[go: up one dir, main page]

MA29213B1 - Quinolones a substitution macrolones - amino - Google Patents

Quinolones a substitution macrolones - amino

Info

Publication number
MA29213B1
MA29213B1 MA29930A MA29930A MA29213B1 MA 29213 B1 MA29213 B1 MA 29213B1 MA 29930 A MA29930 A MA 29930A MA 29930 A MA29930 A MA 29930A MA 29213 B1 MA29213 B1 MA 29213B1
Authority
MA
Morocco
Prior art keywords
macrolones
quinolones
substitution
amino
medicine
Prior art date
Application number
MA29930A
Other languages
English (en)
Inventor
Desmond John Best
John Stephen Elder
Andrea Fajdetic
Andrew Keith Forrest
Robert John Sheppard
Original Assignee
Glaxosmithkline Zagreb
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb, Glaxo Group Ltd filed Critical Glaxosmithkline Zagreb
Publication of MA29213B1 publication Critical patent/MA29213B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSÉS DE FORMULE (I) OU DES DÉRIVÉS ACCEPTABLES SUR LE PLAN PHARMACEUTIQUE DE CEUX-CI POSSÉDANT UNE ACTIVITÉ ANTI-MICROBIENNE, DES PROCÉDÉS DE PRÉPARATION DE CEUX-CI, DES COMPOSTIONS RENFERMANT CEUX-CI ET L'UTILISATION DE CEUX-CI EN MÉDECINE.
MA29930A 2004-11-11 2007-05-22 Quinolones a substitution macrolones - amino MA29213B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0424959A GB0424959D0 (en) 2004-11-11 2004-11-11 Novel compounds

Publications (1)

Publication Number Publication Date
MA29213B1 true MA29213B1 (fr) 2008-02-01

Family

ID=33523587

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29930A MA29213B1 (fr) 2004-11-11 2007-05-22 Quinolones a substitution macrolones - amino

Country Status (19)

Country Link
US (2) US7718621B2 (fr)
EP (1) EP1824870A1 (fr)
JP (1) JP2008519788A (fr)
KR (1) KR20070085919A (fr)
CN (1) CN101098881A (fr)
AR (1) AR053311A1 (fr)
AU (1) AU2005303961A1 (fr)
BR (1) BRPI0517792A (fr)
CA (1) CA2587413A1 (fr)
GB (1) GB0424959D0 (fr)
IL (1) IL182978A0 (fr)
MA (1) MA29213B1 (fr)
MX (1) MX2007005776A (fr)
NO (1) NO20072939L (fr)
PE (1) PE20061137A1 (fr)
RU (1) RU2007121581A (fr)
TW (1) TW200630378A (fr)
WO (1) WO2006050942A1 (fr)
ZA (1) ZA200703603B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1638549A4 (fr) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc Nouveaux agents antibacteriens
EP1879904A1 (fr) * 2005-05-10 2008-01-23 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Macrolides a liaison aminee 4" destines au traitement d'infections microbiennes
EP1951735A1 (fr) * 2005-11-09 2008-08-06 Glaxo Group Limited Nouveau dérivé 4*substitué d' érythromycine
EP1945652A1 (fr) * 2005-11-09 2008-07-23 Glaxo Group Limited Macrolones
JP5461405B2 (ja) 2007-09-14 2014-04-02 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子の調節因子
US9453042B2 (en) 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (fr) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Méthodes de traitement du paludisme, de la tuberculose et des maladies à complexe mycobacterium avium (mac)
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
IN2014DN08939A (fr) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
CA2905975A1 (fr) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Procedes pour traiter des maladies respiratoires et formulations pour la mise en oeuvre de ceux-ci
EP2968384A4 (fr) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Procédés convergents de préparation d'agents antibactériens macrolides
CN106589023A (zh) * 2016-11-22 2017-04-26 宜昌东阳光药业股份有限公司 一种罗红霉素杂质及其合成方法
WO2018178041A1 (fr) 2017-03-30 2018-10-04 F. Hoffmann-La Roche Ag Nouveaux composés pyrido[2,3-b]indole pour le traitement et la prophylaxie d'une infection bactérienne

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
GB0127349D0 (en) * 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
GB0225384D0 (en) * 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
ZA200703603B (en) 2008-07-30
BRPI0517792A (pt) 2008-10-21
GB0424959D0 (en) 2004-12-15
NO20072939L (no) 2007-08-08
TW200630378A (en) 2006-09-01
CN101098881A (zh) 2008-01-02
US7718621B2 (en) 2010-05-18
WO2006050942A1 (fr) 2006-05-18
PE20061137A1 (es) 2006-12-13
RU2007121581A (ru) 2008-12-20
CA2587413A1 (fr) 2006-05-18
KR20070085919A (ko) 2007-08-27
MX2007005776A (es) 2007-07-16
AR053311A1 (es) 2007-05-02
AU2005303961A1 (en) 2006-05-18
IL182978A0 (en) 2007-08-19
EP1824870A1 (fr) 2007-08-29
US20080269146A1 (en) 2008-10-30
JP2008519788A (ja) 2008-06-12
US20080090773A1 (en) 2008-04-17

Similar Documents

Publication Publication Date Title
MA29213B1 (fr) Quinolones a substitution macrolones - amino
MA27427A1 (fr) Composes de benzimidazole-1-yl-thiophene utilises en cancerotherapie
TNSN07145A1 (fr) Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
MA30207B1 (fr) Modulateurs des recepteurs de la progesterone a base d'indole sulfonamide
MA29550B1 (fr) Derives de n- (pyridine-2-yl) - sulfonamide
NO20042596L (no) Inbibitorer av 11-beta-hydroksy steroid dehydrogenase type 1
MA27692A1 (fr) Composes derives de benzoxazinone, leur preparation et utilisation comme medicaments
MA31142B1 (fr) Derives heteroaryles de pyrrolidinyl et piperdinyl cetones.
MA30717B1 (fr) Derives de pyridin-3-yle en tant qu'agents immunomodulateurs
MA30718B1 (fr) Derives de pyridin-4-yle en tant qu'agents immunomodulateurs.
MA27596A1 (fr) Derives d'heteroarylamides benzocondenses de thienopyridines utiles comme agents therapeutiques, compositions pharmaceutiques les contenant et methodes pour leur utilisation
MA30231B1 (fr) Derives de benzamides et d'heteroarenes
ATE452129T1 (de) N-phenyl-2-pyrimidine-amine derivatives
MA34655B1 (fr) Dérivés de 2,3- dihydroimidazo[1,2-c]quinazoléine substitués par un aminoalcool utiles pour traiter des troubles hyperprolifératifs et des maladies associées à l'angiogenèse
SE0001899D0 (sv) New compounds
BRPI0510414A (pt) uso de derivados de quinolina substituìdos para o tratamento de doenças micobacterianas resistentes a fármacos
MY144992A (en) Substituted 1,2,3,4-tetrahydroisoquinoline derivatives.
TNSN06439A1 (fr) Derives de 2-carbamide -4-phenylthiazole, leur preparation et leur application en therapeutique
MXPA04004842A (es) Inhibidores de 11-(-hidroxiesteroide deshidrogenasa de tipo 1.
MXPA04004837A (es) Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1.
MY148480A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
BRPI0418099A (pt) compostos, composição farmacêutica, e uso de um composto
BR0210028A (pt) Agentes antibacterianos
BRPI0514661B8 (pt) antagonistas de vasopressina v1a, composição farmacêutica e uso dos referidos antagonistas
MA28742B1 (fr) Derives de pyrido-pyrimidine, leur preparation, leur application en therapeutique