ZA9811128B - 1,3,8-Triaza-spiro(4,5)decan-4-on derivatives - Google Patents

1,3,8-Triaza-spiro(4,5)decan-4-on derivatives

Info

Publication number: ZA9811128B
Authority: ZA; South Africa
Prior art keywords: triaza; decan; spiro; derivatives
Prior art date: 1997-12-05

Application number

ZA9811128A

Other languages

English (en)

Inventor

Geo Adam

Andrea Cesura

Guido Galley

Francois Jenck

Stephan Roever

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-05

Filing date

1998-12-04

Publication date

1999-06-07

1998-12-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-06-07 Publication of ZA9811128B publication Critical patent/ZA9811128B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Color Printing (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA9811128A 1997-12-05 1998-12-04 1,3,8-Triaza-spiro(4,5)decan-4-on derivatives ZA9811128B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97121427		1997-12-05

Publications (1)

Publication Number	Publication Date
ZA9811128B true ZA9811128B (en)	1999-06-07

Family

ID=8227753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9811128A ZA9811128B (en)	1997-12-05	1998-12-04	1,3,8-Triaza-spiro(4,5)decan-4-on derivatives

Country Status (29)

Country	Link
US (1)	US6043366A (es)
JP (1)	JP3366868B2 (es)
KR (1)	KR19990062800A (es)
CN (1)	CN1118467C (es)
AR (1)	AR016428A1 (es)
AT (1)	ATE212635T1 (es)
AU (1)	AU744338B2 (es)
BR (1)	BR9805297B1 (es)
CA (1)	CA2255171C (es)
CO (1)	CO4990965A1 (es)
CZ (1)	CZ399698A3 (es)
DE (1)	DE69803653T2 (es)
DK (1)	DK0921125T3 (es)
ES (1)	ES2170446T3 (es)
HR (1)	HRP980613A2 (es)
HU (1)	HUP9802807A3 (es)
ID (1)	ID21413A (es)
IL (1)	IL127399A0 (es)
MA (1)	MA26573A1 (es)
NO (1)	NO312161B1 (es)
NZ (1)	NZ333159A (es)
PE (1)	PE135299A1 (es)
PL (1)	PL330062A1 (es)
PT (1)	PT921125E (es)
SG (1)	SG71173A1 (es)
TR (1)	TR199802520A3 (es)
TW (1)	TW408123B (es)
YU (1)	YU55198A (es)
ZA (1)	ZA9811128B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69923744T2 (de) *	1998-10-23	2006-02-23	Pfizer Inc.	1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
AU1948601A (en) *	1999-12-06	2001-06-12	Euro-Celtique S.A.	Triazospiro compounds having nociceptin receptor affinity
ATE396995T1 (de) *	2001-07-23	2008-06-15	Banyu Pharma Co Ltd	4-oxoimidazolidin-2-spiro piperidin derivat
ES2392340T3 (es)	2002-03-29	2012-12-07	Mitsubishi Tanabe Pharma Corporation	Remedio para los trastornos del sueño
MXPA05002622A (es) *	2002-09-09	2005-09-08	Johnson & Johnson	Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano.
WO2004058727A1 (en) *	2002-12-20	2004-07-15	Bayer Pharmaceuticals Corporation	Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
US20080287478A1 (en) *	2003-05-23	2008-11-20	Lars Bo Laurenborg Hansen	Nociceptin Analogues and Uses Thereof
DE602004010419T2 (de) *	2003-10-23	2008-10-09	F. Hoffmann-La Roche Ag	Triazaspiropiperidinderivate zur verwendung als glyt-1-inhibitoren bei der behandlung von neurologischen und neuropsychiatrischen erkrankungen
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
BRPI0609580A2 (pt) *	2005-03-22	2010-04-20	Hoffmann La Roche	composto, polimorfo cristalino, processo para a sua manufatura, composições farmacêuticas que o contêm, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e utilização do composto
EP2035420A2 (en) *	2006-06-20	2009-03-18	Wyeth a Corporation of the State of Delaware	Kv1.5 potassium channel inhibitors
CN101622254B (zh) *	2006-11-28	2013-05-29	詹森药业有限公司	3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
CN101622241B (zh)	2007-03-01	2013-05-22	田边三菱制药株式会社	苯并咪唑化合物及其医药用途
US8741916B2 (en) *	2007-04-09	2014-06-03	Janssen Pharmaceutica Nv	1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor
PA8801401A1 (es) *	2007-10-25	2009-05-15	Janssen Pharmaceutica Nv	Arilindenopirimidinas y su uso como adenosina a2a
TW201016675A (en) *	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
US20100076003A1 (en) *	2008-09-19	2010-03-25	Kathleen Battista	5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators
WO2010037081A1 (en) *	2008-09-29	2010-04-01	Palatin Technologies, Inc.	Melanocortin receptor-specific spiro-piperidine compounds
CN102459278A (zh)	2009-06-16	2012-05-16	默沙东公司	取代的-1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮
CN107849044B (zh) *	2015-07-03	2021-06-25	豪夫迈·罗氏有限公司	作为ddr1抑制剂的三氮杂-螺癸酮类化合物
EP4508037A1 (en) *	2022-04-15	2025-02-19	The Chinese University of Hong Kong	Carbobicyclic nucleosides for treatment of viral infection

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3155669A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3161644A (en) *	1962-06-22	1964-12-15	Res Lab Dr C Janssen N V	1-benzyl-4-substituted piperidines
US3155670A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3238216A (en) *	1963-06-20	1966-03-01	Res Lab Dr C Janssen N V	Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
GB1486546A (en) *	1975-02-28	1977-09-21	Yoshitomo Pharma Ind Ltd	4,4-diphenyl-cyclohexylpiperidine compounds and analogues thereof
JPS51100084A (es) *	1975-02-28	1976-09-03	Yoshitomi Pharmaceutical
JPS5212171A (en) *	1975-07-17	1977-01-29	Yoshitomi Pharmaceut Ind Ltd	Process for preparation of cyclohexane derivatives
JPS5934713B2 (ja) *	1976-01-05	1984-08-24	ウェルファイド株式会社	脂環式誘導体
US4076821A (en) *	1976-02-27	1978-02-28	Yoshitomi Pharmaceutical Industries, Ltd.	4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
MA19091A1 (fr) *	1980-03-10	1981-10-01	Janssen Pharmaceutica Nv	Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
US4329353A (en) *	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
GR73633B (es) *	1980-03-10	1984-03-26	Janssen Pharmaceutica Nv
EP0114787B1 (de) *	1983-01-25	1991-09-25	Ciba-Geigy Ag	Neue Peptidderivate
JPS6012357B2 (ja) *	1984-01-23	1985-04-01	吉富製薬株式会社	脂環式誘導体
CA2226058C (en) *	1997-01-30	2008-01-29	F. Hoffmann-La Roche Ag	8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives

1998
- 1998-11-27 DK DK98122511T patent/DK0921125T3/da active
- 1998-11-27 DE DE69803653T patent/DE69803653T2/de not_active Expired - Lifetime
- 1998-11-27 PT PT98122511T patent/PT921125E/pt unknown
- 1998-11-27 AT AT98122511T patent/ATE212635T1/de active
- 1998-11-27 ES ES98122511T patent/ES2170446T3/es not_active Expired - Lifetime
- 1998-12-03 ID IDP981576A patent/ID21413A/id unknown
- 1998-12-03 PE PE1998001176A patent/PE135299A1/es not_active Application Discontinuation
- 1998-12-03 CA CA002255171A patent/CA2255171C/en not_active Expired - Fee Related
- 1998-12-03 PL PL98330062A patent/PL330062A1/xx unknown
- 1998-12-03 SG SG1998005141A patent/SG71173A1/en unknown
- 1998-12-03 AR ARP980106141A patent/AR016428A1/es active IP Right Grant
- 1998-12-03 NZ NZ333159A patent/NZ333159A/en unknown
- 1998-12-03 US US09/204,184 patent/US6043366A/en not_active Expired - Fee Related
- 1998-12-03 YU YU55198A patent/YU55198A/sh unknown
- 1998-12-04 IL IL12739998A patent/IL127399A0/xx unknown
- 1998-12-04 TR TR1998/02520A patent/TR199802520A3/tr unknown
- 1998-12-04 CO CO98072457A patent/CO4990965A1/es unknown
- 1998-12-04 CZ CZ983996A patent/CZ399698A3/cs unknown
- 1998-12-04 JP JP34527898A patent/JP3366868B2/ja not_active Expired - Fee Related
- 1998-12-04 ZA ZA9811128A patent/ZA9811128B/xx unknown
- 1998-12-04 KR KR1019980053080A patent/KR19990062800A/ko not_active Ceased
- 1998-12-04 MA MA25369A patent/MA26573A1/fr unknown
- 1998-12-04 TW TW087120132A patent/TW408123B/zh not_active IP Right Cessation
- 1998-12-04 NO NO19985684A patent/NO312161B1/no not_active IP Right Cessation
- 1998-12-04 AU AU96087/98A patent/AU744338B2/en not_active Ceased
- 1998-12-04 CN CN98122759A patent/CN1118467C/zh not_active Expired - Fee Related
- 1998-12-04 HR HR97121427.5A patent/HRP980613A2/hr not_active Application Discontinuation
- 1998-12-04 BR BRPI9805297-7A patent/BR9805297B1/pt not_active IP Right Cessation
- 1998-12-04 HU HU9802807A patent/HUP9802807A3/hu unknown

Also Published As

Publication number	Publication date
NO312161B1 (no)	2002-04-02
US6043366A (en)	2000-03-28
ATE212635T1 (de)	2002-02-15
JPH11228575A (ja)	1999-08-24
TW408123B (en)	2000-10-11
HUP9802807A2 (hu)	1999-08-30
CN1222521A (zh)	1999-07-14
BR9805297B1 (pt)	2010-07-13
DE69803653D1 (de)	2002-03-14
AU9608798A (en)	1999-06-24
CZ399698A3 (cs)	1999-06-16
PT921125E (pt)	2002-06-28
CN1118467C (zh)	2003-08-20
PE135299A1 (es)	2000-01-18
TR199802520A2 (xx)	1999-06-21
HUP9802807A3 (en)	2000-01-28
PL330062A1 (en)	1999-06-07
HRP980613A2 (en)	1999-08-31
NO985684L (no)	1999-06-07
DK0921125T3 (da)	2002-05-13
BR9805297A (pt)	2000-02-01
YU55198A (sh)	2001-12-26
DE69803653T2 (de)	2002-08-29
NZ333159A (en)	2000-06-23
JP3366868B2 (ja)	2003-01-14
AR016428A1 (es)	2001-07-04
CA2255171A1 (en)	1999-06-05
ES2170446T3 (es)	2002-08-01
CO4990965A1 (es)	2000-12-26
CA2255171C (en)	2009-09-29
ID21413A (id)	1999-06-10
MA26573A1 (fr)	2004-12-20
NO985684D0 (no)	1998-12-04
TR199802520A3 (tr)	1999-06-21
AU744338B2 (en)	2002-02-21
KR19990062800A (ko)	1999-07-26
SG71173A1 (en)	2000-03-21
IL127399A0 (en)	1999-10-28
HU9802807D0 (en)	1999-02-01

Publication	Publication Date	Title
HU9800138D0 (en)	1998-03-30	8-substituted-1,3,8-triaza-spiro [4,5]-decan-4-on derivatives
EG24081A (en)	2008-05-11	4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives
SI0921125T1 (en)	2002-04-30	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
HUP0003642A3 (en)	2001-11-28	N-alkanoylphenylalanine derivatives
GB9702194D0 (en)	1997-03-26	Sulphonide derivatives
ZA987602B (en)	1999-05-04	N-alkanoylphenylalanine derivatives
PL334847A1 (en)	2000-03-27	Substituted 3-heterocyclyl-benzoyl derivatives
SI0891978T1 (en)	2002-06-30	5H-Thiazolo (3,2-a) pyrimidine derivatives
IL125226A0 (en)	1999-03-12	Heterocycle-condensed morphinoid derivatives (II)
IL127399A0 (en)	1999-10-28	1,3,8-Triaza-spiro (4,5) decan-4-on derivatives
HU9801168D0 (en)	1998-08-28	Triazinylaminostilbene derivatives
IL128701A0 (en)	2000-01-31	1,2,3,4-Tetrahydro-benzofuro (3,2-c)pyridine derivatives
GB2321457B (en)	2001-02-28	5-Aroylnaphthalene derivatives
IL132982A0 (en)	2001-03-19	Cis-disubstituted aminocycloalkyl-pyrrolidine derivatives
ZA982436B (en)	1999-09-23	Thiazolimine derivatives.
GB9715821D0 (en)	1997-10-01	Amidino-camptothecin derivatives
GB9725541D0 (en)	1998-02-04	Amino-benzothiazole derivatives
GB9701628D0 (en)	1997-03-19	Imino-aza-anthracyclinone derivatives
ZA983116B (en)	1998-10-21	Arylsecocholadiene derivatives
HRP970162A2 (en)	1998-04-30	1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
HU9800889D0 (en)	1998-06-29	New naphtylpiperazine derivatives
IL131159A0 (en)	2001-01-28	4-Aminoethoxyindazole derivatives
GB9706753D0 (en)	1997-05-21	Aralkoxy-morphinan derivatives
SI1005445T1 (en)	2004-12-31	N-alkanoylphenylalanine derivatives
ZA983700B (en)	1998-11-24	1-galactose derivatives