[go: up one dir, main page]

MA32804B1 - Antagonistes d'isonicotinamide des récepteurs de l'orexine - Google Patents

Antagonistes d'isonicotinamide des récepteurs de l'orexine

Info

Publication number
MA32804B1
MA32804B1 MA33859A MA33859A MA32804B1 MA 32804 B1 MA32804 B1 MA 32804B1 MA 33859 A MA33859 A MA 33859A MA 33859 A MA33859 A MA 33859A MA 32804 B1 MA32804 B1 MA 32804B1
Authority
MA
Morocco
Prior art keywords
isonicotinamide
orexin receptors
antagonists
compounds
orexin
Prior art date
Application number
MA33859A
Other languages
Arabic (ar)
English (en)
Inventor
Jeffrey M Bergman
Paul J Coleman
Mamio Christa Mattern
Swati P Mercer
Thomas S Reger
Anthony J Roecker
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA32804B1 publication Critical patent/MA32804B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention concerne des composés d'isonicotinamide qui sont des antagonistes des récepteurs de l'orexine et qui sont utiles dans le traitement ou la prévention de troubles et de maladies neurologiques ou psychiatriques dans lesquels sont impliqués les récepteurs de l'orexine. L'invention concerne également des compositions pharmaceutiques comportant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de ces maladies dans lesquelles sont impliqués les récepteurs de l'orexine.
MA33859A 2008-10-30 2011-05-19 Antagonistes d'isonicotinamide des récepteurs de l'orexine MA32804B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19778908P 2008-10-30 2008-10-30
US18057409P 2009-05-22 2009-05-22
PCT/US2009/061987 WO2010051236A1 (fr) 2008-10-30 2009-10-26 Antagonistes d'isonicotinamide des récepteurs de l'orexine

Publications (1)

Publication Number Publication Date
MA32804B1 true MA32804B1 (fr) 2011-11-01

Family

ID=41348271

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33859A MA32804B1 (fr) 2008-10-30 2011-05-19 Antagonistes d'isonicotinamide des récepteurs de l'orexine

Country Status (23)

Country Link
US (1) US8592457B2 (fr)
EP (1) EP2350010B1 (fr)
JP (1) JP5635991B2 (fr)
KR (1) KR101320245B1 (fr)
CN (1) CN102272103B (fr)
AU (1) AU2009308980B2 (fr)
BR (1) BRPI0919876A8 (fr)
CA (1) CA2741644C (fr)
CL (1) CL2011000976A1 (fr)
CO (1) CO6361994A2 (fr)
CR (1) CR20110228A (fr)
DO (1) DOP2011000120A (fr)
EA (1) EA201170624A1 (fr)
EC (1) ECSP11011019A (fr)
IL (1) IL212436A0 (fr)
MA (1) MA32804B1 (fr)
MX (1) MX2011004551A (fr)
NI (1) NI201100084A (fr)
NZ (1) NZ592544A (fr)
PE (1) PE20110852A1 (fr)
TN (1) TN2011000171A1 (fr)
WO (1) WO2010051236A1 (fr)
ZA (1) ZA201103156B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009020642A1 (fr) 2007-08-09 2009-02-12 Merck & Co., Inc. Antagonistes de récepteurs d'orexine au pyridinecarboxamide
AR072899A1 (es) 2008-08-07 2010-09-29 Merck Sharp & Dohme Derivados de terpiridina-carboxamida antagonistas de receptores de orexina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del insomnio y la obesidad.
WO2010051238A1 (fr) 2008-10-30 2010-05-06 Merck Sharp & Dohme Corp. Antagonistes des récepteurs de l’orexine à base de pyridazine-carboxamide
CA2741648A1 (fr) 2008-10-30 2010-05-06 Merck Sharp & Dohme Corp. Antagonistes carboxamide phenyl 2,5-disubstitue du recepteur de l'orexine
US8653263B2 (en) 2009-10-23 2014-02-18 Janssen Pharmaceutica Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
US8680275B2 (en) 2009-10-23 2014-03-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
US9062044B2 (en) 2009-10-23 2015-06-23 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
JP5987005B2 (ja) * 2011-02-18 2016-09-06 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン拮抗薬として有用な新規なピラゾール及びイミダゾール誘導体
WO2012145581A1 (fr) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Octahydropyrrolo [3,4-c] pyrroles disubstitués utilisés comme modulateurs du récepteur de l'orexine
AR088352A1 (es) * 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
ES2672732T3 (es) 2012-02-07 2018-06-15 Eolas Therapeutics Inc. Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
KR20150023390A (ko) * 2012-06-15 2015-03-05 다이쇼 세이야꾸 가부시끼가이샤 분지쇄 알킬 헤테로 방향환 유도체
EP2862860B1 (fr) * 2012-06-15 2016-12-21 Taisho Pharmaceutical Co., Ltd. COMPOSés de 1,3-OXAZOLIDINE OU 1,3-OXAZINANE COMME ANTAGONISTES DU RéCEPTEUR DE L'ORéXINE
JP5907310B2 (ja) * 2013-12-13 2016-04-26 大正製薬株式会社 オキサジナン化合物の結晶形及びその製造方法
JP5930010B2 (ja) * 2013-12-13 2016-06-08 大正製薬株式会社 ヘテロ芳香環メチル環状アミン誘導体を含有する医薬
EP2915811A1 (fr) * 2014-03-04 2015-09-09 Centre Régional de Lutte contre le Cancer - Centre François Baclesse Composés de modulation MCL-1 pour le traitement du cancer
UY36272A (es) 2014-08-13 2016-02-29 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores de los receptores de orexinas
WO2016100161A1 (fr) * 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Éthylène diamine en tant qu'antagonistes du récepteur de l'hypocrétine
WO2016101118A1 (fr) * 2014-12-23 2016-06-30 Merck Sharp & Dohme Corp. Antagonistes des récepteurs d'orexine de type amidoéthylazole
HUE066912T2 (hu) * 2015-08-24 2024-09-28 Zogenix International Ltd Lennox-Gastaut szindróma kezelési eljárása fenfluramin alkalmazásával
CN106749269B (zh) 2015-11-23 2019-01-04 广东东阳光药业有限公司 八氢吡咯并[3,4-c]吡咯衍生物及其用途
TWI710557B (zh) 2016-02-12 2020-11-21 美商伊歐拉斯治療學公司 作為食慾素受體調節劑之經鹵素取代之六氫吡啶
BR112018067906A2 (pt) 2016-03-10 2019-01-29 Janssen Pharmaceutica Nv métodos de tratamento de depressão usando antagonistas do receptor de orexina-2
GB201702174D0 (en) 2017-02-09 2017-03-29 Benevolentai Bio Ltd Orexin receptor antagonists
GB201707504D0 (en) 2017-05-10 2017-06-21 Benevolentai Bio Ltd Orexin receptor antagonists
GB201707499D0 (en) 2017-05-10 2017-06-21 Benevolentai Bio Ltd Orexin receptor antagonists
CN109280027A (zh) * 2018-12-13 2019-01-29 康化（上海）新药研发有限公司 一种5,6-二甲氧基-2-吡啶甲酸的合成方法
CN116600803A (zh) * 2020-11-02 2023-08-15 默沙东有限责任公司 大环脲食欲素受体激动剂

Family Cites Families (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914250A (en) 1974-08-01 1975-10-21 American Home Prod 1,4-Diazepino{8 6,5,4-jk{9 carbazoles
CA1258454A (fr) 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
IT1159765B (it) 1982-09-28 1987-03-04 Zanussi A Spa Industrie Macchina lavabiancheria di tipo modulare
WO1990005525A1 (fr) 1988-11-23 1990-05-31 Pfizer Inc. Derives de quinuclidine en tant qu'antagonsites de substance p
US5232929A (en) 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5081122A (en) 1990-03-05 1992-01-14 Sterling Drug Inc. Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof
US5112820A (en) 1990-03-05 1992-05-12 Sterling Drug Inc. Anti-glaucoma compositions containing 2- and 3-aminomethyl-6-arylcarbonyl- or 6-phenylthio-2,3-dihydropyrrolo-(1,2,3-de)-1,4-benzoxazines and method of use thereof
US5013837A (en) 1990-03-08 1991-05-07 Sterling Drug Inc. 3-Arylcarbonyl-1H-indole-containing compounds
US4973587A (en) 1990-03-08 1990-11-27 Sterling Drug Inc. 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method
DE69220258T2 (de) 1991-02-11 1997-12-18 Merck Sharp & Dohme Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
JPH082901B2 (ja) 1991-03-01 1996-01-17 ファイザー・インコーポレーテッド １−アザビシクロ［３．２．２ノナン−３−アミン誘導体類
EP0600952B1 (fr) 1991-08-20 1996-04-17 MERCK SHARP & DOHME LTD. Composes azacycliques, procedes de preparation et compositions pharmaceutiques les contenant
GB9211193D0 (en) 1992-05-27 1992-07-08 Merck Sharp & Dohme Therapeutic agents
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5637699A (en) 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US5387595A (en) 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
US5536716A (en) 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
US5292736A (en) 1993-02-26 1994-03-08 Sterling Winthrop Inc. Morpholinoalkylindenes as antiglaucoma agents
US5496833A (en) 1993-04-13 1996-03-05 Merck Sharp & Dohme Limited Piperidine tachykinin receptor antagonists
CZ137297A3 (cs) 1994-11-07 1998-04-15 Pfizer Inc. Substituované benzylaminové deriváty
US5532237A (en) 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
US6194581B1 (en) 1995-04-07 2001-02-27 Merck & Co., Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5831115A (en) 1995-04-21 1998-11-03 Abbott Laboratories Inhibitors of squalene synthase and protein farnesyltransferase
US5739106A (en) 1995-06-07 1998-04-14 Rink; Timothy J. Appetite regulating compositions
FR2741621B1 (fr) 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
AU7692696A (en) 1995-12-01 1997-06-27 Novartis Ag Heteroaryl derivatives
AU1328197A (en) 1995-12-01 1997-06-19 Synaptic Pharmaceutical Corporation Aryl sulfonamide and sulfamide derivatives and uses thereof
WO1997020823A2 (fr) 1995-12-01 1997-06-12 Novartis Ag Antagonistes de recepteurs
WO1997020820A1 (fr) 1995-12-01 1997-06-12 Novartis Ag Composes heteroaryles
WO1997020822A1 (fr) 1995-12-01 1997-06-12 Novartis Ag Quinazolin-2,4-diazirines en tant qu'antagoniste du recepteur du neuropeptide y
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
WO1997028149A1 (fr) 1996-02-02 1997-08-07 Merck & Co., Inc. Procede pour augmenter les niveaux de cholesterol hdl
AU1618697A (en) 1996-02-06 1997-08-28 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
GB9606805D0 (en) 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
AU5135998A (en) 1996-12-03 1998-06-29 Banyu Pharmaceutical Co., Ltd. Novel urea derivatives
WO1998025907A1 (fr) 1996-12-12 1998-06-18 Banyu Pharmaceutical Co., Ltd. Derives de pyrazole
US6166038A (en) 1996-12-13 2000-12-26 Banyu Pharmaceutical Co., Ltd. Aminopyrazole derivatives
WO1998027063A1 (fr) 1996-12-16 1998-06-25 Banyu Pharmaceutical Co., Ltd. Derives d'aminopyrazole
ES2213892T3 (es) 1997-01-21 2004-09-01 Smithkline Beecham Corporation Nuevos moduladores del receptor de canabinoides.
KR100510794B1 (ko) 1997-02-04 2005-08-31 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 살진균 카르복스아미드
BRPI9807848B8 (pt) 1997-02-21 2016-05-31 Bayer Schering Pharma Ag compostos de arilsulfonamidas e análogos, bem como composição farmacêutica e uso dos mesmos.
WO1998040356A1 (fr) 1997-03-12 1998-09-17 Banyu Pharmaceutical Co., Ltd. Medicaments contenant des derives d'aminopyridine comme ingredient actif
EP0979228A4 (fr) 1997-03-18 2000-05-03 Smithkline Beecham Corp Nouveaux agonistes de recepteurs de cannabinoides
FR2761265B1 (fr) 1997-03-28 1999-07-02 Sanofi Sa Composition pharmaceutique pour l'administration orale d'un derive du n-piperidino-3-pyrazolecarboxamide, de ses sels et de leurs solvates
FR2761266B1 (fr) 1997-03-28 1999-07-02 Sanofi Sa Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates
WO1998047505A1 (fr) 1997-04-23 1998-10-29 Banyu Pharmaceutical Co., Ltd. Antagoniste de recepteur de neuropeptide y
US6001836A (en) 1997-05-28 1999-12-14 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: cyanoguanidine derivatives
WO1999002499A1 (fr) 1997-07-11 1999-01-21 Japan Tobacco Inc. Composes quinoline et utilisations de ceux-ci en medecine
AU9185598A (en) 1997-09-25 1999-04-12 Banyu Pharmaceutical Co., Ltd. Novel neuropeptide y receptor antagonists
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
WO1999027965A1 (fr) 1997-11-28 1999-06-10 Banyu Pharmaceutical Co., Ltd. Agents anti-hyperlipemiques
US6174901B1 (en) 1998-12-18 2001-01-16 Amgen Inc. Substituted pyridine and pyridazine compounds and methods of use
EP1068207A1 (fr) 1998-04-02 2001-01-17 Neurogen Corporation DERIVES AMINOALKYLE SUBSTITUES DE 9H-PYRIDINO 2,3-b]INDOLE ET 9H-PYRIMIDINO 4,5-b]INDOLE
ID26128A (id) 1998-04-29 2000-11-23 Ortho Mcneil Pharm Inc Senyawa-senyawa aminotetralin tersubstitusi-n sebagai ligan-ligan untuk reseptor neupeptida y y5 yang bermanfaat dalam pengobatan obesitas dan gangguan-gangguan lain
US6329395B1 (en) 1998-06-08 2001-12-11 Schering Corporation Neuropeptide Y5 receptor antagonists
DE19837627A1 (de) 1998-08-19 2000-02-24 Bayer Ag Neue Aminosäureester von Arylsulfonamiden und Analoga
HN1998000027A (es) 1998-08-19 1999-06-02 Bayer Ip Gmbh Arilsulfonamidas y analagos
US6358951B1 (en) 1998-08-21 2002-03-19 Pfizer Inc. Growth hormone secretagogues
US6337332B1 (en) 1998-09-17 2002-01-08 Pfizer Inc. Neuropeptide Y receptor antagonists
ES2255330T3 (es) 1998-11-10 2006-06-16 MERCK & CO., INC. Espiroindolinas como antagonistas del receptor y5.
RU2236402C2 (ru) * 1999-02-24 2004-09-20 Ф.Хоффманн-Ля Рош Аг Производные 3-фенилпиридина и фармацевтическая композиция на их основе
CA2371274A1 (fr) 1999-04-22 2000-11-02 Synaptic Pharmaceutical Corporation Antagonistes selectifs npy (y5)
US6340683B1 (en) 1999-04-22 2002-01-22 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (triazines)
WO2000068197A1 (fr) 1999-05-05 2000-11-16 Ortho-Mcneil Pharmaceutical, Inc. LIGANDS DE RECEPTEURS DU NEUROPEPTIDE Y DERIVES DE 3a,4,5,9b-TETRAHYDRO-1H-BENZ[e]INDOL-2-YL AMINE, UTILISES POUR LE TRAITEMENT DE L'OBESITE ET D'AUTRES ETATS PATHOLOGIQUES
ATE306481T1 (de) 1999-05-12 2005-10-15 Ortho Mcneil Pharm Inc Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen
ES2250126T3 (es) 1999-06-30 2006-04-16 H. Lundbeck A/S Antagonistas selectivos del npy(y5).
AU6000900A (en) 1999-07-23 2001-02-13 Astrazeneca Uk Limited Carbazole derivatives and their use as neuropeptide y5 receptor ligands
NZ516782A (en) 1999-07-28 2004-12-24 Ortho Mcneil Pharm Inc Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders
TWI279402B (en) 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
US6462053B1 (en) 1999-08-20 2002-10-08 Banyu Pharmaceutical Co., Ltd. Spiro compounds
AU7315800A (en) 1999-09-20 2001-04-24 Takeda Chemical Industries Ltd. Mch antagonists
CA2386474A1 (fr) 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
PL354675A1 (en) 1999-09-30 2004-02-09 Neurogen Corporation Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
AU7738000A (en) 1999-09-30 2001-04-30 Neurogen Corporation Certain alkylene diamine-substituted heterocycles
CZ20021089A3 (cs) 1999-09-30 2002-11-13 Neurogen Corporation Aminosustituované pyrazolo[1,5-a]-1,5-pyrimidiny a pyrazolo[1,5-a]-1,3,5-triaziny
SK8452002A3 (en) 1999-12-16 2002-11-06 Schering Corp Substituted 4-(phenyl or pyridyl)imidazole derivatives, pharmaceutical composition comprising the same and use thereof
AU2001228325A1 (en) 2000-02-01 2001-08-14 Novo-Nordisk A/S Use of compounds for the regulation of food intake
US6653304B2 (en) 2000-02-11 2003-11-25 Bristol-Myers Squibb Co. Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
US7064142B2 (en) 2000-02-22 2006-06-20 Banyu Pharmaceutical, Co., Ltd. Imidazonline compounds
US6531478B2 (en) 2000-02-24 2003-03-11 Cheryl P. Kordik Amino pyrazole derivatives useful for the treatment of obesity and other disorders
FR2805818B1 (fr) 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
FR2805817B1 (fr) 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
FR2805810B1 (fr) 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation
EP1132389A1 (fr) 2000-03-06 2001-09-12 Vernalis Research Limited Nouveaux dérivés de l'azaindole pour le traitement de l'obésité
EP1142886A1 (fr) 2000-04-07 2001-10-10 Aventis Pharma Deutschland GmbH Percyquinine, procédé pour sa production et son utilisation comme produit pharmaceutique
EP1285651B1 (fr) 2000-04-28 2010-09-01 Takeda Pharmaceutical Company Limited Antagonistes de l'hormone concentrant la melanine
GB0010757D0 (en) 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
GB0011013D0 (en) 2000-05-09 2000-06-28 Astrazeneca Ab Chemical compounds
US6444675B2 (en) 2000-05-10 2002-09-03 Bristol-Myers Squibb Company 4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists
US6432960B2 (en) 2000-05-10 2002-08-13 Bristol-Myers Squibb Company Squarate derivatives of dihydropyridine NPY antagonists
US6479482B2 (en) 2000-05-10 2002-11-12 Bristol-Myers Squibb Company Alkylamine derivatives of dihydropyridine NPY antagonists
CN1244561C (zh) 2000-05-11 2006-03-08 布里斯托尔-迈尔斯斯奎布公司 可用作生长激素促分泌素的四氢异喹啉类似物
CA2408913A1 (fr) 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
AU2001259056A1 (en) 2000-05-17 2001-11-26 Eli Lilly And Company Method for selectively inhibiting ghrelin action
US6391881B2 (en) 2000-05-19 2002-05-21 Bristol-Myers Squibb Company Thiourea derivatives of dihydropyridine NPY antagonists
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
AU783403B2 (en) 2000-07-05 2005-10-20 H. Lundbeck A/S Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
AU2001279294A1 (en) 2000-07-06 2002-01-21 Neurogen Corporation Melanin concentrating hormone receptor ligands
CA2416643A1 (fr) 2000-07-24 2002-01-31 Ardana Bioscience Limited Antagonistes de la ghreline
DE60113865T2 (de) 2000-07-31 2006-07-20 Vernalis Research Ltd., Winnersh Piperazin derivate
CN1474810A (zh) 2000-09-14 2004-02-11 ���鹫˾ 取代脲,神经肽yy5受体拮抗剂
ATE270280T1 (de) 2000-10-13 2004-07-15 Lilly Co Eli Substituierte dipeptide zur förderung der sekretion von wachstumshormon
ATE403647T1 (de) 2000-10-16 2008-08-15 Hoffmann La Roche Indolinderivate und deren verwendung als 5-ht2 rezeptor liganden
WO2002036596A2 (fr) 2000-11-03 2002-05-10 Wyeth Cycloalkyl[b][1,4]diazepino[6,7,1-hi]indoles et derives
JP4204315B2 (ja) 2000-11-20 2009-01-07 ビオヴィトルム・アクチボラゲット（プブリクト） セロトニン５−ｈｔ２レセプターのアンタゴニストとしてのピペラジニルピラジン化合物
NZ525700A (en) 2000-11-20 2004-12-24 Biovitrum Ab Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5HT-2 receptor
WO2002048152A2 (fr) 2000-12-12 2002-06-20 Neurogen Corporation Spiro[isobenzofuran-1,4'-piperidine]-3-ones et 3h-spiroisobenzofuran-1,4'-piperidines
GB0030710D0 (en) 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
AU2002234056B2 (en) 2000-12-21 2005-04-07 Schering Corporation Heteroaryl urea neuropeptide Y Y5 receptor antagonists
IL155772A0 (en) 2000-12-22 2003-12-23 Schering Corp Piperidine mch antagonists and their use in the treatment of obesity
ES2291374T3 (es) 2000-12-27 2008-03-01 F. Hoffmann-La Roche Ag Derivados de indol y su empleo como ligandos receptores de 5-ht2b y 5-ht2c.
BR0206831A (pt) 2001-02-02 2004-07-06 Takeda Chemical Industries Ltd Composto, cristal, agente farmacêutico, agentes para profilaxia ou tratamento de diabetes, de complicações diabéticas, de tolerância prejudicada à glucose e de obesidade, inibidor de peptidase, uso de um composto, e, método de produção de um composto
NZ527680A (en) 2001-03-21 2005-07-29 Pharmacopeia Drug Discovery Aryl and biaryl compounds having MCH modulatory activity
US6900329B2 (en) 2001-03-21 2005-05-31 Schering Corporation MCH antagonists and their use in the treatment of obesity
EP1373216B1 (fr) 2001-03-22 2004-12-15 Solvay Pharmaceuticals B.V. Derives de 4,5-dihydro-1h-pyrazole ayant une activite d'antagoniste de cb 1
US6573287B2 (en) 2001-04-12 2003-06-03 Bristo-Myers Squibb Company 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
CA2443672C (fr) 2001-04-12 2011-03-29 Pharmacopeia, Inc. Aryl et biaryl piperidines utilisees en tant qu'antagonistes de la mch
FR2824825B1 (fr) 2001-05-15 2005-05-06 Servier Lab Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002094825A1 (fr) 2001-05-22 2002-11-28 Banyu Pharmaceutical Co., Ltd. Nouveau derive de spiropiperidine
EP1389189A2 (fr) 2001-05-22 2004-02-18 Neurogen Corporation Ligands recepteurs de l'hormone de concentration de la melanine: analogues de 1-benzyl-4-aryl piperazine substituee
AU2002310465B2 (en) 2001-06-20 2006-06-15 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
US7098239B2 (en) 2001-06-20 2006-08-29 Merck & Co., Inc Dipeptidyl peptidase inhibitors for the treatment of diabetes
GB0115517D0 (en) 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
PL367527A1 (en) 2001-06-27 2005-02-21 Smithkline Beecham Corporation Fluoropyrrolidines as dipeptidyl peptidase inhibitors
CN1471538A (zh) 2001-06-27 2004-01-28 前体生物药物股份有限公司 用于竞争性调节二肽基肽酶iv催化的肽结构
WO2003002553A2 (fr) 2001-06-27 2003-01-09 Smithkline Beecham Corporation Fluoropyrrolidines inhibitrices de la dipeptidyl peptidase
US7196201B2 (en) 2001-06-27 2007-03-27 Smithkline Beecham Corporation Pyrrolidines as dipeptidyl peptidase inhibitors
ATE388951T1 (de) 2001-07-03 2008-03-15 Novo Nordisk As Dpp-iv-inhibierende purin-derivative zur behandlung von diabetes
JP2004536104A (ja) 2001-07-05 2004-12-02 シナプティック・ファーマスーティカル・コーポレーション Ｍｃｈ選択的アンタゴニストとしての置換されたアニリン−ピペリジン誘導体
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
AU2002319627A1 (en) 2001-07-20 2003-03-03 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
BRPI0104510B8 (pt) 2001-07-27 2021-05-25 Embrapa Pesquisa Agropecuaria peptídeos antibióticos da família das phylloseptinas isolados da secreção da pele de phylloseptina hypocondrialis e composição antimicrobiana relacionada
IL160139A0 (en) 2001-08-07 2004-06-20 Banyu Pharma Co Ltd Spiro compounds
GB0126292D0 (en) 2001-11-01 2002-01-02 Smithkline Beecham Plc Compounds
GB0130341D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
JP2005320249A (ja) 2002-05-01 2005-11-17 Banyu Pharmaceut Co Ltd ２−アミノピラジン誘導体の製造方法
AR040241A1 (es) 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US6869966B2 (en) 2002-09-30 2005-03-22 Banyu Pharmaceutical Co., Ltd. N-substituted-2-oxodihydropyridine derivatives
US20040116479A1 (en) 2002-10-04 2004-06-17 Fortuna Haviv Method of inhibiting angiogenesis
MY134457A (en) 2002-11-22 2007-12-31 Merck & Co Inc Substituted amides
JO2397B1 (en) 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
JP3939744B2 (ja) 2003-06-11 2007-07-04 メルク エンド カムパニー インコーポレーテッド 置換３−アルキルおよび３−アルケニルアゼチジン誘導体
EP1669348A4 (fr) 2003-09-30 2009-03-11 Eisai R&D Man Co Ltd Agent antifongique a compose heterocyclique
HUP0400405A3 (en) 2004-02-10 2009-03-30 Sanofi Synthelabo Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
JP2007524682A (ja) 2004-02-12 2007-08-30 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体−５の調節物質としてのビピリジルアミド
DK1868998T3 (en) 2005-04-01 2016-08-29 Vfp Therapies NEW HETEROCYCLIC COMPOUNDS, MANUFACTURING THEM, AND USE THEREOF AS MEDICINES, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS
JP2008538361A (ja) 2005-04-12 2008-10-23 メルク エンド カムパニー インコーポレーテッド アミドプロポキシフェニルオレキシン受容体アンタゴニスト
WO2007011760A2 (fr) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibiteurs de la kinesine mitotique
EP1954276A2 (fr) 2005-11-22 2008-08-13 Merck & Co., Inc. Antagonistes des recepteurs de l'indole orexine
US20080214301A1 (en) 2007-03-02 2008-09-04 Wildtangent, Inc. In-game advertisements
JP2010520206A (ja) * 2007-03-02 2010-06-10 メルク・シャープ・エンド・ドーム・コーポレイション ビピリジンカルボキサミドオレキシン受容体アンタゴニスト
EP2131839A2 (fr) 2007-03-02 2009-12-16 Northwestern University Compositions et traitements pour des troubles liés à des crises
AU2008285795A1 (en) 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as TAAR1 ligands
WO2009020642A1 (fr) * 2007-08-09 2009-02-12 Merck & Co., Inc. Antagonistes de récepteurs d'orexine au pyridinecarboxamide
AR072899A1 (es) 2008-08-07 2010-09-29 Merck Sharp & Dohme Derivados de terpiridina-carboxamida antagonistas de receptores de orexina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del insomnio y la obesidad.
WO2010051238A1 (fr) 2008-10-30 2010-05-06 Merck Sharp & Dohme Corp. Antagonistes des récepteurs de l’orexine à base de pyridazine-carboxamide
CA2741648A1 (fr) * 2008-10-30 2010-05-06 Merck Sharp & Dohme Corp. Antagonistes carboxamide phenyl 2,5-disubstitue du recepteur de l'orexine
WO2010141275A1 (fr) 2009-06-01 2010-12-09 Merck Sharp & Dohme Corp. Pyrazine carboxamide antagonistes du récepteur de l'orexine

Also Published As

Publication number Publication date
CN102272103B (zh) 2015-10-21
JP5635991B2 (ja) 2014-12-03
ECSP11011019A (es) 2011-05-31
IL212436A0 (en) 2011-06-30
CN102272103A (zh) 2011-12-07
WO2010051236A1 (fr) 2010-05-06
NZ592544A (en) 2013-01-25
US20110201591A1 (en) 2011-08-18
US8592457B2 (en) 2013-11-26
EA201170624A1 (ru) 2011-12-30
EP2350010A1 (fr) 2011-08-03
PE20110852A1 (es) 2011-11-25
BRPI0919876A8 (pt) 2016-02-10
AU2009308980B2 (en) 2013-02-28
CA2741644A1 (fr) 2010-05-06
CL2011000976A1 (es) 2012-02-24
AU2009308980A1 (en) 2010-05-06
KR20110071101A (ko) 2011-06-28
JP2012507538A (ja) 2012-03-29
EP2350010B1 (fr) 2014-03-26
MX2011004551A (es) 2011-05-25
CR20110228A (es) 2011-06-24
TN2011000171A1 (en) 2012-12-17
CA2741644C (fr) 2013-05-07
CO6361994A2 (es) 2012-01-20
DOP2011000120A (es) 2011-10-15
KR101320245B1 (ko) 2013-10-30
BRPI0919876A2 (pt) 2015-08-18
ZA201103156B (en) 2012-01-25
NI201100084A (es) 2011-11-03

Similar Documents

Publication Publication Date Title
MA32804B1 (fr) Antagonistes d'isonicotinamide des récepteurs de l'orexine
MA31016B1 (fr) Composes de diazepan substitues comme antagonistes des recepteurs de l'orexine.
MA31451B1 (fr) Antagonistes des recepteurs de l'orexine de pyridyl piperidine.
DK2049529T3 (da) Substituerede diazepan-orexin-receptor- antagonister
WO2008008551A3 (fr) Prolines bis-amides substituées en 2 antagonistes du récepteur de l'oréxine
MA30462B1 (fr) Composes de pyridylamide antagonistes des canaux calciques de type t
WO2007126935A3 (fr) Antagonistes des récepteurs de l'orexine sous forme de composés diazépane
WO2007126934A3 (fr) Antagonistes des récepteurs de l'orexine sous forme de composés amidoéthylthioéther
WO2008008517A3 (fr) Diazépans pontés antagonistes du récepteur de l'oréxine
WO2007061763A3 (fr) Antagonistes des recepteurs de l’indole orexine
UA100974C2 (ru) Соединения замещенных диазепанов как антагонисты орексиновых рецепторов
MA30340B1 (fr) Nouveaux composes
WO2007025069A3 (fr) Diazaspirodecane utilise comme antagonistes de recepteurs d'orexine
NO20070347L (no) Modulatorer av alfa7 nikotinske acetylkolinreseptorer og terapeutiske anvendelser
MA30077B1 (fr) 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de chimiokines
MA30539B1 (fr) Derives de piperazinyle utiles dans le traitement de maladies induites par le recepteur gpr38.
MA33753B1 (fr) Nouveaux camphènes arylés, procédés de préparation et utilisations de ceux-ci
WO2007019234A3 (fr) Antagonistes des recepteurs d'orexine a base de sulfamide d'aminoethane
MA29625B1 (fr) Immunoglobulines
TNSN08275A1 (fr) 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de chimiokines