ME00083B - Farmaceutski oblik dronedarona za parenteralnu upotrebu - Google Patents
Farmaceutski oblik dronedarona za parenteralnu upotrebuInfo
- Publication number
- ME00083B ME00083B MEP-2008-204A MEP2008204A ME00083B ME 00083 B ME00083 B ME 00083B ME P2008204 A MEP2008204 A ME P2008204A ME 00083 B ME00083 B ME 00083B
- Authority
- ME
- Montenegro
- Prior art keywords
- pharmaceutical form
- form according
- metal
- fact
- cyclodextrin
- Prior art date
Links
- 229960002084 dronedarone Drugs 0.000 title claims abstract 6
- ZQTNQVWKHCQYLQ-UHFFFAOYSA-N dronedarone Chemical compound C1=CC(OCCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CCCC)OC2=CC=C(NS(C)(=O)=O)C=C12 ZQTNQVWKHCQYLQ-UHFFFAOYSA-N 0.000 title claims abstract 6
- 238000007911 parenteral administration Methods 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title claims 2
- 239000008366 buffered solution Substances 0.000 claims abstract 5
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 229910052751 metal Inorganic materials 0.000 claims 15
- 239000002184 metal Substances 0.000 claims 15
- 229910052783 alkali metal Inorganic materials 0.000 claims 4
- 150000001340 alkali metals Chemical class 0.000 claims 4
- -1 monophosphate salt Chemical class 0.000 claims 4
- 239000007853 buffer solution Substances 0.000 claims 3
- 229920000858 Cyclodextrin Polymers 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- CPKOXUVSOOKUDA-UHFFFAOYSA-N 1-bromo-5-fluoro-2-iodo-4-methylbenzene Chemical group CC1=CC(I)=C(Br)C=C1F CPKOXUVSOOKUDA-UHFFFAOYSA-N 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960004853 betadex Drugs 0.000 claims 1
- 229960002919 dronedarone hydrochloride Drugs 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical group CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1
- DSDAICPXUXPBCC-MWDJDSKUSA-N trimethyl-β-cyclodextrin Chemical compound COC[C@H]([C@H]([C@@H]([C@H]1OC)OC)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O3)[C@H](OC)[C@H]2OC)COC)O[C@@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@@H]3O[C@@H]1COC DSDAICPXUXPBCC-MWDJDSKUSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Ovaj se pronalazak odnosi na farmaceutski oblik za parenteralnu upotrebu,okarakterisan je time što uključuje: dronedaron ili neku od njegovih farmaceutski prihvatljivih solikao aktivnog principa; fiziološki prihvatljiv puferovani rastvor koji održava pH farmaceutskogoblika između 3 i 5; fiziološki prihvatljiv u vodi rastvoran β-ciklodekstrinski derivat.
Claims (19)
1. Farmaceutski oblik za parenteralnu primenu, naznačen time što ukljucuje:- kao aktivni princip dronedaron ili jednu od njegovih farmaceutski prihvatljivih soli, fiziološki prihvatljivi puferski rastvor sposoban da održi pH rastvara izmežu 3 i 5,- fiziološki prihvatljivi u vodi rastvorni ciklodekstrinski derivat.
2. Farmaceutski oblik prema zahtevu l, naznacen time što ukljucuje 0,01% do 4% aktivnog principa.
3. Farmaceutski oblik prema zahtevu 2, naznacen time što ukljucuje 0,4% do 0,8% aktivnog prlnclpa.
4. Farmaceutski oblik prema nekom od zahteva l do 3, naznacen time što je puferski rastvor neki vodeni rastvor koji ukljucuje puferski sistem odabran od sledecih: - sircetna kiselina /acetatna so gde je metal alkalni metal, - furrama kiselina l furraratna so gde j e metal alkalni metal, - cilibama kiselina /sukcinatna so gde je metal alkalni metal, - limunska kiselina /citratna so gde je metal alkalni metal, - vinska kiselina /tartaratna so gde je metal alkalni metal, - mlecna kiselina /laktatna so gde je metal alkalni metal, - maleinska kiselina /maleatna so gde je metal alkalni metal, - metansulfonatna kiselina /metansulfonatna so gde je metal alkalni metal, - monofosfatna so gde je metal alkalni metal .
5. Farmaceutski oblik prema zahtevu 4, naznacen time što puferski sistem cini monofosfatna so gde je metal alkalni metal.
6. Farmaceutski oblik prema zahtevu 4, naznacen time što puferski rastvor monofosfatne soli gde je metal alkalni metal održava pH rastvora na 4,5.
7. Farmaceutski oblik prema nekom od zahteva l do 6, naznacen time što je vrednost jonske jacine puferovanog rastvara izmedu 0,005 molarne i 0,5 molarne.
8. Farmaceutski oblik prema zahtevu 7, naznacen je time što je vrednost jonske jacine puferovanog rastvara izmedu 0,01 molarne i 0,2 molarne.
9. Farmaceutski oblik prema zahtevima 7 ili 8, naznacen time što je vrednost jonske jacine puferovanog rastvara izmedu 0,05 i 0,15 molarne.
10. Farmaceutski oblik prema zahtevima l do 9, naznacen time što je puferovani rastvor 0,05 do 0,15 molarni vodeni rastvor monofosfatne soli gde je metal alkalni metal.
11. Farmaceutski oblik prema zahtevu 4, 5, 6 ili 10, naznacen time što je alkalni metal natrijum ili kalijum.
12. Farmaceutski oblik prema nekom od zahteva l do ll, naznacen time što je u vodi rastvorni β ciklodekstrinski derivat odabran izmedu hidroksipropil β-ciklodekstrina, sulfobutil etarskog derivata ciklodekstrina, dimetil-β-ciklodekstrina, trimetil-β ciklodekstrin, kao i njihovih smesa.
13. Farmaceutski oblik prema nekom od zahteva l do 12, naznacen time što je u vodi rastvorni β- ciklodekstrinski derivat hidroksipropil-P-ciklodekstrin.
14. Farmaceutski oblik prema nekom od zahteva l do 13, naznacen time što je u vodi rastvorni p-ciklodekstrinski derivat prisutan u odnosu od 0,5 do 50%.
15. Farmaceutski oblik prema nekom od zahteva l do 14, naznacen time što je u vodi rastvorni β ciklodekstrinski derivat prisutan u odnosu od 5 do 20 puta težine dronedarona ili neke od njegovih farmaceutski prihvatljivih soli.
16. Farmaceutski oblik prema zahtevu 15, naznacen time što je u vodi rastvorni P-ciklodekstrinski derivat prisutan u odnosu od 12 do 13 puta težine dronedarona ili neke od njegovih farmaceutski prihvatljivih soli.
17. Farmaceutski oblik prema nekom od zahteva l do 16, naznacen time što dodatno ukljucuje neko zaštitno sredstvo.
18. Farmaceutski oblik prema nekom od zahteva l do 17, naznacen time što dodatno ukljucuje neko jedinjenje koje omogucava održavanje izotonicnosti.
19. Farmaceutski oblik prema nekom od zahteva l do 18, naznacen time što je aktivni prlnclp dronedaron hidrohlorid. FARMACEUTSKI OBLIK DRONEDARONA ZA PARENTERALNO PRIMENU APSTRAKT
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0016071A FR2817750B1 (fr) | 2000-12-11 | 2000-12-11 | Composition pharmaceutique de dronedarone pour administration parenterale |
| PCT/FR2001/003903 WO2002047660A1 (fr) | 2000-12-11 | 2001-12-10 | Composition pharmaceutique de dronedarone pour administration parenterale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME00083B true ME00083B (me) | 2010-10-10 |
Family
ID=8857483
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-204/08A MEP20408A (en) | 2000-12-11 | 2001-12-10 | Pharmaceutical dronedarone composition for parenteral administration |
| MEP-2008-204A ME00083B (me) | 2000-12-11 | 2001-12-10 | Farmaceutski oblik dronedarona za parenteralnu upotrebu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-204/08A MEP20408A (en) | 2000-12-11 | 2001-12-10 | Pharmaceutical dronedarone composition for parenteral administration |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6939865B2 (me) |
| EP (1) | EP1343473B1 (me) |
| JP (1) | JP4399161B2 (me) |
| KR (1) | KR100849758B1 (me) |
| CN (1) | CN1235566C (me) |
| AR (1) | AR031649A1 (me) |
| AT (1) | ATE348599T1 (me) |
| AU (2) | AU2002217229B2 (me) |
| BG (1) | BG66187B1 (me) |
| BR (1) | BR0116060B1 (me) |
| CA (1) | CA2427375C (me) |
| CZ (1) | CZ297788B6 (me) |
| DE (1) | DE60125411T2 (me) |
| EA (1) | EA005314B1 (me) |
| FR (1) | FR2817750B1 (me) |
| HU (1) | HU229372B1 (me) |
| IL (2) | IL155428A0 (me) |
| IS (1) | IS2349B (me) |
| MA (1) | MA26969A1 (me) |
| ME (2) | MEP20408A (me) |
| MX (1) | MXPA03005221A (me) |
| NO (1) | NO332294B1 (me) |
| NZ (1) | NZ525661A (me) |
| OA (1) | OA12416A (me) |
| PL (1) | PL199846B1 (me) |
| RS (1) | RS50348B (me) |
| SK (1) | SK287115B6 (me) |
| TW (1) | TWI246926B (me) |
| WO (1) | WO2002047660A1 (me) |
| ZA (1) | ZA200303406B (me) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059574A1 (es) * | 2006-02-14 | 2008-04-16 | Wyeth Corp | Formulaciones farmaceuticas acuosas de ligandos selectivos er-beta |
| GB0719180D0 (en) | 2007-10-02 | 2007-11-14 | Cambrex Karlskoga Ab | New process |
| JP2011518785A (ja) * | 2008-04-17 | 2011-06-30 | サノフイ−アベンテイス | 心血管入院または死亡の予防に用いる薬剤を調製するためのドロネダロンの使用 |
| FR2930149B1 (fr) * | 2008-04-17 | 2011-02-18 | Sanofi Aventis | Association de dronedarone avec au moins un diuretique, son application en therapeutique |
| EP2116239A1 (en) * | 2008-04-29 | 2009-11-11 | Sanofi-Aventis | Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment |
| FR2959132A1 (fr) * | 2010-04-22 | 2011-10-28 | Sanofi Aventis | Procedes pour l'evaluation et la reduction des risques |
| TWI508726B (zh) | 2009-12-21 | 2015-11-21 | Gilead Sciences Inc | 治療心房纖維性顫動之方法 |
| US20120005128A1 (en) * | 2010-06-29 | 2012-01-05 | Sanofi | Methods for reducing the risk of an adverse dronedarone / calcium channel blockers interaction in a patient suffering from atrial fibrilation |
| US8602215B2 (en) | 2010-06-30 | 2013-12-10 | Sanofi | Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation |
| CN102342907A (zh) | 2010-07-30 | 2012-02-08 | 江苏恒瑞医药股份有限公司 | 决奈达隆固体分散体及其制备方法 |
| KR20120094557A (ko) * | 2011-02-01 | 2012-08-27 | 동아제약주식회사 | 피에이치 비의존적 용출양상을 갖는 부정맥치료제 제제 |
| CN102908307A (zh) * | 2011-08-03 | 2013-02-06 | 天津市嵩锐医药科技有限公司 | 供注射用盐酸决奈达隆药物组合物及其制备方法 |
| WO2014009500A1 (en) * | 2012-07-12 | 2014-01-16 | Sanofi | Anti-tumoral composition comprising the compound 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-(2-morpholin-4-ylethyl)urea |
| CN114377148B (zh) * | 2020-10-20 | 2023-09-29 | 上海博志研新药物研究有限公司 | 盐酸决奈达隆药物组合物、其制备方法及应用 |
| CN115702878B (zh) * | 2021-08-16 | 2024-05-10 | 上海云晟研新生物科技有限公司 | 盐酸决奈达隆注射组合物、其制备方法及应用 |
| WO2024120458A1 (zh) * | 2022-12-07 | 2024-06-13 | 荣昌生物制药(烟台)股份有限公司 | TACI-Fc融合蛋白液体药物制剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| FR2746013B1 (fr) * | 1996-03-18 | 1998-05-29 | Sanofi Sa | Utilisation de composes antiarythmiques dans la prevention de la mortalite post infarctus |
| JP2004327321A (ja) * | 2003-04-25 | 2004-11-18 | Jst Mfg Co Ltd | コネクタ |
-
2000
- 2000-12-11 FR FR0016071A patent/FR2817750B1/fr not_active Expired - Fee Related
-
2001
- 2001-12-10 US US10/450,320 patent/US6939865B2/en not_active Expired - Lifetime
- 2001-12-10 BR BRPI0116060-5B1A patent/BR0116060B1/pt not_active IP Right Cessation
- 2001-12-10 KR KR1020037007744A patent/KR100849758B1/ko not_active Expired - Fee Related
- 2001-12-10 EA EA200300406A patent/EA005314B1/ru not_active IP Right Cessation
- 2001-12-10 JP JP2002549234A patent/JP4399161B2/ja not_active Expired - Fee Related
- 2001-12-10 ME MEP-204/08A patent/MEP20408A/xx unknown
- 2001-12-10 PL PL362788A patent/PL199846B1/pl unknown
- 2001-12-10 DE DE60125411T patent/DE60125411T2/de not_active Expired - Lifetime
- 2001-12-10 OA OA1200300152A patent/OA12416A/fr unknown
- 2001-12-10 CN CNB018203884A patent/CN1235566C/zh not_active Expired - Fee Related
- 2001-12-10 AU AU2002217229A patent/AU2002217229B2/en not_active Ceased
- 2001-12-10 AU AU1722902A patent/AU1722902A/xx active Pending
- 2001-12-10 EP EP01270322A patent/EP1343473B1/fr not_active Expired - Lifetime
- 2001-12-10 IL IL15542801A patent/IL155428A0/xx active IP Right Grant
- 2001-12-10 NZ NZ525661A patent/NZ525661A/en not_active IP Right Cessation
- 2001-12-10 RS YUP-465/03A patent/RS50348B/sr unknown
- 2001-12-10 HU HU0500842A patent/HU229372B1/hu not_active IP Right Cessation
- 2001-12-10 ME MEP-2008-204A patent/ME00083B/me unknown
- 2001-12-10 WO PCT/FR2001/003903 patent/WO2002047660A1/fr not_active Ceased
- 2001-12-10 ZA ZA200303406A patent/ZA200303406B/en unknown
- 2001-12-10 TW TW090130522A patent/TWI246926B/zh not_active IP Right Cessation
- 2001-12-10 AR ARP010105716A patent/AR031649A1/es not_active Application Discontinuation
- 2001-12-10 MX MXPA03005221A patent/MXPA03005221A/es active IP Right Grant
- 2001-12-10 SK SK726-2003A patent/SK287115B6/sk not_active IP Right Cessation
- 2001-12-10 CZ CZ20031612A patent/CZ297788B6/cs not_active IP Right Cessation
- 2001-12-10 AT AT01270322T patent/ATE348599T1/de not_active IP Right Cessation
- 2001-12-10 CA CA2427375A patent/CA2427375C/fr not_active Expired - Fee Related
-
2003
- 2003-04-14 IL IL155428A patent/IL155428A/en not_active IP Right Cessation
- 2003-04-18 BG BG107748A patent/BG66187B1/bg unknown
- 2003-04-29 NO NO20031958A patent/NO332294B1/no not_active IP Right Cessation
- 2003-04-30 IS IS6801A patent/IS2349B/is unknown
- 2003-06-03 MA MA27190A patent/MA26969A1/fr unknown
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