[go: up one dir, main page]

MC2115A1 - Ribozynes - Google Patents

Ribozynes

Info

Publication number
MC2115A1
MC2115A1 MC882115D MC2115D MC2115A1 MC 2115 A1 MC2115 A1 MC 2115A1 MC 882115 D MC882115 D MC 882115D MC 2115 D MC2115 D MC 2115D MC 2115 A1 MC2115 A1 MC 2115A1
Authority
MC
Monaco
Prior art keywords
ribozynes
Prior art date
Application number
MC882115D
Other languages
English (en)
Inventor
James Haseloff
Wayne Gerlach
Philip Jennings
Fiona Cameron
Original Assignee
Gene Shears Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27507391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MC2115(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gene Shears Pty Ltd filed Critical Gene Shears Pty Ltd
Publication of MC2115A1 publication Critical patent/MC2115A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/60Isolated nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/12Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/12Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121Hammerhead
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/12Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/124Type of nucleic acid catalytic nucleic acids, e.g. ribozymes based on group I or II introns

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
MC882115D 1987-12-15 1988-12-14 Ribozynes MC2115A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPI591187 1987-12-15
AUPI995088 1988-08-19
AUPJ035388 1988-09-09
AUPJ130488 1988-11-04
AUPJ133388 1988-11-07

Publications (1)

Publication Number Publication Date
MC2115A1 true MC2115A1 (fr) 1991-07-05

Family

ID=27507391

Family Applications (1)

Application Number Title Priority Date Filing Date
MC882115D MC2115A1 (fr) 1987-12-15 1988-12-14 Ribozynes

Country Status (19)

Country Link
EP (2) EP0640688A1 (fr)
JP (1) JP3046318B2 (fr)
KR (1) KR970010758B1 (fr)
CN (1) CN1102174C (fr)
AR (1) AR243935A1 (fr)
AT (1) ATE115999T1 (fr)
AU (1) AU632993B2 (fr)
CA (1) CA1340831C (fr)
DE (1) DE3852539T3 (fr)
DK (1) DK175956B1 (fr)
ES (1) ES2065919T5 (fr)
FI (1) FI104562B (fr)
GR (1) GR3015374T3 (fr)
HU (2) HUT54407A (fr)
MC (1) MC2115A1 (fr)
NO (2) NO308610B1 (fr)
NZ (1) NZ227332A (fr)
RO (1) RO114469B1 (fr)
WO (1) WO1989005852A1 (fr)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019556A (en) * 1987-04-14 1991-05-28 President And Fellows Of Harvard College Inhibitors of angiogenin
CA1340323C (fr) * 1988-09-20 1999-01-19 Arnold E. Hampel Catalyseur d'arn pour le clivage de sequences specifiques d'arn
US5866701A (en) * 1988-09-20 1999-02-02 The Board Of Regents For Northern Illinois University Of Dekalb HIV targeted hairpin ribozymes
US5624824A (en) * 1989-03-24 1997-04-29 Yale University Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence
US5168053A (en) * 1989-03-24 1992-12-01 Yale University Cleavage of targeted RNA by RNAase P
DE4091533T (fr) * 1989-08-31 1992-01-30
US5225337A (en) * 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Ribozyme compositions and methods for use
US5225347A (en) * 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Therapeutic ribozyme compositions and expression vectors
DE3933384A1 (de) * 1989-10-06 1991-04-18 Hoechst Ag Multifunktionelle rna mit selbstprozessierungsaktivitaet, ihre herstellung und ihre verwendung
DE3935473A1 (de) * 1989-10-25 1991-05-02 Hoechst Ag Rna mit endonuclease- und antisense-aktivitaet, ihre herstellung und ihre verwendung
EP1418179A3 (fr) * 1990-01-11 2006-03-08 Isis Pharmaceuticals, Inc. Compositions et methodes servant à détecter et à moduler l'activité ARN et l'expression des gènes
DE4002885A1 (de) * 1990-02-01 1991-08-08 Hoechst Ag Expression einer multigen rna mit self-splicing aktivitaet
US5519164A (en) * 1990-02-01 1996-05-21 Hoechst Aktiengesellschaft Expression of a multigene RNA having self-splicing activity
US5180818A (en) * 1990-03-21 1993-01-19 The University Of Colorado Foundation, Inc. Site specific cleavage of single-stranded dna
WO1991018913A1 (fr) * 1990-06-07 1991-12-12 City Of Hope Inversion a mediation ribozymique de transformation par clivage de l'arn oncogene hras
WO1991018625A1 (fr) * 1990-06-07 1991-12-12 City Of Hope Inversion a mediation ribozymique de transformation par clivage de l'arn oncogene hras
EP0535067B1 (fr) * 1990-06-19 1997-03-26 Gene Shears Pty. Ltd. Endonucleases
US6008343A (en) * 1990-06-19 1999-12-28 Gene Shears Pty. Ltd. Nucleotide based endonucleases
US5246921A (en) * 1990-06-26 1993-09-21 The Wistar Institute Of Anatomy And Biology Method for treating leukemias
EP0639226A1 (fr) * 1990-06-26 1995-02-22 The Wistar Institute Molecule d'arn pour utilisation dans le traitement de leucemies
WO1992001786A1 (fr) * 1990-07-26 1992-02-06 Foundation For Research And Technology - Hellas (Fo.R.T.H.) Institute Of Molecular Biology & Biotechnology Cassettes de ribozymes portables, sequences d'adn les contenant, ribozymes codes par ces sequences d'adn, et compositions contenant ces ribozymes
EP0552178B1 (fr) 1990-10-12 1997-01-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Ribozymes modifies
NZ314629A (en) * 1991-01-17 2000-08-25 Gen Hospital Corp Use trans-splicing ribozymes to prepare medicaments for gene therapies
NZ314630A (en) * 1991-01-17 2000-11-24 Harvard College Use of trans-splicing ribozymes for genetic modification and cell ablation in a host cell
FR2675803B1 (fr) * 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
FI913197A0 (fi) 1991-07-01 1991-07-01 Xyrofin Oy Nya jaeststammar med reducerad foermaoga att metabolisera xylitol, foerfarande foer bildande av dessa och deras anvaendning vid framstaellning av xylitol.
JPH07502898A (ja) * 1992-01-13 1995-03-30 デューク・ユニバーシティー 酵素rna分子
EP0592685B1 (fr) * 1992-04-17 2001-11-28 Kirin Beer Kabushiki Kaisha Vegetal resistant a au moins deux virus et sa preparation
JPH08500971A (ja) * 1992-06-29 1996-02-06 ジーン・シアーズ・ピーティーワイ・リミテッド 核酸及びウイルス性病原体をコントロールするためのこれらの使用方法
ATE236975T1 (de) * 1992-07-02 2003-04-15 Sankyo Co Haarnadelförmiges ribozym
US5409823A (en) * 1992-09-24 1995-04-25 Ciba-Geigy Corporation Methods for the production of hybrid seed
US5864028A (en) * 1992-11-03 1999-01-26 Gene Shears Pty. Limited Degradation resistant mRNA derivatives linked to TNF-α ribozymes
ATE269405T1 (de) * 1992-11-03 2004-07-15 Gene Shears Pty Ltd Tnf-alpha ribozyme und abbau-resistente mrna derivative gebunden an tnf-alpha ribozyme
JPH08507203A (ja) * 1992-12-04 1996-08-06 イノーバー ラボラトリーズ,インコーポレイテッド 調節可能な核酸治療およびそれらの使用方法
ES2176233T3 (es) * 1992-12-04 2002-12-01 Univ Yale Deteccion diagnostica amplificada con ribozimas.
US6080851A (en) * 1992-12-04 2000-06-27 American Home Products Corporation Ribozymes with linked anchor sequences
FR2701960B1 (fr) * 1993-02-26 2002-09-13 Gene Shears Pty Ltd Polyribozyme apte à conférer, aux plantes, une résistance aux virus et plantes résistantes produisant ce polyribozyme.
US5817635A (en) * 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
AU5334294A (en) * 1993-10-15 1995-05-04 Dkfz Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Asymmetric hammerhead ribozymes and nucleotide sequences for their construction
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
US5998193A (en) * 1994-06-24 1999-12-07 Gene Shears Pty., Ltd. Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof
US6350934B1 (en) 1994-09-02 2002-02-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid encoding delta-9 desaturase
US5683873A (en) * 1995-01-13 1997-11-04 Innovir Laboratories, Inc. EGS-mediated inactivation of target RNA
US6057153A (en) * 1995-01-13 2000-05-02 Yale University Stabilized external guide sequences
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
WO1996040906A1 (fr) * 1995-06-07 1996-12-19 Commonwealth Scientific And Industrial Research Organisation Minizymes et miniribozymes optimises et utilisation de ces derniers
US6004806A (en) * 1995-06-07 1999-12-21 Commonwealth Scientific And Industrial Research Organization Optimized minizymes and miniribozymes and uses thereof
US6010904A (en) * 1995-06-07 2000-01-04 The General Hospital Corporation Cell ablation using trans-splicing ribozymes
MX9800454A (es) * 1995-07-13 1998-04-30 Ribozyme Pharm Inc Composiciones y metodo para modulacion de expresion de genes en las plantas.
US5824519A (en) * 1995-11-08 1998-10-20 Medical University Of South Carolina Tissue-specific and target RNA-specific ribozymes
US5877162A (en) * 1996-03-14 1999-03-02 Innovir Laboratories, Inc. Short external guide sequences
US6620805B1 (en) 1996-03-14 2003-09-16 Yale University Delivery of nucleic acids by porphyrins
AU4071197A (en) * 1996-08-16 1998-03-06 Yale University Phenotypic conversion of drug-resistant bacteria to drug-sensitivity
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
US6884430B1 (en) 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
US7083786B2 (en) 1997-04-03 2006-08-01 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
IL132393A0 (en) 1997-04-15 2001-03-19 Commw Scient Ind Res Org Plant fatty acid epoxygenase genes and uses therefor
US7589253B2 (en) 1997-04-15 2009-09-15 Commonwealth Scientific And Industrial Research Organisation Fatty acid epoxygenase genes from plants and uses therefor in modifying fatty acid metabolism
CZ299473B6 (cs) 1997-06-30 2008-08-06 Rhone-Poulenc Rorer S. A. Nukleová kyselina a elektrické pole jako sdruženýprodukt pro prenos nukleové kyseliny do bunek prícne pruhovaného svalstva
CA2303759A1 (fr) 1997-09-16 1999-03-25 Cropdesign N.V. Inhibiteurs de la kinase cycline-dependante et utilisations de ceux-ci
DE19741375C2 (de) * 1997-09-19 1999-10-21 Max Planck Gesellschaft Transgene Pflanzen, deren oberirdische Teile früher reifen und vollständig absterben
DE69821011T3 (de) 1997-10-02 2009-01-08 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur Modulierung der Neovaskularisierung und/oder des Wachstums kollateraler Arterien und/oder anderer Arterien aus bestehenden arteriolären Verbindungen
CA2311166C (fr) 1997-11-18 2012-06-19 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Acides nucleiques participant au phenotype du repondeur et leurs applications
US6013447A (en) * 1997-11-21 2000-01-11 Innovir Laboratories, Inc. Random intracellular method for obtaining optimally active nucleic acid molecules
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
KR101054060B1 (ko) 1998-03-20 2011-08-04 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 유전자 발현 조절방법
US6248525B1 (en) 1998-03-30 2001-06-19 Yale University Method for identifying essential or functional genes
CA2331782A1 (fr) 1998-06-24 1999-12-29 Musc Foundation For Research Development Ribozymes specifiques aux tissus et a l'arn cible
DE19836098A1 (de) 1998-07-31 2000-02-03 Hoechst Schering Agrevo Gmbh Pflanzen, die eine modifizierte Stärke synthetisieren, Verfahren zur Herstellung der Pflanzen, ihre Verwendung sowie die modifizierte Stärke
ATE386804T1 (de) 1998-10-15 2008-03-15 Novartis Vaccines & Diagnostic Gene mit veränderter expression in metastatischen brust- oder dickdarm- krebszellen
AU773808B2 (en) * 1998-11-09 2004-06-10 Bayer Cropscience Aktiengesellschaft Nucleic acid molecules from rice and their use for the production of modified starch
EP2322635B1 (fr) 1998-11-12 2014-04-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Promoteurs chimères capables de servir de médiateurs de l'expression génique dans des végétaux en cas d'infection pathogène et procédés d'utilisation correspondants
ATE408695T1 (de) 1998-12-16 2008-10-15 Novartis Vaccines & Diagnostic Menschliche cyclin-abhängige kinase (hpnqalre)
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
EP1169480A4 (fr) 1999-04-14 2005-02-02 Musc Found For Res Dev Agents toxiques et ribozymes specifiques de tissu et specifiques de pathogene
AUPQ005299A0 (en) 1999-04-29 1999-05-27 Commonwealth Scientific And Industrial Research Organisation Novel genes encoding wheat starch synthases and uses therefor
AU778695B2 (en) 1999-07-20 2004-12-16 Ges. Fur Erwerb Und Verwertung Von Schutzrechten-Gvs Mbh Novel method for the generation and selection of transgenic linseed/flax plants
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
AU8466501A (en) 2000-07-21 2002-02-05 Essentia Biosystems Inc Multi-component biological transport systems
CA2428259C (fr) 2000-11-09 2013-08-13 Commonwealth Scientific And Industrial Research Organisation Orge possedant une activite enzymatique ssii limitee et amidon et produits contenant de l'amidon a teneur limitee en amylopectine
ITMI20011364A1 (it) * 2001-06-28 2002-12-28 Metapontum Agrobios S C R L Robozima hammerhead specifico per la stearoyl-acp desaturesi di piante oleaginose differenti
EP1414996B1 (fr) 2001-07-10 2010-12-01 Johnson & Johnson Research Pty Limited Procedes de modification genetique des cellules progenitrices hematopoietiques et utilisation des cellules modifiees
ES2358187T3 (es) 2001-07-10 2011-05-06 JOHNSON & JOHNSON RESEARCH PTY LIMITED Procedimientos para la modificación genética de las células progenitoras hematopoyéticas y utilizaciones de las células modificadas.
US8022272B2 (en) 2001-07-13 2011-09-20 Sungene Gmbh & Co. Kgaa Expression cassettes for transgenic expression of nucleic acids
FR2829136B1 (fr) 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
US7456335B2 (en) 2001-09-03 2008-11-25 Basf Plant Science Gmbh Nucleic acid sequences and their use in methods for achieving pathogen resistance in plants
WO2003025220A2 (fr) 2001-09-18 2003-03-27 Carnegie Institution Of Washington Proteines hybrides destinees a la detection d'analytes
WO2003051314A2 (fr) 2001-12-18 2003-06-26 Medallion Biomedical, Llc Composes antibiotiques
MXPA04007679A (es) 2002-02-07 2005-12-05 Covalent Partners Llc Composiciones de nanopelicula y membrana.
US20040005546A1 (en) 2002-02-28 2004-01-08 Oncolytics Biotech Inc. Use of ribozymes in the detection of adventitious agents
DE10212892A1 (de) 2002-03-20 2003-10-09 Basf Plant Science Gmbh Konstrukte und Verfahren zur Regulation der Genexpression
EP1900827A3 (fr) 2002-05-21 2008-04-16 Bayer HealthCare AG Procédés et compositions pour la prédiction, le diagnostic, le pronostic et la prévention et le traitement de néoplasies malignes
US7771952B2 (en) 2002-06-26 2010-08-10 Abott Laboratories Modulators and modulation of the interaction between RGM and Neogenin
WO2004013333A2 (fr) 2002-07-26 2004-02-12 Basf Plant Science Gmbh Nouveaux procedes de selection
DE60334246D1 (de) 2002-11-21 2010-10-28 Celltech R & D Inc Modulieren von immunantworten
JP4538408B2 (ja) 2002-12-19 2010-09-08 バイエル・クロップサイエンス・アーゲー 高い最終粘度を持つデンプンを合成する植物細胞及び植物
SI1625166T1 (sl) 2003-05-12 2015-08-31 Helion Biotech Aps Protitelesa masp-2
US7812221B2 (en) 2003-06-30 2010-10-12 Commonwealth Scientific And Industrial Research Organization Wheat with altered branching enzyme activity and starch and starch containing products derived therefrom
EP1522594A3 (fr) 2003-10-06 2005-06-22 Bayer HealthCare AG Methode et trousses pour evaluer un cancer
EP1602926A1 (fr) 2004-06-04 2005-12-07 University of Geneva Nouveaux moyens et méthodes pour le traitement de pertes d'audition ou l'audition fantôme
US7604947B2 (en) 2004-06-09 2009-10-20 Cornell Research Foundation, Inc. Detection and modulation of cancer stem cells
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
PT1753456T (pt) 2004-06-10 2016-11-04 Univ Leicester Métodos para tratar condições associadas com a ativação do complemento dependente de masp-2
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
WO2006005520A2 (fr) 2004-07-08 2006-01-19 Dlf-Trifolium A/S Moyens et procedes de commande de la floraison chez des plantes
EP2163635B1 (fr) 2004-08-02 2013-05-22 BASF Plant Science GmbH Procédé d'isolation de séquence de terminaison de transcription
CA2579927A1 (fr) 2004-09-24 2006-03-30 Basf Plant Science Gmbh Cellules vegetales et plantes presentant une tolerance accrue au stress environnemental
WO2006069422A1 (fr) 2004-12-30 2006-07-06 Commonwealth Scientific And Industrial Research Organisation Procede et moyen benefiques pour l'intestin
EP1707632A1 (fr) 2005-04-01 2006-10-04 Bayer CropScience GmbH Amidon de pomme de terre cireux phosphorylé
CA2624562A1 (fr) 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Domaines de liaison de proteines de la famille proteinique des molecules de guidage repulsif (rgm), fragments fonctionnels de ces domaines et leur utilisation
CA2628505A1 (fr) 2005-11-08 2007-05-18 Basf Plant Science Gmbh Utilisation de polynucleotides a repetition armadillo (arm1) pour obtenir une resistance elevees aux agents pathogenes chez des vegetaux
EP2380986A1 (fr) 2006-01-12 2011-10-26 BASF Plant Science GmbH Utilisation de polynucléotides de la stomatine (STM1) pour obtenir une résistance de pathogène dans des plantes
AU2007299219A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
WO2007134818A2 (fr) 2006-05-18 2007-11-29 Univ Muenchen L Maximilians Procédé pour diagnostiquer un dysfonctionnement mitochondrial
US8383597B2 (en) 2006-05-25 2013-02-26 Cornell Research Foundation, Inc. G proteins in tumor growth and angiogenesis
WO2008040095A1 (fr) 2006-10-06 2008-04-10 Johnson & Johnson Research Pty Limited Commutateurs moléculaires et procédés d'utilisation
DK2202314T3 (da) 2007-01-15 2014-06-16 Basf Plant Science Gmbh Anvendelse af subtilisin (RNR9)-polynukleotider til opnåelse af patogenresistens i planter
US20110035840A1 (en) 2007-02-16 2011-02-10 Basf Plant Science Gmbh Nucleic acid sequences for regulation of embryo-specific expression in monocotyledoneous plants
EP2139475B1 (fr) 2007-03-27 2014-12-17 Omeros Corporation Inhibiteurs de PDE7 pour le traitement de troubles du mouvement
US20100162432A1 (en) 2007-05-22 2010-06-24 Basf Plant Science Gmbh Plant cells and plants with increased tolerance and/or resistance to environmental stress and increased biomass production-ko
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
EP2040075A1 (fr) 2007-09-24 2009-03-25 Julius-Maximilians-Universität Würzburg Composés et marqueurs pour la diffusion Raman de surface améliorée
EP2227256A1 (fr) 2007-12-14 2010-09-15 Amgen Inc. Procédé de traitement d'une fracture osseuse à l'aide d'anticorps anti-sclérostine
DE112008003433T5 (de) 2007-12-21 2010-11-04 Basf Plant Science Gmbh Pflanzen mit erhöhtem Ertrag (KO NUE)
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
EP2100962A1 (fr) 2008-03-12 2009-09-16 Biogemma Plantes dotées d'une résistance améliorée aux pathogènes
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
EP2331071A1 (fr) 2008-09-05 2011-06-15 Institut National De La Sante Et De La Recherche Medicale Nouvel ensemble multimodulaire utile à une administration intracellulaire
EP2184351A1 (fr) 2008-10-30 2010-05-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Synthase caryophyllène codant pour les polynucléotides et ses utilisations
ES2363358B1 (es) 2009-04-03 2012-06-21 FUNDACIÓ INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL D'HEBRON (Titular al Agentes terapéuticos para el tratamiento de enfermedades asociadas con una proliferación celular indeseable.
US10519458B2 (en) 2009-04-22 2019-12-31 Basf Plant Science Company Gmbh Whole seed specific promoter
US20130012709A1 (en) 2009-09-10 2013-01-10 Centre National De La Recherche Scientifique NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES
EP2305285A1 (fr) 2009-09-29 2011-04-06 Julius-Maximilians-Universität Würzburg Supports et procédés pour traiter les conditions ischémiques
CA2777845C (fr) 2009-10-16 2017-08-01 Omeros Corporation Methodes pour traiter la coagulation intravasculaire disseminee par inhibition de l'activation du complement dependante de masp-2
EP2493871B1 (fr) 2009-10-30 2014-09-03 Domain Therapeutics Nouveaux dérivés d'oxime et leur utilisation en tant que modulateurs allostériques de récepteurs du glutamate métabotropique
EP2322149A1 (fr) 2009-11-03 2011-05-18 Universidad del Pais Vasco Procédés et compositions de traitement de l'ischémie
AU2010329955A1 (en) 2009-12-08 2012-05-24 Abbott Gmbh & Co. Kg Monoclonal antibodies against the RGM A protein for use in the treatment of retinal nerve fiber layer degeneration
EP2338492A1 (fr) 2009-12-24 2011-06-29 Universidad del Pais Vasco Procédés et compositions pour le traitement de la maladie d'Alzheimer
US8476485B2 (en) 2010-06-24 2013-07-02 Academia Sinica Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
US20120115849A1 (en) 2010-11-08 2012-05-10 Demopulos Gregory A Treatment of Addiction and Impulse-Control Disorders Using PDE7 Inhibitors
KR102217658B1 (ko) 2011-04-08 2021-02-22 유니버시티 오브 레스터 Masp-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
CA2853829C (fr) 2011-07-22 2023-09-26 President And Fellows Of Harvard College Evaluation et amelioration de la specificite de clivage des nucleases
WO2013025936A1 (fr) 2011-08-18 2013-02-21 Cornell University Détection et traitement d'une maladie métastatique
WO2013039880A1 (fr) 2011-09-12 2013-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biomarqueurs et cibles thérapeutiques du cancer hépatocellulaire
WO2013090814A2 (fr) 2011-12-16 2013-06-20 Board Of Trustees Of Michigan State University P-coumaroyl-coa:monolignol transférase
BR112014018592B1 (pt) 2012-01-27 2022-03-15 Abbvie Inc. Anticorpo monoclonal isolado que se liga à molécula de orientação repulsiva a (rgma)
EP2825210B1 (fr) 2012-03-14 2019-06-26 University of Central Florida Research Foundation, Inc. Agents modulant la kinase lim pour thérapie de la neurofibromatose et procédés de criblage pour ceux-ci
EP2666775A1 (fr) 2012-05-21 2013-11-27 Domain Therapeutics Pyrazoloquinazolinones et pyrroloquinazolinones substitués en tant que modulateurs allostériques des récepteurs métabotropiques du glutamate du groupe II
WO2014127835A1 (fr) 2013-02-22 2014-08-28 Christian-Albrechts-Universität Zu Kiel Gène de résistance dérivé d'une plante
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
MX389699B (es) 2013-10-17 2025-03-20 Omeros Corp Composiciones que comprenden anticuerpos inhibidores de masp-2 para usarse en el tratamiento de post-trasplante de celulas madre de microangiopatía trombótica (tma).
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
PH12016501194B1 (en) 2013-12-18 2022-04-22 Commw Scient Ind Res Org Lipid comprising long chain polyunsaturated fatty acids
SG11201610596PA (en) 2014-06-27 2017-01-27 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
EP3177718B1 (fr) 2014-07-30 2022-03-16 President and Fellows of Harvard College Protéines cas9 comprenant des intéines dépendant de ligands
EP3000814A1 (fr) 2014-09-26 2016-03-30 Domain Therapeutics Pyrazoloquinazolinones et pyrroloquinazolinones substitués en tant que modulateurs allostériques des récepteurs métabotropiques du glutamate du groupe II
WO2017070633A2 (fr) 2015-10-23 2017-04-27 President And Fellows Of Harvard College Protéines cas9 évoluées pour l'édition génétique
SG11201803834UA (en) 2015-11-09 2018-06-28 Omeros Corp Methods for treating conditions associated with masp-2 dependent complement activation
KR102475622B1 (ko) 2016-01-05 2022-12-08 유니버시티 오브 레스터 필요로 하는 대상체에서 섬유증의 억제 방법
CA3018774C (fr) 2016-03-31 2023-02-28 Omeros Corporation Procedes d'inhibition d'angiogenese chez un sujet qui en a besoin
MA44031B1 (fr) 2016-05-26 2021-06-30 Nunhemes B V Plantes produisant des fruits sans graines
WO2018027078A1 (fr) 2016-08-03 2018-02-08 President And Fellows Of Harard College Éditeurs de nucléobases d'adénosine et utilisations associées
JP7201153B2 (ja) 2016-08-09 2023-01-10 プレジデント アンド フェローズ オブ ハーバード カレッジ プログラム可能cas9-リコンビナーゼ融合タンパク質およびその使用
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
WO2018119359A1 (fr) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Édition du gène récepteur ccr5 pour protéger contre l'infection par le vih
US11873496B2 (en) 2017-01-09 2024-01-16 Whitehead Institute For Biomedical Research Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops
EP3592853A1 (fr) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression de la douleur par édition de gène
KR20190123328A (ko) 2017-03-09 2019-10-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 암 백신
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
US10883089B2 (en) 2017-04-04 2021-01-05 Wisconsin Alumni Research Foundation Feruloyl-CoA:monolignol transferases
US10883090B2 (en) 2017-04-18 2021-01-05 Wisconsin Alumni Research Foundation P-coumaroyl-CoA:monolignol transferases
EP3655015B1 (fr) 2017-07-17 2024-02-21 The Regents of the University of Colorado Compositions et méthodes de prévention et de traitement d'effets de proximité induits par rayonnement provoqués par un rayonnement ou une radiothérapie
EP3658573A1 (fr) 2017-07-28 2020-06-03 President and Fellows of Harvard College Procédés et compositions pour l'évolution d'éditeurs de bases à l'aide d'une évolution continue assistée par phage (pace)
TWI818919B (zh) 2017-08-15 2023-10-21 美商歐米諾斯公司 用於治療和/ 或預防與造血幹細胞移植有關的移植物抗宿主病和/ 或瀰漫性肺泡出血和/ 或靜脈閉塞性病的方法
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
EP3697906A1 (fr) 2017-10-16 2020-08-26 The Broad Institute, Inc. Utilisations d'éditeurs de bases adénosine
US12406749B2 (en) 2017-12-15 2025-09-02 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
EP3797160A1 (fr) 2018-05-23 2021-03-31 The Broad Institute Inc. Éditeurs de bases et leurs utilisations
CN112867706B (zh) 2018-05-29 2024-11-15 奥默罗斯公司 Masp-2抑制剂和使用方法
US11584714B2 (en) 2018-05-29 2023-02-21 Omeros Corporation MASP-2 inhibitors and methods of use
EP3806619A1 (fr) 2018-06-15 2021-04-21 Nunhems B.V. Plantes à pastèques sans pépins comprenant des modifications dans un gène transporteur abc
WO2020092453A1 (fr) 2018-10-29 2020-05-07 The Broad Institute, Inc. Éditeurs de nucléobases comprenant geocas9 et utilisations associées
WO2020097518A1 (fr) 2018-11-09 2020-05-14 Wisconsin Alumni Research Foundation Bahd acyltransférases
WO2020154500A1 (fr) 2019-01-23 2020-07-30 The Broad Institute, Inc. Protéines chargées supernégativement et utilisations associées
SG11202109882VA (en) 2019-03-19 2021-10-28 Broad Inst Inc Methods and compositions for editing nucleotide sequences
EP3956349A1 (fr) 2019-04-17 2022-02-23 The Broad Institute, Inc. Éditeurs de base d'adénine présentant des effets hors cible réduits
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
CN115052604A (zh) 2019-12-04 2022-09-13 奥默罗斯公司 Masp-2抑制剂和使用方法
AU2020395306B2 (en) 2019-12-04 2025-04-24 Omeros Corporation MASP-2 inhibitors and methods of use
CN115103709A (zh) 2019-12-04 2022-09-23 奥默罗斯公司 Masp-2抑制剂和使用方法
TWI834025B (zh) 2020-03-06 2024-03-01 美商奥默羅斯公司 用於治療和/或預防冠狀病毒誘導的急性呼吸窘迫症候群的抑制masp-2的方法
KR20230019843A (ko) 2020-05-08 2023-02-09 더 브로드 인스티튜트, 인코퍼레이티드 표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물
WO2022034474A1 (fr) 2020-08-10 2022-02-17 Novartis Ag Traitements contre des maladies dégénératives de la rétine
EP4572765A1 (fr) 2022-08-18 2025-06-25 Mitodicure GmbH Utilisation d'un agent thérapeutique ayant une activité inhibitrice de phosphodiestérase-7 pour le traitement et la prévention de maladies associées à la fatigue, à l'épuisement et/ou à l'intolérance à l'effort chroniques
EP4577202A1 (fr) 2022-08-26 2025-07-02 Mitodicure GmbH Utilisation d'un agent thérapeutique ayant une activité inhibitrice de l'antiport sodium-hydrogène 1 pour le traitement et la prévention de maladies associées à la fatigue chronique, à l'épuisement et/ou à l'intolérance à l'effort

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116742A (en) * 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
DE3642623A1 (de) * 1986-12-13 1988-06-23 Burbach & Bender Ohg Gasspuelstein fuer metallurgische gefaesse
DE3939771A1 (de) * 1989-12-01 1991-06-06 Behringwerke Ag Verfahren zur biologischen inaktivierung von nukleinsaeuren

Also Published As

Publication number Publication date
EP0321201A2 (fr) 1989-06-21
FI902923A0 (fi) 1990-06-12
HU211891A9 (en) 1995-12-28
ES2065919T3 (es) 1995-03-01
NO308610B1 (no) 2000-10-02
CA1340831C (fr) 1999-11-30
CN1033838A (zh) 1989-07-12
EP0321201B1 (fr) 1994-12-21
NO902661L (no) 1990-08-14
DE3852539T2 (de) 1995-05-04
NO902661D0 (no) 1990-06-14
KR900700603A (ko) 1990-08-16
DE3852539D1 (de) 1995-02-02
EP0640688A1 (fr) 1995-03-01
JPH03502638A (ja) 1991-06-20
EP0321201B2 (fr) 2004-11-24
JP3046318B2 (ja) 2000-05-29
DK143390D0 (da) 1990-06-12
NZ227332A (en) 1991-08-27
AU2800789A (en) 1989-07-19
ATE115999T1 (de) 1995-01-15
GR3015374T3 (en) 1995-06-30
CN1102174C (zh) 2003-02-26
FI104562B (fi) 2000-02-29
DK143390A (da) 1990-08-14
EP0321201A3 (en) 1990-01-10
DE3852539T3 (de) 2005-08-04
AU632993B2 (en) 1993-01-21
DK175956B1 (da) 2005-08-22
NO20000369L (no) 1990-08-14
RO114469B1 (ro) 1999-04-30
NO20000369D0 (no) 2000-01-25
ES2065919T5 (es) 2005-06-16
NO312105B1 (no) 2002-03-18
KR970010758B1 (ko) 1997-06-30
AR243935A1 (es) 1993-09-30
HUT54407A (en) 1991-02-28
WO1989005852A1 (fr) 1989-06-29

Similar Documents

Publication Publication Date Title
ATA30988A (de) Alpinski
BR8806613A (pt) Corrimao
BR8806369A (pt) Debitometro vorticoso
ATA174488A (de) Alpinski
ATA174288A (de) Alpinski
ATA224788A (de) Calcitoninsuppositorien
BR8807165A (pt) Moluscicidas
BR8805147A (pt) Polieterimidas
BR8705012A (pt) Mini-persiana
AT389045B (de) Paraocclusaler loeffel
ATA48687A (de) Guellefass
ATA294988A (de) Haecksler
DK100388A (da) Thienothiopyraner
ATA162787A (de) Hoergeraet
AT388649B (de) Sportschuh
BR6702354U (pt) Escada-cabide
BR6701551U (pt) Metro-esquadro-profissional
BR6701671U (pt) Dessensibilizador
BR6701723U (pt) Nivel-atmosfera-profissional
BR6701734U (pt) Amnioscopio
BR6701938U (pt) Multi-escada
BR6702263U (pt) Modulo-guiche
BR6701063U (pt) Cesta-cofre
BR6702835U (pt) Prancha salva-vidas
BR8700074A (pt) Diagramador

Legal Events

Date Code Title Description
YP Annual fee paid