| Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified Gq AV Smrcka, JR Hepler, KO Brown, PC Sternweis Science 251 (4995), 804-807, 1991 | 1187 | 1991 |
| Roles of PLC-β2 and-β3 and PI3Kγ in chemoattractant-mediated signal transduction Z Li, H Jiang, W Xie, Z Zhang, AV Smrcka, D Wu Science 287 (5455), 1046-1049, 2000 | 1075 | 2000 |
| A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits L Stephens, A Smrcka, FT Cooke, TR Jackson, PC Sternweis, PT Hawkins Cell 77 (1), 83-93, 1994 | 808 | 1994 |
| Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible B Hinkes, RC Wiggins, R Gbadegesin, CN Vlangos, D Seelow, ... Nature genetics 38 (12), 1397-1405, 2006 | 711 | 2006 |
| G protein βγ subunits: central mediators of G protein-coupled receptor signaling AV Smrcka Cellular and molecular life sciences 65 (14), 2191-2214, 2008 | 612 | 2008 |
| Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits AV Smrcka, PC Sternweis Journal of Biological Chemistry 268 (13), 9667-9674, 1993 | 608 | 1993 |
| Phospholipase Cϵ: a novel Ras effector GG Kelley, SE Reks, JM Ondrako, AV Smrcka The EMBO journal, 2001 | 503 | 2001 |
| Directional sensing requires Gβγ-mediated PAK1 and PIXα-dependent activation of Cdc42 Z Li, M Hannigan, Z Mo, B Liu, W Lu, Y Wu, AV Smrcka, G Wu, L Li, M Liu, ... Cell 114 (2), 215-227, 2003 | 493 | 2003 |
| Reconstitution of agonist-stimulated phosphatidylinositol 4, 5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1. G Berstein, JL Blank, AV Smrcka, T Higashijima, PC Sternweis, JH Exton, ... Journal of Biological Chemistry 267 (12), 8081-8088, 1992 | 415 | 1992 |
| Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4, 5-bisphosphate hydrolysis by … S Gutowski, A Smrcka, L Nowak, DG Wu, M Simon, PC Sternweis Journal of Biological Chemistry 266 (30), 20519-20524, 1991 | 385 | 1991 |
| Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits JR Hepler, T Kozasa, AV Smrcka, MI Simon, SG Rhee, PC Sternweis, ... Journal of Biological Chemistry 268 (19), 14367-14375, 1993 | 344 | 1993 |
| Regulation of phospholipase C by G proteins PC Sternweis, AV Smrcka Trends in biochemical sciences 17 (12), 502-506, 1992 | 328 | 1992 |
| Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation DM Lehmann, A Seneviratne, AV Smrcka Molecular pharmacology 73 (2), 410-418, 2008 | 309 | 2008 |
| Differential targeting of Gβγ-subunit signaling with small molecules TM Bonacci, JL Mathews, C Yuan, DM Lehmann, S Malik, D Wu, JL Font, ... Science 312 (5772), 443-446, 2006 | 307 | 2006 |
| Epac and phospholipase Cϵ regulate Ca2+ release in the heart by activation of protein kinase Cϵ and calcium-calmodulin kinase II EA Oestreich, S Malik, SA Goonasekera, BC Blaxall, GG Kelley, ... Journal of Biological Chemistry 284 (3), 1514-1522, 2009 | 267 | 2009 |
| Epac-mediated activation of phospholipase Cɛ plays a critical role in β-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes EA Oestreich, H Wang, S Malik, KA Kaproth-Joslin, BC Blaxall, GG Kelley, ... Journal of Biological Chemistry 282 (8), 5488-5495, 2007 | 251 | 2007 |
| Targeting G protein-coupled receptor signalling by blocking G proteins AP Campbell, AV Smrcka Nature reviews Drug discovery 17 (11), 789-803, 2018 | 239 | 2018 |
| G protein beta gamma subunits. Simplified purification and properties of novel isoforms. N Ueda, JA Iñiguez-Lluhi, E Lee, AV Smrcka, JD Robishaw, AG Gilman Journal of Biological Chemistry 269 (6), 4388-4395, 1994 | 234 | 1994 |
| Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy L Zhang, S Malik, J Pang, H Wang, KM Park, DI Yule, BC Blaxall, ... Cell 153 (1), 216-227, 2013 | 207 | 2013 |
| Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids W Xie, GM Samoriski, JP McLaughlin, VA Romoser, A Smrcka, PM Hinkle, ... Proceedings of the National Academy of Sciences 96 (18), 10385-10390, 1999 | 202 | 1999 |
