| Accurate prediction of protein structures and interactions using a three-track neural network M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ... Science 373 (6557), 871-876, 2021 | 5916 | 2021 |
| Ras binder induces a modified switch-II pocket in GTP and GDP states DR Gentile, MK Rathinaswamy, ML Jenkins, SM Moss, BD Siempelkamp, ... Cell chemical biology 24 (12), 1455-1466. e14, 2017 | 133 | 2017 |
| Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease MK Rathinaswamy, JE Burke Advances in Biological Regulation 75, 100657, 2020 | 128 | 2020 |
| Conformational sampling of membranes by Akt controls its activation and inactivation I Lučić, MK Rathinaswamy, L Truebestein, DJ Hamelin, JE Burke, ... Proceedings of the National Academy of Sciences 115 (17), E3940-E3949, 2018 | 120 | 2018 |
| Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas BD Siempelkamp, MK Rathinaswamy, ML Jenkins, JE Burke Journal of Biological Chemistry 292 (29), 12256-12266, 2017 | 81 | 2017 |
| Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation MK Rathinaswamy, U Dalwadi, KD Fleming, C Adams, JTB Stariha, ... Science Advances 7 (35), eabj4282, 2021 | 47 | 2021 |
| Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus ML Jenkins, H Ranga-Prasad, MAH Parson, NJ Harris, MK Rathinaswamy, ... Nature Communications 14 (1), 181, 2023 | 46 | 2023 |
| Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors MK Rathinaswamy, Z Gaieb, KD Fleming, C Borsari, NJ Harris, ... Elife 10, e64691, 2021 | 40 | 2021 |
| Neolymphostin A is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic vinylogous ester G Castro-Falcón, GS Seiler, O Demir, MK Rathinaswamy, D Hamelin, ... Journal of medicinal chemistry 61 (23), 10463-10472, 2018 | 33 | 2018 |
| Defining how oncogenic and developmental mutations of PIK3R1 alter the regulation of class IA phosphoinositide 3-kinases GL Dornan, JTB Stariha, MK Rathinaswamy, CJ Powell, MJ Boulanger, ... Structure 28 (2), 145-156. e5, 2020 | 27 | 2020 |
| HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases MK Rathinaswamy, KD Fleming, U Dalwadi, E Pardon, NJ Harris, CK Yip, ... Structure 29 (12), 1371-1381. e6, 2021 | 18 | 2021 |
| Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs MK Rathinaswamy, ML Jenkins, BR Duewell, X Zhang, NJ Harris, ... Cell Reports 42 (3), 2023 | 11 | 2023 |
| Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex Q Hao, MK Rathinaswamy, KL Klinge, M Bratkowski, A Mafi, ... Communications Chemistry 7 (1), 183, 2024 | 7 | 2024 |
| Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain NJ Harris, ML Jenkins, SE Nam, MK Rathinaswamy, MAH Parson, ... Elife 12, RP88058, 2023 | 7 | 2023 |
| ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding GQ Gong, GR Masson, WJ Lee, JMJ Dickson, JD Kendall, ... Biochemical Journal 481 (23), 1787-1802, 2024 | 3 | 2024 |
| Structural basis of MPL activation by thrombopoietin A Mafi, M Bratkowski, J Geng, AA Brito, J Sridar, D Hu, AT Darcy, ... Blood Vessels, Thrombosis & Hemostasis 1 (3), 100018, 2024 | 2 | 2024 |
| Molecular basis for the regulation of phosphoinositide 3-kinase γ (PI3Kγ) MK Rathinaswamy | 1 | 2021 |
| Systematic metabolite screening identifies functional regulators of the adenosine A2A receptor P Rao, M Rathinaswamy, M Chan, AG Paredes, C Patel, BJ Wranik, ... Communications Chemistry, 2025 | | 2025 |
| Systematic metabolite screening identifies orthosteric and allosteric regulators of the adenosine A2A receptor P Rao, M Rathinaswamy, M Chan, K Hicks, A Mafi, Q Hao Structural Dynamics 12 (5_Supplement), A72-A72, 2025 | | 2025 |
| Structural Basis for Activation of the Thrombopoietin Receptor (MPL) By Its Ligand (TPO) M Bratkowski, A Mafi, J Geng, Y Kutskova, A Brito, MK Rathinaswamy, ... Blood 142, 1306, 2023 | | 2023 |
