MA28038A1 - Thienopyrazoles - Google Patents
ThienopyrazolesInfo
- Publication number
- MA28038A1 MA28038A1 MA28871A MA28871A MA28038A1 MA 28038 A1 MA28038 A1 MA 28038A1 MA 28871 A MA28871 A MA 28871A MA 28871 A MA28871 A MA 28871A MA 28038 A1 MA28038 A1 MA 28038A1
- Authority
- MA
- Morocco
- Prior art keywords
- thienopyrazoles
- modulable
- itk
- inhibition
- compounds
- Prior art date
Links
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Les thiénopyrazoles, leur préparation, les compositions pharmaceutiques comprenant ces composés, et leurs utilisations pharmaceutiques dans le traitement d'états pathologiques modulables par l'inhibition des protéines kinases, en particulier de la tyrosine kinase inductible par l'interleukine-2 (ITK).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50115903P | 2003-09-08 | 2003-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA28038A1 true MA28038A1 (fr) | 2006-07-03 |
Family
ID=34312256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28871A MA28038A1 (fr) | 2003-09-08 | 2006-03-13 | Thienopyrazoles |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7518000B2 (fr) |
| JP (1) | JP4879739B2 (fr) |
| KR (1) | KR20060069490A (fr) |
| CN (1) | CN100398545C (fr) |
| AT (1) | ATE468341T1 (fr) |
| AU (1) | AU2004272507B2 (fr) |
| BR (1) | BRPI0414215A (fr) |
| CA (1) | CA2538032C (fr) |
| CR (1) | CR8255A (fr) |
| DE (1) | DE602004027288D1 (fr) |
| DK (1) | DK1682553T3 (fr) |
| EC (1) | ECSP066411A (fr) |
| ES (1) | ES2345257T3 (fr) |
| HR (1) | HRP20100398T1 (fr) |
| IL (1) | IL173916A (fr) |
| MA (1) | MA28038A1 (fr) |
| ME (1) | MEP20908A (fr) |
| MX (1) | MXPA06001827A (fr) |
| MY (1) | MY144339A (fr) |
| NO (1) | NO20061626L (fr) |
| NZ (1) | NZ545421A (fr) |
| OA (1) | OA13252A (fr) |
| PT (1) | PT1682553E (fr) |
| RS (2) | RS51846B (fr) |
| RU (1) | RU2358978C2 (fr) |
| TN (1) | TNSN06058A1 (fr) |
| TW (1) | TWI352705B (fr) |
| WO (1) | WO2005026175A1 (fr) |
| ZA (1) | ZA200601947B (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006101454A1 (fr) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Derives du benzothiophene: preparation et applications pharmaceutiques |
| EP1968580A2 (fr) * | 2005-12-20 | 2008-09-17 | Boehringer Ingelheim International Gmbh | Derivés 2-(1h-thieno [3,2-c] pyrazol-3yl)-1h-indol et composés similaires en tant que inhibiteurs de la kinase tec pour le traitement de inflammations et maladies immunologiques |
| EP2151434A1 (fr) | 2008-08-05 | 2010-02-10 | Institut Pasteur | Alkoxypyrazoles et leur procédé de préparation |
| EP2151433A1 (fr) | 2008-08-05 | 2010-02-10 | Institut Pasteur | Alkoxypyrazoles et leur procédé de préparation |
| US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
| US20130158066A1 (en) * | 2011-12-20 | 2013-06-20 | Hoffmann-La Roche Inc. | 4-azaindole inhibitors of crac |
| WO2013153539A1 (fr) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Composés tricycliques à titre d'inhibiteurs de kinases tec |
| CN103467481B (zh) * | 2012-06-07 | 2016-08-31 | 上海汇伦生命科技有限公司 | 二氢吡啶类化合物、其组合物、制备方法和用途 |
| TW201414734A (zh) | 2012-07-10 | 2014-04-16 | Takeda Pharmaceutical | 氮雜吲哚衍生物 |
| WO2014041518A1 (fr) * | 2012-09-14 | 2014-03-20 | Glenmark Pharmaceuticals S.A. | Composés thiénopyrrole comme inhibiteurs de l'itk |
| CN103720694A (zh) * | 2012-10-11 | 2014-04-16 | 韩冰 | 一类治疗脑性瘫痪的化合物及其用途 |
| CN103772391A (zh) * | 2012-10-23 | 2014-05-07 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| KR101571590B1 (ko) * | 2012-11-21 | 2015-11-25 | 주식회사 두산 | 유기 화합물 및 이를 이용하는 유기 전계 발광 소자 |
| MX392373B (es) | 2013-10-25 | 2025-03-24 | Pharmacyclics Llc | Uso de ibrutinib en el tratamiento de enfermedad injerto contra huesped cronica |
| US9371321B2 (en) | 2014-01-09 | 2016-06-21 | Astrazeneca Ab | Azaindole derivatives |
| WO2016010108A1 (fr) * | 2014-07-18 | 2016-01-21 | 塩野義製薬株式会社 | Dérivés hétérocycliques contenant de l'azote et compositions médicinales le contenant |
| CN108135904A (zh) | 2015-08-31 | 2018-06-08 | 药品循环有限责任公司 | 用于治疗多发性骨髓瘤的btk抑制剂组合 |
| WO2018085731A2 (fr) | 2016-11-03 | 2018-05-11 | Juno Therapeutics, Inc. | Polythérapie de type thérapie cellulaire t et inhibiteur de btk |
| EP3787751A1 (fr) | 2018-05-03 | 2021-03-10 | Juno Therapeutics, Inc. | Polythérapie d'une thérapie par lymphocytes t à récepteur antigénique chimérique (car) et d'un inhibiteur de btk |
| WO2023139248A1 (fr) * | 2022-01-21 | 2023-07-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Inhibiteurs de thioestérases de protéine acyle contre des infections microbiennes |
| WO2023220655A1 (fr) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Méthodes pour surmonter la résistance aux médicaments par ré-sensibilisation de cellules cancéreuses à un traitement avec une thérapie antérieure par l'intermédiaire d'un traitement avec une thérapie par lymphocytes t |
| WO2024123175A1 (fr) | 2022-12-06 | 2024-06-13 | Erasmus University Medical Center Rotterdam | Compositions pour le traitement de cancers résistants à la thérapie par blocage de point de contrôle immunitaire |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679683A (en) * | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| US6462036B1 (en) * | 1998-11-06 | 2002-10-08 | Basf Aktiengesellschaft | Tricyclic pyrazole derivatives |
| US6297238B1 (en) * | 1999-04-06 | 2001-10-02 | Basf Aktiengesellschaft | Therapeutic agents |
| NZ516348A (en) * | 1999-06-23 | 2003-06-30 | Aventis Pharma Gmbh | Substituted benzimidazole |
| YU54202A (sh) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| US7101884B2 (en) * | 2001-09-14 | 2006-09-05 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP1441725A1 (fr) * | 2001-10-26 | 2004-08-04 | Aventis Pharmaceuticals Inc. | Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases |
| FR2831536A1 (fr) * | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
-
2004
- 2004-07-23 ME MEP-209/08A patent/MEP20908A/xx unknown
- 2004-07-23 RU RU2006111470/04A patent/RU2358978C2/ru not_active IP Right Cessation
- 2004-07-23 MX MXPA06001827A patent/MXPA06001827A/es active IP Right Grant
- 2004-07-23 TW TW093122172A patent/TWI352705B/zh active
- 2004-07-23 AU AU2004272507A patent/AU2004272507B2/en not_active Ceased
- 2004-07-23 RS RS20060162A patent/RS51846B/sr unknown
- 2004-07-23 KR KR1020067004795A patent/KR20060069490A/ko not_active Abandoned
- 2004-07-23 OA OA1200600080A patent/OA13252A/en unknown
- 2004-07-23 RS YUP-2006/0162A patent/RS20060162A/sr unknown
- 2004-07-23 JP JP2006525328A patent/JP4879739B2/ja not_active Expired - Fee Related
- 2004-07-23 CN CNB2004800257424A patent/CN100398545C/zh not_active Expired - Fee Related
- 2004-07-23 CA CA2538032A patent/CA2538032C/fr not_active Expired - Fee Related
- 2004-07-23 NZ NZ545421A patent/NZ545421A/en not_active IP Right Cessation
- 2004-07-23 ES ES04779049T patent/ES2345257T3/es not_active Expired - Lifetime
- 2004-07-23 DK DK04779049.8T patent/DK1682553T3/da active
- 2004-07-23 WO PCT/US2004/023814 patent/WO2005026175A1/fr not_active Ceased
- 2004-07-23 PT PT04779049T patent/PT1682553E/pt unknown
- 2004-07-23 HR HR20100398T patent/HRP20100398T1/hr unknown
- 2004-07-23 BR BRPI0414215-2A patent/BRPI0414215A/pt not_active IP Right Cessation
- 2004-07-23 DE DE602004027288T patent/DE602004027288D1/de not_active Expired - Lifetime
- 2004-07-23 MY MYPI20042959A patent/MY144339A/en unknown
- 2004-07-23 AT AT04779049T patent/ATE468341T1/de active
-
2006
- 2006-02-15 TN TNP2006000058A patent/TNSN06058A1/en unknown
- 2006-02-23 IL IL173916A patent/IL173916A/en not_active IP Right Cessation
- 2006-02-23 CR CR8255A patent/CR8255A/es not_active Application Discontinuation
- 2006-03-06 US US11/368,566 patent/US7518000B2/en not_active Expired - Fee Related
- 2006-03-06 EC EC2006006411A patent/ECSP066411A/es unknown
- 2006-03-07 ZA ZA200601947A patent/ZA200601947B/en unknown
- 2006-03-13 MA MA28871A patent/MA28038A1/fr unknown
- 2006-04-10 NO NO20061626A patent/NO20061626L/no not_active Application Discontinuation
-
2009
- 2009-03-26 US US12/411,818 patent/US7928231B2/en not_active Expired - Fee Related
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