07-26 | 2021-02-04 | Evolve Biosystems, Inc. | Nutritive compositions with bioactive proteins |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1268M (en) * | 1961-06-29 | 1962-04-24 | Puiseux | Antimitotic and antiviral drug. |
| FR4020M (en) * | 1965-01-29 | 1966-03-21 | ||
| DE1517751C3 (en) * | 1965-07-08 | 1975-02-27 | Eisai Co., Ltd., Tokio | Method for preventing the formation of flaky lysozyme and / or lysozyme salt precipitates in aqueous solutions containing lysozyme and / or lysozyme salts |
| DE1545644A1 (en) * | 1965-12-06 | 1969-08-07 | Boehringer Sohn Ingelheim | Process for the preparation of new quaternary scopolammonium salts |
| GB1110504A (en) * | 1966-03-18 | 1968-04-18 | Prodotti Antibiotici Spa | Pharmaceutical compositions |
| US4221794A (en) * | 1979-06-21 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | Method of imparting immunomodulating and antiviral activity |
| US4510144A (en) * | 1981-08-26 | 1985-04-09 | Newport Pharmaceuticals International | Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives |
| EP0187705A3 (en) * | 1985-01-08 | 1988-05-11 | Norwich Eaton Pharmaceuticals, Inc. | Imidazo(4,5-f)quinolines useful as immunomodulating agents |
| US4739046A (en) * | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
| US4744984A (en) * | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
| US5200182A (en) * | 1988-05-26 | 1993-04-06 | Nika Health Products, Ltd. | Antiviral or antibacterial composition and method of use |
-
1988
- 1988-05-26 US US07/459,738 patent/US5200182A/en not_active Expired - Lifetime
- 1988-05-26 JP JP63504463A patent/JPH0649659B2/en not_active Expired - Fee Related
- 1988-05-26 AT AT88905146T patent/ATE93143T1/en not_active IP Right Cessation
- 1988-05-26 RU SU884743095A patent/RU2092183C1/en active
- 1988-05-26 FI FI900412A patent/FI900412A7/en not_active IP Right Cessation
- 1988-05-26 AU AU19408/88A patent/AU624331B2/en not_active Expired
- 1988-05-26 HU HU883981A patent/HU204710B/en unknown
- 1988-05-26 EP EP88905146A patent/EP0380484B1/en not_active Expired - Lifetime
- 1988-05-26 WO PCT/US1988/001785 patent/WO1989011294A1/en not_active Ceased
-
1989
- 1989-04-20 CA CA000597341A patent/CA1335425C/en not_active Expired - Fee Related
- 1989-04-27 IL IL9009289A patent/IL90092A/en not_active IP Right Cessation
- 1989-05-08 ZA ZA893382A patent/ZA893382B/en unknown
- 1989-05-16 ES ES8901637A patent/ES2011577A6/en not_active Expired - Fee Related
- 1989-05-23 PH PH38684A patent/PH26284A/en unknown
- 1989-05-24 MA MA21811A patent/MA21560A1/en unknown
- 1989-05-26 CS CS893180A patent/CS277030B6/en not_active IP Right Cessation
- 1989-05-26 YU YU01092/89A patent/YU109289A/en unknown
-
1990
- 1990-01-22 MW MW3/90A patent/MW390A1/en unknown
- 1990-01-22 DK DK199000168A patent/DK173078B1/en not_active IP Right Cessation
- 1990-01-26 OA OA59731A patent/OA09785A/en unknown
- 1990-02-22 BG BG91270A patent/BG60544B1/en unknown
-
1992
- 1992-04-08 US US07/865,002 patent/US5466449A/en not_active Expired - Lifetime
- 1992-12-28 LV LVP-92-508A patent/LV10054B/en unknown
-
1994
- 1994-05-05 HK HK42394A patent/HK42394A/en not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/474,663 patent/US6099835A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU624331B2 (en) | 1992-06-11 |
| BG91270A (en) | 1993-12-24 |
| MA21560A1 (en) | 1989-12-31 |
| CS318089A3 (en) | 1992-05-13 |
| YU109289A (en) | 1991-08-31 |
| EP0380484A1 (en) | 1990-08-08 |
| DK16890A (en) | 1990-01-22 |
| HUT54060A (en) | 1991-01-28 |
| ZA893382B (en) | 1991-01-30 |
| US5200182A (en) | 1993-04-06 |
| CS277030B6 (en) | 1992-11-18 |
| EP0380484B1 (en) | 1993-08-18 |
| LV10054A (en) | 1994-05-10 |
| WO1989011294A1 (en) | 1989-11-30 |
| CA1335425C (en) | 1995-05-02 |
| PH26284A (en) | 1992-04-10 |
| DK173078B1 (en) | 1999-12-20 |
| US5466449A (en) | 1995-11-14 |
| JPH0649659B2 (en) | 1994-06-29 |
| HU204710B (en) | 1992-02-28 |
| JPH03504121A (en) | 1991-09-12 |
| RU2092183C1 (en) | 1997-10-10 |
| IL90092A (en) | 1995-03-30 |
| HK42394A (en) | 1994-05-13 |
| ES2011577A6 (en) | 1990-01-16 |
| AU1940888A (en) | 1989-12-12 |
| BG60544B1 (en) | 1995-08-28 |
| ATE93143T1 (en) | 1993-09-15 |
| FI900412A0 (en) | 1990-01-25 |
| LV10054B (en) | 1995-02-20 |
| US6099835A (en) | 2000-08-08 |
| FI900412A7 (en) | 1990-01-25 |
| OA09785A (en) | 1994-04-15 |
| HU883981D0 (en) | 1990-12-28 |
| DK16890D0 (en) | 1990-01-22 |
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