| Accurate prediction of protein structures and interactions using a three-track neural network M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ... Science 373 (6557), 871-876, 2021 | 5916 | 2021 |
| Phospholipase A2 structure/function, mechanism, and signaling1 JE Burke, EA Dennis Journal of lipid research 50, S237-S242, 2009 | 1194 | 2009 |
| Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ... Nature methods 16 (7), 595-602, 2019 | 755 | 2019 |
| Phospholipase A2 Biochemistry JE Burke, EA Dennis Cardiovascular drugs and therapy 23 (1), 49-59, 2009 | 591 | 2009 |
| Structural basis for activation and inhibition of class I phosphoinositide 3-kinases O Vadas, JE Burke, X Zhang, A Berndt, RL Williams Science signaling 4 (195), re2-re2, 2011 | 348 | 2011 |
| Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA) JE Burke, O Perisic, GR Masson, O Vadas, RL Williams Proceedings of the National Academy of Sciences, 2012 | 330 | 2012 |
| Structural basis for regulation of phosphoinositide kinases and their involvement in human disease JE Burke Molecular cell 71 (5), 653-673, 2018 | 284 | 2018 |
| Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes K Rostislavleva, N Soler, Y Ohashi, L Zhang, E Pardon, JE Burke, ... Science 350 (6257), aac7365, 2015 | 284 | 2015 |
| Diversity-oriented synthesis yields novel multistage antimalarial inhibitors N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ... Nature 538 (7625), 344-349, 2016 | 283 | 2016 |
| Synergy in activating class I PI3Ks JE Burke, RL Williams Trends in biochemical sciences 40 (2), 88-100, 2015 | 238 | 2015 |
| Novel roles of phosphoinositides in signaling, lipid transport, and disease GRV Hammond, JE Burke Current Opinion in Cell Biology 63, 57-67, 2020 | 230 | 2020 |
| An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery GR Masson, ML Jenkins, JE Burke Expert opinion on drug discovery 12 (10), 981-994, 2017 | 200 | 2017 |
| G protein–coupled receptor–mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness HA Dbouk, O Vadas, A Shymanets, JE Burke, RS Salamon, BD Khalil, ... Science signaling 5 (253), ra89-ra89, 2012 | 183 | 2012 |
| Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi G D’Angelo, T Uemura, CC Chuang, E Polishchuk, M Santoro, ... Nature 501 (7465), 116-120, 2013 | 179 | 2013 |
| Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne TET Mevissen, Y Kulathu, MPC Mulder, PP Geurink, SL Maslen, M Gersch, ... Nature 538 (7625), 402-405, 2016 | 177 | 2016 |
| Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors JE Burke, AJ Inglis, O Perisic, GR Masson, SH McLaughlin, F Rutaganira, ... Science 344 (6187), 1035-1038, 2014 | 166 | 2014 |
| Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs) O Vadas, HA Dbouk, A Shymanets, O Perisic, JE Burke, WF Abi Saab, ... Proceedings of the National Academy of Sciences 110 (47), 18862-18867, 2013 | 164 | 2013 |
| Beyond PI3Ks: targeting phosphoinositide kinases in disease JE Burke, J Triscott, BM Emerling, GRV Hammond Nature Reviews Drug Discovery 22 (5), 357-386, 2023 | 133 | 2023 |
| Ras binder induces a modified switch-II pocket in GTP and GDP states DR Gentile, MK Rathinaswamy, ML Jenkins, SM Moss, BD Siempelkamp, ... Cell chemical biology 24 (12), 1455-1466. e14, 2017 | 133 | 2017 |
| Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease MK Rathinaswamy, JE Burke Advances in Biological Regulation 75, 100657, 2020 | 128 | 2020 |
Roger L WilliamsGroup leader, Medical Research Council, Laboratory of Molecular BiologyVerified email at mrc-lmb.cam.ac.uk
