GB1110504A - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- GB1110504A GB1110504A GB1208566A GB1208566A GB1110504A GB 1110504 A GB1110504 A GB 1110504A GB 1208566 A GB1208566 A GB 1208566A GB 1208566 A GB1208566 A GB 1208566A GB 1110504 A GB1110504 A GB 1110504A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lysozyme
- salt
- contain
- histaminic
- toxic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- 102000016943 Muramidase Human genes 0.000 abstract 4
- 108010014251 Muramidase Proteins 0.000 abstract 4
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 4
- 230000001387 anti-histamine Effects 0.000 abstract 4
- 239000000739 antihistaminic agent Substances 0.000 abstract 4
- 239000004325 lysozyme Substances 0.000 abstract 4
- 229960000274 lysozyme Drugs 0.000 abstract 4
- 235000010335 lysozyme Nutrition 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- DBAKFASWICGISY-DASCVMRKSA-N Dexchlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 DBAKFASWICGISY-DASCVMRKSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000007832 Na2SO4 Substances 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960000725 brompheniramine Drugs 0.000 abstract 1
- ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229960000428 carbinoxamine Drugs 0.000 abstract 1
- OJFSXZCBGQGRNV-UHFFFAOYSA-N carbinoxamine Chemical compound C=1C=CC=NC=1C(OCCN(C)C)C1=CC=C(Cl)C=C1 OJFSXZCBGQGRNV-UHFFFAOYSA-N 0.000 abstract 1
- 229960003291 chlorphenamine Drugs 0.000 abstract 1
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 229960000520 diphenhydramine Drugs 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229960000582 mepyramine Drugs 0.000 abstract 1
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 235000011008 sodium phosphates Nutrition 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Pharmaceutical compositions having anti-bacterial, anti-viral, anaesthetic, analgesic and anti-leukopenic effects comprise a neutral salt of lysozyme with a non-toxic, stable, inorganic or organic acid and an anti-histaminic compound which is completely compatible with said salt of lysozyme. The composition may contain 50-1000 parts by weight of the lysozyme salt per part by weight of anti-histaminic compound. Antihistaminics specified include chlorpheniramine, polaramine, parabromdylamine, carbinoxamine, diphenhydramine and pyrilamine. Salts of lysozyme and the antihistaminic may be formed with hydrochloric, sulphuric, phosphoric, acetic, maleic, citric and tartaric acids. The compositions may also contain a solid or liquid pharmaceutical carrier and may be formulated as tablets and capsules, preferably enteric-coated, or as a sterile, isotonic, aqueous solution buffered to pH 4-6.5 with a phosphate, citrate or tartrate buffer. Such a solution may additionally contain a non-toxic, water-soluble salt (e.g. Na, Cl, Ca Cl2, Na2SO4 and sodium phosphates) and/or a polymeric material (e.g. polyvinyl pyrrolidone and dextran).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1208566A GB1110504A (en) | 1966-03-18 | 1966-03-18 | Pharmaceutical compositions |
| BE695717D BE695717A (en) | 1966-03-18 | 1967-03-17 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1208566A GB1110504A (en) | 1966-03-18 | 1966-03-18 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1110504A true GB1110504A (en) | 1968-04-18 |
Family
ID=9998141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1208566A Expired GB1110504A (en) | 1966-03-18 | 1966-03-18 | Pharmaceutical compositions |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE695717A (en) |
| GB (1) | GB1110504A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466449A (en) * | 1988-05-26 | 1995-11-14 | Nika Health Products, Ltd. | Antibacterial composition and method of use |
-
1966
- 1966-03-18 GB GB1208566A patent/GB1110504A/en not_active Expired
-
1967
- 1967-03-17 BE BE695717D patent/BE695717A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466449A (en) * | 1988-05-26 | 1995-11-14 | Nika Health Products, Ltd. | Antibacterial composition and method of use |
| US6099835A (en) * | 1988-05-26 | 2000-08-08 | Nika Health Products Limited | Method of using antiviral composition |
Also Published As
| Publication number | Publication date |
|---|---|
| BE695717A (en) | 1967-09-01 |
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