RU2634264C1 - Cream-milk for zoster treatment - Google Patents

Abstract

FIELD: pharmacology.

SUBSTANCE: invention is a cream milk for the immediate relief of pain in the area of skin eruptions in the form of watery blisters arising during zoster, containing an oil phase, structure-forming emulsifiers and an aqueous phase with lidocaine hydrochloride and a softening agent, characterized by emollient sodium hydrogencarbonate application as the softening agent and aqueous phase containing ingredients at a certain ratio, wt %, at pH of 8.4 and osmotic activity less than 280 mOsmol/l of water.

EFFECT: enveloping and softening effect, quickly dilutes dry crusts, thick serous fluid, pus and blood, facilitates their painless removal from the surface, promotes formation of a uniform film on the skin surface, which protects the skin from drying and irritation, makes it soft and elastic, reduces the value of the interstitial pressure, accelerates penetration of the local anesthetic into the tissue and its absorption into the blood.

1 cl

Description

The invention relates to medicine, pharmacy and, in particular, to dermatology, and is intended for the emergency elimination of pain in the area of skin rashes in the form of watery blisters that occur during shingles (Herpes zoster).

Known agent for the treatment of herpetic viral infection, made on the basis of vegetable fat and alcohol tincture of flowers and leaves of the blood-red hawthorn and young leaves of the maple tree with a ratio of 2-4: 1-2, and the ratio of raw materials and alcohol is 1: 3, or as plant material, it contains flowers and leaves of blood-red hawthorn, young leaves of the maple-tree platyphus, leaves of blackberry gray, roots of the cinquefoil erect, roots of the prickly steel, grass of the mallow forest and grass of the borage drug at a ratio of 2-4: 1-2: 1-2: 1-2: 1-2: 1-2: 1-2, and the ratio of raw materials and fat base is 1: 5, while it is a fat base contains interior fat (RU 2196598).

A disadvantage of the known means is a narrow scope, low safety and effectiveness. The fact is that the tool is not intended for emergency elimination of intense pain that has arisen in the skin with the sudden rash of many watery blisters on it with shingles. The fact is that the known product does not contain an anesthetic substance that easily penetrates the skin. Moreover, the product contains ethyl alcohol, so the product has a local irritant effect and therefore can cause a local irritant and cauterizing effect in some people, as well as a chemical burn. Such local lesions in the skin can occur with high probability after the bursting of watery vesicles and the epithelialized area of the skin at the site of the blisters is exposed.

In addition, the known product is not a milk cream or emulsion, because it does not contain an emulsifier, therefore, the product does not provide gentle application to a sore spot without local irritating effect. That is why the product does not provide invisible to the patient (not felt by the patient) application to the affected area of the skin, creating a uniform film on it, softening the crusts, high stickiness and prolonged exposure to the skin after a single application. Moreover, the known agent has high fluidity and volatility (volatility), therefore, does not provide long-term interaction with the surface of the skin.

In addition, the known agent is a mixture of plant allergens. Therefore, when applied to the skin, it can cause an allergic reaction of an immediate type in some people prone to allergies, which can manifest itself in the form of acute dermatitis. Acute dermatitis that occurs in some people with shingles can worsen skin rashes.

In addition, the well-known tool is not able to eliminate not only pain, but also other symptoms of inflammation, since it does not have anti-inflammatory and emollient action. In particular, the product does not dissolve crusts, thick and dried biological masses that can appear in the area of skin rashes due to viral inflammation of the skin, the presence of watery blisters on it, an additional purulent-inflammatory process and / or due to bleeding of wounds that may appear after opening watery blisters and mechanical injury to a bare epithelized surface. These biological masses thicken over time due to the evaporation of water, which evaporates due to the heat energy emanating from the human body. As a result, the area of skin rash in some people may be covered with a thick and / or dried serous, purulent, and even bloody biological mass in the form of a film. At the same time, the known agent does not provide alkalinity within pH 8.4, which is necessary for dissolving thick pus, thick serous fluid and blood clots (Urakov A.L., Urakova N.A. Rheology and physical-chemical characteristics of the solutions of the medicines. Journal of Physics: Conference Series. 2015. T. 602. No. 1. C. 012043). Therefore, the known tool does not provide emergency dissolution of thick and / or dried biological masses, emergency cleansing (sanitation) of the affected part of the skin and emergency local anti-inflammatory effect.

In addition, the well-known remedy does not have sleeping pills, because it does not contain a remedy that is easily absorbed into the blood and restores sleep for long periods of nervous tension and insomnia. The fact is that the alcohol contained in the product evaporates easily and therefore quickly disappears from the surface of the skin. At the same time, skin rashes that occur with shingles are accompanied by severe and painful pains, which increases excitement, creates nervous tension, causes a feeling of fear and insomnia.

Known liquid milk cream (such as an oil / water emulsion), made for children, containing structure-forming emulsifiers, an oil phase, emollients, triethanolamine, dietary supplements, preservatives, perfume composition, drinking water, water softener, gelling agents, allantoin and acid lemon food (RU 2162317).

A disadvantage of the known agent is that the cream does not contain a local anesthetic that penetrates easily through the skin, so the agent does not have an emergency anesthetic and quick sleeping pills. In addition, the cream contains citric acid in its composition, which makes the cream acidic and excludes its emollient effect on biological media containing protein. The fact is that acidic agents condense proteins and have an irritating effect. This local action prevents the absorption of dissolved ingredients and underlies the local irritant effect, which enhances the feeling of pain in the area of skin rash with shingles.

Known antiviral drugs are acyclovir, zovirax, valtrex, acyclovir-acry and others, produced in the form of ointments and tablets (Russian Drug Register. Encyclopedia of Medicines, 2001, ed. 8, p. 116, 216, 830, 1004, 1020).

The disadvantage of these funds is that the ointments of these funds are not alkaline hypoosmotic liquid creams and emulsions, and also do not contain a local anesthetic that easily penetrates the skin. Moreover, known ointments may contain an acidic and hyperosmotic liquid phase. Therefore, when applied to the skin, these antiviral drugs do not have an emollient and emergency anesthetic and soon onset sleeping pills. Moreover, well-known agents in the form of acidic and hyperosmotic ointments have a local irritant effect, therefore, they intensify, but not reduce, the feeling of pain in the skin in the affected area with shingles. On the other hand, tablets of these agents taken orally do not provide an immediate analgesic effect due to their slow disintegration, solubility and absorption in the gastrointestinal tract. In addition, tablets cause local damage to the mucous membranes of the oral cavity, stomach and intestines, and after absorption into the blood from the gastrointestinal tract, known drugs cause headaches, inhibit hematopoiesis, worsen hematological parameters, increase the activity of liver enzymes and the content of bilirubin in plasma. In addition, taking tablets is contraindicated in the elderly, with severe violations of the liver and kidneys.

Known tool designed for the treatment of skin diseases, containing as an active substance 0.1-20 wt. % toluenesulfochloramide and, as an adjuvant, cortisone, which may be a gaseous, dry, liquid or soft dosage form, including cream and emulsion (RU 2233151).

The disadvantage of this tool is low efficiency and safety, since it does not provide alkaline and hypotonic activity of the liquid medium. Moreover, the known agent, due to the active substance, has a denaturing and irritating, rather than a local anesthetic effect, since it releases active chlorine. On the other hand, cortisone refers to steroidal anti-inflammatory drugs, which is an analogue of steroidal hormones related to glucocorticoids. Therefore, the known tool carries an additional risk of adrenal insufficiency and drug dependence on glucocorticoids.

In addition, the known product does not contain a local anesthetic, which easily penetrates the skin and mucous membranes and is then absorbed into the blood. Therefore, it does not provide an immediate local anesthetic and general hypnotic effect and does not break the vicious circle that forms in connection with a neurosis. In this regard, the known remedy does not provide an immediate elimination of feelings of high excitement and fear in sick people and an early elimination of insomnia in them.

In addition, the tool does not provide optimal values of alkaline and osmotic activity in the optimal range of values. In particular, the product does not provide alkalinity at pH 8.4 and an osmotic activity of less than 280 mOsmol / l of water. Moreover, the known agent may be acidic and have an acidity below pH 7.0, and may also be hyperosmotic and have an osmotic activity above 300 mOsm / l of water. High acid activity irritates the sensitive nerve endings, condenses the proteins of purulent masses, serous fluid and blood, which does not contribute to pain relief and dissolution of the dense biological masses covering the skin surface in the area of skin rash. Therefore, the known remedy does not improve skin sanitation during a viral rash with a purulent-inflammatory process that has joined it. A high hyperosmotic activity promotes cell dehydration, therefore it slows down the absorption of dissolved ingredients and additionally irritates sensitive receptors, causing a feeling of itching and pain. All this slows down the speed of action of the applied means and slows down the development of local anesthesia and general sleeping pills.

In addition, in patients with diabetes mellitus, due to excessively high hyperosmotic activity, the drug can increase the osmotic activity of blood plasma with hyperglycemia and therefore can provoke the development of hyperosmotic coma.

Known spray lidocaine hydrochloride for topical use, dosed 10% (4.8 mg / 1 dose), which is a colorless alcohol solution with the smell of menthol for terminal (surface) anesthesia of the skin and mucous membranes during various medical procedures. The solution contains:

Ethanol 96% - 27.3 g

Lidocaine hydrochloride - 3.8 g

Propylene glycol - 6.82 g

Peppermint leaf oil - 0.08 g

(Found on the Internet 06/23/2016: http://www.vidal.ru/drugs/lidocain_2343)

The disadvantage of this tool is the low safety and effectiveness. The fact is that the product is not intended for application to wound surfaces of the skin and mucous membranes with the aim of local action on them, since the solvent in it is 96% ethyl alcohol. The product does not have an emollient effect and does not soften crusts and thick purulent masses. The product has a local irritating and cauterizing effect, causes a burn, which causes the appearance of watery blisters on the skin and / or mucous membrane.

In addition, the product has a tanning effect, since ethanol denatures and condenses proteins. In this regard, the known tool when applied to a surface containing serous fluid, pus or blood, compacts them. The astringent effect of alcohol slows down the absorption of dissolved ingredients and puts off the moment they reach an effective concentration in the skin, subcutaneous fat and in circulating blood, which inhibits the onset of pharmacological effects characteristic of the local and general types of action of lidocaine hydrochloride.

Another disadvantage of the drug is that it has a pronounced hypertonic activity, which provides it with a dehydrating effect. The dehydrating effect provided by the agent reduces edema in the area of inflammation, but at the same time it can cause the death of epidermal cells and granulation tissue from excessive dehydration. In this regard, the tool slows the healing and regeneration of tissues in the area of skin rashes with shingles.

In addition, the known agent relates to combustible and explosive substances. In this regard, the product can not be used in public places, in places of the likely occurrence of open flame and sparks, as this can lead to an explosion and fire. In particular, it is forbidden to use this tool for air passengers inside the air liner, people on the battlefield, during terrorist attacks, as well as in places designated for smoking, at the time of burning matches, cigarettes, sparklers and fireworks.

The objective of the invention is the expansion of the scope, increasing safety and effectiveness due to good penetration, hypotonic, buffering, alkaline, emollient, local anesthetic and general hypnotic activity.

This goal is achieved through a liquid cream-milk prepared from an aqueous hypotonic solution of lidocaine hydrochloride and sodium bicarbonate, which has a local softening, anesthetic and general sedative and hypnotic effect.

The essence of the proposed liquid milk cream for the treatment of shingles containing an oil phase, structure-forming emulsifiers and an aqueous phase with lidocaine hydrochloride and emollient is that sodium bicarbonate is used as an emollient, and the aqueous phase contains ingredients in the following ratio (wt. .%):

Lidocaine hydrochloride - 1.0-1.2;

Sodium bicarbonate - 0.45;

Double-distilled water - the rest at a pH of 8.4 and an osmotic activity of less than 280 mOsmol / l of water.

The fact is that the proposed composition of the components and the ratio of their concentration in an aqueous solution with alkalinity with pH values of 8.4 and an osmotic activity of less than 280 mOsmol / l of water are optimal for softening the crusts and clots of serous fluid, pus and / or blood that cover the skin in the area of rash of watery blisters, and to ensure the rapid penetration of lidocaine hydrochloride through the skin and without local irritating and cauterizing effects, without the risk of explosion and fire in order to quickly absorb lidocaine hydrochloride for emergency painkiller due to local anesthesia and sleeping pills due to resorptive action.

The fact is that in case of cutaneous application, liquid cream-milk prepared from an aqueous solution of 1.0-1.2% lidocaine hydrochloride and 0.45% sodium bicarbonate has emollient and anesthetic activity without local irritating effect, and when absorbed with water phase in the blood has hypnotic activity. The proposed composition of the ingredients and the ratio of their concentration in aqueous solution are optimal for safe skin application with the aim of thinning thick serous fluid, pus and blood and surface anesthesia in the area of skin rash. During the application, tissue is impregnated with cream, softening of crusts and thick pus, blood clots, inhibition of sensitive receptors, deprivation of pain sensitivity. Moreover, local superficial deprivation of sensitivity and a softening effect on dried and / or thickened biological mass covering the skin surface in the area of skin rash is carried out without local irritating and cauterizing effects, and the general (resorptive) action that develops after absorption of lidocaine hydrochloride into the blood is carried out without poisoning the patient with the ingredients of the solution.

The total concentration of ingredients in the solution provides him with an osmotic activity of 242-272 mOsmol / l of water. In particular, the presence in the proposed aqueous solution of 1.0-1.2% lidocaine hydrochloride provides a basic osmotic activity of the solution within 160-200 mOsmol / l of water. The presence of 0.45% sodium bicarbonate in the solution increases its osmotic activity by another 72 mOsmol / l of water. Therefore, the solution has an osmotic activity of 242-272 mOsmol / l of water, that is, it has a lower osmotic activity than the osmotic activity of plasma and human extracellular fluid is normal (280-300 m / Osmol / l of water).

- Journal of Silicate Based and Composite Materials. 2015. Vol. 67, No. 1 (2015), P. 2-6; Urakov A., Urakova N., Chernova L. Possibility of Dissolution and Removal of Thick Pus due to the Physical-Chemical Characteristics of the Medicines. Journal of Materials Science and Engineering B. 2013. V. 3. N 11. P. 714-720).In addition, the presence in the proposed solution of 0.45% sodium bicarbonate ensures optimal alkalinity of the solution within pH 8.4 in the presence of buffering properties. Such buffering and alkaline activity is sufficient to effectively dissolve thick pus and blood clots (Urakov AL The change of physical-chemical factors of the local interaction with the human body as the basis for the creation of materials with new properties.

- Journal of Silicate Based and Composite Materials. 2015. Vol. 67, No. 1 (2015), P. 2-6; Urakov A., Urakova N., Chernova L. Possibility of Dissolution and Removal of Thick Pus due to the Physical-Chemical Characteristics of the Medicines. Journal of Materials Science and Engineering B. 2013. V. 3. N 11. P. 714-720).

In this case, sodium bicarbonate is identical to the main component of alkaline bicarbonate buffer, which is normal in human blood plasma. Therefore, liquid cream milk is safe. An aqueous solution of 1.0-1.2% lidocaine hydrochloride has good penetrating activity, so it quickly penetrates the softened tissue that covers the skin and through the skin itself, after which it is rapidly absorbed into the blood. The proposed concentration range of lidocaine hydrochloride provides the tool with the creation of effective surface anesthesia and a common beneficial effect, which reduces the feeling of pain and restores sleep in the absence of toxic effects. Moreover, solutions of 1-2% lidocaine hydrochloride are traditionally used precisely for terminal anesthesia in medical practice, in particular for applications. At the same time, the ingredients that make up the milk cream are in it in doses and in concentrations that exclude human poisoning during general action (Mashkovsky M.D. Medicines. V. 2. - 14th edition. M.: LLC “ Publishing House "New Wave". 2000. T. 1. S. 294-295; T. 2. S. 140).

The developed tool that eliminates the feeling of pain in the area of the skin affected by watery vesicles with shingles can be used for painless skin applications. For this purpose, a liquid cream milk is applied to the area of skin rashes carefully and carefully with a soft spatula. The fact is that a liquid cream milk is a liquid emulsion of the type oil / water and its consistency resembles milk. Therefore, it is very convenient to use: apply it lightly to the skin of the affected area with a light touch and distribute it evenly, without additional effort. Milk cream promotes the formation of a uniform layer on the skin surface, which, as an enveloping substance, protects the skin from drying out, makes it soft and supple. Application application of the proposed milk cream on the skin in the area of skin rash with shingles quickly dilutes dry crusts, thick pus, thick serous fluid and blood, facilitates their painless removal from the surface, facilitates the penetration of the main active substance into the tissue and its absorption into the blood. This provides high speed and effectiveness in eliminating the sensation of pain in the area of skin rash, symptoms of neurosis and sleep recovery. Sleep, in turn, enhances and prolongs the analgesic effect, because sleep provides general anesthesia.

Therefore, the proposed liquid cream milk expands the range of application, increases efficiency and safety, as it creates optimal conditions on the surface of the affected area for emergency and long-lasting emollient, enveloping, anesthetic effects on the skin and general sedative effect on the whole body when applied in the area of water bubbles caused by shingles. Liquid milk cream preserves alkalinity and hypotonic activity of the liquid medium on the surface of the skin, which is necessary to interrupt the vicious cycle caused by severe pain. The application of the proposed milk cream on the area of skin rashes softens the skin, increases its elasticity, reduces the value of interstitial pressure in it, reduces soreness and other symptoms of local inflammation. In this regard, cream milk is a very soft enveloping and emollient, covering the affected area with a uniform layer. The enveloping effect provides high elasticity of soft tissues and a decrease in their interstitial pressure. The presence of lidocaine hydrochloride in the aqueous environment of the cream provides an emergency anesthetic and the rapid elimination of insomnia.

Thus, the claimed tool can be used for application to the area of skin rash with shingles in order to protect it from external irritation and physico-chemical softening of dense, thick and dry biological tissues covering the surface due to the liquid state of aggregation (liquid emulsion) alkalinity and buffering, as well as for local anesthesia, general sleeping pills due to lidocaine hydrochloride without irritating, cauterizing, toxic effects and without explosion hazard and fire.

Liquid cream milk for the treatment of shingles is a homogeneous mass from white to light cream in color with a delicate, almost imperceptible odor.

An experimental batch of liquid milk cream has been developed. The inventive cream milk for the treatment of shingles has passed experimental tests. Experimental studies have shown that after 10 cutaneous applications of milk cream in 10 guinea pigs - males of light color weighing 200-220 g, its general toxic effect on the animal organism was not revealed. This was evidenced by the results of a comparative analysis of animal behavior, body weight dynamics, the state of internal organs, skin, and animal hair in the experimental and control groups. The cream does not have an irritating and allergenic effect. Pathological changes in the structures of the skin and liver of animals were not detected.

Clinical observations were carried out on 5 clinically healthy volunteers without a burdened allergic history at the age of 21-23 years. According to patchwork and application samples, it is shown that milk cream is harmless, does not have an irritating and allergenic effect.

In the summer of 2016, clinical observations were made of a woman S., aged 62, who suddenly became ill with herpes zoster and sought medical help. When examining a sick woman, it was revealed that she had many watery blisters of different sizes on the skin of the lower back and both sides of the abdomen. In this case, the affected area looked like a continuous belt 10-15 cm wide, consisting of closely located watery blisters and ring-shaped zones of skin hyperemia around the base of each bladder. The affected area caused a strong feeling of pain, which intensified from any touch on him and, in particular, from the friction of clothes. Therefore, the woman was not able to lie on her back and side. Moreover, the patient suffered from intense pain and did not sleep for 2 days.

For treatment, several drugs were sequentially applied. The selected agents at room temperature were administered by application in a continuous layer over the entire area of the affected skin surface in one of the following lesion sites: each in the right or left side. Each agent was applied to a selected area repeatedly during the day with an interval of 2 hours. The back area was left without local drug administration and thus acted as a control. In each side, the next test agent was applied no earlier than 12 hours after the last application of the previous agent.

In this case, the following agents were applied to the affected skin surface:

Means No. 1 - made on the basis of refined sunflower oil and alcohol tincture of flowers and leaves of the blood-red hawthorn and young leaves of the maple tree with their ratio of 4: 1 and with the ratio of raw materials and alcohol 1: 3;

Means No. 2 - liquid cream milk containing DGL hostacerin, liquid paraffin, Trilon B, triethanolamine, preservatives, perfume composition, drinking water, carbopol, allantoin and citric acid;

Means No. 3 - 10% acyclovir ointment;

Means No. 4 - ointment 20% chloramine B and 1% cortisone;

Means No. 5 - spray of 10% lidocaine hydrochloride;

Means No. 6 is a liquid cream milk, the aqueous phase of which includes 1.2% lidocaine hydrochloride and 0.45% sodium bicarbonate in bidistilled water at a pH of 8.4 and an osmotic activity of less than 280 mOsmol / l of water.

As the results of our studies showed, the application of the agent No. 1 on the left side of the affected area each time increased the elasticity of the skin, but in no case did it reduce the feeling of pain in the treated area of the skin, nor did it eliminate nervous excitement. All day and almost all night, the woman continued to feel severe pain in her left side and in the lumbar region. However, she could not lie on her left side and on her back. A study of the dynamics of the skin condition in the affected area showed a constant preservation of watery blisters. Moreover, around the base of each of the bubbles, the skin retained a bright red color.

Application administration of agent No. 2 on the same day on the right side of the affected area each time increased the elasticity of the skin, but never reduced the feeling of pain in the area of skin rash on the right, did not eliminate the foci of hyperemia located around the base of the blisters, and did not reduce the pain and nervous excitement. And day and night, the woman continued to feel severe pain in the lumbar region and the right side of the abdomen and from this could not lie on her back and on her right side. Therefore, she was forced to doze while sitting in bed.

Application introduction of funds No. 3 and funds No. 4 was carried out 12 hours after the last application of the previous funds (funds No. 1 and funds No. 2). In this case, the application of the introduction of funds No. 3 was carried out on the left side of the affected area, and the application of the introduction of funds No. 4 was carried out on the right side of the affected area.

The results showed that the application of the introduction of means No. 3 each time increased the elasticity of the skin, but in no case did it reduce the feeling of pain in the treated area of the skin, nor did it eliminate nervous excitement. All day and almost all night, the woman continued to feel severe pain in her left side and in the lumbar region. However, she could not lie on her left side and on her back. A study of the dynamics of the skin condition in the area of the virus lesion showed a constant preservation of watery blisters. Moreover, around the base of each of the bubbles, the skin retained a bright red color.

Application application of means No. 4 on the right side of the affected area each time increased the elasticity of the skin and increased the feeling of pain in the area of skin rash. In addition, each time the drug caused an increase in the brightness of foci of hyperemia around the blisters. At the same time, it retained nervous excitement in a woman. And day and night, the woman continued to feel severe pain in the lumbar region and the right side of the abdomen and from this could not lie on her back and on her right side. Therefore, she was forced to doze while sitting in bed.

Application application of funds No. 5 and funds No. 6 was carried out 12 hours after the last application of funds No. 3 and No. 4. In this case, tool No. 5 was applied to the left side of the skin lesion strip, and tool No. 6 was applied to the right skin lesion strip.

The results obtained revealed the following.

The agent No. 5 after each subsequent administration caused the woman a burning sensation and pain in the area of skin rash. This sensation lasted about 7-10 seconds. Immediately there was an increase in redness of the skin around the base of watery blisters, while crusts on the surface of the lesion were denser. Then, after 5-7 minutes, a period of decrease in the feeling of pain began, which lasted about 75-90 minutes, after which soreness reappeared, which intensified. Subsequent re-use of the drug caused a similar change. Therefore, the woman had a feeling of fear and excitement before applying the product, which in her experience caused sharp pain at the time of applying the product. In this regard, the woman refused to use this tool in the future. The fact is that at the same time, tool No. 6 was used in the opposite side of the abdomen, which did not cause an increase in the feeling of pain and irritation.

Means No. 6 increased the elasticity of the skin, reduced the feeling of pain and redness of the skin in the area of skin rash. In this case, after the first application of the product, the pain sensation decreased after 20-40 seconds, and 3 minutes after the first application of the product the pain sensation disappeared almost completely and the woman's nervous excitement disappeared. 7 minutes after the first application, the woman fell asleep while sitting in bed. The dream lasted about 6 hours. Repeated application of the drug retained the therapeutic effect, and therefore the woman fell asleep again. The dream also lasted several hours. And such an action was observed all day. In the evening, it was decided to apply funds to the entire area of skin rashes, including the back and left side. After applying the product to the entire lesion area, the woman did not feel pain on the right, after 4 minutes the pain disappeared from the back and left side. In this regard, after 10 minutes, the woman was able to lie on her side and fell asleep. She woke up only after midnight. At the same time, she felt a slight pain on the right, but connected it with the fact that she was lying on her right side. Nevertheless, at night, she independently applied the remedy once again to the entire area of the skin lesion, after which she again fell asleep, but at the same time lay on her left side and slept until the morning.

Thus, the claimed liquid cream milk, representing an oil / water emulsion, in which the aqueous phase is a solution of 1.0-1.2% lidocaine hydrochloride and 0.45% sodium bicarbonate in bidistilled water at a pH of 8.4 and osmotic activity less than 280 mOsmol / l, is the only tool that, when first introduced, quickly eliminates the feeling of pain in the focus of foot rashes and helps to eliminate insomnia with shingles without local irritating and toxic effects. In this regard, it is this tool that is a safe and effective emergency tool for suddenly arising watery blisters on the skin with shingles.

Therefore, the proposed liquid cream milk, representing an oil / water emulsion, in which the aqueous phase is represented by a solution in bidistilled water of 1.0-1.2% lidocaine hydrochloride and 0.45% sodium bicarbonate at a pH of 8.4 and less than an osmotic activity 280 mOsmol / l of water, when applied, quickly eliminates the feeling of pain and breaks the vicious circle of its formation without local irritating and cauterizing effects and restores sleep.

The invention extends the scope, increases efficiency and safety due to enveloping, emollient, hypotonic, buffering, alkaline, good penetrating ability, local anesthetic and general hypnotic activity.

Claims (6)

Milk cream for emergency pain relief in the area of skin rashes in the form of watery blisters that occur with shingles, containing an oil phase, structure-forming emulsifiers and an aqueous phase with lidocaine hydrochloride and emollient, characterized in that as the emollient is used sodium bicarbonate, and the aqueous phase contains the ingredients in the following ratio, in wt. %: Lidocaine hydrochloride 1.0-1.2 Sodium bicarbonate 0.45 Bidistilled water the rest, at a pH of 8.4 and an osmotic activity of less than 280 mOsmol / l of water.