ME02286B - Jedinjenje za inhalaciju koje sadrži aklidinijum za lečenje hronične opstruktivne bolesti pluća - Google Patents
Jedinjenje za inhalaciju koje sadrži aklidinijum za lečenje hronične opstruktivne bolesti plućaInfo
- Publication number
- ME02286B ME02286B MEP-2015-161A MEP16115A ME02286B ME 02286 B ME02286 B ME 02286B ME P16115 A MEP16115 A ME P16115A ME 02286 B ME02286 B ME 02286B
- Authority
- ME
- Montenegro
- Prior art keywords
- aclidinium
- use according
- pharmaceutically acceptable
- pharmaceutical compound
- acceptable salt
- Prior art date
Links
- ASMXXROZKSBQIH-VITNCHFBSA-N aclidinium Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 ASMXXROZKSBQIH-VITNCHFBSA-N 0.000 title claims 26
- 229940019903 aclidinium Drugs 0.000 title claims 19
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 title claims 4
- 239000000203 mixture Substances 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims 13
- 239000013543 active substance Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 229960005012 aclidinium bromide Drugs 0.000 claims 7
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical group C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 7
- 229960002848 formoterol Drugs 0.000 claims 7
- 239000000843 powder Substances 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 3
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 229960004436 budesonide Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 229960000289 fluticasone propionate Drugs 0.000 claims 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960004017 salmeterol Drugs 0.000 claims 2
- OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical group OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 229960000193 formoterol fumarate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (18)
1. Farmaceutskojedinjenje koje sadrži aklidinijum u obliku suvog praha farmaceutski prihvatljive soli umešavini sa farmaceutski prihvatljivim suvim nosačem praha, omogućava izmerenunominalnu dozuekvivalenta aklidinijumu do 400 µg (plus/minus 10%) aklidinijum bromide za upotrebu udisanjem kod lečenja hronične opstruktivne bolesti pluća.
2. Farmaceutsko jedinjenje za upotrebu prema patentnom zahtjevu 1, u obliku jednodozne formulacije suvog praha koja sadrži jednu izmerenu nominalnu dozu aklidinijuma ekvivalentnu 400 mikrograma (plus/minus 10%) aklidinijum bromida.
3. Farmaceutsko jedinjenje za upotrebu prema patentnom zahtjevu 1, u obliku višedozne formulacije suhog praha za primenu u višedoznom uređaju za inhalaciju suvg praha kalibriranom da obezbedi izmerenu nominalnu dozu aklidinijuma koja je jednaka 400 mikrograma (plus/minus 10%) aklidinijum bromida.
4. Farmaceutsko jedinjenje za upotrebu prema bilo kom od prethodnih patentnih zahtjeva gde (a) farmaceutski prihvatljiva so aklidinijuma jeste aklidinijum bromid, i/ili (b) farmaceutski prihvatliv nosač jesu čestice?
5.Farmaceutsko jedinjenje za upotrebu prema bilo kom od prethodnih patentnih zahtjeva, gde je odnos težine aklidinijuma prema nosaču od 1:25 do 1:75.
6.Farmaceutsko jedinjenje za upotrebu prema patentnom zahtjevu 5, gde je odnos težine aklidinijuma prema nosaču od 1:50 do 1:75.
7. Farmaceutsko jedinjenje za upotrebu prema bilo kom od prethodnih patentnih zahtjeva gde (a) pečnik prosečne čestice aklidinijuma iznosi od 2 do 5 µm, i/ili (b) čestice nosača imaju d10 od 90 -160 µm, d50 od 170-270 µm, i d90 od 290-400 µm.
8.Farmaceutsko jedinjenje za upotrebu prema bilo kom od prethodnih patentnih zahtjeva, gde farmaceutsko jedinjenje još sadrži delotvornu količinu jednog ili više dodatnih aktivnih agenasa izabranih iz 2-agonista, POE IV inhibitora, i kortikosteroida.
9.Farmaceutsko jedinjenje za upotrebu prema patentnom zahtevu 8 gde se dodatni aktivni agens bira iz formoterola, salmeterola, budesonida, i flutikason propionata, u slobodnom ili u obliku farmaceutski prihvatljive soli.
10.Farmaceutsko jedinjenje za upotrebu prema patentnom zahtjevu 9 gde je (a) dodatni aktivni agens formoterol tumarat u količini od 5-25 J,Jg po dozi, ili (b) dodatni aktivni agens je formoterol tumarat u količini od 6 J,Jg po dozi, ili (e) dodatni aktivni agens je formoterol tumarat u količini od 12 J,Jg po dozi.
11.Aklidinijum u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za upotrebu u lečenju hronične opstruktivne bolesti pluća kod pacijenta kome je potrebno takvo lečenje, pomenuta upotreba obuhvata primenu udisanjem jednom ili dvaput dnevno izmerene nominalne doze aklidinijuma koja odgovara količini od 400 J,Jg (plus/minus 10%) aklidinijum bromida.
12.Aklidinijum je slobodan ili farmaceutski prihvatljiv oblik soli za upotrebu prema patentnom zahtjevu 11, pomenuta upotreba obuhvata primenu farmaceutskog jedinjenja prema bilo kom patentnom zahtevu 1 do 1O .
13.Aklidinijum u obliku slobodne ili farmaceutski prihvatljive soli za upotrebu prema patentnom zahtjevu 11 ili 12, pomenuta upotreba još sadrži primenu delotvorne količine jednog ili više aktivnih agenasa koji se biraju iz grupe 132-agonista, POE IV inhibitora i kortikosteroida.
14.Aklidinijum u obliku slobodne ili farmaceutski prihvatljive soli za upotrebu prema patentnom zahtjevu 13, gde se dodatni aktivni agens bira iz formoterola, salmeterola, budesonida, i flutikason propionata, u slobodnom obliku ili u obliku farmaceutski prihvatljive soli.
15.Aklidinijum u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za upotrebu prema patentnom zahtjevu 14, gde je (a) dodatni aktivni agens formoterol tumarat u količini od 5-25 j.Jg po dozi, ili (b) dodatni aktivni agens formoterol tumarat u količini od 6 j.Jg po dozi, ili (e) dodatni aktivni agens je formoterol fumarat u količini od 12 j.Jg po dozi.
16.Upotreba aklidinijuma u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za proizvodnju leka za lečenje hronične opstruktivne bolesti pluća kod pacijenta kome je potrebno takvo lečenje, pomenuta upotreba obuhvata primenu udisanjem jednom ili dvaput dnevno izmerene nominalne doze aklidinijuma koja odgovara količini od 400 j.Jg (plus/minus 10%) aklidinijum bromida.
17.Upoteba prema patentnom zahtjevu 16, gde upotreba obuhvata primenu farmaceutskog jedinjenja kako je definisano u bilo kom patentnom zahtevu od 1 do 1O.
18.Uređaj za udisanje suvog praha u vidu više doza sadrži aklidinijum, koji se kalibrira da isporuči, posle aktiviranja, izmerenu nominalnu dozu aklidinijuma ekvivalentnu količini 400 mikrograma (plus/minus 10%) aklidinijum bromida.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08382010A EP2100599A1 (en) | 2008-03-13 | 2008-03-13 | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP09719213.2A EP2265257B2 (en) | 2008-03-13 | 2009-03-13 | Inhalation composition containing aclidinium for treatment of chronic obstructive pulmonary disease |
| PCT/EP2009/001832 WO2009112274A2 (en) | 2008-03-13 | 2009-03-13 | Novel dosage and formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02286B true ME02286B (me) | 2016-02-20 |
Family
ID=39645012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-161A ME02286B (me) | 2008-03-13 | 2009-03-13 | Jedinjenje za inhalaciju koje sadrži aklidinijum za lečenje hronične opstruktivne bolesti pluća |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US20110020412A1 (me) |
| EP (5) | EP2100599A1 (me) |
| JP (3) | JP2011513451A (me) |
| KR (3) | KR20180125055A (me) |
| CN (2) | CN102083416A (me) |
| AR (1) | AR070835A1 (me) |
| AU (1) | AU2009224895B9 (me) |
| BR (1) | BRPI0905775B1 (me) |
| CA (1) | CA2716724C (me) |
| CL (1) | CL2009000602A1 (me) |
| CO (1) | CO6290636A2 (me) |
| CY (3) | CY1116926T1 (me) |
| DK (3) | DK2954891T3 (me) |
| EC (1) | ECSP10010300A (me) |
| ES (3) | ES2916831T3 (me) |
| FI (1) | FI2265257T4 (me) |
| HR (3) | HRP20220929T3 (me) |
| HU (3) | HUE059020T2 (me) |
| IL (3) | IL271132B2 (me) |
| LT (2) | LT2954891T (me) |
| ME (1) | ME02286B (me) |
| MX (2) | MX368774B (me) |
| MY (1) | MY177027A (me) |
| NZ (1) | NZ585857A (me) |
| PE (3) | PE20091672A1 (me) |
| PL (3) | PL2265257T5 (me) |
| PT (3) | PT2954889T (me) |
| RS (3) | RS63399B1 (me) |
| RU (3) | RU2608713C3 (me) |
| SG (1) | SG188825A1 (me) |
| SI (3) | SI2954889T1 (me) |
| TW (1) | TWI439296B (me) |
| UA (1) | UA101652C2 (me) |
| UY (1) | UY31687A1 (me) |
| WO (1) | WO2009112274A2 (me) |
| ZA (1) | ZA201003900B (me) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2298049B1 (es) | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2510928A1 (en) * | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| EP2666465A1 (en) * | 2012-05-25 | 2013-11-27 | Almirall, S.A. | Novel dosage and formulation |
| US20150202297A1 (en) * | 2012-07-05 | 2015-07-23 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Dry powder inhalers comprising a carrier other than lactose and a ternary component |
| WO2014007771A2 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising muscarinic receptor antagonist |
| US10111957B2 (en) | 2012-07-05 | 2018-10-30 | Arven Ilac Snayi ve Ticaret A.S. | Inhalation compositions comprising glucose anhydrous |
| EA201590019A1 (ru) * | 2012-07-05 | 2015-09-30 | Арвен Айлак Санайи Ве Тиджарет А.С. | Ингаляторы сухого порошка, содержащие носитель, отличный от лактозы |
| RS63476B1 (sr) | 2012-12-17 | 2022-08-31 | Almirall Sa | Aklidinijum za upotrebu u povećanju fizičke aktivnosti u dnevnom životu kod pacijenta koji pati od hronične opstruktivne bolesti pluća |
| US20160074318A1 (en) * | 2013-04-29 | 2016-03-17 | Sanofi Sa | Inhalable Pharmaceutical Compositions and the Inhaler Devices Containing Them |
| EP2923702A1 (en) * | 2014-03-28 | 2015-09-30 | Universite De Liege | Composition of cyclodextrin with budesonide derivatives for treatment and prevention of pulmonary inflammatory disease |
| US10864213B2 (en) | 2014-05-12 | 2020-12-15 | Verona Pharma Plc | Treatment |
| CZ2015257A3 (cs) * | 2015-04-16 | 2016-10-26 | Zentiva, K.S. | Způsob pro zmenšování velikosti částic bromidu [(3R)-1-(3-fenoxypropyl)chinuklidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetátu |
| CN107823193B (zh) * | 2017-11-16 | 2021-02-05 | 广州迈达康医药科技有限公司 | 一种阿地溴铵吸入型粉雾剂及其制备方法 |
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| US3091570A (en) | 1960-08-08 | 1963-05-28 | Lakeside Lab Inc | Antidepressant: 3-pyrrolidyl glycolates |
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| IT1116047B (it) | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
| CY1492A (en) | 1981-07-08 | 1990-02-16 | Draco Ab | Powder inhalator |
| FR2539135B1 (fr) | 1983-01-11 | 1986-02-28 | Essilor Int | Hydrogels de polyurethane et procede de fabrication |
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| EP2666465A1 (en) † | 2012-05-25 | 2013-11-27 | Almirall, S.A. | Novel dosage and formulation |
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