ZA983618B - Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them - Google Patents

Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them

Info

Publication number: ZA983618B
Authority: ZA; South Africa
Prior art keywords: contain; preparation; pharmaceutical compositions; cyclosporin derivatives; novel cyclosporin
Prior art date: 1997-04-30

Application number

ZA983618A

Other languages

English (en)

Inventor

Michel Evers

Jean-Christophe Carry

Georges Bashiardes

Jean-Christophe Gueguen

Serge Mignani

Bruno Filoche

Claude Bensoussan

Jean-Claude Barriere

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-30

Filing date

1998-04-29

Publication date

1998-11-04

1998-04-29 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1998-11-04 Publication of ZA983618B publication Critical patent/ZA983618B/xx

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA983618A 1997-04-30 1998-04-29 Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them ZA983618B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9705351A FR2762843B1 (fr)	1997-04-30	1997-04-30	Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ZA983618B true ZA983618B (en)	1998-11-04

Family

ID=9506467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA983618A ZA983618B (en)	1997-04-30	1998-04-29	Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them

Country Status (13)

Country	Link
US (1)	US5977067A (xx)
EP (1)	EP0979244B1 (xx)
JP (1)	JP2001524105A (xx)
AT (1)	ATE290015T1 (xx)
AU (1)	AU7535798A (xx)
DE (1)	DE69829175T2 (xx)
ES (1)	ES2236902T3 (xx)
FR (1)	FR2762843B1 (xx)
MA (1)	MA26488A1 (xx)
PT (1)	PT979244E (xx)
TN (1)	TNSN98057A1 (xx)
WO (1)	WO1998049193A1 (xx)
ZA (1)	ZA983618B (xx)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
CN100334106C (zh)	2001-10-19	2007-08-29	伊索泰克尼卡股份有限公司	环孢菌素类似物的合成
US7060672B2 (en) *	2001-10-19	2006-06-13	Isotechnika, Inc.	Cyclosporin analog formulations
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
WO2004020454A2 (en) *	2002-08-30	2004-03-11	Biorexis Pharmaceutical Corporation	Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains
JP2006524232A (ja)	2003-03-17	2006-10-26	アルバニーモレキュラーリサーチインコーポレーティッド	新規サイクロスポリン
DE602004030105D1 (de) *	2003-05-05	2010-12-30	Virxsys Corp	Erhöhte transduktion mit abc-transportersubstratenhemmern
US7511013B2 (en)	2004-09-29	2009-03-31	Amr Technology, Inc.	Cyclosporin analogues and their pharmaceutical uses
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
NZ554514A (en) *	2004-10-01	2010-10-29	Scynexis Inc	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
AU2006299426B2 (en) *	2005-09-30	2012-07-26	Scynexis, Inc.	Methods and pharmaceutical compositions for the treatment and prevention of hepatitis C infection
DE602006020152D1 (de) *	2005-09-30	2011-03-31	Scynexis Inc	Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
CA2625700A1 (en) *	2005-10-14	2007-04-26	Allergan, Inc.	Prevention and treatment of drug-associated ocular side effects with a cyclosporin
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
CA2652662C (en)	2006-05-19	2015-11-03	Scynexis, Inc.	Methods for the treatment and prevention of ocular disorders
US20100194497A1 (en) *	2006-06-02	2010-08-05	Claude Annie Perrichon	Management of active electrons
WO2008069917A2 (en)	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
EP2280989B1 (en)	2008-06-06	2016-02-10	Scynexis, Inc.	Cyclosporin analogs and their use in the treatment of hcv infections
MX2011001152A (es) *	2008-07-30	2011-06-09	Isotechnika Pharma Inc	Moleculas de analogo de ciclosporina no-inmunesupresoras.
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2010076329A1 (en)	2008-12-31	2010-07-08	Scynexis, Inc.	Derivatives of cyclosporin a
WO2010088573A1 (en)	2009-01-30	2010-08-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) *	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
CA2763207A1 (en) *	2009-05-27	2010-12-02	Allergan, Inc.	Cyclosporin derivatives for treating inflammatory diseases and conditions
US20100305047A1 (en) *	2009-05-27	2010-12-02	Allergan, Inc.	Cyclosporin derivatives for enhancing the growth of hair
US8685917B2 (en) *	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
JP2013516424A (ja)	2009-12-30	2013-05-13	サイネクシス，インコーポレーテッド	シクロスポリン類似体
US9175042B2 (en)	2010-10-12	2015-11-03	Allergan, Inc.	Cyclosporin analogs
BR112013008864A2 (pt)	2010-10-12	2016-06-28	Allergan Inc	análogos d ciclosporina
PL2651965T3 (pl)	2010-12-15	2019-04-30	Contravir Pharmaceuticals Inc	Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3
DE102011111991A1 (de) *	2011-08-30	2013-02-28	Lead Discovery Center Gmbh	Neue Cyclosporin-Derivate
EP2705856A1 (en)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Compounds for the treatment of neurodegenerative disorders
CN104603146B (zh)	2012-09-29	2018-01-02	诺华股份有限公司	环肽类化合物及其作为药物的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (en) *	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
US4798823A (en) *	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
US4885276A (en) *	1987-06-03	1989-12-05	Merck & Co., Inc.	Cyclosporin analogs with modified "C-9 amino acids"
DE69124459T3 (de) *	1990-11-02	2001-05-31	Novartis Ag, Basel	Zyklosporine
US5512555A (en) *	1994-07-21	1996-04-30	Merck & Co., Inc.	Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one
ATE209216T1 (de) *	1995-07-17	2001-12-15	Chem Ag C	Cyclosporin-derivate mit anti-hiv-wirkung

1997
- 1997-04-30 FR FR9705351A patent/FR2762843B1/fr not_active Expired - Fee Related
1998
- 1998-04-27 PT PT98922872T patent/PT979244E/pt unknown
- 1998-04-27 DE DE69829175T patent/DE69829175T2/de not_active Expired - Lifetime
- 1998-04-27 ES ES98922872T patent/ES2236902T3/es not_active Expired - Lifetime
- 1998-04-27 WO PCT/FR1998/000838 patent/WO1998049193A1/fr not_active Ceased
- 1998-04-27 EP EP98922872A patent/EP0979244B1/fr not_active Expired - Lifetime
- 1998-04-27 MA MA25048A patent/MA26488A1/fr unknown
- 1998-04-27 AU AU75357/98A patent/AU7535798A/en not_active Abandoned
- 1998-04-27 AT AT98922872T patent/ATE290015T1/de active
- 1998-04-27 JP JP54666498A patent/JP2001524105A/ja active Pending
- 1998-04-29 ZA ZA983618A patent/ZA983618B/xx unknown
- 1998-04-29 TN TNTNSN98057A patent/TNSN98057A1/fr unknown
- 1998-04-30 US US09/069,959 patent/US5977067A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT979244E (pt)	2005-06-30
EP0979244A1 (fr)	2000-02-16
WO1998049193A1 (fr)	1998-11-05
EP0979244B1 (fr)	2005-03-02
FR2762843A1 (fr)	1998-11-06
FR2762843B1 (fr)	1999-12-10
ES2236902T3 (es)	2005-07-16
DE69829175D1 (de)	2005-04-07
US5977067A (en)	1999-11-02
MA26488A1 (fr)	2004-12-20
AU7535798A (en)	1998-11-24
ATE290015T1 (de)	2005-03-15
DE69829175T2 (de)	2006-02-16
TNSN98057A1 (fr)	2005-03-15
JP2001524105A (ja)	2001-11-27

Publication	Publication Date	Title
ZA983618B (en)	1998-11-04	Novel cyclosporin derivatives their preparation and the pharmaceutical compositions which contain them
ZA9711607B (en)	1998-06-24	Novel cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
ZA9711606B (en)	1998-06-25	Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.
BG103945A (en)	2000-07-31	Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a
AUPR213700A0 (en)	2001-01-25	Antiviral agents
ZA200104396B (en)	2002-11-29	Compositions and methods for stimulating gastrointestinal motility.
BG103947A (en)	2000-07-31	Derivatives of 9-oxymerythromycin
KR0141913B1 (en)	1998-06-01	Anti-virus agents
CZ77995A3 (en)	1995-10-18	Derivatives of lipopeptides, process of their preparation and use
EP1274443A4 (en)	2008-12-31	MICELLES
HU9601649D0 (en)	1996-08-28	Hiv protease inhibitors
GR3019274T3 (en)	1996-06-30	Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use
CA2282279A1 (en)	1998-09-03	Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions
PH31395A (en)	1998-10-29	Bis-naphthalimides for the treatment of cancer.
NZ514425A (en)	2002-12-20	Compositions based on chondroitin sulphate and chitosan for preventing or treating rheumatic disorders by general administration
ZA981430B (en)	1998-08-24	Anticancer composition
AP9801235A0 (en)	1999-11-07	Erythromycin derivatives.
IL112110A0 (en)	1995-03-15	Octahydro-1h-isoindoles and pharmaceutical compositions containing them
GR3023941T3 (en)	1997-09-30	Cyclic derivatives of angiopeptin, their preparation and their pharmaceutical compositions.
CA2352332A1 (en)	2000-06-08	Hygromycin a derivatives
PT1451184E (pt)	2008-09-17	Compostos diméricos e sua utilização como agentes antivirais
MXPA99003849A (es)	2003-09-23	Derivados 9a, 11b-deshidro de 9-oxima-3-ceto-6-0-metileritromicina.
GEP20053513B (en)	2005-05-10	2-Aminocarbonyl-9H-Purine Derivatives
HUT68015A (en)	1995-05-29	New compound leustroducsin h, its preparation and pharmaceutical compositions containing them
MY111630A (en)	2000-10-31	Amino acid derivatives.